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1. 发明授权

US08877900B2 AX132 PCSK9 antagonists 有权
标题翻译： AX132 PCSK9拮抗剂
公开(公告)号：US08877900B2
公开(公告)日：2014-11-04
申请号：US13503729
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
发明人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

2. 发明申请

US20120213794A1 AX213 AND AX132 PSCK9 ANTAGONISTS AND VARIANTS 有权
标题翻译： AX213和AX132 PSCK9 ANTAGONISTS和VARIANTS
公开(公告)号：US20120213794A1
公开(公告)日：2012-08-23
申请号：US13503729
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
发明人： Peter Peizhi Luo , Kevin Caili Wangr , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon , Sujata Sharma , Jon Condra , Jun Lu , Gopalakrishnan Parthasarathy , Stephen Soisson , Noel Byrne
IPC分类号： A61K39/395 , C12N15/13 , C12P21/02 , A61P3/06 , C12N5/10 , C12N1/19 , C12N1/21 , C07K16/40 , C12N15/63
CPC分类号： C07K16/40 , C07K2299/00 , C07K2317/21 , C07K2317/52 , C07K2317/55 , C07K2317/76 , C07K2317/94 , C07K2319/00
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

3. 发明申请

US20120231005A1 AX1 AND AX189 PSCK9 ANTAGONISTS AND VARIANTS 有权
标题翻译： AX1和AX189 PSCK9 ANTAGONISTS和变量
公开(公告)号：US20120231005A1
公开(公告)日：2012-09-13
申请号：US13503726
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
发明人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
IPC分类号： C07K16/40 , C12N9/99 , C12N1/21 , C12N15/13 , C12N5/10 , C12P21/02 , A61K39/395 , C12N15/63 , C12N1/19
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

4. 发明授权

US08802827B2 AX1 PCSK9 antagonists 有权
标题翻译： AX1 PCSK9拮抗剂
公开(公告)号：US08802827B2
公开(公告)日：2014-08-12
申请号：US13503726
申请日：2010-10-29
申请人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
发明人： Peter Peizhi Luo , Kevin Caili Wang , Pingyu Zhong , Mark Hsieh , Yan Li , Xinwei Wang , Feng Dong , Andrei Golosov , Yan Ni , Weirong Wang , Laurence B. Peterson , Rose Cubbon
IPC分类号： C07K16/40 , C07K16/00 , A61K39/395
CPC分类号： C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/41 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/90 , C07K2317/92 , C07K2317/94
摘要： Antagonists of human proprotein convertase subtilisin-kexin type 9 (“PCSK9”) are disclosed. The disclosed antagonists are effective in the inhibition of PCSK9 function and, accordingly, present desirable antagonists for use in the treatment of conditions associated with PCSK9 activity. The present invention also discloses nucleic acid encoding said antagonists, vectors, host cells, and compositions comprising the antagonists. Methods of making PCSK9-specific antagonists as well as methods of using the antagonists for inhibiting or antagonizing PCSK9 function are also disclosed and form important additional aspects of the present disclosure.
摘要翻译：公开了人前体蛋白转化酶枯草杆菌蛋白酶-Kexin 9型（“PCSK9”）的拮抗剂。所公开的拮抗剂在抑制PCSK9功能方面是有效的，因此，呈现用于治疗与PCSK9活性相关的病症的所需拮抗剂。本发明还公开了编码所述拮抗剂，载体，宿主细胞和包含拮抗剂的组合物的核酸。还公开了制备PCSK9特异性拮抗剂的方法以及使用拮抗剂抑制或拮抗PCSK9功能的方法，并形成了本公开的重要的附加方面。

