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1. 发明申请

US20020161035A1 Medicaments for chemotherapeutic treatment of disease 失效
标题翻译：化疗药物治疗疾病
公开(公告)号：US20020161035A1
公开(公告)日：2002-10-31
申请号：US09900355
申请日：2001-07-06
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott
IPC分类号： A61K039/395 , A61K031/352
CPC分类号： A61K41/0057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0014 , A61K9/0019 , A61K31/352 , A61K41/0071 , A61K47/10 , A61K47/12 , A61K47/20 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/193333
摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的化学治疗药物和用于治疗人或动物组织中的这种化学治疗药物的某些医疗用途和方法，其中这种药物的主要活性成分是卤化呫吨或卤代呫吨衍生物。优选地，卤代呫吨是玫瑰红或玫瑰红的功能衍生物。卤代呫吨构成一系列有用的化学治疗剂，其在某些组织中提供选择性的，持续的积累。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物可用于体内或局部给药的各种制剂，包括在液体，半固体，固体或气溶胶输送载体中。

2. 发明申请

US20030133940A1 Medicaments for chemotherapeutic treatment of disease 审中-公开
公开(公告)号：US20030133940A1
公开(公告)日：2003-07-17
申请号：US10331735
申请日：2002-12-30
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott
IPC分类号： A61K039/395 , A61K031/353 , A61K048/00
CPC分类号： A61K41/0057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0014 , A61K9/0019 , A61K31/352 , A61K41/0071 , A61K47/10 , A61K47/12 , A61K47/20 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/193333
摘要： New chemotherapeutic medicaments and certain medical uses and methods for use of such chemotherapeutic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. Preferably, the halogenated xanthene is Rose Bengal or a functional derivative of Rose Bengal. The halogenated xanthenes constitute a family of useful chemotherapeutic agents that afford selective, persistent accumulation in certain tissues. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations useful for intracorporeal or topical administration, including in liquid, semisolid, solid or aerosol delivery vehicles.

3. 发明申请

US20030125376A1 Intracorporeal medicaments for high energy phototherapeutic treatment of disease 有权
公开(公告)号：US20030125376A1
公开(公告)日：2003-07-03
申请号：US10331854
申请日：2002-12-30
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K031/353
CPC分类号： A61K41/0038 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K31/352 , A61K41/0057 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y10S436/813 , Y10S436/819
摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.

4. 发明申请

US20020107281A1 Phototherapeutic and chemotherapeutic immunotherapy against tumors 审中-公开
标题翻译：针对肿瘤的光治疗和化疗免疫治疗
公开(公告)号：US20020107281A1
公开(公告)日：2002-08-08
申请号：US09952448
申请日：2001-09-14
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter
IPC分类号： A61K031/352
CPC分类号： A61K41/0057
摘要： The present invention is directed to new methods, medicaments and pharmaceutical compositions and agents for improved cancer treatment that lower recurrence of the primary tumor by causing selective, acute destruction of tumor tissue and thereby exposing the immune system to large amounts of substantially non-denatured tumor material over a short period of time. This effectively vaccinates the host against tumor tissue, allowing the host's immune system to attack any residual tumor tissue, and thereby reduces the recurrence rate and metastasis to remote sites. In preferred embodiments, this enhancement is achieved through application of phototherapeutic or chemotherapeutic modalities that are capable of producing such an acute, necrotic effect on treated lesions without completely denaturing tumor antigens.
摘要翻译：本发明涉及用于改善癌症治疗的新方法，药物和药物组合物和试剂，其通过引起肿瘤组织的选择性，急性破坏并由此使免疫系统暴露于大量基本上非变性的肿瘤而降低原发性肿瘤的复发材料在短时间内。这有效地使宿主免疫肿瘤组织，允许宿主的免疫系统攻击任何残留的肿瘤组织，从而降低远端部位的复发率和转移。在优选的实施方案中，通过应用能够对治疗的病变产生这种急性坏死作用的光疗法或化学治疗方式而不使肿瘤抗原完全变性来实现该增强。

