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    • 10. 发明授权
    • Method and system for comprehensive patient-specific modeling of the heart
    • 心脏综合患者特异性建模的方法和系统
    • US08682626B2
    • 2014-03-25
    • US13091076
    • 2011-04-20
    • Razvan Ioan IonasecIngmar VoigtViorel MihalefSasa GrbicDime VitanovskiYang WangYefeng ZhengBogdan GeorgescuDorin ComaniciuPuneet SharmaTommaso Mansi
    • Razvan Ioan IonasecIngmar VoigtViorel MihalefSasa GrbicDime VitanovskiYang WangYefeng ZhengBogdan GeorgescuDorin ComaniciuPuneet SharmaTommaso Mansi
    • G06G7/48
    • G06T13/20G06F19/321G06T2210/24G06T2210/41G16H50/50
    • A method and system for patient-specific modeling of the whole heart anatomy, dynamics, hemodynamics, and fluid structure interaction from 4D medical image data is disclosed. The anatomy and dynamics of the heart are determined by estimating patient-specific parameters of a physiological model of the heart from the 4D medical image data for a patient. The patient-specific anatomy and dynamics are used as input to a 3D Navier-Stokes solver that derives realistic hemodynamics, constrained by the local anatomy, along the entire heart cycle. Fluid structure interactions are determined iteratively over the heart cycle by simulating the blood flow at a given time step and calculating the deformation of the heart structure based on the simulated blood flow, such that the deformation of the heart structure is used in the simulation of the blood flow at the next time step. The comprehensive patient-specific model of the heart representing anatomy, dynamics, hemodynamics, and fluid structure interaction can be used for non-invasive assessment and diagnosis of the heart, as well as virtual therapy planning and cardiovascular disease management. Parameters of the comprehensive patient-specific model are changed or perturbed to simulate various conditions or treatment options, and then the patient specific model is recalculated to predict the effect of the conditions or treatment options.
    • 公开了一种用于针对4D医学图像数据的整个心脏解剖结构,动力学,血流动力学和流体结构相互作用的患者特异性建模的方法和系统。 通过从患者的4D医学图像数据估计心脏的生理模型的患者特异性参数来确定心脏的解剖学和动力学。 患者特异性解剖学和动力学被用作3D Navier-Stokes求解器的输入,该解算器在整个心脏周期中导出由局部解剖结构约束的现实血液动力学。 流体结构相互作用是通过在给定的时间步长模拟血液流动而在心脏周期上迭代地确定的,并且基于模拟的血液流量计算心脏结构的变形,使得心脏结构的变形用于模拟 血液流动在下一个时间步。 代表解剖学,动力学,血液动力学和流体结构相互作用的心脏综合患者特异性模型可用于心脏的非侵入性评估和诊断,以及虚拟治疗计划和心血管疾病管理。 全面的患者特异性模型的参数被改变或扰动以模拟各种条件或治疗选择,然后重新计算患者特异性模型以预测条件或治疗选择的影响。