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1. 发明授权

US5763450A Substituted benzyl pyrimidines 失效
标题翻译：取代苄基嘧啶
公开(公告)号：US5763450A
公开(公告)日：1998-06-09
申请号：US836857
申请日：1997-05-21
申请人： Philippe Guerry , Synese Jolidon , Raffaello Masciadri , Henri Stalder , Rudolf Then
发明人： Philippe Guerry , Synese Jolidon , Raffaello Masciadri , Henri Stalder , Rudolf Then
IPC分类号： A61K31/505 , A61K31/506 , A61K31/53 , A61K31/535 , A61K31/675 , A61K31/695 , A61P31/04 , C07C255/37 , C07D215/56 , C07D239/48 , C07D239/49 , C07D401/06 , C07D401/10 , C07D401/12 , C07D401/14 , C07D403/10 , C07D405/10 , C07D405/12 , C07D405/14 , C07D409/10 , C07D413/10 , C07D417/10 , C07D471/04 , C07F7/10 , C07F7/18 , C07F9/6512
CPC分类号： C07D239/49 , C07D401/10 , C07D403/10 , C07D405/10 , C07D405/14 , C07D471/04 , C07F7/1856 , C07F9/65122
摘要： Compounds of the formula: ##STR1## in which R.sup.1 is lower alkoxy, R.sup.2 is bromine or lower alkoxy, and R.sup.3 is aryl, heteroaryl or a group --Q--R.sup.30, wherein Q is ethylene, vinylene or ethynylene and R.sup.30 is aryl, heteroaryl, lower alkoxycarbonyl or carbamoyl; hydrolyzable esters of carboxylic acids of formula I; and pharmaceutically acceptable salts of these compounds are useful for treating infectious diseases.
摘要翻译： PCT No.PCT / EP95 / 04451 Sec。 371日期1997年5月21日 102（e）日期1997年5月21日PCT提交1995年11月13日PCT公布。公开号WO96 / 16046 日期：1996年5月30日化学式为：其中R1为低级烷氧基，R2为溴或低级烷氧基，R3为芳基，杂芳基或基团-Q-R30的式Ⅰ化合物，其中Q为亚乙基，亚乙烯基或亚乙炔基， R30是芳基，杂芳基，低级烷氧基羰基或氨基甲酰基; 式I的羧酸的可水解的酯; 和这些化合物的药学上可接受的盐可用于治疗感染性疾病。

2. 发明授权

US6114330A Substituted 2,4-diaminopyrimidines 失效
标题翻译：取代的2,4-二氨基嘧啶
公开(公告)号：US6114330A
公开(公告)日：2000-09-05
申请号：US28980
申请日：1998-02-25
申请人： Philippe Guerry , Christian Hubschwerlen , Synese Jolidon , Jean-Luc Specklin , Pierre-Charles Wyss
发明人： Philippe Guerry , Christian Hubschwerlen , Synese Jolidon , Jean-Luc Specklin , Pierre-Charles Wyss
IPC分类号： A61K31/505 , A61K31/506 , A61K31/5377 , A61P31/04 , C07D401/14 , C07D403/10 , C07D403/14 , C07D405/14 , C07D409/14 , C07D247/02
CPC分类号： C07D403/10 , C07D403/14 , C07D405/14
摘要： The invention is concerned with compounds of formula ##STR1## wherein R.sup.1 is lower-alkoxy, R.sup.2 is hydroxy or lower-alkoxy, R.sup.3 is hydrogen, cyano, alkyl, alkenyl, cycloalkyl, aryl, heterocycyl, aryl-Q-alkyl, or a group of the formula --CR.sup.4 R.sup.4 'COR.sup.5 --, Q is --SO-- or --SO.sub.2 --; R.sup.4, R.sup.4 ' are each independently hydrogen, alkyl, aryl or heterocyclyl, R.sup.5 is hydrogen, alkyl, alkoxy, hydroxy, aryl or heterocycyl, or R.sup.4 and R.sup.5 together form --(CH.sub.2).sub.n --, and n is a whole number between 2 to 5 inclusive and the enantiomers, epimers, and diastereomers thereof, as well as pharmaceutically acceptable salts thereof. These compounds have valuable antibacterial activity.
摘要翻译：本发明涉及下式的化合物，其中R 1是低级烷氧基，R 2是羟基或低级烷氧基，R 3是氢，氰基，烷基，烯基，环烷基，芳基，杂环基，芳基-C-烷基或式-CR4R4'COR5-，Q是-SO-或-SO2-; R 4，R 4'各自独立地为氢，烷基，芳基或杂环基，R 5为氢，烷基，烷氧基，羟基，芳基或杂环基，或者R 4和R 5一起形成 - （CH 2）n - ，n为2 5和其对映异构体，差向异构体和非对映异构体，以及其药学上可接受的盐。这些化合物具有有价值的抗菌活性。