5. 发明申请

US20020001567A1 Intracorporeal medicaments for high energy phototherapeutic treatment of disease 审中-公开
标题翻译：用于高能量光疗治疗疾病的体内药物
公开(公告)号：US20020001567A1
公开(公告)日：2002-01-03
申请号：US09817448
申请日：2001-03-26
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K031/365 , A61K031/352 , A61N001/30
CPC分类号： A61K41/0038 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K31/352 , A61K41/0057 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y10S436/813 , Y10S436/819
摘要： New intracorporeal radiodense medicaments and certain medical uses and methods for use of such high energy phototherapeutic medicaments for treatment of human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. The halogenated xanthenes constitute a family of potent radiosensitizers that become photoactivated upon irradiation of the treatment site with ionizing radiation. In embodiments of the present invention, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内放射碘化物药物和用于治疗人或动物组织的这种高能光疗药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤化呫吨衍生物。卤化呫吨构成了一种有效的放射增敏剂，其在用电离辐射照射治疗部位时变得光活化。在本发明的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官的各种病症，循环系统和相关器官，头颈部，内分泌和淋巴系统及相关器官，各种其他组织，例如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个实施方案中，这些药物是以包括液体，半固体，固体或气溶胶输送载体在内的各种制剂生产的。

6. 发明申请

US20010022970A1 Intracorporeal medicaments for photodynamic treatment of disease 有权
标题翻译：用于光动力治疗疾病的体内药物
公开(公告)号：US20010022970A1
公开(公告)日：2001-09-20
申请号：US09799785
申请日：2001-03-06
申请人： Photogen, Inc.
发明人： H. Craig Dees , Timothy C. Scott , Eric A. Wachter , Walter G. Fisher , John Smolik
IPC分类号： A61K048/00 , A61K039/395 , A61K031/352
CPC分类号： A61K31/352 , A61B2017/00057 , A61B2017/22062 , A61B2017/22087 , A61F7/00 , A61K9/0019 , A61K41/0038 , A61K41/0057 , A61K41/0071 , A61K41/008 , A61K47/10 , A61K47/12 , A61K47/20 , A61K47/6803 , A61K49/0041 , A61K49/0433 , A61N5/0601 , A61N5/062 , C07D311/82 , Y02A50/473 , Y10T436/153333 , Y10T436/19 , Y10T436/193333
摘要： New intracorporeal photodynamic medicaments and certain medical uses and methods for use of such photodynamic medicaments for treatment of disease in human or animal tissue are described, wherein a primary active component of such medicaments is a halogenated xanthene or halogenated xanthene derivative. In preferred embodiments, such medicaments are used for treatment of a variety of conditions affecting the skin and related organs, the mouth and digestive tract and related organs, the urinary and reproductive tracts and related organs, the respiratory tract and related organs, the circulatory system and related organs, the head and neck, the endocrine and lymphoreticular systems and related organs, various other tissues, such as connective tissues and various tissue surfaces exposed during surgery, as well as various tissues exhibiting microbial or parasitic infection. In another preferred embodiment, such medicaments are produced in various formulations including liquid, semisolid, solid or aerosol delivery vehicles.
摘要翻译：描述了新的体内光动力学药物和用于治疗人或动物组织中的这种光动力药物的某些医学用途和方法，其中这种药物的主要活性成分是卤代呫吨或卤代呫吨衍生物。在优选的实施方案中，这些药物用于治疗影响皮肤和相关器官，口腔和消化道及相关器官，泌尿生殖道和相关器官，呼吸道及相关器官，循环系统内脏和淋巴系统及相关器官，各种其他组织，如结缔组织和手术期间暴露的各种组织表面，以及表现出微生物或寄生虫感染的各种组织。在另一个优选的实施方案中，这些药物以包括液体，半固体，固体或气溶胶递送载体的各种制剂生产。

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