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1. 发明申请

US20050282810A1 Oxindole derivatives 审中-公开
标题翻译：羟吲哚衍生物
公开(公告)号：US20050282810A1
公开(公告)日：2005-12-22
申请号：US11196597
申请日：2005-08-03
申请人： Philip Harris , Robert Hunter , Lee Kuyper , Karen Lackey , Robert McNutt , Michael Peel , Edgar Wood
发明人： Philip Harris , Robert Hunter , Lee Kuyper , Karen Lackey , Robert McNutt , Michael Peel , Edgar Wood
IPC分类号： A61K31/404 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , A61P7/02 , A61P9/10 , A61P29/00 , A61P29/02 , A61P35/00 , A61P43/00 , C07D209/14 , C07D209/34 , C07D401/12 , C07D403/12 , C07D405/12 , C07D487/04
CPC分类号： C07D401/12 , A61K31/4045 , A61K31/405 , A61K31/4184 , A61K31/4196 , A61K31/4245 , A61K31/454 , A61K31/53 , C07D209/14 , C07D209/34 , C07D403/12 , C07D405/12 , C07D487/04
摘要： The present invention is related to oxindole derivatives, compositions containing the same, and methods of use and manufacture of the same. Such compounds generally are useful pharmacologically as agents in those disease states alleviated by the alteration of mitogen activated signaling pathways in general, and in particular in the inhibition or antagonism of protein kinases, which pathologically involve aberrant cellular proliferation. Such disease states include tumor growth, restenosis, atherosclerosis, pain and thrombosis. In particular, the present invention relates to a series of substituted oxindole compounds, which exhibit Trk family protein tyrosine kinase inhibition, and which are useful in cancer therapy and chronic pain indications.
摘要翻译：本发明涉及羟吲哚衍生物，含有它们的组合物及其使用和制造方法。这些化合物通常在药理学上作为通常通过改变促分裂原活化的信号通路而减轻的疾病状态中的药物有用，特别是在病理学上涉及异常细胞增殖的蛋白激酶的抑制或拮抗作用中。这种疾病状态包括肿瘤生长，再狭窄，动脉粥样硬化，疼痛和血栓形成。特别地，本发明涉及一系列取代的羟吲哚化合物，其表现出Trk家族蛋白酪氨酸激酶抑制，并且其可用于癌症治疗和慢性疼痛适应症。

2. 发明申请

US20080114439A1 Non-occluding dilation device 审中-公开
标题翻译：非闭塞扩张装置
公开(公告)号：US20080114439A1
公开(公告)日：2008-05-15
申请号：US11977415
申请日：2007-10-23
申请人： Venkatesh Ramaiah , Robert McNutt
发明人： Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61F2/90 , A61F2/84
CPC分类号： A61F2/95 , A61F2/88 , A61F2/958 , A61F2230/0008 , A61F2230/005 , A61F2250/0059 , A61M29/02
摘要： An assembly including a device for dilating a vessel or a structure (such as a stent or stent graft) within a vessel wherein the device comprises a plurality of wires that are spaced apart when the device is dilated so as to allow fluid to flow through the device. Thus, when in use the device does not occlude or substantially hinder the flow of blood through a vessel or into side vessels. The device may also be flexible enough to be easily maneuvered through tight bends in a vessel and/or be able to conform to varying diameters within a single vessel or within multiple vessels.
摘要翻译：一种组件，其包括用于在容器内扩张容器或结构（例如支架或支架移植物）的装置，其中，所述装置包括当所述装置膨胀时间隔开的多个线，以允许流体流过所述装置设备。因此，当使用时，该装置不会堵塞或基本上妨碍血液通过血管或侧血管的流动。该装置还可以具有足够的灵活性，以容易地通过容器中的弯曲弯曲操作和/或能够在单个容器内或多个容器内符合不同的直径。

3. 发明申请

US20070016243A1 Non-occlusive, retrievable dilation system 审中-公开
标题翻译：非闭塞，可回收的扩张系统
公开(公告)号：US20070016243A1
公开(公告)日：2007-01-18
申请号：US11478340
申请日：2006-06-28
申请人： Venkatesh Ramaiah , Robert McNutt
发明人： Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61F2/958 , A61M2025/1054
摘要： A device for dilating either a vessel within a body or a structure positioned within the vessel is designed so that it does not occlude or substantially hinder the flow of blood through the vessel, thereby decreasing the windsock effect in blood vessels by maintaining fluid flow through the device during dilation. The device includes a plurality of wires that can be expanded from a first position wherein the device can be moved into or retrieved from the vessel, to a second position wherein it dilates the vessel or structure. When dilated, blood or other bodily fluid passes through the openings between the wires rather than being blocked.
摘要翻译：设计用于扩张体内的容器或位于容器内的结构的装置，其设计使得其不会堵塞或基本上妨碍血液通过血管的流动，从而通过保持流体流过血管中的流体流动来降低血管中的风向效应装置在扩张期间。该装置包括多个电线，其可从第一位置膨胀，其中该装置能够移动到该容器中或从该容器取回，该第二位置扩张容器或结构。当血液膨胀时，血液或其他体液通过电线之间的开口而不是被阻塞。