3. 发明授权

US5214046A Substituted aminoalkoxybenzene anti-fungicidal compositions and use 失效
标题翻译：取代氨基烷氧基苯类杀真菌剂及用途
公开(公告)号：US5214046A
公开(公告)日：1993-05-25
申请号：US832190
申请日：1992-02-06
申请人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
发明人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
IPC分类号： C07C217/18 , C07C217/20 , C07C217/22 , C07C217/46 , C07D205/04 , C07D295/092
CPC分类号： C07D295/088 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/46 , C07D205/04
摘要： The compound of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 to 4 carbon atoms, R.sup.3 is hydrogen, halogen or lower alkyl, Q is alkylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies or alkenylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies and each of Y and Y' individually is a direct bond or the group --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--, the group R.sup.1 R.sup.2 N--Q--O-- is attached to the 3- or 4 -position of ring A and the symbol R designates that the ring to which it is attached is unsubstituted or is substituted with at least one substitutent selected from the group consisting of halogen, trifluoromethyl, cyano, nitro, lower alkyl and lower alkoxy,and their pharmaceutically acceptable acid addition salts can be used for the control or prevention of fungal infections, especially of topical or systemic infections which are caused by pathogenic fungi, and for the manufacture of antifungally-active medicaments. The compounds of formula I have not only a pronounced antifungal activity, but they also exhibit synergistic effects in combination with other known antifungally-active substances which inhibit sterol biosynthesis such as ketoconazole and terbinafine.
摘要翻译：式Ⅰ化合物其中R 1和R 2各自独立地为氢，低级烷基或低级烯基或一起表示具有2至4个碳原子的直链亚烷基，R 3为氢，卤素或低级烷基，Q为亚烷基在两个自由价之间具有4至11个碳原子和至少4个碳原子，在两个自由价之间具有4至11个碳原子和至少4个碳原子的亚烯基，Y和Y'各自独立地是直接键合或基团-CH 2 - ， - CH 2 CH 2 - ， - CH = CH-或-CB 3 -C-基团，R 1 R 2 N-QO-连接到环A的3-或4-位，符号R表示环其连接是未取代的或被至少一个选自卤素，三氟甲基，氰基，硝基，低级烷基和低级烷氧基的取代基取代，并且其药学上可接受的酸加成盐可用于控制或预防真菌感染，特别是局部或全身疾病由致病真菌引起的作用和用于制造抗真菌药物。式I化合物不仅具有显着的抗真菌活性，而且还与抑制甾醇生物合成的其它已知的抗真菌活性物质如酮康唑和特比萘芬组合显示协同效应。

