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1. 发明申请

US20060089330A1 Solid-phase and solution-phase synthesis of glycosylphosphatidylinositol glycans 有权
标题翻译：糖基磷脂酰肌醇聚糖的固相和溶液相合成
公开(公告)号：US20060089330A1
公开(公告)日：2006-04-27
申请号：US10520963
申请日：2003-07-10
申请人： Peter Seeberger , Michael Hewitt
发明人： Peter Seeberger , Michael Hewitt
IPC分类号： C08B37/00 , A61K31/715
CPC分类号： C08B37/006 , C07H15/203 , C07H15/207
摘要： One aspect of the present invention relates to solution-phase approaches to GPI synthesis. Another aspect of the present invention relates to key building blocks, and syntheses thereof, useful for GPI assembly. Yet another aspect of the invention relates to an automated method for the synthesis of GPIs and fragments thereof.
摘要翻译：本发明的一个方面涉及GPI合成的溶液相方法。本发明的另一方面涉及可用于GPI组装的关键构造块及其合成。本发明的另一方面涉及用于合成GPI及其片段的自动化方法。

2. 发明申请

US20130261211A1 PROCESS FOR THE MODIFICATION OF POLYMERS, IN PARTICULAR POLYMER NANOPARTICLES 有权
标题翻译：聚合物，特别是聚合物纳米粒子改性方法
公开(公告)号：US20130261211A1
公开(公告)日：2013-10-03
申请号：US13880055
申请日：2011-10-17
申请人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
发明人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
IPC分类号： C08F8/00
CPC分类号： C08F8/00 , B01J19/121 , B01J19/123 , B82Y40/00 , C08F2/24 , C08F2/48 , C08F8/40 , C08F12/08 , C08F257/02 , C09D125/08 , C09J125/08 , C08F220/18 , C08F218/08
摘要： A process for the preparation of modified polymers by a photo-initiated polymerization includes preparing a polymerization medium comprising at least one photoinitiator comprising at least one phosphorous oxide (P═O) group or at least one phosphorous sulfide (P═S) group, and at least one polymerizable monomer. The at least one polymerizable monomer is polymerized by irradiating the polymerization medium with electromagnetic radiation so as to induce a generation of radicals so as to obtain a polymer. The polymer is modified by irradiating the polymer with electromagnetic radiation so as to induce a generation of radicals from the polymer in a presence of at least one modifying agent.
摘要翻译：通过光引发聚合制备改性聚合物的方法包括制备包含至少一种包含至少一种氧化磷（P = O）基团或至少一种硫化磷（P = S）基团的光引发剂的聚合介质，以及至少一种可聚合单体。通过用电磁辐射照射聚合介质来聚合至少一种可聚合单体，以引起自由基的产生，从而获得聚合物。通过用电磁辐射照射聚合物来改性聚合物，以便在存在至少一种改性剂的情况下诱导聚合物产生自由基。

3. 发明申请

US20070265441A1 Apparatus and methods for the automated synthesis of oligosaccharides 审中-公开
公开(公告)号：US20070265441A1
公开(公告)日：2007-11-15
申请号：US11651398
申请日：2007-01-09
申请人： Peter Seeberger , Obadiah Plante
发明人： Peter Seeberger , Obadiah Plante
IPC分类号： C08B37/00
CPC分类号： C40B50/14 , B01J19/0046 , B01J2219/00286 , B01J2219/00351 , B01J2219/00416 , B01J2219/00418 , B01J2219/00423 , B01J2219/00454 , B01J2219/00495 , B01J2219/00497 , B01J2219/005 , B01J2219/00572 , B01J2219/00576 , B01J2219/00578 , B01J2219/0059 , B01J2219/00596 , B01J2219/00689 , B01J2219/00731 , C07B2200/11 , C40B40/12 , C40B60/14
摘要： One aspect of the present invention relates to an apparatus for the efficient synthesis of oligosaccharides on a solid support, e.g., formed by subunit addition to terminal subunits immobilized on solid-phase particles. In certain embodiments, the apparatus of the present invention is used in combinatorial methods, e.g., as described herein, of synthesizing oligosaccharides.

