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1. 发明授权

US07309867B2 Methods and apparatus for characterization of tissue samples 失效
标题翻译：组织样本表征的方法和装置
公开(公告)号：US07309867B2
公开(公告)日：2007-12-18
申请号：US10418668
申请日：2003-04-18
申请人： Peter J. Costa , Stephen T. Sum , Ross F. Flewelling , Kevin T. Schomacker , Jean-Pierre Schott , Bret F. Draayer
发明人： Peter J. Costa , Stephen T. Sum , Ross F. Flewelling , Kevin T. Schomacker , Jean-Pierre Schott , Bret F. Draayer
IPC分类号： G01N21/64
CPC分类号： G01N21/31 , A61B5/0059 , A61B5/7203 , A61B5/725 , A61B5/7257 , A61B5/7264 , A61B5/7267
摘要： The invention provides methods for determining the probability that a given region of a tissue sample contains tissue of a given category, such as CIN 1 (cervical intraepithelial neoplasia, grade 1), CIN 2/3 (cervical intraepithelial neoplasia grades 2 and/or 3), normal squamous, normal columnar, and metaplasia, for example. The invention provides increased diagnostic accuracy by combining a plurality of statistical classification techniques. Furthermore, in one embodiment, the invention comprises combining one or more statistical techniques with one or more non-statistical classification techniques.
摘要翻译：本发明提供了用于确定组织样本的给定区域含有给定类别的组织（例如CIN1（宫颈上皮内瘤变1级，1级），CIN 2/3（宫颈上皮内瘤变2级和/或3级）），正常鳞状，正常柱状和化生。本发明通过组合多种统计分类技术来提供增加的诊断精度。此外，在一个实施例中，本发明包括将一种或多种统计技术与一种或多种非统计分类技术相结合。

2. 发明授权

US06385484B2 Spectroscopic system employing a plurality of data types 有权
标题翻译：采用多种数据类型的光谱系统
公开(公告)号：US06385484B2
公开(公告)日：2002-05-07
申请号：US09738613
申请日：2000-12-15
申请人： Robert J. Nordstrom , Peter J. Costa , Kwong Hui , Ross Flewelling , Howard Kaufman
发明人： Robert J. Nordstrom , Peter J. Costa , Kwong Hui , Ross Flewelling , Howard Kaufman
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0068
摘要： A system and method for classifying specimens using a plurality of spectral data types. Spectra are recorded as amplitudes at a series of discrete wavelengths. Pluralities of reference spectra are recorded for specimens having known conditions. A spectrum of a first type is observed for a test specimen. The specimen is characterized as to a first known condition. In the event that the specimen does not exhibit the first known condition, a spectrum of a second type is observed and analyzed to determine which of a plurality of conditions is to be ascribed to the test specimen. In some embodiments, the test specimen can comprise human cervical tissue, and the known conditions can include normal health, metaplasia, CIN I and CIN II/II.
摘要翻译：一种使用多种光谱数据类型分类样本的系统和方法。光谱被记录为一系列离散波长的幅度。对于具有已知条件的样品记录多个参考光谱。对于试样观察到第一类光谱。样品的特征在于第一已知条件。在样本不显示第一已知条件的情况下，观察并分析第二类型的光谱，以确定将多个条件中的哪一个归因于测试样本。在一些实施方案中，测试样品可以包含人宫颈组织，并且已知条件可以包括正常健康，化生，CIN I和CIN II / II。

3. 发明授权

US06839661B2 System for normalizing spectra 失效
标题翻译：光谱归一化系统
公开(公告)号：US06839661B2
公开(公告)日：2005-01-04
申请号：US09738612
申请日：2000-12-15
申请人： Peter J. Costa , Kwong Hui , Robert J. Nordstrom
发明人： Peter J. Costa , Kwong Hui , Robert J. Nordstrom
IPC分类号： G01N21/64 , G01N21/27 , G06F15/00
CPC分类号： G01N21/274
摘要： A method and system for normalizing optical spectra using a non-uniform segment normalization. A spectrum is obtained and is represented as a function of wavelength as an amplitude at each of a plurality of wavelengths. At least one segment of the spectrum is selected, each selected segment being bounded by an upper wavelength and a lower wavelength. A normalization factor is computed as the sum of the areas for each of the selected segments. The spectrum is normalized by dividing at least one amplitude of the spectrum by the normalization factor. Segments can be selected with different wavelength ranges, that is, segments can be non-uniform. Test specimens can be categorized based on an analysis of normalized spectra. In particular, the specimen to be tested can be human cervical tissue, and the state of health of the tissue can be determined.

4. 发明授权

US06421553B1 Spectral data classification of samples 有权
标题翻译：样品的光谱数据分类
公开(公告)号：US06421553B1
公开(公告)日：2002-07-16
申请号：US09738481
申请日：2000-12-15
申请人： Peter J. Costa , Kwong Hui , Robert J. Nordstrom
发明人： Peter J. Costa , Kwong Hui , Robert J. Nordstrom
IPC分类号： A61B600
CPC分类号： A61B5/0059 , A61B5/0068
摘要： A system and method for classifying tissue by application of discriminant analysis to spectral data. Spectra are recorded as amplitudes at a series of discrete wavelengths. Pluralities of reference spectra are recorded for specimens having known conditions. The reference spectra are subjected to discriminant analysis to determine wavelength regions of interest for the analysis. A plurality of amplitudes are selected for the analysis, and are plotted in an N-dimensional space. For each plurality of reference spectra corresponding to a specific known condition, a characteristic point is determined and plotted, the characteristic point representative of the known condition. A test spectrum is recorded from a test specimen, and the plurality of amplitudes corresponding in wavelength to the wavelength regions of interest are selected. A characteristic point in N-dimensional space is determined for the test spectrum. The distance of the characteristic point of the test spectrum from each of the plurality of characteristic points representative of known conditions is determined. The test specimen is assigned the condition corresponding to the characteristic point of a plurality of reference spectra, based on a distance relationship with at least two distances, provided that at least one distance is less than a pre-determined maximum distance. In some embodiments, the test specimen can comprise human cervical tissue, and the known conditions can include normal health, metaplasia, CIN I and CIN II/III.
摘要翻译：一种通过将判别分析应用于光谱数据对组织进行分类的系统和方法。光谱被记录为一系列离散波长的幅度。对于具有已知条件的样品记录多个参考光谱。对参考光谱进行鉴别分析，以确定分析所关注的波长区域。选择多个幅度用于分析，并绘制在N维空间中。对于对应于特定已知条件的每个多个参考光谱，确定和绘制特征点，表示已知条件的特征点。从测试样本记录测试光谱，并且选择波长对应于感兴趣的波长区域的多个幅度。确定测试光谱的N维空间中的特征点。确定表示已知条件的多个特征点中的每一个的测试光谱的特征点的距离。基于与至少两个距离的距离关系，将测试样本分配给与多个参考光谱的特征点相对应的条件，条件是至少一个距离小于预定的最大距离。在一些实施方案中，测试样品可以包含人宫颈组织，并且已知的条件可以包括正常健康，化生，CIN I和CIN II / III。

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