5. 发明申请

US20070114877A1 End cap for interconnecting winding coils of segmented stator to reduce phase-on-phase conditions and associated methods 有权
标题翻译：用于互连分段定子的绕组线圈的端盖，以减少相间条件和相关方法
公开(公告)号：US20070114877A1
公开(公告)日：2007-05-24
申请号：US11542033
申请日：2006-10-02
申请人： Weirong Wang , Paul Michaels , John Rose , Mark Carrier , Jason Jurkowski
发明人： Weirong Wang , Paul Michaels , John Rose , Mark Carrier , Jason Jurkowski
IPC分类号： H02K1/00 , H02K1/28 , H02K1/12
CPC分类号： H02K1/148 , H02K3/522 , Y10T29/49009 , Y10T29/49073 , Y10T29/49194 , Y10T29/49201 , Y10T29/5187
摘要： A stator for an electromagnetic machine includes a plurality of discrete and individually wound stator segments having end caps positioned on the segments. The end caps have legs for positioning the end cap on the segments with an interference fit. The end caps have angled surfaces to facilitate winding of wire on the segments. The end caps have male and female couplings that mate together to couple adjacent segments together. The end caps have fingers and slots for aligning the segments on substantially the same plane. The end caps have wire isolation features, including hooks, shelves and ledges, for separating the interconnect wires routed on the stator to electrically interconnect the segments. The segments include scalloped contours on their outer edges for draining oil, and the end caps have passages for draining oil.
摘要翻译：一种用于电磁机器的定子包括多个离散且单独缠绕的定子段，其具有位于所述段上的端盖。端盖具有用于将端盖定位在具有过盈配合的段上的腿。端盖具有成角度的表面，以便于将线缠绕在段上。端盖具有连接在一起以将相邻节段连接在一起的阳和阴联轴器。端盖具有用于将片段在基本相同的平面上对准的手指和狭槽。端盖具有电线隔离特征，包括钩，搁架和凸缘，用于分离在定子上布线的互连线，以电连接该段。这些段在其外边缘上包括扇形轮廓，用于排出油，并且端盖具有用于排出油的通道。

6. 发明申请

US20050212378A1 End cap for interconnecting winding coils of a segmented stator to reduce phase-on-phase conditions and associated methods 有权
标题翻译：用于互连分段定子的绕组线圈的端盖，以减少相间条件和相关方法
公开(公告)号：US20050212378A1
公开(公告)日：2005-09-29
申请号：US10806561
申请日：2004-03-23
申请人： Weirong Wang , Paul Michaels , John Rose , Mark Carrier , Jason Jurkowski
发明人： Weirong Wang , Paul Michaels , John Rose , Mark Carrier , Jason Jurkowski
IPC分类号： H02K1/14 , H02K3/38 , H02K3/52 , H02K1/28 , H02K15/085 , H02K21/38
CPC分类号： H02K1/148 , H02K3/522 , Y10T29/49009 , Y10T29/49073 , Y10T29/49194 , Y10T29/49201 , Y10T29/5187
摘要： A stator for an electromagnetic machine includes a plurality of discrete and individually wound stator segments having end caps positioned on the segments. The end caps have legs for positioning the end cap on the segments with an interference fit. The end caps have angled surfaces to facilitate winding of wire on the segments. The end caps have male and female couplings that mate together to couple adjacent segments together. The end caps have fingers and slots for aligning the segments on substantially the same plane. The end caps have wire isolation features, including hooks, shelves and ledges, for separating the interconnect wires routed on the stator to electrically interconnect the segments. The segments include scalloped contours on their outer edges for draining oil, and the end caps have passages for draining oil.
摘要翻译：一种用于电磁机器的定子包括多个离散且单独缠绕的定子段，其具有位于所述段上的端盖。端盖具有用于将端盖定位在具有过盈配合的段上的腿。端盖具有成角度的表面，以便于将线缠绕在段上。端盖具有连接在一起以将相邻节段连接在一起的阳和阴联轴器。端盖具有用于将片段在基本相同的平面上对准的手指和狭槽。端盖具有电线隔离特征，包括钩，搁架和凸缘，用于分离在定子上布线的互连线，以电连接该段。这些段在其外边缘上包括扇形轮廓，用于排出油，并且端盖具有用于排出油的通道。

7. 发明授权

US07116023B2 End cap for interconnecting winding coils of a segmented stator to reduce phase-on-phase conditions and associated methods 有权
标题翻译：用于互连分段定子的绕组线圈的端盖，以减少相间条件和相关方法
公开(公告)号：US07116023B2
公开(公告)日：2006-10-03
申请号：US10806561
申请日：2004-03-23
申请人： Weirong Wang , Paul G Michaels , John Scott Rose , Mark E Carrier , Jason J Jurkowski
发明人： Weirong Wang , Paul G Michaels , John Scott Rose , Mark E Carrier , Jason J Jurkowski
IPC分类号： H02K3/52 , H02K1/18
CPC分类号： H02K1/148 , H02K3/522 , Y10T29/49009 , Y10T29/49073 , Y10T29/49194 , Y10T29/49201 , Y10T29/5187
摘要： A stator for an electromagnetic machine includes a plurality of discrete and individually wound stator segments having end caps positioned on the segments. The end caps have legs for positioning the end cap on the segments with an interference fit. The end caps have angled surfaces to facilitate winding of wire on the segments. The end caps have male and female couplings that mate together to couple adjacent segments together. The end caps have fingers and slots for aligning the segments on substantially the same plane. The end caps have wire isolation features, including hooks, shelves and ledges, for separating the interconnect wires routed on the stator to electrically interconnect the segments. The segments include scalloped contours on their outer edges for draining oil, and the end caps have passages for draining oil.
摘要翻译：一种用于电磁机器的定子包括多个离散且单独缠绕的定子段，其具有位于所述段上的端盖。端盖具有用于将端盖定位在具有过盈配合的段上的腿。端盖具有成角度的表面，以便于将线缠绕在段上。端盖具有连接在一起以将相邻节段连接在一起的阳和阴联轴器。端盖具有用于将片段在基本相同的平面上对准的手指和狭槽。端盖具有电线隔离特征，包括钩，搁架和凸缘，用于分离在定子上布线的互连线，以电连接该段。这些段在其外边缘上包括扇形轮廓，用于排出油，并且端盖具有用于排出油的通道。