4. 发明授权

US08921444B2 Process for the modification of polymers, in particular polymer nanoparticles 有权
标题翻译：用于改性聚合物，特别是聚合物纳米颗粒的方法
公开(公告)号：US08921444B2
公开(公告)日：2014-12-30
申请号：US13880055
申请日：2011-10-17
申请人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
发明人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
IPC分类号： C08F2/50 , C08F2/46 , B29C71/04 , A61L2/08 , A61L24/00 , C08G61/04 , C09D125/08 , C08F8/40 , C08F12/08 , C08F2/24 , C08F2/48 , B01J19/12 , C08F257/02 , B82Y40/00 , C08F8/00 , C09J125/08
CPC分类号： C08F8/00 , B01J19/121 , B01J19/123 , B82Y40/00 , C08F2/24 , C08F2/48 , C08F8/40 , C08F12/08 , C08F257/02 , C09D125/08 , C09J125/08 , C08F220/18 , C08F218/08
摘要： A process for the preparation of modified polymers by a photo-initiated polymerization includes preparing a polymerization medium comprising at least one photoinitiator comprising at least one phosphorous oxide (P═O) group or at least one phosphorous sulfide (P═S) group, and at least one polymerizable monomer. The at least one polymerizable monomer is polymerized by irradiating the polymerization medium with electromagnetic radiation so as to induce a generation of radicals so as to obtain a polymer. The polymer is modified by irradiating the polymer with electromagnetic radiation so as to induce a generation of radicals from the polymer in a presence of at least one modifying agent.
摘要翻译：通过光引发聚合制备改性聚合物的方法包括制备包含至少一种包含至少一种氧化磷（P = O）基团或至少一种硫化磷（P = S）基团的光引发剂的聚合介质，以及至少一种可聚合单体。通过用电磁辐射照射聚合介质来聚合至少一种可聚合单体，以引起自由基的产生，从而获得聚合物。通过用电磁辐射照射聚合物来改性聚合物，以便在存在至少一种改性剂的情况下诱导聚合物产生自由基。

5. 发明授权

US08273357B2 Antigen-carbohydrate conjugates 有权
标题翻译：抗原 - 碳水化合物缀合物
公开(公告)号：US08273357B2
公开(公告)日：2012-09-25
申请号：US11632442
申请日：2005-07-18
申请人： Nir Hacohen , Eddie Adams , Peter Seeberger
发明人： Nir Hacohen , Eddie Adams , Peter Seeberger
IPC分类号： A61K39/00
CPC分类号： A61K47/646 , A61K47/59 , A61K47/61 , A61K47/643
摘要： The present invention generally relates to compositions comprising antigen-carbohydrate conjugates and methods of immune modulation featuring these reagents.
摘要翻译：本发明一般涉及包含抗原 - 碳水化合物缀合物的组合物和具有这些试剂的免疫调节方法。

6. 发明授权

US08921442B2 Ultra fast process for the preparation of polymer nanoparticles 有权
标题翻译：用于制备聚合物纳米颗粒的超快速工艺
公开(公告)号：US08921442B2
公开(公告)日：2014-12-30
申请号：US13880054
申请日：2011-10-17
申请人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
发明人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
IPC分类号： A61L27/34 , C08F2/50 , C08F2/46 , B29C71/04 , A61L2/08 , A61L24/00 , C08G61/04 , C08F2/24 , C08F20/12 , C08F8/40 , C08F20/18 , B82Y40/00 , C08F2/48 , C08F12/08
CPC分类号： C08F2/46 , B82Y40/00 , C08F2/24 , C08F2/48 , C08F8/40 , C08F12/08 , C08F20/12 , C08F20/18 , C08L25/08
摘要： A process for the preparation of polymer lattices comprising polymer nanoparticles by a photo-initiated heterophase polymerization includes preparing a heterophase medium comprising a dispersed phase and a continuous phase and at least one of at least one surfactant, at least one photoinitiator, and at least one polymerizable monomer. The at least one polymerizable monomer is polymerized by irradiating the heterophase medium with electromagnetic radiation so as to induce a generation of radicals. The at least one photoinitiator is selected from compounds comprising at least one phosphorous oxide group (P═O) or at least one phosphorous sulfide (P═S) group. The irradiating of the heterophase medium is effected so that a ratio of an irradiated surface of the heterophase medium to a volume of the heterophase medium is at least 200 m−1.
摘要翻译：通过光引发的异相聚合制备包含聚合物纳米颗粒的聚合物晶格的方法包括制备包含分散相和连续相的多相介质，以及至少一种表面活性剂，至少一种光引发剂和至少一种光引发剂中的至少一种可聚合单体。通过用电磁辐射照射异相培养基来聚合至少一种可聚合单体，以引起自由基的产生。所述至少一种光引发剂选自包含至少一种氧化磷基团（P = O）或至少一种硫化磷（P = S）基团的化合物。进行异相培养基的照射，使得异相培养基的照射表面与异相培养基的体积的比例为至少200μm-1。

