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1. 发明授权

US07030247B2 Method for the production of biperidin 失效
标题翻译：生产丁吡啶的方法
公开(公告)号：US07030247B2
公开(公告)日：2006-04-18
申请号：US10477761
申请日：2002-05-17
申请人： Peter Klein , Marco Thyes , Markus Grosse , Klaus Martin Weber
发明人： Peter Klein , Marco Thyes , Markus Grosse , Klaus Martin Weber
IPC分类号： C07D211/06
CPC分类号： C07D295/088 , C07D295/108
摘要： The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenyl magnesium compound to form an isomer mixture of 1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-piperidino-1-propanol, whereby biperiden is obtained therefrom by conversion of said mixture into corresponding hydrochloride, isolation of said hydrochloride, reconversion to the free base and crystallization of said biperiden.
摘要翻译：本发明涉及一种通过使1-（双环[2.2.1]庚-5-烯-2-基）-3-哌啶子基-1-丙酮的外部/内部混合物与苯基镁化合物形成1-（双环[2.2.1]庚-5-烯-2-基）-1-苯基-3-哌啶-1-基-1-异丙醇的异构体混合物，由此通过转化得到二哌啶的所述混合物转化成相应的盐酸盐，分离所述盐酸盐，重新转化为游离碱并结晶所述双倍哌啶。

2. 发明授权

US07501519B2 Method for producing biperiden IV 失效
标题翻译：双倍叶甙生产方法IV
公开(公告)号：US07501519B2
公开(公告)日：2009-03-10
申请号：US10478384
申请日：2002-05-17
申请人： Markus Grosse , Klaus Martin Weber , Marco Thyes , Peter Klein , Elmar Vilsmaier
发明人： Markus Grosse , Klaus Martin Weber , Marco Thyes , Peter Klein , Elmar Vilsmaier
IPC分类号： C07D211/06
CPC分类号： C07D295/088 , C07D295/108
摘要： The invention relates to a method for producing biperiden by reacting exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone with a phenylmagnesium compound. According to the invention, exo-1-(bi-cyclo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone can be obtained by reacting the exo-ether of enol silylene of formula (IV) with a compound of N-methylenepiperidinium.
摘要翻译：本发明涉及通过使外-1-（双环[2.2.1]庚-5-烯-2-基）-3-哌啶子基-1-丙酮与苯基镁化合物反应制备双倍哌啶的方法。根据本发明，外环1-（双环[2.2.1]庚-5-烯-2-基）-3-哌啶子基-1-丙酮可以通过使式（Ⅳ）与N-亚甲基哌啶鎓的化合物反应。

3. 发明授权

US06835839B2 Method for the production of biperiden II 失效
标题翻译：双倍二烯生产方法二
公开(公告)号：US06835839B2
公开(公告)日：2004-12-28
申请号：US10477766
申请日：2004-04-05
申请人： Peter Klein , Marco Thyes , Markus Grosse , Klaus Martin Weber , Elmar Vilsmaier
发明人： Peter Klein , Marco Thyes , Markus Grosse , Klaus Martin Weber , Elmar Vilsmaier
IPC分类号： C07D21106
CPC分类号： C07D295/088
摘要： The invention relates to a method for the production of biperiden by reacting an exo/endo mixture of 1-(bicyclo[2.2.1.]hept-5-en-2-yl) 3-piperidino-1-propanone with a phenyl magnesium compound, wherein the exo/endo ratio of 1-(bicylo[2.2.1]hept-5-en-2-yl)-3-piperidino-1-propanone is at least 4.5:1.
摘要翻译：本发明涉及通过使1-（双环[2.2.1。]庚-5-烯-2-基）-3-哌啶子基-1-丙酮与苯基镁的外部/内部混合物反应来生产双倍哌啶的方法化合物，其中1-（双环[2.2.1]庚-5-烯-2-基）-3-哌啶子基-1-丙酮的外/内比为至少4.5:1。

