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1. 发明申请

US20060110363A1 Mutant having uracil phosphoribosyl transferase activity 有权
公开(公告)号：US20060110363A1
公开(公告)日：2006-05-25
申请号：US11261561
申请日：2005-10-31
申请人： Philippe Erbs , Richard Jund
发明人： Philippe Erbs , Richard Jund
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C12N9/10 , C12N1/18 , C12N15/74
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.

2. 发明授权

US08211421B2 Mutant having uracil phosphoribosyl transferase activity 有权
标题翻译：具有尿嘧啶磷酸核糖基转移酶活性的突变体
公开(公告)号：US08211421B2
公开(公告)日：2012-07-03
申请号：US12495492
申请日：2009-06-30
申请人： Philippe Erbs , Richard Jund
发明人： Philippe Erbs , Richard Jund
IPC分类号： A61K48/00 , A61K31/70 , A01N65/00 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
摘要翻译：本发明涉及通过UPRT酶的一个或几个残基的突变具有尿嘧啶磷酸核糖转移酶（UPRTase）的多肽。本发明还涉及编码UPRT酶突变体的核苷酸序列，用于表达后者的载体，病毒颗粒，宿主细胞和含有它们的组合物。本发明还涉及它们的治疗用途和使用它们的治疗方法。本发明在自杀基因治疗的上下文中特别有用，特别是用于治疗增殖性和感染性疾病。

3. 发明授权

US06596533B1 Mutant having uracil phosphoribosyl transferase activity 有权
标题翻译：具有尿嘧啶磷酸核糖基转移酶活性的突变体
公开(公告)号：US06596533B1
公开(公告)日：2003-07-22
申请号：US09446084
申请日：2000-08-14
申请人： Philippe Erbs , Richard Jund
发明人： Philippe Erbs , Richard Jund
IPC分类号： C12N1585
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The focus of the present invention is a polypeptide having a uracil phosphoribosyl transferase (UPRTase) activity achieved by mutation of one or more residues of the UPRTase. The invention also relates to a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the nucleotide sequence, a viral particle, and a host cell, as well as a composition containing these. The invention further relates to the therapeutic use and method of treatment by using the mutant UPRTases and related compositions. The invention is particularly useful in the context of therapy by suicide genes, notably for treating proliferative and infectious diseases.
摘要翻译：本发明的重点是具有通过UPRT酶的一个或多个残基的突变而实现的尿嘧啶磷酸核糖转移酶（UPRTase）活性的多肽。本发明还涉及编码UPRTase突变体的核苷酸序列，用于表达核苷酸序列的载体，病毒颗粒和宿主细胞，以及含有它们的组合物。本发明还涉及通过使用突变型UPRT酶和相关组合物的治疗用途和治疗方法。本发明在自杀基因治疗的上下文中特别有用，特别是用于治疗增殖性和感染性疾病。

4. 发明授权

US07572438B2 Mutant having uracil phosphoribosyl transferase activity 有权
标题翻译：具有尿嘧啶磷酸核糖基转移酶活性的突变体
公开(公告)号：US07572438B2
公开(公告)日：2009-08-11
申请号：US11261561
申请日：2005-10-31
申请人： Philippe Erbs , Richard Jund
发明人： Philippe Erbs , Richard Jund
IPC分类号： A61K48/00 , A01N65/00 , A61K31/70 , C12N5/00 , C12N15/00
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
摘要翻译：本发明涉及通过UPRT酶的一个或几个残基的突变具有尿嘧啶磷酸核糖转移酶（UPRTase）的多肽。本发明还涉及编码UPRT酶突变体的核苷酸序列，用于表达后者的载体，病毒颗粒，宿主细胞和含有它们的组合物。本发明还涉及它们的治疗用途和使用它们的治疗方法。本发明在自杀基因治疗的上下文中特别有用，特别是用于治疗增殖性和感染性疾病。

5. 发明授权

US07049117B2 Mutant possessing uracil phosphoribosyl transferase activity 有权
标题翻译：具有尿嘧啶磷酸核糖转移酶活性的突变体
公开(公告)号：US07049117B2
公开(公告)日：2006-05-23
申请号：US10437037
申请日：2003-05-14
申请人： Philippe Erbs , Richard Jund
发明人： Philippe Erbs , Richard Jund
IPC分类号： C12N15/85 , C12N15/54 , C12N15/55 , C12N15/62
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
摘要翻译：本发明涉及通过UPRT酶的一个或几个残基的突变具有尿嘧啶磷酸核糖转移酶（UPRTase）的多肽。本发明还涉及编码UPRT酶突变体的核苷酸序列，用于表达后者的载体，病毒颗粒，宿主细胞和含有它们的组合物。本发明还涉及它们的治疗用途和使用它们的治疗方法。本发明在自杀基因治疗的上下文中特别有用，特别是用于治疗增殖性和感染性疾病。

6. 发明申请

US20100316610A1 MUTANT HAVING URACIL PHOSPHORIBOSYL TRANSFERASE ACTIVITY 有权
标题翻译：具有尿嘧啶磷酸转移酶活性的突变体
公开(公告)号：US20100316610A1
公开(公告)日：2010-12-16
申请号：US12495492
申请日：2009-06-30
申请人： Philippe ERBS , Richard Jund
发明人： Philippe ERBS , Richard Jund
IPC分类号： A61K35/76 , A61P35/00
CPC分类号： C12N9/1077 , A61K38/00 , A61K48/00 , C07K2319/00 , C12N2799/022
摘要： The invention concerns a polypeptide having a uracil phosphoribosyl transferase (UPRTase) by mutation of one or several residues of the UPRTase. The invention also concerns a nucleotide sequence coding for the UPRTase mutant, a vector for expressing the latter, a viral particle, a host cell, and a composition containing them. The invention further concerns their therapeutic use and a treatment method using them. The invention is particularly useful in the context of therapy by suicide genes, in particular, for treating proliferative and infectious diseases.
摘要翻译：本发明涉及通过UPRT酶的一个或几个残基的突变具有尿嘧啶磷酸核糖转移酶（UPRTase）的多肽。本发明还涉及编码UPRT酶突变体的核苷酸序列，用于表达后者的载体，病毒颗粒，宿主细胞和含有它们的组合物。本发明还涉及它们的治疗用途和使用它们的治疗方法。本发明在自杀基因治疗的上下文中特别有用，特别是用于治疗增殖性和感染性疾病。

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