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1. 发明申请

US20090217463A1 DETERGENT COMPOSITION COMPRISING LIPASE 审中-公开
标题翻译：包含脂肪酸的洗涤剂组合物
公开(公告)号：US20090217463A1
公开(公告)日：2009-09-03
申请号：US12393115
申请日：2009-02-26
申请人： Philip Frank Souter , Neil Joseph Lant , Theresa Clare Haynes , Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen
发明人： Philip Frank Souter , Neil Joseph Lant , Theresa Clare Haynes , Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen
IPC分类号： C11D3/386 , C12S11/00 , C11D3/50
CPC分类号： C12N9/20 , C11D3/38627
摘要： This invention relates to compositions comprising certain lipase enzymes and processes for making and using such compositions, including the use of such compositions to clean and/or treat a situs.
摘要翻译：本发明涉及包含某些脂肪酶的组合物和制备和使用这些组合物的方法，包括使用这种组合物来清洁和/或治疗部位。

2. 发明授权

US08187854B2 Lipase variants 有权
标题翻译：脂肪酶变体
公开(公告)号：US08187854B2
公开(公告)日：2012-05-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jürgen Carsten Franz Knötzel , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
IPC分类号： C12N9/20 , C12N1/20 , C12N15/00 , C07H21/04
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

3. 发明申请

US20090029440A1 Lipase Variants 有权
标题翻译：脂肪酶变体
公开(公告)号：US20090029440A1
公开(公告)日：2009-01-29
申请号：US12161582
申请日：2007-01-22
申请人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
发明人： Jesper Vind , Jurgen Carsten Franz , Kim Borch , Allan Svendsen , Thomas Honger Callisen , Debbie Yaver , Mads Eskelund Bjornvad , Peter Kamp Hansen , Haiyan Ge , Michael Lamsa
IPC分类号： C12N9/20 , C12N15/55 , C12N1/15 , C12N1/21
CPC分类号： C12N9/20 , C12N9/18
摘要： The invention provides variant lipases, preferably, variants with reduced tendency to odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明提供了变体脂肪酶，优选具有通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味产生倾向的变体。

4. 发明申请

US20090221033A1 Polypeptides Having Lipase Activity And Polynucleotides Encoding Same 有权
标题翻译：具有脂肪酶活性的多肽和编码相同的多核苷酸
公开(公告)号：US20090221033A1
公开(公告)日：2009-09-03
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
IPC分类号： C12P21/06 , C12P7/64 , C12N9/20 , C12N5/00 , C12N15/63 , C07H21/04
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译：本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。

5. 发明授权

US07919298B2 Polypeptides having lipase activity and polynucleotides encoding same 有权
标题翻译：具有脂肪酶活性的多肽和编码该多肽的多核苷酸
公开(公告)号：US07919298B2
公开(公告)日：2011-04-05
申请号：US12393283
申请日：2009-02-26
申请人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
发明人： Jesper Vind , Jurgen Carsten Franz Knotzel , Kim Borch , Allan Svendsen , Thomas Hoenger Callisen , Debbie Yaver , Mads Eskelund Bjoernvad , Peter Kamp Hansen
IPC分类号： C12N9/20 , C12N1/20 , C12N15/00 , C12Q1/00 , C12Q1/68 , C12P21/04 , C12P7/00 , C07H21/04
CPC分类号： C12N9/20
摘要： The invention provides polypeptides obtained by introducing mutations in one or more regions identified in a parent lipase. The polypeptides of the present invention have surprisingly been found to have a low specific activity towards short chain fatty acids leading to a reduced odor generation and an increased BR over the lipases known in the art.
摘要翻译：本发明提供通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的多肽。令人惊奇地发现本发明的多肽对短链脂肪酸具有低比活性，导致气味产生减少，并且在本领域已知的脂肪酶上增加BR。

6. 发明申请

US20070179074A1 Detergent compositions 审中-公开
标题翻译：洗涤剂组合物
公开(公告)号：US20070179074A1
公开(公告)日：2007-08-02
申请号：US11656254
申请日：2007-01-22
申请人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
发明人： Philip Souter , John Burdis , Allan Svendsen , Thomas Callisen , Jesper Vind , Debbie Yaver , Jurgen Knotzel , Kim Borch , Mads Bjornvad , Peter Hansen , Michael Lamsa
IPC分类号： C11D3/386 , C12N9/18
CPC分类号： C11D3/38627 , C12N9/20
摘要： The present invention relates to detergent compositions comprising a detergent ingredient and a lipase variant with reduced potential for odor generation obtained by introducing mutations in one or more regions identified in a parent lipase.
摘要翻译：本发明涉及洗涤剂组合物，其包含洗涤剂成分和通过在母体脂肪酶中鉴定的一个或多个区域中引入突变获得的具有降低的气味生成潜力的脂肪酶变体。

