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1. 发明授权

US5736535A 1-pyrimidinylacetamide compounds which are inhibitors of human leukocyte elastase 失效
标题翻译：作为人白细胞弹性蛋白酶抑制剂的1-嘧啶基乙酰胺化合物
公开(公告)号：US5736535A
公开(公告)日：1998-04-07
申请号：US375136
申请日：1995-01-19
申请人： Peter Robert Bernstein , Philip Duke Edwards , Andrew Shaw , Ashokkumar Bhikkappa Shenvi , Royston Martin Thomas , Chris Allan Veale , Peter Warner , Donald John Wolanin
发明人： Peter Robert Bernstein , Philip Duke Edwards , Andrew Shaw , Ashokkumar Bhikkappa Shenvi , Royston Martin Thomas , Chris Allan Veale , Peter Warner , Donald John Wolanin
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P29/00 , C07K5/06 , A61K31/69 , C07F5/02 , C07F5/04
CPC分类号： C07K5/06191 , A61K38/00
摘要： The present invention relates to certain novel substituted derivatives which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these substituted derivatives, processes for preparing the substituted derivatives, pharmaceutical compositions containing such substituted derivatives and methods for their use.
摘要翻译：本发明涉及作为人白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的式I的1-嘧啶基乙酰胺衍生物的某些新的取代衍生物，使其在这种抑制是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。本发明还包括可用于合成这些取代衍生物的中间体，制备取代衍生物的方法，含有这种取代的衍生物的药物组合物及其使用方法。

2. 发明授权

US5721222A Heterocyclic ketones 失效
标题翻译：杂环酮
公开(公告)号：US5721222A
公开(公告)日：1998-02-24
申请号：US519651
申请日：1995-08-25
申请人： Peter Robert Bernstein , Andrew Shaw , Royston Martin Thomas , Chris Allan Veale , Peter Warner , Donald John Wolanin
发明人： Peter Robert Bernstein , Andrew Shaw , Royston Martin Thomas , Chris Allan Veale , Peter Warner , Donald John Wolanin
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , C07D211/84 , A61K31/44 , C07D213/81 , C07D401/12
CPC分类号： C07K5/06191 , C07K5/0205 , C07K5/06139 , A61K38/00
摘要： The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
摘要翻译：本发明涉及作为人类白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的本文列出的作为式I的1-吡啶基乙酰胺酮的某些新型杂环酮，只要这种抑制是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。本发明还包括可用于合成这些杂环酮的中间体，制备杂环酮的方法，含有该杂环酮的药物组合物及其使用方法。

3. 发明授权

US5521179A Heterocyclic amides 失效
标题翻译：杂环酰胺
公开(公告)号：US5521179A
公开(公告)日：1996-05-28
申请号：US045009
申请日：1993-04-08
申请人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Peter Warner , Donald J. Wolanin
发明人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Peter Warner , Donald J. Wolanin
IPC分类号： A61K38/00 , C07K5/06 , C07D237/00 , C07D211/72 , C07D215/14 , C07D401/00
CPC分类号： C07K5/06191 , A61K38/00
摘要： The present invention relates to certain novel heterocyclic amides which are 1-pyridylacetamide compounds of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic amides, processes for preparing the heterocyclic amides, pharmaceutical compositions containing such heterocyclic amides and methods for their use.
摘要翻译：本发明涉及某些新颖的杂环酰胺，它们是本文列出的式I的1-吡啶基乙酰胺化合物，其是人类白细胞弹性蛋白酶（HLE）的抑制剂，也被称为人嗜中性粒细胞弹性蛋白酶（HNE）），使得它们在这种抑制是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。本发明还包括可用于合成这些杂环酰胺的中间体，制备杂环酰胺的方法，含有这种杂环酰胺的药物组合物及其使用方法。

