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1. 发明授权

US08518919B2 Compositions comprising azelastine and methods of use thereof 有权
标题翻译：包含氮卓斯汀的组合物及其使用方法
公开(公告)号：US08518919B2
公开(公告)日：2013-08-27
申请号：US13294069
申请日：2011-11-10
申请人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
发明人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
IPC分类号： A61K31/55 , A61P11/00 , A61P27/14 , A61P37/08
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K9/7007 , A61K31/55 , A61K45/06 , Y02A90/22 , Y02A90/26 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.
摘要翻译：本发明提供包含氮卓斯汀或其药学上可接受的盐或酯的药物组合物，包括盐酸萘曲斯汀和任选的一种或多种另外的活性剂。优选的这种组合物还包含一种或多种药学上可接受的载体或赋形剂，其减少鼻后滴液的量，和/或将组合物与鼻腔滴注相关的令人不快的苦味最小化或掩盖到口腔中鼻内或眼部给药组合物。用于本发明组合物中的特别有效的赋形剂是作为粘度调节剂的羟丙甲纤维素和作为掩味剂的三氯蔗糖。本发明还提供了通过向患者施用本发明组合物，例如用于过敏性鼻炎，非过敏性血管舒缩性鼻炎，过敏性结膜炎以及其他疾病。

2. 发明授权

US10064817B2 Compositions comprising azelastine and methods of use thereof 有权
公开(公告)号：US10064817B2
公开(公告)日：2018-09-04
申请号：US13284836
申请日：2011-10-28
申请人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
发明人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
IPC分类号： A61K31/56 , A61K31/57 , A61K31/573 , A61K31/58 , A61K31/575 , A61P11/02 , A61P27/14 , A61P29/00 , A61P37/08 , A61K9/00 , A61K9/70 , A61K31/55 , A61K45/06
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.

3. 发明申请

US20120083479A1 Compositions Comprising Azelastine and Methods of Use Thereof 审中-公开
公开(公告)号：US20120083479A1
公开(公告)日：2012-04-05
申请号：US13284836
申请日：2011-10-28
申请人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
发明人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
IPC分类号： A61K31/56 , A61K31/573 , A61K31/58 , A61P37/08 , A61P11/02 , A61P27/14 , A61P29/00 , A61K31/57 , A61K31/575
CPC分类号： A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K9/7007 , A61K31/55 , A61K31/56 , A61K31/573 , A61K31/58 , A61K45/06 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.

4. 发明申请

US20120149690A1 Compositions Comprising Azelastine and Methods of Use Thereof 有权
标题翻译：包含阿曲斯他汀的组合物及其使用方法
公开(公告)号：US20120149690A1
公开(公告)日：2012-06-14
申请号：US13294069
申请日：2011-11-10
申请人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
发明人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
IPC分类号： A61K31/55 , A61P27/14 , A61P37/08 , A61P11/00
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K9/7007 , A61K31/55 , A61K45/06 , Y02A90/22 , Y02A90/26 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders.
摘要翻译：本发明提供包含氮卓斯汀或其药学上可接受的盐或酯的药物组合物，包括盐酸萘曲斯汀和任选的一种或多种另外的活性剂。优选的这种组合物还包含一种或多种药学上可接受的载体或赋形剂，其减少鼻后滴液的量，和/或将组合物与鼻腔滴注相关的令人不快的苦味最小化或掩盖到口腔中鼻内或眼部给药组合物。用于本发明组合物中的特别有效的赋形剂是作为粘度调节剂的羟丙甲纤维素和作为掩味剂的三氯蔗糖。本发明还提供了通过将本发明的组合物给予患者来治疗或预防某些疾病或症状缓解的方法，例如用于过敏性鼻炎，非过敏性血管舒缩性鼻炎，过敏性结膜炎的症状缓解以及其他疾病。

5. 发明授权

US08071073B2 Compositions comprising azelastine and methods of use thereof 有权
标题翻译：包含氮卓斯汀的组合物及其使用方法
公开(公告)号：US08071073B2
公开(公告)日：2011-12-06
申请号：US11284109
申请日：2005-11-22
申请人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
发明人： Phuong Grace Dang , Brian D. Lawrence , Gul Balwani , Alexander D. D'Addio
IPC分类号： A61L9/04 , A61K31/55 , A61K9/20
CPC分类号： A61K47/26 , A61K9/0043 , A61K9/0048 , A61K9/0056 , A61K9/0073 , A61K9/7007 , A61K31/55 , A61K45/06 , Y02A90/22 , Y02A90/26 , A61K2300/00
摘要： The present invention provides pharmaceutical compositions comprising azelastine, or a pharmaceutically acceptable salt or ester thereof including azelastine hydrochloride, and optionally one or more additional active agents. Preferred such compositions further comprise one or more pharmaceutically acceptable carriers or excipients that reduce the amount of post-nasal drip, and/or that minimize or mask the unpleasant bitter taste associated with post-nasal drip, of the compositions into the oral cavity, upon intranasal or ocular administration of the compositions. Especially effective excipients used in the compositions of the present invention are hypromellose as a viscosity modifier and sucralose as a taste-masking agent. The invention also provides methods of treating or preventing certain disorders, or symptomatic relief therefrom, by administering the compositions of the invention to a patient, e.g., for the symptomatic relief of allergic rhinitis, non-allergic vasomotor rhinitis, allergic conjunctivitis, as well as other disorders. The compositions and methods of the present invention provide significant value in terms of patient acceptability, convenience, and compliance.
摘要翻译：本发明提供包含氮卓斯汀或其药学上可接受的盐或酯的药物组合物，包括盐酸萘曲斯汀和任选的一种或多种另外的活性剂。优选的这种组合物还包含一种或多种药学上可接受的载体或赋形剂，其减少鼻后滴液的量，和/或将组合物与鼻腔滴注相关的令人不快的苦味最小化或掩盖到口腔中鼻内或眼部给药组合物。用于本发明组合物中的特别有效的赋形剂是作为粘度调节剂的羟丙甲纤维素和作为掩味剂的三氯蔗糖。本发明还提供了通过将本发明的组合物给予患者来治疗或预防某些疾病或症状缓解的方法，例如用于过敏性鼻炎，非过敏性血管舒缩性鼻炎，过敏性结膜炎的症状缓解以及其他疾病。本发明的组合物和方法在患者可接受性，方便性和依从性方面提供了显着的价值。

6. 发明授权

US06462094B1 Decongestant/expectorant compositions 有权
标题翻译：减充血/祛痰组合物
公开(公告)号：US06462094B1
公开(公告)日：2002-10-08
申请号：US09938149
申请日：2001-08-22
申请人： Phuong Grace Dang , Alexander D. D'Addio
发明人： Phuong Grace Dang , Alexander D. D'Addio
IPC分类号： A01N2500
CPC分类号： A61K31/09 , A61K31/7024 , A61K2300/00
摘要： Compositions consisting essentially of phenylephrine tannate and guaifenesin which are effective when administered orally for the symptomatic relief of cough associated with respiratory tract conditions such as the common cold, bronchial asthma, acute and chronic bronchitis are disclosed.
摘要翻译：公开了基本上由苯肾上腺素鞣酸酯和愈创甘油醚组成的组合物，其在口服用于与呼吸道疾病如呼吸道疾病如普通感冒，支气管哮喘，急性和慢性支气管炎相关的咳嗽症状缓解时有效。

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