8. 外观设计

USD525196S1 Contoured stator 失效
标题翻译：轮廓定子
公开(公告)号：USD525196S1
公开(公告)日：2006-07-18
申请号：US29201939
申请日：2004-03-23
申请人： John Scott Rose , Mark E. Carrier , Weirong Wang
设计人： John Scott Rose , Mark E. Carrier , Weirong Wang

9. 发明授权

US07919898B2 Rotor core assembly for electric motor 有权
标题翻译：电动机转子芯组件
公开(公告)号：US07919898B2
公开(公告)日：2011-04-05
申请号：US11766448
申请日：2007-06-21
申请人： Weirong Wang , Thomas E. Kirkley, Jr.
发明人： Weirong Wang , Thomas E. Kirkley, Jr.
IPC分类号： H02K1/06
CPC分类号： H02K1/276
摘要： A rotor core assembly for an electric motor includes a stack of laminations and first and second end plates disposed at opposite ends of the stack of laminations. A plurality of concentric fastener holes extend through the laminations and the end plates for receiving stainless steel pins. Each pin has a head against one of the end plates, and each pin has spaced apart grooves thereon extending from the other end plate. A stainless steel collar engages each of the pins and contacts one of the end plates. Each collar has a deformed portion in at least one of the grooves of the pin.
摘要翻译：用于电动马达的转子芯组件包括一叠叠片，以及布置在叠片堆叠的相对端的第一和第二端板。多个同心紧固件孔穿过叠片和端板，用于接收不锈钢销。每个销具有头部抵靠其中一个端板，并且每个销在其上延伸有间隔开的槽。不锈钢套管接合每个销并接触其中一个端板。每个轴环在销的至少一个凹槽中具有变形部分。

10. 发明授权

US07586231B2 End cap for segmented stator 有权
标题翻译：分段定子端盖
公开(公告)号：US07586231B2
公开(公告)日：2009-09-08
申请号：US12193476
申请日：2008-08-18
申请人： Weirong Wang , John Scott Rose , Paul G. Michaels , Mark E. Carrier , Jason J. Jurkowski
发明人： Weirong Wang , John Scott Rose , Paul G. Michaels , Mark E. Carrier , Jason J. Jurkowski
IPC分类号： H02K3/34 , H02K3/38
CPC分类号： H02K3/522 , H02K1/148 , H02K3/325 , Y10T29/49009
摘要： A stator for an electromagnetic machine includes a plurality of discrete and individually wound stator segments having end caps positioned on the segments. The end caps have legs for positioning the end cap on the segments with an interference fit. The end caps have angled surfaces to facilitate winding of wire on the segments. The end caps have male and female couplings that mate together to couple adjacent segments together. The end caps have fingers and slots for aligning the segments on substantially the same plane. The end caps have wire isolation features, including hooks, shelves and ledges, for separating the interconnect wires routed on the stator to electrically interconnect the segments. The segments include scalloped contours on their outer edges for draining oil, and the end caps have passages for draining oil.
摘要翻译：一种用于电磁机器的定子包括多个离散且单独缠绕的定子段，其具有位于所述段上的端盖。端盖具有用于将端盖定位在具有过盈配合的段上的腿。端盖具有成角度的表面，以便于将线缠绕在段上。端盖具有连接在一起以将相邻节段连接在一起的阳和阴联轴器。端盖具有用于将片段在基本相同的平面上对准的手指和狭槽。端盖具有电线隔离特征，包括钩，搁架和凸缘，用于分离在定子上布线的互连线，以电连接该段。这些段在其外边缘上包括扇形轮廓，用于排出油，并且端盖具有用于排出油的通道。

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