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1. 发明申请

US20130004963A1 Tyrosine, serine and threonine phosphorylation sites 有权
标题翻译：酪氨酸，丝氨酸和苏氨酸磷酸化位点
公开(公告)号：US20130004963A1
公开(公告)日：2013-01-03
申请号：US12310852
申请日：2007-09-08
申请人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
发明人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
IPC分类号： G01N33/566 , C07K16/18 , G01N33/573
CPC分类号： G01N33/6842 , C07K16/44 , G01N2440/14
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的155个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

2. 发明申请

US20140336360A1 Tyrosine, Serine and Threonine Phosphorylation Sites 审中-公开
标题翻译：酪氨酸，丝氨酸和苏氨酸磷酸化位点
公开(公告)号：US20140336360A1
公开(公告)日：2014-11-13
申请号：US14144717
申请日：2013-12-31
申请人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
发明人： Peter Hornbeck , Judit Villen , Albrecht Moritz , John Rush , Steven Gygi , Sean Beausoleil , Scott Gerber
IPC分类号： C07K16/18
CPC分类号： C07K16/18 , C07K16/28 , C07K16/2833 , C07K16/2863 , C07K16/30 , C07K2317/30 , C07K2317/34
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和白血病中鉴定的155个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

3. 发明授权

US08618260B2 Tyrosine, serine and threonine phosphorylation sites 有权
公开(公告)号：US08618260B2
公开(公告)日：2013-12-31
申请号：US12310852
申请日：2007-09-08
申请人： Peter Hornbeck , Albrecht Moritz , John Rush , Steven Gygi
发明人： Peter Hornbeck , Albrecht Moritz , John Rush , Steven Gygi
IPC分类号： C07K16/00
CPC分类号： G01N33/6842 , C07K16/44 , G01N2440/14
摘要： The invention discloses 155 novel phosphorylation sites identified in carcinoma and leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.

4. 发明授权

US07977462B2 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US07977462B2
公开(公告)日：2011-07-12
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： C07K16/00 , C12P21/08
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

5. 发明申请

US20090081659A1 Reagents for the detection of protein phosphorylation in carcinoma signaling pathways 审中-公开
标题翻译：用于检测癌症信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20090081659A1
公开(公告)日：2009-03-26
申请号：US12075065
申请日：2008-03-07
申请人： Peter Hornbeck , Ailan Guo , Albrecht Moritz , John Rush , Charles Farnsworth , Matthew Stokes , Anthony Passemato
发明人： Peter Hornbeck , Ailan Guo , Albrecht Moritz , John Rush , Charles Farnsworth , Matthew Stokes , Anthony Passemato
IPC分类号： G01N33/574 , C07K16/18 , C12Q1/68
CPC分类号： C07K16/18 , C07K16/22 , C07K16/30 , C07K16/40 , C07K2317/34
摘要： The invention discloses 364 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的364个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

6. 发明申请

US20090098581A1 Tyrosine phosphorylation sites 有权
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20090098581A1
公开(公告)日：2009-04-16
申请号：US12148547
申请日：2008-04-18
申请人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
发明人： Peter Hornbeck , Ailan Guo , Ting-Lei Gu , Klarisa Rikova , Albrecht Moritz , Charles Farnsworth , Matthew Stokes , Jian Yu , Erik Spek , Yu Li , Anthony Possemato , Jessica Cherry , Valerie Goss , Jeffrey Mitchell , John Rush , Corinne Michaud
IPC分类号： G01N33/574 , C07K16/30 , G01N33/566
CPC分类号： G01N33/6842 , C07K16/30 , C07K16/44 , C07K2317/34 , G01N33/57407 , G01N33/57426
摘要： The invention discloses 482 novel phosphorylation sites identified in carcinoma and/or leukemia, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌和/或白血病中鉴定的482个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

7. 发明申请

US20100120055A1 TYROSINE PHOSPHORYLATION SITES 审中-公开
标题翻译：酪氨酸磷酸化位点
公开(公告)号：US20100120055A1
公开(公告)日：2010-05-13
申请号：US12311464
申请日：2007-09-28
申请人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
发明人： Peter Hornbeck , Ailan Guo , Klarisa Rikova , Albrecht Moritz , Erik Spek , Anthony Possemato , Charles Farnsworth , Francesco Boccalatte , Jian Yu , Jefrey Mitchell , John Rush , Valerie Goss , Ting-Lei Gu , Yu Li , Matthew Stokes
IPC分类号： G01N33/53 , C07K16/18
CPC分类号： C12Q1/485 , A61K38/00 , A61K39/0011 , C07K14/4748 , C07K16/30 , C07K16/3007 , C07K16/40 , C07K16/44 , C07K2317/34 , C12Q1/42 , G01N33/574 , G01N33/6812 , G01N33/6842
摘要： The invention discloses 318 novel phosphorylation sites identified in carcinoma, peptides (including AQUA peptides) comprising a phosphorylation site of the invention, antibodies specifically bind to a novel phosphorylation site of the invention, and diagnostic and therapeutic uses of the above.
摘要翻译：本发明公开了在癌中鉴定的318个新的磷酸化位点，包含本发明的磷酸化位点的肽（包括AQUA肽），特异性结合本发明的新的磷酸化位点的抗体，以及上述的诊断和治疗用途。

