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1. 发明授权

US4105788A Diacylated derivates of .gamma.-glutamyl dopamine 失效
标题翻译： {65-谷氨酰多巴胺的二酰化衍生物
公开(公告)号：US4105788A
公开(公告)日：1978-08-08
申请号：US793468
申请日：1977-05-03
申请人： Peter H. Jones , Carroll W. Curs , Jaroslav Kyncl
发明人： Peter H. Jones , Carroll W. Curs , Jaroslav Kyncl
IPC分类号： A61K31/225 , A61K31/235 , A61P9/08 , A61P9/12 , C07C237/08 , C07C271/22 , A61K31/24 , C07C101/24
CPC分类号： C07C271/22
摘要： This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.
摘要翻译：本发明包括选自下组的γ-谷氨酰多巴胺的二酰化衍生物：其中R是C1-C12直链或支链烷基，苯环或取代苯环，R'是H或C1- C7烷基及其药学上可接受的酸加成盐。

2. 发明授权

US4105787A Diacylated derivatives of .gamma.-glutamyl dopamine 失效
标题翻译： {65-谷氨酰多巴胺的二酰化衍生物
公开(公告)号：US4105787A
公开(公告)日：1978-08-08
申请号：US793467
申请日：1977-05-03
申请人： Peter H. Jones , Carroll W. Curs , Jaroslav Kyncl
发明人： Peter H. Jones , Carroll W. Curs , Jaroslav Kyncl
IPC分类号： A61K31/225 , A61K31/235 , A61P9/08 , A61P9/12 , C07C237/08 , C07C271/22 , A61K31/24 , C07C69/76
CPC分类号： C07C271/22
摘要： This invention covers diacylated derivatives of .gamma.-glutamyl dopamine selected from the group consisting of ##STR1## where R is a C.sub.1 -C.sub.12 straight or branched chain alkyl radical, a phenyl ring or a substituted phenyl ring and R' is H or a C.sub.1 -C.sub.7 alkyl, and a pharmaceutically acceptable acid addition salt thereof.The compounds of this invention are useful to increase the renal blood flow by being administered to warm-blooded animals by clinically accepted routes of administration such as oral, parenteral, rectal and the like.
摘要翻译：本发明包括选自下组的γ-谷氨酰多巴胺的二酰化衍生物：其中R是C1-C12直链或支链烷基，苯环或取代苯环，R'是H或C1- C7烷基及其药学上可接受的酸加成盐。

3. 发明授权

US4166819A 4-Aroyl substituted phenoxy methylene-5-tetrazoles 失效
标题翻译： 4-芳酰基取代的苯氧基亚甲基-5-四唑
公开(公告)号：US4166819A
公开(公告)日：1979-09-04
申请号：US830975
申请日：1977-09-06
申请人： Peter H. Jones , Dilbagh S. Bariana , Anthony K. L. Fung , Yvonne C. Martin , Jaroslav Kyncl , Amrit Lall
发明人： Peter H. Jones , Dilbagh S. Bariana , Anthony K. L. Fung , Yvonne C. Martin , Jaroslav Kyncl , Amrit Lall
IPC分类号： C07C59/90 , C07C205/45 , C07D257/04
CPC分类号： C07D257/04 , C07C205/45 , C07C45/46 , C07C45/673 , C07C59/90
摘要： This invention provides 4-aroyl substituted phenoxy acetic acids and tetrazoles of the formula ##STR1## wherein R is a phenyl ring, a substituted phenyl ring, or naphthyl; R.sub.1 is --CH.sub.2 COOH or methyl tetrazole, and X.sub.1 and X.sub.2 are each a halogen or loweralkyl, or when taken together form with the two attached carbons a phenyl ring.These compounds are useful as antihypertensive agents, diuretics and uricosuric agents.
摘要翻译：本发明提供4-芳酰取代的苯氧基乙酸和式IMA的四唑，其中R是苯环，取代的苯环或萘基; R1是-CH2COOH或甲基四唑，X1和X2各自是卤素或低级烷基，或者与两个连接的碳一起形成苯环。