4. 发明授权

US5177067A Substituted aminoalkyl biphenyl compounds and method of treating fungal infections 失效
标题翻译：取代的氨基胆碱化合物和治疗真菌感染的方法
公开(公告)号：US5177067A
公开(公告)日：1993-01-05
申请号：US718495
申请日：1991-06-19
申请人： Philippe Guerry , Synese Jolidon
发明人： Philippe Guerry , Synese Jolidon
IPC分类号： A61K31/135 , A61P31/04 , A61P31/10 , C07C215/30 , C07C217/48 , C07C225/16 , C07C255/58 , C07D295/10
CPC分类号： C07C225/16 , C07C215/30 , C07C255/58
摘要： Antimycotically-active compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are hydrogen, C.sub.1-7 -alkyl or C.sub.2-7 -alkenyl or together are a straight chain C.sub.2-4 -alkylene; R.sup.3 and R.sup.4 each independently are hydrogen or C.sub.1-7 -alkyl; R.sup.5 and R.sup.6 each independently are hydrogen, halogen, trifluoromethyl, nitro, cyano, C.sub.1-7 -alkoxy or C.sub.1-7 -alkyl; and Q is an unsubstituted or substituted phenyl or naphthyl group, wherein the substituents are at least one of halogen, trifluoromethyl, cyano, nitro, C.sub.1-7 -alkyl, C.sub.1-7 -alkoxy; C.sub.2-10 -alkenyl; or a substituted or unsubstituted C.sub.1-10 -alkyl group wherein said substituents are at least one hydroxy group; andpharmaceutically acceptable acid addition salts thereof.
摘要翻译：式IMA的抗真菌活性化合物，其中R 1和R 2各自独立地为氢，C 1-7 - 烷基或C 2-7 - 烯基或一起为直链C 2-4 - 亚烷基; R 3和R 4各自独立地为氢或C 1-7 - 烷基; R 5和R 6各自独立地为氢，卤素，三氟甲基，硝基，氰基，C 1-7 - 烷氧基或C 1-7 - 烷基; Q为未取代或取代的苯基或萘基，其中取代基为卤素，三氟甲基，氰基，硝基，C 1-7 - 烷基，C 1-7 - 烷氧基， C2-10-烯基; 或取代或未取代的C 1-10 - 烷基，其中所述取代基是至少一个羟基; 及其药学上可接受的酸加成盐。

5. 发明授权

US5239084A Substituted aminoalkyl biphenyl compounds 失效
标题翻译：取代的氨基烷基联苯化合物
公开(公告)号：US5239084A
公开(公告)日：1993-08-24
申请号：US943268
申请日：1992-09-10
申请人： Philippe Guerry , Synese Jolidon
发明人： Philippe Guerry , Synese Jolidon
IPC分类号： C07C215/30 , C07C225/16 , C07C255/58
CPC分类号： C07C225/16 , C07C215/30 , C07C255/58
摘要： Antimycotically-active compounds of the formula ##STR1## wherein R.sup.1 and R.sup.2 each independently are hydrogen, C.sub.1-7 -alkyl or C.sub.2-7 -alkenyl or together are a straight chain C.sub.2-4 -alkylene; R.sup.3 and R.sup.4 each independently are hydrogen or C.sub.1-7 -alkyl; R.sup.5 and R.sup.6 each independently are hydrogen, halogen, trifluoromethyl, nitro, cyano, C.sub.1-7 -alkoxy or C.sub.1-7 -alkyl; and Q is an unsubstituted or substituted phenyl or naphthyl group, wherein the substituents are at least one of halogen, trifluoromethyl, cyano, nitro, C.sub.1-7 -alkyl, C.sub.1-7 -alkoxy; C.sub.2-10 -alkenyl; or a substituted or unsubstituted C.sub.1-10 -alkyl group wherein said substituents are at least one hydroxy group; andpharmaceutically acceptable acid addition salts thereof.
摘要翻译：式IMA的抗真菌活性化合物，其中R 1和R 2各自独立地为氢，C 1-7 - 烷基或C 2-7 - 烯基或一起为直链C 2-4 - 亚烷基; R 3和R 4各自独立地为氢或C 1-7 - 烷基; R 5和R 6各自独立地为氢，卤素，三氟甲基，硝基，氰基，C 1-7 - 烷氧基或C 1-7 - 烷基; Q为未取代或取代的苯基或萘基，其中取代基为卤素，三氟甲基，氰基，硝基，C 1-7 - 烷基，C 1-7 - 烷氧基， C2-10-烯基; 或取代或未取代的C 1-10 - 烷基，其中所述取代基是至少一个羟基; 及其药学上可接受的酸加成盐。

