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1. 发明授权

US5412468A Grouping of spectral bands for data acquisition in a spectrophotometer 失效
标题翻译：在分光光度计中对数据采集的光谱带进行分组
公开(公告)号：US5412468A
公开(公告)日：1995-05-02
申请号：US28515
申请日：1993-03-09
申请人： Peter L. Lundberg , Michael I. Crockett , David H. Tracy
发明人： Peter L. Lundberg , Michael I. Crockett , David H. Tracy
IPC分类号： G01J3/28 , G01J3/36 , G01J3/32
CPC分类号： G01J3/2803 , G01J3/027
摘要： Spectral bands are grouped for data acquisition in a spectrophotometer with a charge-coupled detector having a plurality of pixels. Preliminary data is generated on time-integrated radiation to the pixels for a sample. Maximum permitted exposure times for the pixels are calculated from the data and a predetermined maximum exposure. The maximum times are grouped so that for each group the ratio of the highest to the lowest maximum times is less than 100. A group run time is established for each group nominally less than the lowest maximum time in the group. Subgroups are created and ordered so that accumulated readout times for the pixels are less than wait times established to prevent readout contamination from subsequent charge buildup. The spectrophotometer is further operated on the sample for the run time of each group and subgroup to generate spectral data.
摘要翻译：光谱带被分组用于在具有多个像素的电荷耦合检测器的分光光度计中进行数据采集。将时间积分辐射产生初步数据给样本的像素。从数据和预定的最大曝光计算像素的最大允许曝光时间。最大时间被分组，使得对于每个组，最高到最低最大时间的比率小于100.对于组中名义上小于组中最低最大时间的组，建立组运行时间。子组被创建和排序，使得像素的累积读出时间小于建立的等待时间，以防止后续电荷累积的读出污染。分光光度计进一步在样品上运行，用于每组和亚组的运行时间，以产生光谱数据。

2. 发明授权

US06180942B2 Ion detector, detector array and instrument using same 有权
标题翻译：离子检测器，检测器阵列和仪器使用相同
公开(公告)号：US06180942B2
公开(公告)日：2001-01-30
申请号：US09180157
申请日：1998-11-03
申请人： David H. Tracy , Adam J. Patkin , David G. Welkie , Michael I. Crockett
发明人： David H. Tracy , Adam J. Patkin , David G. Welkie , Michael I. Crockett
IPC分类号： H01J4902
CPC分类号： G01T1/2928 , H01J49/025
摘要： An array of ion detectors (30) comprising a plurality of pickup electrodes (20, 34) for receiving ions; a substrate (32); a plurality of insulators (22, 35) positioned respectively between said pickup electrodes (20, 34) and said substrate (32); a plurality of charge storage areas (12, 38) for storing charge received by said pickup electrodes (20, 34), wherein each area (12, 38) is connected to a particular pickup electrode (20, 34) and means (44) for determining the amount of charge collected by each charge storage area.
摘要翻译：包括用于接收离子的多个拾取电极（20,34）的离子检测器阵列（30）衬底（32）; 分别位于所述拾取电极（20,34）和所述衬底（32）之间的多个绝缘体（22,35）; 多个电荷存储区域（12,38），用于存储由所述拾取电极（20,34）接收的电荷，其中每个区域（12,38）连接到特定拾取电极（20,34）和装置（44）用于确定由每个电荷存储区域收集的电荷量。

3. 发明授权

US09228898B2 Scalable spectroscopic detection and measurement 有权
标题翻译：可扩展的光谱检测和测量
公开(公告)号：US09228898B2
公开(公告)日：2016-01-05
申请号：US14008964
申请日：2012-03-27
申请人： Sepehr Kiani , Peter Lewis Stokes , David H. Tracy
发明人： Sepehr Kiani , Peter Lewis Stokes , David H. Tracy
IPC分类号： G01J3/28 , G01J3/42 , G01J3/02 , G01J3/06 , G01N21/64 , G01N15/14 , G01J3/44 , G01J3/08 , G01J3/10 , G01J3/14 , G01J3/18
CPC分类号： G01J3/42 , G01J3/0208 , G01J3/021 , G01J3/0216 , G01J3/0248 , G01J3/0291 , G01J3/06 , G01J3/08 , G01J3/10 , G01J3/14 , G01J3/18 , G01J3/2803 , G01J3/44 , G01J3/4406 , G01N15/1434 , G01N15/1459 , G01N15/1484 , G01N21/6456
摘要： The present invention generally pertains to a system, method and kit for the detection and measurement of spectroscopic properties of light from a sample, or the scalable detection and measurement of spectroscopic properties of light from each sample present among multiple samples, simultaneously, wherein the system comprises: an optical train comprising a dispersing element; and an image sensor. The light detected and measured may comprise light scattered from a sample, emitted as chemiluminescence by a chemical process within a sample, selectively absorbed by a sample, or emitted as fluorescence from a sample following excitation.
摘要翻译：本发明一般涉及一种用于检测和测量来自样品的光的光谱特性的系统，方法和试剂盒，或同时进行多个样品中存在的每个样品的光的光谱特性的可伸缩检测和测量，其中系统包括：包括分散元件的光学系列; 和图像传感器。检测和测量的光可以包括从样品散射的光，通过样品内的化学过程作为化学发光发射，被样品选择性吸收，或者在激发后作为荧光从样品中发射。

