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1. 发明申请

US20050119762A1 Hydrogel providing cell-specific ingrowth 审中-公开
标题翻译：水凝胶提供细胞特异性向内生长
公开(公告)号：US20050119762A1
公开(公告)日：2005-06-02
申请号：US10980989
申请日：2004-11-03
申请人： Peter Zilla , Neil Davies , Terri Dower , Mona Bracher
发明人： Peter Zilla , Neil Davies , Terri Dower , Mona Bracher
IPC分类号： A61F2/02 , A61L27/34 , A61L27/44 , A61L27/52 , A61L27/54 , A61L27/58 , A61L29/08 , A61L31/10 , A61L31/14 , C12N5/08
CPC分类号： A61L31/148 , A61L27/34 , A61L27/52 , A61L27/54 , A61L27/58 , A61L31/10 , A61L2300/25 , A61L2300/604
摘要： A polymeric biomaterial that facilitates cell-specific ingrowth. The polymeric biomaterial encourages the ingrowth of cell types while reducing the ingrowth of undesirable cell types. This activity encourages proper integration of prosthetic implants or scaffolds utilizing this biomaterial by discouraging encapsulation or the accumulation of inflammatory cells such as macrophages, while encouraging infiltration by desirable cells such as endothelial or smooth muscle cells. Short peptide sequences are included in a polymeric biomaterial that result in complementary activities. Peptide sequences that are specifically cleaved by proteases found within preferred cells are used to cross-link the biomaterial and lead to degradation by those cells. Peptide sequences taken from proteins involved in cell adhesion can also be attached to the biomaterial to encourage adhesion by preferred cells. Combined use of both peptides in the polymeric biomaterial provides both specific adhesion and selective ingrowth.
摘要翻译：促进细胞特异性向内生长的聚合物生物材料。聚合物生物材料鼓励细胞类型的向内生长，同时减少不期望的细胞类型的向内生长。该活动鼓励通过阻止炎症细胞如巨噬细胞的包囊或积累，同时鼓励所需细胞如内皮细胞或平滑肌细胞的渗透，利用该生物材料适当地整合假体植入物或支架。短肽序列被包括在导致互补活性的聚合物生物材料中。使用在优选细胞内发现的蛋白酶特异性切割的肽序列用于交联生物材料并导致这些细胞的降解。从参与细胞粘附的蛋白质获取的肽序列也可附着于生物材料上以促进优选细胞的粘附。在聚合物生物材料中两种肽的组合使用提供特异性粘附和选择性向内生长。

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