6. 发明授权

US5137920A Method of treating fungal infections 失效
标题翻译：治疗真菌感染的方法
公开(公告)号：US5137920A
公开(公告)日：1992-08-11
申请号：US533605
申请日：1990-06-05
申请人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
发明人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
IPC分类号： A61K31/135 , A61K31/275 , A61K31/40 , A61P31/04 , C07C215/28 , C07C217/48 , C07C225/16 , C07C253/30 , C07C255/58 , C07D295/10 , C07D295/108
CPC分类号： C07D295/108 , C07C215/28 , C07C217/48 , C07C225/16 , C07C255/58
摘要： Compunds having the formula ##STR1## wherein each of R.sup.1 and R.sup.2 individually is hydrogen, lower alkyl, or lower alkenyl, R.sup.3 is hydrogen, halogen or lower alkyl, Q is alkylene with 2 to 11 carbon atoms and at least 2 carbon atoms between the two free valencies or alkenylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies and each of Y and Y' individually is a direct bond, the group R.sup.1 R.sup.2 --N--Q--CH.sub.2 -- is attached to the 3- or 4-position of ring A and the symbol R represents that the ring to which it is attached is unsubstituted or is substituted with at least one of halogen, trifluoromethyl, cyano, nitro, lower alkyl or lower alkoxy, and their pharmaceutically acceptable acid addition salts have valuable pharmacological properties. In particular, they have a pronounced antifungal activity and can be used as medicaments, especially for the control or prevention of topical or systemic infections which are caused by pathogenic fungi.
摘要翻译：具有式“IMAGE”I的组合物，其中R 1和R 2各自独立地为氢，低级烷基或低级烯基，R 3为氢，卤素或低级烷基，Q为具有2至11个碳原子的亚烷基和至少2个碳原子两个自由价之间具有4至11个碳原子和至少4个碳原子的两个自由价或亚烯基，Y和Y'各自独立地为直接键，R1R2-NQ-CH2-基团连接到3- 或环A的4位，符号R表示其所连接的环是未取代的或被至少一个卤素，三氟甲基，氰基，硝基，低级烷基或低级烷氧基取代的化合物及其药学上可接受的酸加成盐具有宝贵的药理性质。特别地，它们具有显着的抗真菌活性，并且可以用作药物，特别是用于控制或预防由病原真菌引起的局部或全身感染。

7. 发明授权

US5106878A Use of substituted aminoalkoxybenzene derivatives in the control or prevention of fungal infections 失效
标题翻译：在控制或预防真菌感染中使用取代的氨基甲苯苯衍生物
公开(公告)号：US5106878A
公开(公告)日：1992-04-21
申请号：US556241
申请日：1990-07-20
申请人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
发明人： Philippe Guerry , Synese Jolidon , Rene Zurfluh
IPC分类号： A61K31/13 , A61K31/135 , A61K31/395 , A61P31/04 , C07C43/205 , C07C49/84 , C07C213/02 , C07C213/08 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/46 , C07D205/04 , C07D207/08 , C07D295/08 , C07D295/092
CPC分类号： C07D295/088 , C07C217/18 , C07C217/20 , C07C217/22 , C07C217/46 , C07D205/04
摘要： The compound of the formula ##STR1## wherein each of R.sup.1 and R.sup.2 individually is hydrogen, lower alkyl or lower alkenyl or together signify straight-chain alkylene with 2 or 4 carbon atoms, R.sup.3 is hydrogen, halogen or lower alkyl, Q is alkylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies or alkenylene with 4 to 11 carbon atoms and at least 4 carbon atoms between the two free valencies and each of Y and Y' individually is a direct bond or the group --CH.sub.2 --, --CH.sub.2 CH.sub.2 --, --CH.dbd.CH-- or --C.tbd.C--, the group R.sup.1 R.sup.2 N--Q--O-- is attached to the 3- or 4-position of ring A and the symbol R designates that the ring to which it is attached is unsubstituted or is substituted with at least one substituent selected from the group consisting of halogen, trifluoromethyl, cyano, nitro, lower alkyl and lower alkoxy, and their pharmaceutically acceptable acid addition salts can be used for the control or prevention of fungal infections, especially of topical or systemic infections which are caused by pathogenic fungi, and for the manufacture of antifungally-active medicaments. The compounds of formula I have not only a pronounced antifungal activity, but they also exhibit synergistic effects in combination with other known antifungally-active substances which inhibit sterol biosynthesis such as ketoconazole and terbinafine.
摘要翻译：式Ⅰ化合物，其中R 1和R 2各自独立地为氢，低级烷基或低级烯基或一起表示具有2或4个碳原子的直链亚烷基，R 3为氢，卤素或低级烷基，Q为亚烷基在两个自由价之间具有4至11个碳原子和至少4个碳原子，在两个自由价之间具有4至11个碳原子和至少4个碳原子的亚烯基，Y和Y'各自独立地是直接键合或基团-CH 2 - ， - CH 2 CH 2 - ， - CH = CH-或-C 3BOND C-，基团R 1 R 2 N-QO-连接到环A的3-或4-位，符号R表示环其连接是未取代的或被至少一个选自卤素，三氟甲基，氰基，硝基，低级烷基和低级烷氧基的取代基取代，并且其药学上可接受的酸加成盐可用于控制或预防真菌感染，特别是局部或全身感染由致病真菌引起的离子和用于制造抗真菌药物的离子。式I化合物不仅具有显着的抗真菌活性，而且还与抑制甾醇生物合成的其它已知的抗真菌活性物质如酮康唑和特比萘芬组合显示协同效应。