4. 发明申请

US20110082490A1 Non-Occlusive Dilation Devices 有权
标题翻译：非闭塞扩张装置
公开(公告)号：US20110082490A1
公开(公告)日：2011-04-07
申请号：US12780350
申请日：2010-05-14
申请人： Ryan Connelly , Jennifer Egan , Venkatesh Ramaiah , Robert McNutt
发明人： Ryan Connelly , Jennifer Egan , Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61M29/00
CPC分类号： A61M29/02 , A61F2/95 , A61F2/966
摘要： Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.
摘要翻译：公开了一种非闭塞造型导管，其包括用于扩张植入血管内的假体的扩张装置。在一个实施例中，建模导管包括包括以双重重叠图案编织的多个柔顺丝线的装置，并且具有跨越装置的近端和装置的远端之间的长度，其中该装置至少位于植入在容器中的内置假体的一部分，其中，当所述装置处于松弛状态时，在所述多根线之间形成多个空间，以允许流体通过所述多个空间自由移动，并且其中，当所述装置处于扩张状态，多个线被充分地设计成在内部假体上施加径向力，同时持续允许流体自由移动通过多个空间。

5. 发明申请

US20050255151A1 Compositions and methods for reducing respiratory depression and attendant side effects of mu opioid compounds 审中-公开
标题翻译：减少呼吸抑制和阿片样物质副作用的组合物和方法
公开(公告)号：US20050255151A1
公开(公告)日：2005-11-17
申请号：US11184762
申请日：2005-07-19
申请人： Kwen-Jen Chang , Robert McNutt , Hugh Pettit , Michael Bishop
发明人： Kwen-Jen Chang , Robert McNutt , Hugh Pettit , Michael Bishop
IPC分类号： A61K45/00 , A61K9/70 , A61K31/00 , A61K31/40 , A61K31/435 , A61K31/445 , A61K31/485 , A61K31/495 , A61K31/496 , A61K31/55 , A61K45/06 , A61P11/00 , A61P11/16 , A61P43/00 , C07D295/096 , C07D295/155
CPC分类号： A61K31/495 , A61K31/00 , A61K31/40 , A61K31/445 , A61K31/485 , A61K31/496 , A61K31/55 , A61K45/06 , C07D295/096 , C07D295/155 , A61K2300/00
摘要： A method of reducing, treating or preventing drug-mediated respiratory depression, muscle rigidity, or nausea/vomiting in an animal, incident to the administration to said animal of a mixed delta/mu opioid agonist or a respiratory depression-mediating drug, comprising administering to the animal receiving said drug an effective amount of a delta receptor agonist compound. Preferred examples of such delta receptor agonist compound include diarylmethyl piperazine compounds and diarylmethyl piperidine compounds, and pharmaceutical compositions thereof, having utility in medical therapy for reducing respiratory depression associated with certain analgesics, such as mu opiates.
摘要翻译：一种减少，治疗或预防动物中药物介导的呼吸抑制，肌肉僵硬或恶心/呕吐的方法，该方法是向所述动物施用混合的δ/μ阿片样物质激动剂或呼吸抑制介导药物，包括施用给予接受所述药物的动物有效量的δ受体激动剂化合物。这种δ受体激动剂化合物的优选实例包括二芳基甲基哌嗪化合物和二芳基甲基哌啶化合物及其药物组合物，其在医学疗法中具有用于减少与某些镇痛药相关的呼吸抑制作用，例如阿片剂。

6. 发明授权

US08784467B2 Non-occlusive dilation devices 有权
标题翻译：非闭塞性扩张装置
公开(公告)号：US08784467B2
公开(公告)日：2014-07-22
申请号：US12780350
申请日：2010-05-14
申请人： Ryan Connelly , Jennifer Egan , Venkatesh Ramaiah , Robert McNutt
发明人： Ryan Connelly , Jennifer Egan , Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61F2/06 , A61M29/02 , A61F2/95 , A61F2/966
CPC分类号： A61M29/02 , A61F2/95 , A61F2/966
摘要： Non-occlusive modeling catheters including a dilation device for expanding an endoprosthesis implanted in a vessel are disclosed. In an embodiment, a modeling catheter includes a device comprising a plurality of compliant wires braided in a double overlapping pattern and having a length spanning between a proximal end of the device and a distal end of the device, wherein the device is positioned in at least a portion of an endoprosthesis implanted in a vessel, wherein, when the device is in a relaxed state, a plurality of spaces are formed between the plurality of wires to allow fluid to move freely through the plurality of spaces, and wherein, when the device is in a dilated state, the plurality of wires are sufficiently designed to exert a radial force on the endoprosthesis while continually allowing the fluid to move freely through the plurality of spaces.
摘要翻译：公开了一种非闭塞造型导管，其包括用于扩张植入血管内的假体的扩张装置。在一个实施例中，建模导管包括包括以双重重叠图案编织的多个柔顺丝线的装置，并且具有跨越装置的近端和装置的远端之间的长度，其中该装置至少位于植入在容器中的内置假体的一部分，其中，当所述装置处于松弛状态时，在所述多根线之间形成多个空间，以允许流体通过所述多个空间自由移动，并且其中，当所述装置处于扩张状态，多个线被充分地设计成在内部假体上施加径向力，同时持续允许流体自由移动通过多个空间。