4. 发明授权

US5486529A Certain pyridyl ketones for treating diseases involving leukocyte elastase 失效
标题翻译：某些用于治疗涉及白细胞弹性蛋白酶的疾病的吡啶酮
公开(公告)号：US5486529A
公开(公告)日：1996-01-23
申请号：US45496
申请日：1993-04-08
申请人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
发明人： Peter R. Bernstein , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/078 , C07K5/08 , A61K31/44 , C07D211/84 , C07D213/81 , C07D401/12
CPC分类号： C07K5/06191 , C07K5/0205 , C07K5/06139 , A61K38/00
摘要： The present invention relates to certain novel heterocyclic ketones which are 1-pyridylacetamide ketones of formula I, set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates useful in the synthesis of these heterocyclic ketones, processes for preparing the heterocyclic ketones, pharmaceutical compositions containing such heterocyclic ketones and methods for their use.
摘要翻译：本发明涉及作为人类白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的本文列出的作为式I的1-吡啶基乙酰胺酮的某些新型杂环酮，只要这种抑制是期望的，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗。本发明还包括可用于合成这些杂环酮的中间体，制备杂环酮的方法，含有该杂环酮的药物组合物及其使用方法。

5. 发明授权

US5441960A 1-pyrimidinylacetamide human leukocyte elastate inhibitors 失效
标题翻译： 1-嘧啶基乙酰胺人类白细胞弹性蛋白酶抑制剂
公开(公告)号：US5441960A
公开(公告)日：1995-08-15
申请号：US44866
申请日：1993-04-08
申请人： Peter R. Bernstein , Philip D. Edwards , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
发明人： Peter R. Bernstein , Philip D. Edwards , Andrew Shaw , Royston M. Thomas , Chris A. Veale , Peter Warner , Donald J. Wolanin
IPC分类号： A61K38/55 , A61K38/00 , A61P7/02 , A61P9/00 , A61P9/08 , A61P9/10 , A61P9/12 , A61P11/00 , A61P29/00 , C07K5/02 , C07K5/06 , C07K5/08 , A61K31/505 , C07D239/22
CPC分类号： C07K5/0205 , C07K5/06191 , A61K38/00
摘要： The present invention relates to certain novel substituted ketones which are 1-pyrimidinylacetamide derivatives of formula I, ##STR1## set out herein, which are inhibitors of human leukocyte elastase (HLE), also known as human neutrophil elastase (HNE), making them useful whenever such inhibition is desired, such as for research tools in pharmacological, diagnostic and related studies and in the treatment of diseases in mammals in which HLE is implicated. The invention also includes intermediates ##STR2## useful in the synthesis of these substituted ketones processes for preparing the substituted ketones pharmaceutical compositions containing such substituted ketones and methods for their use.
摘要翻译：本发明涉及作为人白细胞弹性蛋白酶（HLE）抑制剂（也称为人嗜中性粒细胞弹性蛋白酶（HNE））的式I所示的1-嘧啶基乙酰胺衍生物的某些新的取代酮，其为如果需要这种抑制作用，例如在药理学，诊断和相关研究中的研究工具以及涉及HLE的哺乳动物的疾病的治疗中是有用的。本发明还包括可用于合成这些取代酮的中间体制备含取代酮的取代酮的药物组合物的方法及其使用方法。