8. 发明申请

US20130345199A1 1-[M-CARBOXAMIDO(HETERO)ARYL-METHYL]-PIPERIDINE-4-CARBOXAMIDE DERIVATIVES 审中-公开
标题翻译： 1- [M-CARBOXAMIDO（HETERO）ARYL-METHYL] - 哌啶-4-羧酰胺衍生物
公开(公告)号：US20130345199A1
公开(公告)日：2013-12-26
申请号：US13923981
申请日：2013-06-21
申请人： Heinz FRETZ , Markus Gude , Philippe Guerry , Thierry Kimmerlin , Francois Lehembre , Thomas Pfeifer , Anja Valdenaire
发明人： Heinz FRETZ , Markus Gude , Philippe Guerry , Thierry Kimmerlin , Francois Lehembre , Thomas Pfeifer , Anja Valdenaire
IPC分类号： C07D211/66 , C07D401/14 , C07D417/12 , C07D409/12 , C07D401/12 , C07D405/12
摘要： The present invention relates to 1-[m-Carboxamido(hetero)aryl-methyl]-piperidine-4-carboxamide derivatives of formula (I) wherein X, Ar1, R1, R2, R3, R4, R5 and p are as described in the description, to their preparation, to pharmaceutically acceptable salts thereof, and to their use as pharmaceuticals, to pharmaceutical compositions containing one or more compounds of formula (I), and especially to their use as CXCR7 receptor modulators.
摘要翻译：本发明涉及式（I）的1- [间 - 甲酰氨基（杂）芳基 - 甲基] - 哌啶-4-甲酰胺衍生物，其中X，Ar1，R1，R2，R3，R4，R5和p如对其制备的描述，其药学上可接受的盐及其作为药物的用途，含有一种或多种式（I）化合物的药物组合物，特别是其作为CXCR7受体调节剂的用途。