4. 发明授权

US06500830B1 Conversion of modification D to modification A of doxazosin mesylate 有权
标题翻译：修饰D转化为甲磺酸多沙唑嗪的修饰A.
公开(公告)号：US06500830B1
公开(公告)日：2002-12-31
申请号：US09582778
申请日：2000-07-03
申请人： Peter Klein , Marco Thyes , Dieter Hix
发明人： Peter Klein , Marco Thyes , Dieter Hix
IPC分类号： A61K31497
CPC分类号： C07D405/12
摘要： A process for preparing doxazosin mesylate in modification A which comprises dissolving doxazosin with methanesulfonic acid in methanol or a mixture of an aprotic, polar organic solvent and methanol, removing any turbidity from the resulting solution, and stirring the resulting clear solution until no further precipitate separates out, removing, washing with methanol, heating the precipitate in the moist state in ethanol and, after cooling, isolating the resulting product is described.
摘要翻译：在修饰A中制备甲磺酸多沙唑嗪的方法，其包括将甲磺酸与甲磺酸或非质子传递性极性有机溶剂和甲醇的混合物溶解于多沙唑嗪中，从所得溶液中除去任何浊度，并搅拌所得澄清溶液直到不再沉淀分离除去，用甲醇洗涤，在乙醇中加热潮湿状态的沉淀物，冷却后分离所得产物。

5. 发明授权

US06476033B1 Medicaments containing doxazosin mesylate of crystalline modification D 有权
标题翻译：含有甲磺酸多沙唑嗪的药物结晶改性D
公开(公告)号：US06476033B1
公开(公告)日：2002-11-05
申请号：US09936792
申请日：2001-09-18
申请人： Marco Thyes , Heinz Einig , Peter Klein , Dieter Hix
发明人： Marco Thyes , Heinz Einig , Peter Klein , Dieter Hix
IPC分类号： A61K3100
CPC分类号： A61K31/517
摘要： Drugs comprising modification D of doxazosin mesylate are described. They are suitable for treating high blood pressure.
摘要翻译：描述了包含甲磺酸多沙唑嗪的修饰D的药物。它们适合治疗高血压。

6. 发明申请

US20120295725A1 SYSTEM AND APPARATUS FOR MEASURING PARAMETER DATA ON IMPACT OF A GOLF CLUB FACE WITH A TARGET SURFACE 有权
标题翻译：用于测量高尔夫球杆面与目标表面碰撞的参数数据的系统和装置
公开(公告)号：US20120295725A1
公开(公告)日：2012-11-22
申请号：US13473741
申请日：2012-05-17
申请人： Garry Peters , Peter Klein
发明人： Garry Peters , Peter Klein
IPC分类号： A63B57/00
CPC分类号： G09B19/0038
摘要： A system for measuring golf club parameter data on impact of a club face of a user's golf club with a target surface includes a static impact bag having a front facing surface for receiving an impact thereon with the club face, and a plurality of sensors for detecting force data upon impact of the club face with the front facing surface. The system includes a processor connected to sensors for receiving the force data and determining golf club parameter data related to the club face's impact with the front surface of the bag.
摘要翻译：用于测量使用者具有目标表面的使用者高尔夫球杆的球杆面的冲击的高尔夫球杆参数数据的系统包括：具有前表面的静态冲击袋，用于接收与球杆面的冲击;以及多个用于检测的传感器在球杆面与前表面碰撞时强制数据。该系统包括连接到传感器的处理器，用于接收力数据并确定与球杆表面与袋的前表面的冲击相关的高尔夫球杆参数数据。

7. 发明申请

US20070210608A1 Tonneau cover for a truck box 失效
标题翻译： Tonneau一个卡车箱盖
公开(公告)号：US20070210608A1
公开(公告)日：2007-09-13
申请号：US11442652
申请日：2006-05-30
申请人： Peter Klein
发明人： Peter Klein
IPC分类号： B60P7/02
CPC分类号： B60J7/1621
摘要： A tonneau cover is arranged to mount on the truck box of a conventional pick up truck for enclosing the box. The cover comprises a pair of panels which are pivotally mounted on respective sides of the box. The panels extend laterally inward such that free ends of the panels engage each other in a closed position. The panels may be pivoted upward and secured in an upward orientation by a pair of rails connected between the free ends of the respective panels in an extended position of the panels. The panels form a pair of side walls in the extended position for supporting large cargo in the box. The rails form a rack in the extended position for supporting additional cargo thereon. A locking device secures the panels in the closed position while a plurality of struts provides additional support to the panels when pivoting the panels between the closed and extended positions.
摘要翻译：一个吨罩被布置成安装在用于封闭箱的传统拾取车的卡车箱上。盖子包括一对可枢转地安装在箱体的相应侧面上的面板。面板横向向内延伸，使得面板的自由端在闭合位置彼此接合。面板可以向上枢转并且通过在面板的延伸位置中连接在相应面板的自由端之间的一对轨道向上固定。面板在延伸位置形成一对侧壁，用于支撑箱子中的大货物。轨道形成延伸位置的支架，用于在其上支撑附加货物。锁定装置将面板固定在关闭位置，同时当多个支柱在闭合位置和延伸位置之间枢转面板时向板提供额外的支撑。

