专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US08153765B2 Anti-CD38 antibodies for the treatment of cancer 有权
标题翻译：抗CD38抗体治疗癌症
公开(公告)号：US08153765B2
公开(公告)日：2012-04-10
申请号：US12441466
申请日：2007-10-16
申请人： Peter U. Park , Laura M. Bartle , Anna Skaletskaya , Viktor Golmakher , Daniel Tavares , Jutta Deckert , Vincent Mikol , Veronique Blanc
发明人： Peter U. Park , Laura M. Bartle , Anna Skaletskaya , Viktor Golmakher , Daniel Tavares , Jutta Deckert , Vincent Mikol , Veronique Blanc
IPC分类号： C12P21/08
CPC分类号： G01N33/57426 , A61K47/6803 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K16/462 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57484 , G01N2333/924
摘要： Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD38+ cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and/or complement-dependent cytotoxicity (CDC). Said antibodies and fragments thereof may be used in the treatment of tumors that express CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autoimmune and inflammatory diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. Said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of CD38. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.
摘要翻译：与CD38特异性结合的抗体，人源化抗体，表面抗体，抗体片段，衍生化抗体和与细胞毒性剂的缀合物能够通过细胞凋亡，抗体依赖性细胞介导的细胞毒性（ADCC）和/ 或补体依赖性细胞毒性（CDC）。所述抗体及其片段可用于治疗表达CD38蛋白的肿瘤，例如多发性骨髓瘤，慢性淋巴细胞性白血病，慢性骨髓性白血病，急性骨髓性白血病或急性淋巴细胞白血病，或治疗自身免疫性和炎性疾病如系统性红斑狼疮，类风湿关节炎，多发性硬化症，红斑狼疮和哮喘。所述衍生化抗体可用于表达CD38水平升高的肿瘤的诊断和成像。还提供了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法以及包含细胞毒性缀合物的试剂盒。特别地，细胞结合剂是识别并结合CD38蛋白的单克隆抗体及其表位结合片段。

2. 发明申请

US20090304710A1 NOVEL ANTI-CD38 ANTIBODIES FOR THE TREATMENT OF CANCER 有权
标题翻译：用于治疗癌症的新型抗CD38抗体
公开(公告)号：US20090304710A1
公开(公告)日：2009-12-10
申请号：US12441466
申请日：2007-10-16
申请人： Peter U. Park , Laura M. Bartle , Anna Skaletskaya , Viktor Golmakher , Daniel Tavares , Jutta Deckert , Vincent Mikol , Veronique Blanc
发明人： Peter U. Park , Laura M. Bartle , Anna Skaletskaya , Viktor Golmakher , Daniel Tavares , Jutta Deckert , Vincent Mikol , Veronique Blanc
IPC分类号： A61K39/395 , C07K16/28 , A61P35/00 , G01N33/53 , C07H21/04 , C12N15/63 , C12N5/10
CPC分类号： G01N33/57426 , A61K47/6803 , A61K47/6867 , A61K2039/505 , C07K16/2896 , C07K16/462 , C07K2317/24 , C07K2317/30 , C07K2317/34 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/734 , G01N33/57484 , G01N2333/924
摘要： Antibodies, humanized antibodies, resurfaced antibodies, antibody fragments, derivatized antibodies, and conjugates of same with cytotoxic agents, which specifically bind to CD38, are capable of killing CD38+ cells by apoptosis, antibody-dependent cell-mediated cytotoxicity (ADCC), and/or complement-dependent cytotoxicity (CDC). Said antibodies and fragments thereof may be used in the treatment of tumors that express CD38 protein, such as multiple myeloma, chronic lymphocytic leukemia, chronic myelogenous leukemia, acute myelogenous leukemia, or acute lymphocytic leukemia, or the treatment of autoimmune and inflammatory diseases such as systemic lupus, rheumatoid arthritis, multiple sclerosis, erythematosus, and asthma. Said derivatized antibodies may be used in the diagnosis and imaging of tumors that express elevated levels of CD38. Also provided are cytotoxic conjugates comprising a cell binding agent and a cytotoxic agent, therapeutic compositions comprising the conjugate, methods for using the conjugates in the inhibition of cell growth and the treatment of disease, and a kit comprising the cytotoxic conjugate. In particular, the cell binding agent is a monoclonal antibody, and epitope-binding fragments thereof, that recognizes and binds the CD38 protein.
摘要翻译：与CD38特异性结合的抗体，人源化抗体，表面抗体，抗体片段，衍生化抗体和与细胞毒性剂的缀合物能够通过细胞凋亡，抗体依赖性细胞介导的细胞毒性（ADCC）和/ 或补体依赖性细胞毒性（CDC）。所述抗体及其片段可用于治疗表达CD38蛋白的肿瘤，例如多发性骨髓瘤，慢性淋巴细胞性白血病，慢性骨髓性白血病，急性骨髓性白血病或急性淋巴细胞白血病，或治疗自身免疫性和炎性疾病如系统性红斑狼疮，类风湿关节炎，多发性硬化症，红斑狼疮和哮喘。所述衍生化抗体可用于表达CD38水平升高的肿瘤的诊断和成像。还提供了包含细胞结合剂和细胞毒性剂的细胞毒性缀合物，包含缀合物的治疗组合物，用于抑制细胞生长和治疗疾病的方法以及包含细胞毒性缀合物的试剂盒。特别地，细胞结合剂是识别并结合CD38蛋白的单克隆抗体及其表位结合片段。