8. 发明授权

US07973134B2 Reagents for the detection of protein phosphorylation in anaplastic large cell lymphoma signaling pathways 有权
标题翻译：用于检测间变性大细胞淋巴瘤信号通路中蛋白质磷酸化的试剂
公开(公告)号：US07973134B2
公开(公告)日：2011-07-05
申请号：US11503096
申请日：2006-08-11
申请人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
发明人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
IPC分类号： C07K16/00 , C07K16/18
CPC分类号： G01N33/6842 , C07K16/44
摘要： The invention discloses 211 novel phosphorylation sites identified in signal transduction proteins and pathways underlying Anaplastic Large Cell Lymphoma (ALCL) involving the ALK-NPM translocation/fusion, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Protein Kinases (including Receptor Tyrosine Kinases), Adaptor/Scaffold Proteins, Cellular Metabolism or Miscellaneous Enzymes, Oxidoreductases, Transcription Factors, Cytoskeletal Proteins, Translation Initiation Complexes, RNA Binding Proteins, Proteases, Acetyltransferases, G protein regulators/GTPases, Helicases, Apoptosis/Cell Cycle Regulation proteins, and Hydrolases.
摘要翻译：本发明公开了在信号转导蛋白中鉴定的211个新的磷酸化位点和涉及ALK-NPM易位/融合的间变性大细胞淋巴瘤（ALCL）的途径，并且为磷酸化位点特异性抗体和重同位素标记的肽（AQUA肽）提供了这些磷酸化位点/蛋白质的选择性检测和定量，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型发生的位点：蛋白激酶（包括受体酪氨酸激酶），适配器/支架蛋白，细胞代谢或其他酶，氧化还原酶，转录因子，细胞骨架蛋白，翻译起始复合物，RNA结合蛋白，蛋白酶，乙酰转移酶，G蛋白调节剂/ GTP酶，Helicases，细胞凋亡/细胞周期调节蛋白和水解酶。

9. 发明申请

US20070059845A1 Reagents for the detection of protein phosphorylation in T-cell receptor signaling pathways 有权
标题翻译：用于检测T细胞受体信号通路中蛋白质磷酸化的试剂
公开(公告)号：US20070059845A1
公开(公告)日：2007-03-15
申请号：US11503336
申请日：2006-08-11
申请人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
发明人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
IPC分类号： G01N33/543
CPC分类号： G01N33/6872 , C12Q1/25 , C12Q1/485 , G01N33/6842
摘要： The invention discloses 95 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of the T-cell receptor, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Actin Binding proteins, Adaptor/Scaffold proteins, Adhesion proteins, Calcium-binding proteins, Cell Cycle Regulation or Channel proteins, Chaperones, Cofactor proteins, Cytoskeletal proteins, DNA Binding proteins, G protein or GTPase Activating proteins, Ligases, Lipid Kinases and Binding proteins, Oxidoreductases, Protein Kinases, Protein Phosphatases, Receptor proteins, RNA Binding proteins, Transcription Factor/Initiation Complex proteins, Transcription Coactivator/Corepressor proteins, Translation Initiation Complex proteins, Ubitquitin Conjugating System proteins, and Vesicle proteins.
摘要翻译：本发明公开了在T细胞受体下游的信号转导蛋白和途径中鉴定的95个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/ 蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是发生在以下蛋白质类型中的位点：肌动蛋白结合蛋白，衔接/支架蛋白，粘附蛋白，钙结合蛋白，细胞周期调节或通道蛋白，伴侣蛋白，辅因子蛋白，细胞骨架蛋白，DNA结合蛋白， G蛋白或GTPase激活蛋白，连接酶，脂质激酶和结合蛋白，氧化还原酶，蛋白激酶，蛋白磷酸酶，受体蛋白，RNA结合蛋白，转录因子/起始复合蛋白，转录共激活因子/ Corepressor蛋白，翻译起始复合蛋白，Ubitquitin缀合系统蛋白和囊泡蛋白。

10. 发明授权

US07939636B2 Reagents for the detection of protein phosphorylation in c-Src signaling pathways 有权
标题翻译：用于检测c-Src信号通路中蛋白质磷酸化的试剂
公开(公告)号：US07939636B2
公开(公告)日：2011-05-10
申请号：US11503335
申请日：2006-08-11
申请人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
发明人： Albrecht Moritz , Kimberly Lee , John Rush , Roberto Polakiewicz
IPC分类号： G07K16/00 , G07K16/18
CPC分类号： G01N33/5041 , C07K16/18 , C07K16/3015 , C07K16/32 , C07K16/40 , C07K2317/34 , G01N2333/91215
摘要： The invention discloses 102 novel phosphorylation sites identified in signal transduction proteins and pathways downstream of c-Src kinase, and provides phosphorylation-site specific antibodies and heavy-isotope labeled peptides (AQUA peptides) for the selective detection and quantification of these phosphorylated sites/proteins, as well as methods of using the reagents for such purpose. Among the phosphorylation sites identified are sites occurring in the following protein types: Adaptor/Scaffold proteins, Actin Binding proteins, Cytoskeletal proteins, G protein/GTPase Activating protein/Guanine Nucleotide Exchange Factor proteins, Helicases, RNA Binding proteins, Transcription/Translation Factor or Initiation Complex proteins, Cellular Metabolism Enzymes, and Vesicle proteins.
摘要翻译：本发明公开了在c-Src激酶下游的信号转导蛋白和途径中鉴定的102个新的磷酸化位点，并提供磷酸化位点特异性抗体和重同位素标记肽（AQUA肽），用于选择性检测和定量这些磷酸化位点/蛋白质，以及使用试剂用于此目的的方法。鉴定的磷酸化位点是以下蛋白质类型的位点：适配器/支架蛋白，肌动蛋白结合蛋白，细胞骨架蛋白，G蛋白/ GTPase激活蛋白/鸟嘌呤核苷酸交换因子蛋白，Helicases，RNA结合蛋白，转录因子/翻译因子或起始复合蛋白，细胞代谢酶和囊泡蛋白。

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