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1. 发明申请

US20090074786A1 FORMULATIONS FOR TREATING OCULAR DISEASES AND CONDITIONS 有权
标题翻译：治疗卵巢疾病和病症的制剂
公开(公告)号：US20090074786A1
公开(公告)日：2009-03-19
申请号：US12193686
申请日：2008-08-18
申请人： Philippe J.M. Dor , Sreenivasu Mudumba , Thierry Nivaggioli , David A. Weber , Sidiq Farooq , Sudeep K. Takhar
发明人： Philippe J.M. Dor , Sreenivasu Mudumba , Thierry Nivaggioli , David A. Weber , Sidiq Farooq , Sudeep K. Takhar
IPC分类号： A61K31/436 , A61P27/02 , A61K39/395
CPC分类号： A61K31/436
摘要： Diseases and conditions associated with tissues of the body, including but not limited to tissues in the eye, can be effectively treated, prevented, inhibited, onset delayed, or regression caused by administering therapeutic agents to those tissues. Described herein are liquid formulations which deliver a variety of therapeutic agents, including but not limited to rapamycin, to a subject for an extended period of time; liquid formulations which form a non-dispersed mass when placed in an aqueous medium of a subject; non-dispersed mass-forming liquid formulations which form a gel or gel-like substance in an aqueous medium; liquid formulations, comprising a therapeutic agent and a plurality of polymers; and methods for delivering therapeutic agents to a subject for an extended period of time using the liquid formulations. The liquid formulation may be placed in an aqueous medium of a subject, including but not limited to via intraocular or periocular administration, or placement proximate to a site of a disease or condition to be treated in a subject. A method may be used to administer rapamycin to treat or prevent angiogenesis, choroidal neovascularization, or age-related macular degeneration, or wet age-related macular degeneration in a subject. The liquid formulations may comprise rapamycin or other therapeutic agents.
摘要翻译：包括但不限于眼睛中的组织的疾病和病症可被有效治疗，预防，抑制，发作延迟或由给予这些组织的治疗剂引起的回归。本文描述的是液体制剂，其将多种治疗剂（包括但不限于雷帕霉素）递送给受试者较长时间; 当被置于受试者的水性介质中时形成非分散物质的液体制剂; 在水性介质中形成凝胶或凝胶状物质的非分散质量形成液体制剂; 液体制剂，包含治疗剂和多种聚合物; 以及使用液体制剂将治疗剂递送给受试者较长时间的方法。液体制剂可以放置在受试者的水性介质中，包括但不限于通过眼内或眼周内施用，或靠近受试者待治疗的疾病或病症的位置放置。可以使用方法来施用雷帕霉素以治疗或预防受试者的血管生成，脉络膜新生血管形成或年龄相关性黄斑变性或湿性年龄相关性黄斑变性。液体制剂可以包含雷帕霉素或其它治疗剂。

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