4. 发明授权

US08373854B2 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US08373854B2
公开(公告)日：2013-02-12
申请号：US12813389
申请日：2010-06-10
申请人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Kevin S. Bodner , Aldrich N. K. Lau , Steven J. Boege , Mark F. Oldham , Donald R. Sandell , David H. Tracy
IPC分类号： G01N1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： The present teachings provide for systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards utilizing luminophores, such as nanocrystals, for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：本教导提供了用于检测和/或分析光的系统及其组件。这些系统尤其可以包括在样品分析之前，期间和/或之后利用发光体（例如纳米晶体）用于校准，验证和/或监测光检测系统的光学参考标准。

5. 发明授权

US08060328B2 Method and apparatus for quantitating surface-binding optical resonance profiles 有权
标题翻译：用于定量表面结合光学共振谱的方法和装置
公开(公告)号：US08060328B2
公开(公告)日：2011-11-15
申请号：US12881403
申请日：2010-09-14
申请人： David H. Tracy
发明人： David H. Tracy
IPC分类号： G01R9/00 , G01R9/04 , G01C7/00 , G01F25/00
CPC分类号： G01N21/274 , G01N21/553 , G01N21/648
摘要： An apparatus for quantitation of surface-binding optical resonance profiles includes a calibration module including a calibration scan result fetcher, a calibration profile creation module, and a fitting module. The fitting module includes an experimental scan result fetcher, a calibration profile fetcher, and a resonance shift determination module. A method for qualifying a surface plasmon resonance chip is also described herein.
摘要翻译：用于定量表面结合光学共振分布的装置包括校准模块，其包括校准扫描结果读取器，校准曲线创建模块和拟合模块。配件模块包括实验扫描结果提取器，校准配置文件取出器和谐振位移确定模块。本文还描述了用于限定表面等离子体共振芯片的方法。

6. 发明授权

US6049762A Standardizing a spectrometric instrument 失效
标题翻译：标准化光谱仪
公开(公告)号：US6049762A
公开(公告)日：2000-04-11
申请号：US993482
申请日：1997-12-18
申请人： Alan M. Ganz , Yongdong Wang , David H. Tracy , Robert A. Hoult , Jerry E. Cahill , David A. Huppler
发明人： Alan M. Ganz , Yongdong Wang , David H. Tracy , Robert A. Hoult , Jerry E. Cahill , David A. Huppler
IPC分类号： G01J3/28 , G01J3/453 , G01R35/00
CPC分类号： G01J3/453 , G01J2003/2866
摘要： Standardization is achieved for FTIR spectrometric instruments that effect an intrinsic distortion in spectral information, the distortion being associated with an aperture size. An idealized function of spectral line shape is specified. With a small calibration aperture, spectral data is obtained for a basic sample having known "true" spectral data, and standard spectral data also is obtained for a standard sample. With a larger, normal sized aperture, standard spectral data is obtained again for the calibration sample. A transformation factor, that is a function of this data and the standardized function, is applied to spectral data for test samples to effect standardized information. In another embodiment, the standard sample has known true spectral data, and the basic sample is omitted. In either case, the transformation factor is applied to the sample data in logarithm form, the antilogarithm of the result effects the standardized information.
摘要翻译：对于影响光谱信息中的固有失真的FTIR光谱仪器实现标准化，失真与孔径尺寸相关联。规定了光谱线形状的理想化功能。使用小的校准孔径，获得具有已知“真实”光谱数据的基本样品的光谱数据，并且还为标准样品获得标准光谱数据。对于较大的正常尺寸的孔径，再次为校准样品获得标准光谱数据。作为该数据和标准化函数的函数的变换因子被应用于测试样本的光谱数据以实现标准化信息。在另一个实施例中，标准样品具有已知的真实光谱数据，并省略了基本样品。在任一种情况下，转换因子以对数形式应用于样本数据，结果的反对数效应影响标准化信息。