8. 发明授权

US07126424B2 Interface circuit for connecting to an output of a frequency converter 失效
标题翻译：用于连接变频器输出的接口电路
公开(公告)号：US07126424B2
公开(公告)日：2006-10-24
申请号：US10482720
申请日：2002-07-02
申请人： Peter Klein , Bernhard Lustig , Dieter Sewald
发明人： Peter Klein , Bernhard Lustig , Dieter Sewald
IPC分类号： H03F3/45
CPC分类号： H03F3/45677 , H03F2200/372 , H03F2203/45028 , H03F2203/45298 , H03F2203/45418 , H03F2203/45424
摘要： In an interface circuit for connection to an output of a frequency converter, at least two current paths are coupled to one another in parallel. Each current path includes at least one cascode stage for signal processing. The circuit compensates for DC voltage offsets of the frequency converter, and has a gain ratio that can be changed over for signals with a large dynamic range.
摘要翻译：在用于连接到变频器的输出的接口电路中，至少两个电流路径彼此并联耦合。每个电流路径包括用于信号处理的至少一个共源共栅级。该电路补偿变频器的直流电压偏移，并且具有可以对具有大动态范围的信号进行改变的增益比。

9. 发明申请

US20050077962A1 Interface circuit for connecting to an output of a frequency converter 失效
标题翻译：用于连接变频器输出的接口电路
公开(公告)号：US20050077962A1
公开(公告)日：2005-04-14
申请号：US10482720
申请日：2002-07-02
申请人： Peter Klein , Bernhard Lustig , Dieter Sewald
发明人： Peter Klein , Bernhard Lustig , Dieter Sewald
IPC分类号： H03F3/45
CPC分类号： H03F3/45677 , H03F2200/372 , H03F2203/45028 , H03F2203/45298 , H03F2203/45418 , H03F2203/45424
摘要： In an interface circuit for connection to an output of a frequency converter, at least two current paths are coupled to one another in parallel. Each current path includes at least one cascode stage for signal processing. The circuit compensates for DC voltage offsets of the frequency converter, and has a gain ratio that can be changed over for signals with a large dynamic range.
摘要翻译：在用于连接到变频器的输出的接口电路中，至少两个电流路径彼此并联耦合。每个电流路径包括用于信号处理的至少一个共源共栅级。该电路补偿变频器的直流电压偏移，并且具有可以对具有大动态范围的信号进行改变的增益比。

10. 发明授权

US4987217A Wholly aromatic polyamide 失效
标题翻译：全芳香族聚酰胺
公开(公告)号：US4987217A
公开(公告)日：1991-01-22
申请号：US422116
申请日：1989-10-16
申请人： Gunter Keil , Karl Heinrich , Peter Klein
发明人： Gunter Keil , Karl Heinrich , Peter Klein
IPC分类号： C08G69/32
CPC分类号： C08G69/32
摘要： Aromatic copolyamides, soluble in organic polyamide solvents, comprise at least 95 mol % of the recurrent structural units of the formulae ##STR1## and up to 5 mol % of structural units containing m-bonds. --Ar-- and --Ar'-- are here divalent, unsubstituted or substituted aromatic radicals, the valency bonds of which are in the para-position or in a comparable coaxial or parallel position, and --R and --R' are different from one another and are lower alkyl radicals or lower alkoxy radicals.
摘要翻译：可溶于有机聚酰胺溶剂的芳族共聚酰胺包含至少95mol％的式OCArCO A HNAr'NH B＆amp; C＆gt; D的复发结构单元和至多5mol％的含有m键的结构单元。 -Ar-和-Ar'-在这里是二价，未取代或取代的芳族基团，其价键位于对位或相当的同轴或平行位置，并且-R和-R'彼此不同并且是低级烷基或低级烷氧基。

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