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1. 发明申请

US20100092992A1 LYSINE ACETYLATION SITES 审中-公开
标题翻译： LYSINE乙酰化网站
公开(公告)号：US20100092992A1
公开(公告)日：2010-04-15
申请号：US12310292
申请日：2007-08-17
申请人： Peter Hornbeck , Ting-Lei Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
发明人： Peter Hornbeck , Ting-Lei Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C07K16/44 , C07B59/008 , C07K14/47
摘要： The invention discloses 322 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在各种癌症中鉴定的322个新的乙酰化位点，包含本发明的乙酰化位点的肽（包括AQUA肽），特异性结合本发明的新乙酰化位点的抗体，以及上述的诊断和治疗用途。

2. 发明申请

US20090098581A1 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090098581A1
公开(公告)日：2009-04-16
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： G01N33/574 , C07K16/30 , G01N33/566
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

3. 发明授权

US07977462B2 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US07977462B2
公开(公告)日：2011-07-12
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

4. 发明申请

US20100120055A1 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20100120055A1
公开(公告)日：2010-05-13
申请号：US12311464
申请日：2007-09-28
申请人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
发明人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

5. 发明申请

US20100093000A1 Tyrosine phosphorylation sites 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20100093000A1
公开(公告)日：2010-04-15
申请号：US12148550
申请日：2008-04-18
申请人： Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
发明人： Jessica Cherry , Charles Farnsworth , Valerie L. Goss , Ting-Lei Gu , Ailan Guo , Peter Hornbeck , Yu Li , Albrecht Moritz , Anthony Possemato , Klarisa Rikova , Matthew Stokes , Jian Yu , Erik Spek , Corinne Michaud
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C07K16/44 , G01N33/574 , G01N33/57426 , G01N2333/4725 , G01N2333/98
摘要： The invention discloses novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

6. 发明申请

US20090053831A1 Tyrosine phosphorylation sites 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090053831A1
公开(公告)日：2009-02-26
申请号：US12150903
申请日：2008-04-30
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Valerie Goss , Francesco Boccalatte
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Valerie Goss , Francesco Boccalatte
IPC分类号： G01N33/536 , C07K16/18
CPC分类号： C07K16/30 , C07K16/44 , G01N33/57426 , G01N33/57484 , G01N33/577
摘要： The invention discloses 405 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的405个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体以及上述的诊断和治疗用途。

7. 发明申请

US20090305297A1 Tyrosine phosphorylation sites 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090305297A1
公开(公告)日：2009-12-10
申请号：US12157179
申请日：2008-06-06
申请人： Peter Hornbeck , Francesco Boccalatte , Charles Farnsworth , Valerie Goss , Ting-Lei Gu , Ailan Guo , Yu Li , Albrecht Moritz , Klarisa Rikova , Erik Spek , Matthew Stokes , Jian Yu
发明人： Peter Hornbeck , Francesco Boccalatte , Charles Farnsworth , Valerie Goss , Ting-Lei Gu , Ailan Guo , Yu Li , Albrecht Moritz , Klarisa Rikova , Erik Spek , Matthew Stokes , Jian Yu
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： G01N33/573 , C07K16/40 , C12Q1/485 , G01N33/574 , G01N33/57426
摘要： The invention discloses 397 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的397个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

8. 发明申请

US20090325312A1 Reagens for the detection of protein acetylation signaling pathways 审中-公开
标题翻译：用于检测蛋白质乙酰化信号通路的试剂
公开(公告)号：US20090325312A1
公开(公告)日：2009-12-31
申请号：US12227320
申请日：2007-05-11
申请人： Ailan Guo , Ting-Lei Gu , Peter Hornbeck , Jeffrey Mitchell , Yu Li
发明人： Ailan Guo , Ting-Lei Gu , Peter Hornbeck , Jeffrey Mitchell , Yu Li
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 426 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Methyltransferases, Transcription factors, Transcription coactivators, Translation initiation complex proteins, Oxireductases, Protein kinases, RNA binding proteins, Secreted proteins, Transferases, Transporter proteins, Ubiquitin conjugating system proteins, Motor proteins, Phosphotases, Proteases, Phospholipases, Receptor proteins and Vesicle proteins.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的426个新的乙酰化位点和人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：甲基转移酶，转录因子，转录共激活因子，翻译起始复合蛋白，氧化还原酶，蛋白激酶，RNA结合蛋白，分泌蛋白，转移酶，转运蛋白，泛素缀合系统蛋白，马达蛋白质，磷酸酶，蛋白酶，磷脂酶，受体蛋白和囊泡蛋白。