7. 发明申请

US20130261210A1 ULTRA FAST PROCESS FOR THE PREPARATION OF POLYMER NANOPARTICLES 有权
标题翻译：用于制备聚合物纳米颗粒的超快速方法
公开(公告)号：US20130261210A1
公开(公告)日：2013-10-03
申请号：US13880054
申请日：2011-10-17
申请人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
发明人： Peter Seeberger , Hansjoerg Gruetzmacher , Klaus Tauer , Judith Braeuer , Paola Laurino
IPC分类号： C08F2/46
CPC分类号： C08F2/46 , B82Y40/00 , C08F2/24 , C08F2/48 , C08F8/40 , C08F12/08 , C08F20/12 , C08F20/18 , C08L25/08
摘要： A process for the preparation of polymer lattices comprising polymer nanoparticles by a photo-initiated heterophase polymerization includes preparing a heterophase medium comprising a dispersed phase and a continuous phase and at least one of at least one surfactant, at least one photoinitiator, and at least one polymerizable monomer. The at least one polymerizable monomer is polymerized by irradiating the heterophase medium with electromagnetic radiation so as to induce a generation of radicals. The at least one photoinitiator is selected from compounds comprising at least one phosphorous oxide group (P═O) or at least one phosphorous sulfide (P═S) group. The irradiating of the heterophase medium is effected so that a ratio of an irradiated surface of the heterophase medium to a volume of the heterophase medium is at least 200 m−1.
摘要翻译：通过光引发的异相聚合制备包含聚合物纳米颗粒的聚合物晶格的方法包括制备包含分散相和连续相的多相介质，以及至少一种表面活性剂，至少一种光引发剂和至少一种光引发剂中的至少一种可聚合单体。通过用电磁辐射照射异相培养基来聚合至少一种可聚合单体，以引起自由基的产生。所述至少一种光引发剂选自包含至少一种氧化磷基团（P = O）或至少一种硫化磷（P = S）基团的化合物。进行异相培养基的照射，使得异相培养基的照射表面与异相培养基的体积的比例为至少200μm-1。

8. 发明申请

US20050187381A1 Solid- and solution-phase synthesis of heparin and other glycosaminoglycans 审中-公开
公开(公告)号：US20050187381A1
公开(公告)日：2005-08-25
申请号：US11040834
申请日：2005-01-21
申请人： Peter Seeberger , Hernan Orgueira , Peter Schell
发明人： Peter Seeberger , Hernan Orgueira , Peter Schell
IPC分类号： C07H3/04 , C07H3/06 , C08B37/00 , C07H5/04
CPC分类号： C07H3/06 , C07H3/04 , C08B37/0075
摘要： Described is a modular, general synthetic strategy for the preparation in solution and on a solid support of heparin, heparin-like glycosaminoglycans, glycosaminoglycans and non-natural analogs of each of them. Additionally, the modular strategy provides the basis for the preparation of combinatorial libraries and parallel libraries of defined glycosaminoglycan oligosaccharides. The defined glycosaminoglycan structures may be used in high-throughput screening experiments to identify carbohydrate sequences that regulate a host of recognition and signal-transduction processes. The determination of specific sequences involved in receptor binding holds great promise for the development of molecular tools which will allow modulation of processes underlying viral entry, angiogenesis, kidney diseases and diseases of the central nervous system. Notably, the present invention enables the automated synthesis of glycosaminoglycans in much the same fashion that peptides and oligonucleotides are currently assembled.

9. 发明申请

US20090004218A1 Antigen-Carbohydrate Conjugates 有权
标题翻译：抗原 - 碳水化合物缀合物
公开(公告)号：US20090004218A1
公开(公告)日：2009-01-01
申请号：US11632442
申请日：2005-07-18
申请人： Nir Hacohen , Eddie Adams , Peter Seeberger
发明人： Nir Hacohen , Eddie Adams , Peter Seeberger
IPC分类号： A61K39/00 , A61P37/02 , C07K14/00 , A61P35/02 , C40B30/04 , C12N5/06 , C07H3/00 , C07H3/02
CPC分类号： A61K47/646 , A61K47/59 , A61K47/61 , A61K47/643
摘要： The present invention generally relates to compositions comprising antigen-carbohydrate conjugates and methods of immune modulation featuring these reagents.
摘要翻译：本发明一般涉及包含抗原 - 碳水化合物缀合物的组合物和具有这些试剂的免疫调节方法。

10. 发明申请

US20060127929A1 Polymers for analyte detection 有权
公开(公告)号：US20060127929A1
公开(公告)日：2006-06-15
申请号：US11230308
申请日：2005-09-19
申请人： Timothy Swager , Peter Seeberger , Juan Zheng , Matthew Disney
发明人： Timothy Swager , Peter Seeberger , Juan Zheng , Matthew Disney
IPC分类号： C12Q1/68 , G01N33/53 , G01N33/00
CPC分类号： G01N33/542 , C12Q1/6818 , G01N2400/10
摘要： The present invention generally relates to organic polymers able to participate in an analyte-recognition process, where an analyte facilitates an energy transfer between an energy donor and an energy acceptor. Certain embodiments of the invention make use of fluorescent conjugated polymers, such as poly(phenylene ethynylene)s and other polymers comprising pi-conjugated backbones. For example, one aspect of the invention provides a fluorescent conjugated polymer and an indicator that can interact with each other in the presence of an analyte to produce an emissive signal. In some cases, the interaction may include energy exchange mechanisms, such as Dexter energy transfer or the strong coupling effect. The interaction of the conjugated polymer and the indicator, in some instances, may be facilitated through specific interactions, such as a protein/carbohydrate interaction, a ligand/receptor interaction, etc. Another aspect of the invention provides for the detection of biological entities, for example, pathogenic bacteria such as E. coli, or viruses such as influenza virus. In some cases, biological recognition elements may be used to determine the biological entity, for instance, carbohydrates that can be used to specifically interact with at least part of the biological entity, such as a protein in the cell membrane of a bacterium. Still other aspects of the invention involve articles, devices, and kits using any of the above-described systems.

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