7. 发明申请

US20080058856A1 Non-occluding dilation device 审中-公开
标题翻译：非闭塞扩张装置
公开(公告)号：US20080058856A1
公开(公告)日：2008-03-06
申请号：US11820726
申请日：2007-06-19
申请人： Venkatesh Ramaiah , Robert McNutt
发明人： Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61M29/00
CPC分类号： A61F2/95 , A61B17/221 , A61F2/958 , A61M25/1002 , A61M29/02
摘要： A device for dilating a vessel or a structure (such as a stent or stent graft) within a vessel comprises a plurality of wires that are spaced apart when the device is dilated so as to allow fluid to flow through the device. Thus, when in use the device does not occlude or substantially hinder the flow of blood through a vessel or into side vessels.
摘要翻译：用于在容器内扩张容器或结构（例如支架或支架移植物）的装置包括当装置膨胀以间隔开以允许流体流过装置的多根线。因此，当使用时，该装置不会堵塞或基本上妨碍血液通过血管或侧血管的流动。

8. 发明申请

US20070173515A1 DELTA OPIOID RECEPTOR AGONIST COMPOUNDS 审中-公开
标题翻译： DELTA OPIOID RECEPTOR AGONIST化合物
公开(公告)号：US20070173515A1
公开(公告)日：2007-07-26
申请号：US11696806
申请日：2007-04-05
申请人： Kwen-Jen Chang , Klim King , Kestutis Biciunas , Robert McNutt , William Pendergast , Shyi-Tai Jan
发明人： Kwen-Jen Chang , Klim King , Kestutis Biciunas , Robert McNutt , William Pendergast , Shyi-Tai Jan
IPC分类号： A61K31/495 , C07D241/04
CPC分类号： C07D241/04 , A61K31/00 , A61K31/445 , A61K31/495 , A61K31/519 , A61K38/33 , A61K2300/00
摘要： Compositions and methods for treatment of sexual dysfunctions by administering to a subject a pharmaceutical composition comprising a delta opioid receptor agonist in an amount effective to delay the onset of ejaculation in the subject during sexual stimulation.
摘要翻译：用于治疗性功能障碍的组合物和方法，其通过向受试者施用包含δ阿片受体激动剂的药物组合物，所述药物组合物有效地延迟性刺激期间受试者的射精发作。

9. 发明申请

US20070016106A1 Single puncture antegrade-retrograde endovascular sheath 审中-公开
标题翻译：单次穿刺顺行逆行血管内皮鞘
公开(公告)号：US20070016106A1
公开(公告)日：2007-01-18
申请号：US11481575
申请日：2006-07-05
申请人： Venkatesh Ramaiah , Robert McNutt
发明人： Venkatesh Ramaiah , Robert McNutt
IPC分类号： A61M25/00
CPC分类号： A61M25/01 , A61M25/0662 , A61M25/09041 , A61M2025/018 , A61M2025/0681
摘要： The present invention provides a system for directing a first guidewire in a retrograde direction in a blood vessel and for directing a second guidewire in an antegrade direction in a blood vessel. The system includes a dual-lumen obturator having a first lumen leading to a first obturator opening and a second lumen leading to a second obturator opening, and a sheath having a first end having a first sheath opening, a second end having a second opening, a sheath lumen extending from the first end to the second end, and a third sheath opening between the first end and the second end. The first, second, and third sheath openings are in communication with the lumen. A first guidewire is directed through the first lumen and through the second sheath opening in a retrograde direction in the blood vessel, while a second guidewire is directed through the second lumen and through the third sheath opening in an antegrade direction in a blood vessel.
摘要翻译：本发明提供了一种用于在血管中沿逆行方向引导第一导丝并且用于在血管中沿顺向的方向引导第二导丝的系统。该系统包括双腔闭孔器，其具有通向第一闭孔开口的第一腔和通向第二闭孔开口的第二腔，以及具有第一端部的护套，第一端部具有第一护套开口，第二端部具有第二开口，从第一端延伸到第二端的护套腔，以及在第一端和第二端之间的第三护套开口。第一，第二和第三鞘开口与内腔连通。第一导丝在血管中沿逆行方向被引导通过第一内腔并穿过第二鞘开口，而第二导丝在血管中被引导通过第二内腔并沿着顺行方向穿过第三鞘开口。

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