9. 发明申请

US20100015724A1 LYSINE ACETYLATION SITES 审中-公开
标题翻译： LYSINE乙酰化网站
公开(公告)号：US20100015724A1
公开(公告)日：2010-01-21
申请号：US12310279
申请日：2007-08-17
申请人： Peter Hornbeck , Ting-Lie Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
发明人： Peter Hornbeck , Ting-Lie Gu , Ailan Guo , Charles Farnsworth , Yu Li , Jeffrey Mitchell
IPC分类号： G01N33/53 , C07K16/00
CPC分类号： C07K16/44 , A61K38/00 , G01N33/574 , G01N2500/04
摘要： The invention discloses 332 novel acetylation sites identified in various cancers, peptides (including AQUA peptides) comprising a acetylation site of the invention, antibodies specifically bind to a novel acetylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在各种癌症中鉴定的332个新的乙酰化位点，包含本发明的乙酰化位点的肽（包括AQUA肽），特异性结合本发明的新型乙酰化位点的抗体，以及上述的诊断和治疗用途。

10. 发明申请

US20090124023A1 Reagens for the Detection of Protein Acetylation Signaling Pathways 审中-公开
标题翻译：用于检测蛋白质乙酰化信号通路的试剂
公开(公告)号：US20090124023A1
公开(公告)日：2009-05-14
申请号：US12227321
申请日：2007-05-11
申请人： Ailan Guo , Ting-Lei Gu , Jeffrey Mitchell , Peter Hornbeck
发明人： Ailan Guo , Ting-Lei Gu , Jeffrey Mitchell , Peter Hornbeck
IPC分类号： G01N33/566 , C07K16/18
CPC分类号： G01N33/68 , C07K16/18 , C07K16/44 , G01N33/6842
摘要： The invention discloses 432 novel acetylation sites identified in signal transduction proteins and pathways underlying human protein acetylation signaling pathways, and provides acetylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these acetylated sites/proteins, as well as methods of using the reagents for such purpose. Among the acetylation sites identified are sites occurring in the following protein types: Acetyltransferases, Adaptor/Scaffold proteins, Actin binding proteins, Adhesion proteins, Apoptosis proteins, Calcium-binding proteins, Cell Cycle Regulation proteins, Cell Surface proteins, DNA binding proteins, DNA replication proteins, Channel proteins, Chaperone proteins, Cellular Metabolism enzymes, Cytoskeletal proteins, DNA repair proteins, Endoplasmic reticulum proteins, Enzyme proteins, G protein and GTPase Activating proteins, Guanine Nucleotide Exchange Factors, Helicase proteins, Isomerase proteins, Extracelluar matrix proteins, Hydrolases, Ligase proteins, Lipid kinases, Inhibtor proteins, Lipid Binding proteins and Lyases.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的432个新的乙酰化位点和基于人蛋白质乙酰化信号通路的途径，并提供乙酰化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些乙酰化位点/蛋白质，以及使用试剂用于此目的的方法。确定的乙酰化位点之间的位点是发生在以下蛋白质类型中的位点：乙酰转移酶，适配器/支架蛋白，肌动蛋白结合蛋白，粘附蛋白，细胞凋亡蛋白，钙结合蛋白，细胞周期调节蛋白，细胞表面蛋白，DNA结合蛋白，DNA 复制蛋白，通道蛋白，伴侣蛋白，细胞代谢酶，细胞骨架蛋白，DNA修复蛋白，内质网蛋白，酶蛋白，G蛋白和GTP酶活化蛋白，鸟嘌呤核苷酸交换因子，Helicase蛋白，异构酶蛋白，Extracelluar基质蛋白，水解酶，连接酶蛋白，脂质激酶，抑制蛋白，脂质结合蛋白和裂解酶。

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