7. 发明申请

US20090253171A1 Methods For Producing Secreted Polypeptides Having Biological Activity 失效
标题翻译：用于生产具有生物活性的分泌多肽的方法
公开(公告)号：US20090253171A1
公开(公告)日：2009-10-08
申请号：US12373470
申请日：2007-07-13
申请人： Debbie Yaver , Mads Eskelund Bjornvad
发明人： Debbie Yaver , Mads Eskelund Bjornvad
IPC分类号： C12P21/02 , C12N9/20 , C12N15/11
CPC分类号： C12P21/02 , C07K14/37 , C07K2319/02 , C12N9/20 , C12N15/625 , C12N15/81 , C12Y301/01003
摘要： The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.
摘要翻译：本发明涉及生产具有生物活性的多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一多核苷酸，其可操作地连接到编码变体信号肽或变体前肽的第二个多核苷酸; 和（b）从培养基中分离具有生物活性的分泌多肽。

8. 发明授权

US08586330B2 Methods for producing secreted polypeptides having biological activity 失效
标题翻译：生产具有生物活性的分泌多肽的方法
公开(公告)号：US08586330B2
公开(公告)日：2013-11-19
申请号：US12373470
申请日：2007-07-13
申请人： Debbie Yaver , Mads Eskelund Bjornvad
发明人： Debbie Yaver , Mads Eskelund Bjornvad
IPC分类号： C12P21/00 , A61K38/00
CPC分类号： C12P21/02 , C07K14/37 , C07K2319/02 , C12N9/20 , C12N15/625 , C12N15/81 , C12Y301/01003
摘要： The present invention relates to methods for producing a polypeptide having biological activity, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide encoding the polypeptide operably linked to a second polynucleotide encoding a variant signal peptide or a variant prepropeptide; and (b) isolating the secreted polypeptide having biological activity from the cultivation medium.
摘要翻译：本发明涉及生产具有生物活性的多肽的方法，其包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含编码多肽的第一多核苷酸，其可操作地连接到编码变体信号肽或变体前肽的第二个多核苷酸; 和（b）从培养基中分离具有生物活性的分泌多肽。

9. 发明授权

US08940502B2 Nucleic acid constructs and methods of making protein 有权
标题翻译：核酸构建体和蛋白质的制备方法
公开(公告)号：US08940502B2
公开(公告)日：2015-01-27
申请号：US12373715
申请日：2007-07-13
申请人： Debbie Yaver , Mads Eskelund Bjornvad , Barbara Cherry
发明人： Debbie Yaver , Mads Eskelund Bjornvad , Barbara Cherry
IPC分类号： C12P21/06 , C12N15/00 , C12N1/00 , C12N15/09 , C07H21/04 , C12N15/81 , C07K14/395
CPC分类号： C12N15/81 , C07K14/395
摘要： The present invention relates to methods for producing a polypeptide, comprising: (a) cultivating a fungal host cell in a medium conducive for the production of the polypeptide, wherein the fungal host cell comprises a first polynucleotide comprising a nucleic acid sequence encoding the polypeptide operably linked to a copper-inducible promoter sequence comprising a copper-responsive upstream activation sequence activated by a copper-dependent trans-acting transcription factor and a second polynucleotide comprising one or more (several) additional copper-responsive upstream activation sequences operably linked upstream to the promoter sequence, wherein the promoter sequence is foreign to the nucleic acid sequence encoding the polypeptide and the copper-responsive upstream activation sequences are responsible for copper-induced transcription of the promoter sequence, and a third polynucleotide comprising at least one copy of a gene encoding the copper-dependent trans-acting transcription factor; and (b) isolating the polypeptide from the cultivation medium.
摘要翻译：本发明涉及产生多肽的方法，包括：（a）在有助于产生多肽的培养基中培养真菌宿主细胞，其中真菌宿主细胞包含第一多核苷酸，其包含可操作地编码多肽的核酸序列与包含由铜依赖性反式作用转录因子活化的铜响应上游激活序列的铜诱导型启动子序列连接，第二多核苷酸包含一个或多个（几个）另外的铜响应性上游激活序列，其可操作地连接到上游启动子序列，其中所述启动子序列对于编码所述多肽的核酸序列是外来的，并且所述铜响应性上游激活序列负责所述启动子序列的铜诱导的转录，以及第三多核苷酸，其包含至少一个编码铜依赖的反作用转录 n因素和（b）从培养基中分离多肽。

10. 发明申请

US20120192316A1 POLYPEPTIDES HAVING LIPASE ACTIVITY AND POLYNUCLEOTIDES ENCODING SAME 有权
公开(公告)号：US20120192316A1
公开(公告)日：2012-07-26
申请号：US13440626
申请日：2012-04-05
申请人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
发明人： Debbie Yaver , Suzanne Otani , Janine Lin , Christopher Amolo , Kim Borch , Shamkant Anant Patkar , Michael Lamsa , Barbara Cherry
IPC分类号： A01H5/00 , C07H21/04 , C12N15/63 , C12N9/20 , C12N5/10
CPC分类号： C12N9/20
摘要： The present invention relates to isolated polypeptides having lipase activity and isolated polynucleotides encoding the polypeptides. The invention also relates to nucleic acid constructs, vectors, and host cells comprising the polynucleotides as well as methods for producing and using the polypeptides.

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