3. 发明授权

US07449450B2 Compounds, methods of screening, and in vitro and in vivo uses involving anti-apoptotic genes and anti-apoptotic gene products 失效
标题翻译：化合物，筛选方法以及涉及抗凋亡基因和抗凋亡基因产物的体外和体内用途
公开(公告)号：US07449450B2
公开(公告)日：2008-11-11
申请号：US11104506
申请日：2005-04-13
申请人： Viktor S Goldmakher , Anna Skaletskaya , Laura M Bartle
发明人： Viktor S Goldmakher , Anna Skaletskaya , Laura M Bartle
IPC分类号： A61K31/7088 , A61K31/7125
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16122 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N2510/00
摘要： Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; Compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; Methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; Methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; Pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.
摘要翻译：具有抗细胞凋亡活性的新型多肽，以及筛选具有抗凋亡活性的新型多肽的方法，以及编码该多肽的多核苷酸; 调节或调节凋亡和/或抗凋亡活性的化合物，例如具有抗凋亡活性的化合物，以及诸如诱导，恢复或调节凋亡和/或抑制，减少或调节抗凋亡活性的化合物，方法对这些化合物进行筛选，以及在治疗疾病中使用这些化合物的方法; 用调节或调节凋亡和/或抗凋亡活性的化合物治疗真核细胞的方法; 提高真核细胞的稳定性，生长和/或生产力的方法; 调节或调节凋亡和/或抗凋亡活性的药物组合物。

4. 发明授权

US06605426B1 Compounds, methods of screening, and in vitro and in vivo uses involving anti-apoptotic genes and anti-apoptotic gene products 失效
标题翻译：化合物，筛选方法以及涉及抗凋亡基因和抗凋亡基因产物的体外和体内用途
公开(公告)号：US06605426B1
公开(公告)日：2003-08-12
申请号：US09716504
申请日：2000-11-21
申请人： Viktor S. Goldmakher , Anna Skaletskaya , Laura M. Bartle
发明人： Viktor S. Goldmakher , Anna Skaletskaya , Laura M. Bartle
IPC分类号： C12Q170
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16122 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N2510/00
摘要： Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; Compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; Methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; Methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; Pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.
摘要翻译：具有抗细胞凋亡活性的新型多肽，以及筛选具有抗凋亡活性的新型多肽的方法，以及编码该多肽的多核苷酸; 调节或调节凋亡和/或抗凋亡活性的化合物，例如具有抗凋亡活性的化合物，以及诸如诱导，恢复或调节凋亡和/或抑制，减少或调节抗凋亡活性的化合物，方法对这些化合物进行筛选，以及在治疗疾病中使用这些化合物的方法; 用调节或调节凋亡和/或抗凋亡活性的化合物治疗真核细胞的方法; 提高真核细胞的稳定性，生长和/或生产力的方法; 调节或调节凋亡和/或抗凋亡活性的药物组合物。

5. 发明授权

US06902885B2 Compounds, methods of screening, and in vitro and in vivo uses involving anti-apoptotic genes and anti-apoptotic gene products 失效
标题翻译：化合物，筛选方法以及涉及抗凋亡基因和抗凋亡基因产物的体外和体内用途
公开(公告)号：US06902885B2
公开(公告)日：2005-06-07
申请号：US10463756
申请日：2003-06-18
申请人： Viktor S. Goldmakher , Anna Skaletskaya , Laura M. Bartle
发明人： Viktor S. Goldmakher , Anna Skaletskaya , Laura M. Bartle
IPC分类号： A61B17/80 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61F2/46 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P9/10 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/045 , C07K16/08 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/15 , G01N33/50 , G01N33/68
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16122 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N2510/00
摘要： Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; Compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; Methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; Methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; Pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.
摘要翻译：具有抗细胞凋亡活性的新型多肽，以及筛选具有抗凋亡活性的新型多肽的方法，以及编码该多肽的多核苷酸; 调节或调节凋亡和/或抗凋亡活性的化合物，例如具有抗凋亡活性的化合物，以及诸如诱导，恢复或调节凋亡和/或抑制，减少或调节抗凋亡活性的化合物，方法对这些化合物进行筛选，以及在治疗疾病中使用这些化合物的方法; 用调节或调节凋亡和/或抗凋亡活性的化合物治疗真核细胞的方法; 提高真核细胞的稳定性，生长和/或生产力的方法; 调节或调节凋亡和/或抗凋亡活性的药物组合物。

