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1. 发明申请

US20080104732A1 METHODS AND MEANS FOR OBTAINING MODIFIED PHENOTYPES 审中-公开
标题翻译：用于获取修饰的基因的方法和手段
公开(公告)号：US20080104732A1
公开(公告)日：2008-05-01
申请号：US11841737
申请日：2007-08-20
申请人： Peter Waterhouse , Ming-Bo Wang , Michael Graham , Neil Smith
发明人： Peter Waterhouse , Ming-Bo Wang , Michael Graham , Neil Smith
IPC分类号： A01H5/00 , C12N15/82 , C12N15/87 , C12N5/04 , C12N5/06 , C12N7/00 , C12Q1/68
CPC分类号： C12N15/8218 , C12N15/8247
摘要： Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.
摘要翻译：提供了通过引入编码针对靶核酸的正义和反义RNA分子的嵌合基因来降低真核细胞，特别是植物细胞中感兴趣的核酸的表型表达的方法和手段，其能够形成双链 RNA区域通过有义和反义核苷酸序列的区域之间的碱基配对或通过引入RNA分子本身。优选地，RNA分子同时包含有义和反义核苷酸序列。

2. 发明申请

US20070078105A1 Methods and means for obtaining modified phenotypes 审中-公开
标题翻译：获得修饰表型的方法和手段
公开(公告)号：US20070078105A1
公开(公告)日：2007-04-05
申请号：US11607062
申请日：2006-12-01
申请人： Peter Waterhouse , Ming-Bo Wang , Michael Graham , Neil Smith
发明人： Peter Waterhouse , Ming-Bo Wang , Michael Graham , Neil Smith
IPC分类号： A61K48/00
CPC分类号： C12N15/8218 , C12N15/8247
摘要： Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.
摘要翻译：提供了通过引入编码针对靶核酸的正义和反义RNA分子的嵌合基因来降低真核细胞，特别是植物细胞中感兴趣的核酸的表型表达的方法和手段，其能够形成双链 RNA区域通过有义和反义核苷酸序列的区域之间的碱基配对或通过引入RNA分子本身。优选地，RNA分子同时包含有义和反义核苷酸序列。

3. 发明申请

US20060178335A1 Methods and means for obtaining modified phenotypes 有权
公开(公告)号：US20060178335A1
公开(公告)日：2006-08-10
申请号：US11364183
申请日：2006-03-01
申请人： Peter Waterhouse , Ming-Bo Wang , Michael Graham
发明人： Peter Waterhouse , Ming-Bo Wang , Michael Graham
IPC分类号： A61K48/00
CPC分类号： C12N15/8218 , A01K2217/05 , A61K48/00 , C12N15/8203 , C12N15/8247 , C12N15/8282 , C12N15/8283
摘要： Methods and means are provided for reducing the phenotypic expression of a nucleic acid of interest in eucaryotic cells, particularly in plant cells, by introducing chimeric genes encoding sense and antisense RNA molecules directed towards the target nucleic acid, which are capable of forming a double stranded RNA region by base-pairing between the regions with sense and antisense nucleotide sequence or by introducing the RNA molecules themselves. Preferably, the RNA molecules comprises simultaneously both sense and antisense nucleotide sequence.

4. 发明申请

US20210128313A1 Sinus tarsi implant 有权
公开(公告)号：US20210128313A1
公开(公告)日：2021-05-06
申请号：US17109121
申请日：2020-12-01
申请人： Michael Graham
发明人： Michael Graham
IPC分类号： A61F2/42
摘要： A sinus tarsi implant for the purpose of stabilizing and restoring motion between the talus and calcaneus while allowing normal motion and alignment. In a preferred embodiment, the implant is composed of a titanium alloy that is a combination of a cylindrical portion and an axially connected conical portion. The cylindrical portion has a surface with multiple parallel grooves that are each parallel to the transverse axis of the cylinder. The grooves are uniquely shaped with a perpendicular medial side and an angled lateral side. The implant is cannulated to enable use of a guide wire that insures proper alignment during insertion.