9. 发明授权

US5866583A Substituted 2,4-diaminopyrimidines 失效
标题翻译：取代的2,4-二氨基嘧啶
公开(公告)号：US5866583A
公开(公告)日：1999-02-02
申请号：US842459
申请日：1997-04-24
申请人： Philippe Guerry , Henri Stalder , Pierre-Charles Wyss
发明人： Philippe Guerry , Henri Stalder , Pierre-Charles Wyss
IPC分类号： A61K31/00 , A61K31/505 , A61K31/506 , A61K31/535 , A61K31/5375 , A61K31/5377 , A61P31/00 , A61P31/04 , C07D217/06 , C07D401/04 , C07D401/10 , C07D401/14 , C07D405/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
CPC分类号： C07D401/04 , C07D217/06 , C07D401/10 , C07D401/14 , C07D409/04 , C07D409/14 , C07D417/04 , C07D417/14
摘要： Compounds of formula I ##STR1## wherein R.sup.1 is lower-alkoxy, R.sup.2 is bromine, lower-alkoxy or hydroxy, R.sup.3 is hydrogen, lower-alkyl, cycloalkyl, aryl, heterocyclyl, aralkyl, heterocyclyl-lower-alkyl or cyano, R.sup.4 and R.sup.5 each independently are hydrogen, lower-alkyl, lower-alkoxy, halogen, hydroxy, amino, di(lower alkyl)amino, cyano or nitro and Q is ethynylene or vinylene, or pharmaceutically usable salts thereof, the use of these compounds and their salts as therapeutically active substances; medicaments based on these substances and their production; the use of these substances as medicaments and for the production of antibacterially-active medicaments; as well as the manufacture of the compounds of formula I and their pharmaceutically acceptable salts and intermediates for their manufacture.
摘要翻译：式I的化合物其中R 1是低级烷氧基，R 2是溴，低级烷氧基或羟基，R 3是氢，低级烷基，环烷基，芳基，杂环基，芳烷基，杂环基 - 低级 - 烷基或氰基，R 4 和R 5各自独立地为氢，低级烷基，低级烷氧基，卤素，羟基，氨基，二（低级烷基）氨基，氰基或硝基，Q为亚乙炔基或亚乙烯基或其药学上可用的盐，使用这些化合物和其盐作为治疗活性物质; 基于这些物质及其生产的药物; 使用这些物质作为药物和生产抗菌活性药物; 以及式I化合物及其药学上可接受的盐和其制备中间体的制备。

10. 发明授权

US06821980B1 Substituted 5-benzyl-2,4-diaminopyrimidines 失效
标题翻译：取代的5-苄基-2,4-二氨基嘧啶
公开(公告)号：US06821980B1
公开(公告)日：2004-11-23
申请号：US10129461
申请日：2002-07-18
申请人： Philippe Guerry , Peter Mohr , Marc Muller , Werner Mueller , Philippe Pflieger
发明人： Philippe Guerry , Peter Mohr , Marc Muller , Werner Mueller , Philippe Pflieger
IPC分类号： A61K31505
CPC分类号： C07D239/49 , A61K31/505
摘要： The invention relates to substituted 5-benzyl-2,4-diaminopyrimidines of general formula (A) wherein R1 is C2-C3 alkyl an R2 is heterocyclyl, phenyl or naphthyl, bonded by one of its C-atoms and R3 is C2-C6 alkyl, alkenyl, cycloalkyl, cycloalkylalkyl, heterocyclylalkyl, alkylsulfonyl, cycloalkylsulfonyl, cycloalkylalkylsulfamoyl, heterocyclysylfonyl, heterocyclylalkylsulfonyl or dialkylsulfamoyl; wherein alkyl, cycloalkyl and alyenyl can carry up to 6 carbon atoms alone or in compositions and can carry up to 6 ring members heterocyclically, alone, or in compositions and the groups R2 and R3 can be substituted; and to acid addition salts of compounds. The invention also relates to a method for producing the above 5-benzyl-2,4-diaminopyrimidines, to the intermediate. products that are produced, to corresponding medicaments and to the use of 5-benzyl-2,4-diaminopyrimidines as medicinal preparations. The products have antibiotic properties and are useful for combating or preventing infectious diseases.
摘要翻译：本发明涉及通式（A）的取代的5-苄基-2,4-二氨基嘧啶，其中R 1是C 2 -C 3烷基，R 2是其一个C原子键合的杂环基，苯基或萘基， R 3为C 2 -C 6烷基，烯基，环烷基，环烷基烷基，杂环基烷基，烷基磺酰基，环烷基磺酰基，环烷基烷基氨磺酰基，杂芳基磺酰基，杂环基烷基磺酰基或二烷基氨磺酰基。其中烷基，环烷基和亚烯基可以单独或组合物中携带多达6个碳原子，并且可以单独携带多达6个环成员，或者在组合物中并且基团R 2和R 3可以被取代; 和化合物的酸加成盐。本发明还涉及制备上述5-苄基-2,4-二氨基嘧啶的方法。生产的产品，相应的药物和使用5-苄基-2,4-二氨基嘧啶作为药物制剂。该产品具有抗生素特性，可用于对抗或预防传染病。

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