6. 发明授权

US09040278B2 Production of glucose from starch using alpha-amylases from Bacillus subtilis 有权
标题翻译：使用来自枯草芽孢杆菌的α-淀粉酶从淀粉生产葡萄糖
公开(公告)号：US09040278B2
公开(公告)日：2015-05-26
申请号：US12478266
申请日：2009-06-04
申请人： Luis G. Cascao-Pereira , Regina Chin , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Michael J. Pepsin , Scott D. Power , Sandra W. Ramer , Carol A. Requadt , Andrew Shaw , Amr R. Toppozada , Louise Wallace
发明人： Luis G. Cascao-Pereira , Regina Chin , William A. Cuevas , David A. Estell , Sang-Kyu Lee , Michael J. Pepsin , Scott D. Power , Sandra W. Ramer , Carol A. Requadt , Andrew Shaw , Amr R. Toppozada , Louise Wallace
IPC分类号： C12N9/28 , C12P19/14 , C12P7/06 , C08B37/00 , C07H21/04 , C12P19/02 , C11D3/22 , D06L1/14 , C11D3/386
CPC分类号： C12P19/02 , C11D3/221 , C11D3/386 , C12N9/2417 , D06L1/14 , Y02E50/17
摘要： An α-amylase from Bacillus subtilis (AmyE) produces significant amounts of glucose from various carbohydrate substrates, including vegetable starch, maltoheptaose, and maltotriose. Among other things, this advantageous property allows AmyE or variants thereof to be used in a saccharification reaction having a reduced or eliminated requirement for glucoamylase. The reduction or elimination of the glucoamylase requirement significantly improves the efficiency of the production of ethanol or high fructose corn syrup, for example.
摘要翻译：来自枯草芽孢杆菌（AmyE）的α-淀粉酶从各种碳水化合物底物（包括植物淀粉，麦芽庚糖和麦芽三糖）产生显着量的葡萄糖。除此之外，这种有利的性质允许AmyE或其变体用于具有葡糖淀粉酶降低或消除的糖化反应中。葡糖淀粉酶需求的减少或消除显着提高了乙醇或高果糖玉米糖浆的生产效率。

7. 发明授权

US08232080B2 Variant Hyprocrea jecorina CBH1 cellulases 有权
标题翻译：变异Hyprocrea jecorina CBH1纤维素酶
公开(公告)号：US08232080B2
公开(公告)日：2012-07-31
申请号：US13107702
申请日：2011-05-13
申请人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
发明人： Anthony Day , Frits Goedegebuur , Peter Gualfetti , Colin Mitchinson , Paulien Neefe , Mats Sandgren , Andrew Shaw , Jerry Stahlberg
IPC分类号： C12P19/02 , C12P19/00 , C12P21/06 , C12N9/42 , C12N1/20 , G01N33/53 , C07H21/04
CPC分类号： C12N9/2437 , C11D3/38645 , C12P7/10 , C12P19/02 , C12P19/14 , C12Y302/01091 , D21C5/005 , Y02E50/16
摘要： Described herein are variants of H. jecorina CBH I, a Cel7 enzyme. The present invention provides novel cellobiohydrolases that have improved thermostability and reversibility.
摘要翻译：本文描述的是H.jecorina CBH I，Cel7酶的变体。本发明提供了具有改善的热稳定性和可逆性的新型纤维二糖水解酶。

8. 发明授权

US08206960B1 Endoglucanases 有权
公开(公告)号：US08206960B1
公开(公告)日：2012-06-26
申请号：US13323724
申请日：2011-12-12
申请人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
发明人： Jie Yang , Andrew Shaw , Ish Kumar Dhawan , Onorato Campopiano , Kripa Rao
IPC分类号： C12N9/00
CPC分类号： C12N9/2437 , C07K2319/02 , C12N9/2445 , C12N15/75 , C12P7/10 , C12P19/14 , C12Y302/01004 , C12Y302/01021 , C12Y302/01091 , Y02E50/16
摘要： The present invention relates to variant endoglucanases and particularly endoglucanases having improved properties over wild-type endoglucanase.