5. 外观设计

USD728757S1 Gasket 有权
公开(公告)号：USD728757S1
公开(公告)日：2015-05-05
申请号：US29441369
申请日：2013-01-04
申请人： Michael Graham
设计人： Michael Graham

6. 发明申请

US20130325138A1 Interphalangeal Joint Implant Methods and Apparatus 有权
标题翻译：指间关节植入方法与装置
公开(公告)号：US20130325138A1
公开(公告)日：2013-12-05
申请号：US13484861
申请日：2012-05-31
申请人： Michael Graham
发明人： Michael Graham
IPC分类号： A61F2/42
CPC分类号： A61B17/846 , A61B17/68 , A61F2/4225 , A61F2/4241 , A61F2002/30622 , A61F2002/4228 , A61F2002/4233 , A61F2002/4243 , A61F2002/4246 , A61F2002/4248
摘要： A method and apparatus for correcting malformed joints, in particular the “hammer toe” contraction of the proximal interphalangeal joint. The disclosure comprises a two-component implant: a proximal phalanx component and a middle phalanx component. An endosseous stem on each component is inserted axially into the end of a respective host bone and, after insertion, the components are attached. The attached components are held together in various ways, for example a detent arm/aperture mechanism. Each component can be cannulated to allow for the passage of a kirschner wire, if necessary, to stabilize adjacent joints such as the proximal interphalangeal joint. The bones of the treated joint can be set to form a desired angle by adjusting the angle formed by the corresponding endosseous stems.
摘要翻译：用于矫正畸形关节的方法和装置，特别是近端指间关节的“脚趾”收缩。本公开内容包括双组分植入物：近指骨组件和中指骨组件。每个部件上的内骨柄轴向插入相应主体骨的端部，并且在插入后，附接组件。附接的部件以各种方式保持在一起，例如制动臂/孔机构。如果需要，每个组件可以被插入以允许克氏针通过以稳定相邻的关节，例如近端指间关节。经处理的关节的骨骼可以通过调节由相应的内骨柄形成的角度来设定成所需的角度。

7. 发明授权

US08373040B2 Plants and seeds of corn variety CV400845 有权
标题翻译：玉米品种CV400845的植物和种子
公开(公告)号：US08373040B2
公开(公告)日：2013-02-12
申请号：US12775692
申请日：2010-05-07
申请人： Michael Graham , Slobodan Trifunovic , Marcelo Queijo
发明人： Michael Graham , Slobodan Trifunovic , Marcelo Queijo
IPC分类号： A01H5/00 , C12N15/82
CPC分类号： A23D9/00 , A01H5/10
摘要： According to the invention, there is provided seed and plants of the corn variety designated CV400845. The invention thus relates to the plants, seeds and tissue cultures of the variety CV400845, and to methods for producing a corn plant produced by crossing a corn plant of variety CV400845 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV400845 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV400845.
摘要翻译：根据本发明，提供了称为CV400845的玉米品种和植物。因此，本发明涉及品种CV400845的植物，种子和组织培养物，以及通过将品种CV400845的玉米植物与其他玉米植物（例如另一种植物）杂交而产生的玉米植物的生产方法。本发明还涉及通过将品种CV400845的植物与另一品种的植物如另一近交系产生的玉米种子和植物。本发明还涉及品种CV400845的植物的近交和杂交遗传互补。