7. 发明授权

US5308982A Method and apparatus for comparing spectra 失效
标题翻译：比较光谱的方法和装置
公开(公告)号：US5308982A
公开(公告)日：1994-05-03
申请号：US956519
申请日：1992-10-05
申请人： Juan Ivaldi , David H. Tracy , Robert Hoult , Richard Spragg
发明人： Juan Ivaldi , David H. Tracy , Robert Hoult , Richard Spragg
IPC分类号： G01N21/27 , G01J3/28 , G01J3/433 , G01N21/73 , G01N21/25
CPC分类号： G01J3/433 , G01J3/28
摘要： A method for determining concentration of an analyte in a sample includes generating a spectrum of a selected analyte and interferents, generating a spectrum of an unknown sample, computing first and second derivatives of the sample spectrum, deriving a matrix model that includes the analyte spectrum and the derivatives, and applying the matrix model to the sample spectrum so as to yield a parameter representing concentration of the selected analyte in the unknown sample. Multiple linear least squares regression is utilized to fit the model and calculate the parameter.
摘要翻译：用于确定样品中分析物浓度的方法包括产生所选分析物和干扰物的光谱，产生未知样品的光谱，计算样品光谱的第一和第二导数，导出包括分析物光谱的矩阵模型，以及衍生物，并将矩阵模型应用于样本光谱，以产生表示未知样品中所选分析物浓度的参数。利用多元线性最小二乘回归拟合模型并计算参数。

8. 发明授权

US07871183B2 Light source 有权
标题翻译：光源
公开(公告)号：US07871183B2
公开(公告)日：2011-01-18
申请号：US12054136
申请日：2008-03-24
申请人： David H. Tracy , Bernhard H. Radziuk , Klaus Fischer
发明人： David H. Tracy , Bernhard H. Radziuk , Klaus Fischer
IPC分类号： F21S8/00
CPC分类号： G01N21/3103 , G01N2021/3118
摘要： A light source for an atomizing device, specifically an atom absorption spectrometer comprising one, two, or more lamps, whose ray can be selected by means of at least one two-dimensionally moveable optical selection element, and which can be directed in the direction of atomizing device. Fine-tuning is thereby achieved quickly with little constructive expenditure and with low costs. A very high degree of accuracy is possible from the selector through a rotational and highly adjustable rotation spindle.
摘要翻译：用于雾化装置的光源，特别是包括一个，两个或更多个灯的原子吸收光谱仪，其光线可以通过至少一个二维可移动的光学选择元件选择，并且可以沿着雾化装置微调由此得以快速建设，成本低廉。选择器可以通过旋转和高度可调的旋转主轴非常高的精度。

9. 发明授权

US07656521B2 Method of instrument standardization for a spectroscopic device 有权
标题翻译：光谱仪器标准化方法
公开(公告)号：US07656521B2
公开(公告)日：2010-02-02
申请号：US12119239
申请日：2008-05-12
申请人： Yongdong Wang , Bernhard H. Radziuk , David H. Tracy
发明人： Yongdong Wang , Bernhard H. Radziuk , David H. Tracy
IPC分类号： G01J3/00
CPC分类号： G01J3/28 , G01J3/42
摘要： In a spectroscopic process a sample for producing a test spectral line or spectrum of at least one component contained in the sample is stimulated and the transmitted and/or emitted electromagnetic rays are used to create the test spectral line or spectrum. In order to improve such a spectroscopic process to such an extent that variations of certain parameters, which alter the shape and/or occurrence of a spectral line, are compensated, a comparison spectral line or spectrum of a known comparison material is produced under substantially the same parameters as the sample. The comparison spectral line or spectrum is compared with an ideal comparison spectral line or spectrum in order to calculate a transfer function, andthe transfer function is applied to the test spectral line or spectrum in order to calculate a corrected test spectral line or spectrum.
摘要翻译：在分光过程中，刺激用于产生测试谱线或样品中包含的至少一种组分的光谱的样品，并且使用透射和/或发射的电磁波来产生测试光谱线或光谱。为了改进这种光谱过程，使得补偿了改变光谱线的形状和/或出现的某些参数的变化，已知比较材料的比较光谱线或光谱基本上在与样品相同的参数。将比较谱线或频谱与理想的比较谱线或频谱进行比较，以计算传递函数，并将传递函数应用于测试谱线或频谱，以便计算校正的测试谱线或频谱。

10. 发明授权

US07480042B1 Luminescence reference standards 有权
标题翻译：发光参考标准
公开(公告)号：US07480042B1
公开(公告)日：2009-01-20
申请号：US11173609
申请日：2005-06-30
申请人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
发明人： J. Michael Phillips , Aldrich N. K. Lau , Mark F. Oldham , Kevin S. Bodner , Steven J. Boege , Donald R. Sandell , David H. Tracy
IPC分类号： G01J1/10
CPC分类号： G01N21/278 , B82Y15/00 , G01J1/10 , G01N21/01 , G01N21/4785 , G01N21/6452 , G01N21/76 , G01N2201/06113 , G01N2201/0612 , G01N2201/062 , G01N2201/0691 , G01N2201/0697 , Y10S977/943 , Y10S977/949
摘要： Systems, and components thereof, for detecting and/or analyzing light. These systems can include, among others, optical reference standards for calibrating, validating, and/or monitoring light-detection systems, before, during, and/or after sample analysis.
摘要翻译：系统及其组件，用于检测和/或分析光。样品分析之前，期间和/或之后，这些系统可以包括用于校准，验证和/或监测光检测系统的光学参考标准。

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