9. 发明授权

US08114656B2 Thermostable neutral metalloproteases 有权
标题翻译：耐热中性金属蛋白酶
公开(公告)号：US08114656B2
公开(公告)日：2012-02-14
申请号：US12473735
申请日：2009-05-28
申请人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
发明人： Andrew Shaw , Louise Wallace , David A. Estell , Ronaldus W. J. Hommes , Sang-Kyu Lee , Hiroshi Oh , Eugene S. Sadlowski
IPC分类号： C12N9/50 , C12N9/54 , C12N9/00 , D06M16/00 , C02F3/34 , C07K1/00 , C07H21/04
CPC分类号： C12N9/54 , C11D1/02 , C11D3/386 , C11D3/38663 , C12Y304/24
摘要： The present invention provides methods and compositions comprising at least one neutral metalloprotease enzyme that has improved storage stability. In some embodiments, the neutral metalloprotease finds use in cleaning and other applications. In some particularly preferred embodiments, the present invention provides methods and compositions comprising neutral metalloprotease(s) obtained from Bacillus sp. In some more particularly preferred embodiments, the neutral metalloprotease is obtained from B. amyloliquefaciens. In still further preferred embodiments, the neutral metalloprotease is a variant of the B. amyloliquefaciens neutral metalloprotease. In yet additional embodiments, the neutral metalloprotease is a homolog of the B. amyloliquefaciens neutral metalloprotease. The present invention finds particular use in applications including, but not limited to cleaning, bleaching and disinfecting.
摘要翻译：本发明提供包含至少一种具有改善的储存稳定性的中性金属蛋白酶的方法和组合物。在一些实施方案中，中性金属蛋白酶可用于清洁和其它应用。在一些特别优选的实施方案中，本发明提供了包含从芽孢杆菌属芽孢杆菌获得的中性金属蛋白酶的方法和组合物。在一些更特别优选的实施方案中，中性金属蛋白酶从解淀粉芽孢杆菌获得。在另外的优选实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的变体。在另外的实施方案中，中性金属蛋白酶是解淀粉芽孢杆菌中性金属蛋白酶的同系物。本发明特别用于包括但不限于清洁，漂白和消毒的应用。

10. 发明申请

US20120021485A1 HYBRID ALPHA-AMYLASES 有权
标题翻译：混合阿尔法胺
公开(公告)号：US20120021485A1
公开(公告)日：2012-01-26
申请号：US13132881
申请日：2009-12-11
申请人： Scott D. Power , Andrew Shaw
发明人： Scott D. Power , Andrew Shaw
IPC分类号： C12N9/96 , G06G7/60 , C12N1/21 , C12N1/15 , C12N15/62 , C12N15/63
CPC分类号： C12N9/2417 , C07K2319/00 , G06F19/12 , G06F19/16
摘要： Hybrid alpha-amylases are provided that share a conserved 3D structure in whole or in part with a wild-type Termamyl-like ?-amylase, e.g., a Bacillus amylase. In the hybrid, an N terminal portion of a Termamyl-like ?-amylase is replaced with sequences from an archae ? amylase. The sequence similarity between the two amylase sequences may be less than 60%. Conserving the wild-type 3D structure in the hybrid facilitates obtaining enzymatically active amylases. In one embodiment, one or both amylase sequences contribute residues to the B domain, resulting in particularly advantageous properties. For instance, replacement of the Ca2+ binding site in the B domain of the Termamyl-like ?-amylase with a B domain sequence of an archae ? amylase that does not bind Ca2+ can produce a hybrid that is fully active in the absence of Ca2+.
摘要翻译：提供杂交α-淀粉酶，其与野生型类戊酰样α-淀粉酶（例如芽孢杆菌淀粉酶）全部或部分共享保守的3D结构。在杂交体中，类戊酰样α-淀粉酶的N末端部分被来自古细菌的序列替代淀粉酶。两个淀粉酶序列之间的序列相似性可以小于60％。在杂交中保护野生型3D结构有助于获得酶活性淀粉酶。在一个实施方案中，一个或两个淀粉酶序列向B结构域贡献残基，导致特别有利的性质。例如，用具有古细菌的B结构域序列的Termamyl样α-淀粉酶的B结构域中的Ca 2+结合位点的替换不结合Ca2 +的淀粉酶可以产生在不存在Ca 2+的情况下完全活性的杂交体。

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