8. 发明申请

US20110277064A1 PLANTS AND SEEDS OF CORN VARIETY CV397769 有权
标题翻译：玉米品种CV397769的植物和种子
公开(公告)号：US20110277064A1
公开(公告)日：2011-11-10
申请号：US12773285
申请日：2010-05-04
申请人： Slobodan Trifunovic , Michael Graham , Marcelo Queijo
发明人： Slobodan Trifunovic , Michael Graham , Marcelo Queijo
IPC分类号： A01H1/02 , C12N5/04 , C07K14/425 , A01H5/00 , C11B1/00 , C12N15/82 , C12N15/31 , A23L1/00 , C08B31/00
CPC分类号： A01H5/10 , C11B1/00
摘要： According to the invention, there is provided seed and plants of the corn variety designated CV397769. The invention thus relates to the plants, seeds and tissue cultures of the variety CV397769, and to methods for producing a corn plant produced by crossing a corn plant of variety CV397769 with itself or with another corn plant, such as a plant of another variety. The invention further relates to corn seeds and plants produced by crossing plants of variety CV397769 with plants of another variety, such as another inbred line. The invention further relates to the inbred and hybrid genetic complements of plants of variety CV397769.
摘要翻译：根据本发明，提供了指定为CV397769的玉米品种和植物。因此，本发明涉及品种CV397769的植物，种子和组织培养物，以及通过将品种CV397769的玉米植物与其他玉米植物（例如另一品种的植物）杂交而产生的玉米植物的生产方法。本发明还涉及通过将品种CV397769的植物与另一品种的植物（例如另一近交系）杂交而产生的玉米种子和植物。本发明还涉及品种CV397769的植物的近交和杂种遗传互补物。

9. 发明申请

US20060181743A1 Method of making optics element 有权
标题翻译：制造光学元件的方法
公开(公告)号：US20060181743A1
公开(公告)日：2006-08-17
申请号：US11165610
申请日：2005-06-23
申请人： Melville Ulmer , Michael Graham , Semyon Vaynman
发明人： Melville Ulmer , Michael Graham , Semyon Vaynman
IPC分类号： H04N1/04
CPC分类号： B29D11/00596 , G02B5/0808 , Y10T29/49885 , Y10T29/49888 , Y10T29/49982
摘要： An optics element, such as an optical, IR, or X-ray mirror or mirror segment, is made by a combination of replication and lamination by depositing a first metallic layer on a replicating surface of a master or mandrel, depositing a light weight backing layer that adheres on the first metallic layer, and depositing a cover layer that adheres on the backing layer whereby the optics element comprises an in-situ deposited composite lamination of the first metallic layer, the backing layer, and the cover layer.
摘要翻译：光学元件，例如光学，IR或X射线镜或镜片段，通过复制和层压的组合制成，通过在母版或心轴的复制表面上沉积第一金属层，沉积重量轻的背衬层，其附着在第一金属层上，以及沉积附着在背衬层上的覆盖层，由此光学元件包括第一金属层，背衬层和覆盖层的原位沉积复合层压体。

10. 发明申请

US20060006610A1 Gasket for duct, pipe and tube joints 审中-公开
标题翻译：管道，管道和管接头垫片
公开(公告)号：US20060006610A1
公开(公告)日：2006-01-12
申请号：US11151786
申请日：2005-06-14
申请人： Michael Graham
发明人： Michael Graham
IPC分类号： F16L17/00
CPC分类号： F16L21/035 , F16L17/02 , F24F13/0209
摘要： A gasket or sealing ring designed to fit over an unrolled or unfolded edge of an inner (male) duct section or connector to be joined, for sealing various types of connections between duct sections and/or connectors, includes a sealing ring having a base portion for receiving an end of an inner (male) duct section or connector to be joined and a substantially J-shaped cross-section, and a flexible hollow sealing portion of substantially circular cross-sectional shape affixed to the base portion and protruding in a radially outward direction, for engagement with an outer (female) duct section or connector to be joined. In one embodiment, the base portion also includes a lip protruding in a radially inward direction for engagement with a complimentary groove or depression on the inner (male) duct section to be joined.
摘要翻译：一种垫圈或密封环，其设计成配合在待连接的内部（公）管道部分或连接器的展开或展开的边缘上，用于密封管道部分和/或连接器之间的各种类型的连接，所述密封环包括密封环，所述密封环具有基部用于接收要连接的内（公）管道部分或连接器的端部和基本上为J形的横截面，以及柔性中空密封部分，其基本上圆形的横截面形状固定到基部并且以径向用于与待连接的外（母）管道部分或连接器接合。在一个实施例中，基部还包括沿径向向内突出的唇缘，用于与要连接的内（阳）导管部分上的互补凹槽或凹部接合。

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