6. 发明申请

US20050191696A1 Compounds, methods of screening, and in vitro and in vivo uses involving anti-apoptotic genes and anti-apoptotic gene products 失效
公开(公告)号：US20050191696A1
公开(公告)日：2005-09-01
申请号：US11104506
申请日：2005-04-13
申请人： Viktor Goldmakher , Anna Skaletskaya , Laura Bartle
发明人： Viktor Goldmakher , Anna Skaletskaya , Laura Bartle
IPC分类号： A61B17/80 , A61B17/86 , A61F2/00 , A61F2/02 , A61F2/30 , A61F2/38 , A61F2/46 , A61K31/7088 , A61K38/00 , A61K39/395 , A61K48/00 , A61P9/10 , A61P31/00 , A61P31/12 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C07H21/04 , C07K14/045 , C07K16/08 , C12N15/09 , C12P21/08 , C12Q1/02 , C12Q1/68 , C12Q1/70 , G01N33/15 , G01N33/50 , G01N33/68 , C12P21/06 , G01N33/53
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16122 , G01N33/5008 , G01N33/5011 , G01N33/5017 , G01N33/5035 , G01N2510/00
摘要： Novel polypeptides having anti-apoptotic activity, and methods of screening for such novel polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides; Compounds that regulate or modulate apoptosis and/or anti-apoptotic activity, such as compounds having anti-apoptotic activity, and such as compounds that induce, restore, or modulate apoptosis and/or inhibit, diminish, or modulate anti-apoptotic activity, methods of screening for such compounds, and methods of using such compounds in the therapeutic treatment of diseases; Methods of treating eukaryotic cells with compounds that regulate or modulate apoptosis and/or anti-apoptotic activity; Methods of enhancing the stability, growth, and/or productivity of eukaryotic cells; Pharmaceutical compositions that regulate or modulate apoptosis and/or anti-apoptotic activity.

7. 发明授权

US06218511B1 Anti-apoptotic genes of human cytomegalovirus (HCMV) and their use 失效
标题翻译：人巨细胞病毒（HCMV）的抗凋亡基因及其用途
公开(公告)号：US06218511B1
公开(公告)日：2001-04-17
申请号：US09080265
申请日：1998-05-18
申请人： Viktor S. Goldmakher , Anna Skaletskaya , Laura Bartle
发明人： Viktor S. Goldmakher , Anna Skaletskaya , Laura Bartle
IPC分类号： A61K39245
CPC分类号： G01N33/502 , A61K38/00 , A61K48/00 , C07K14/005 , C12N2710/16122 , G01N33/5008 , G01N33/5011 , G01N33/5091 , G01N2510/00
摘要： Disclosed are compositions and methods of screening for targets for antiviral chemotherapy having anti-apoptotic activity, and compositions and methods of screening for antiviral compounds that interfere with the anti-apoptotic activity of such targets. The targets comprise viral polypeptides having anti-apoptotic activity, and polynucleotides encoding such polypeptides. An example of such targets is a group of viral polypeptides of human cytomegalovirus (HCMV) having anti-apoptotic activity, such as pUL36, pUL37S, and pUL37L, and the polynucleotides encoding such polypeptides. The antiviral compounds comprise polypeptide, polynucleotide, DNA, RNA, amino acid, nucleic acid, and chemical compositions, including the chemically modified forms of such compositions, that interfere with the anti-apoptotic function of the target polypeptides and polynucleotides, leading to the induction of apoptosis and, consequently, the prevention or inhibition of replication.
摘要翻译：公开了筛选具有抗凋亡活性的抗病毒化疗靶标的组合物和方法，以及筛选干扰这些靶标的抗凋亡活性的抗病毒化合物的组合物和方法。靶包含具有抗凋亡活性的病毒多肽和编码这些多肽的多核苷酸。这样的靶的一个例子是具有抗细胞凋亡活性的人巨细胞病毒（HCMV）的一组病毒多肽，例如pUL36，pUL37S和pUL37L，以及编码这些多肽的多核苷酸。抗病毒化合物包括干扰靶多肽和多核苷酸的抗凋亡功能的多肽，多核苷酸，DNA，RNA，氨基酸，核酸和化学组合物，包括这些组合物的化学修饰形式，导致诱导的细胞凋亡，因此，预防或抑制复制。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式