4. 发明申请

US20120302598A1 IMIDAZOPYRIDINONES 审中-公开
标题翻译：咪达唑仑
公开(公告)号：US20120302598A1
公开(公告)日：2012-11-29
申请号：US13302085
申请日：2011-11-22
申请人： Peter H. Jones , David Cameron Pryde , Thien Duc Tran
发明人： Peter H. Jones , David Cameron Pryde , Thien Duc Tran
IPC分类号： A61K31/437 , A61P31/14 , A61P31/22 , C07D471/04 , A61P31/20
CPC分类号： C07D471/04 , C07D405/14
摘要： The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases.We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is O; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.
摘要翻译：本发明涉及咪唑并吡啶酮，其在医药中的用途，含有它们的组合物，其制备方法和用于此类方法的中间体。通过激活TLRs，应该可以诱导或刺激免疫细胞以产生免疫应答。特别地，TLR7涉及病毒感染（例如HCV或HBV），癌症和肿瘤以及T2辅助细胞（TH2）介导的疾病，因此TLR7激动剂潜在地用于治疗这些疾病。我们现在发现了一系列作为TLR7激动剂的咪唑并吡啶酮。提供式（I）化合物或其药学上可接受的盐或溶剂化物，其中R1为3-8元饱和杂环基，其中一个环成员为O; 且R 2为苯基或吡啶基，各自任选被C 1 -C 6烷基取代。

5. 发明授权

US4523020A Substituted 2-(3-aminophenoxymethyl)imidazolines 失效
标题翻译：取代的2-（3-氨基苯氧基甲基）咪唑啉
公开(公告)号：US4523020A
公开(公告)日：1985-06-11
申请号：US550334
申请日：1983-11-10
申请人： Alan E. Moormann , Barnett S. Pitzele , Peter H. Jones
发明人： Alan E. Moormann , Barnett S. Pitzele , Peter H. Jones
IPC分类号： C07C205/37 , C07D233/22 , C07D307/33
CPC分类号： C07D307/33 , C07C205/37 , C07D233/22
摘要： This invention relates to novel substituted 2-(3-aminophenoxymethyl)imidazolines which are useful for the treatment of diarrhea and useful as analgesics.
摘要翻译：本发明涉及可用于治疗腹泻并用作止痛剂的新型取代的2-（3-氨基苯氧基甲基）咪唑啉。

6. 发明申请

US20110039884A1 Imidazopyridinones 审中-公开
标题翻译：咪唑并吡啶酮
公开(公告)号：US20110039884A1
公开(公告)日：2011-02-17
申请号：US12914530
申请日：2010-10-28
申请人： Peter H. Jones , David Cameron Pryde , Thien Duc Tran
发明人： Peter H. Jones , David Cameron Pryde , Thien Duc Tran
IPC分类号： A61K31/437 , C07D471/04 , A61P31/12 , A61P31/22 , A61P31/14
CPC分类号： C07D471/04 , C07D405/14
摘要： The invention relates to imidazopyridinones, to their use in medicine, to compositions containing them, to processes for their preparation and to intermediates used in such processes.By activating TLRs, it should be possible to induce or stimulate immune cells to mount an immune response. In particular, the TLR7 has been implicated in viral infections (such as HCV or HBV), cancers and tumours, and T2 Helper cell (TH2) mediated diseases, and hence TLR7 agonists are potentially useful in the treatment of such diseases.We have now found a series of imidazopyridinones which are agonists of TLR7. According, there is provided a compound of formula (I) or a pharmaceutically acceptable salt or solvate thereof, wherein R1 is 3- to 8-membered saturated heterocyclic group wherein one ring member is —O—; and R2 is phenyl or pyridinyl, each optionally substituted by C1-C6alkyl.
摘要翻译：本发明涉及咪唑并吡啶酮，其在医药中的用途，含有它们的组合物，其制备方法和用于此类方法的中间体。通过激活TLRs，应该可以诱导或刺激免疫细胞以产生免疫应答。特别地，TLR7涉及病毒感染（例如HCV或HBV），癌症和肿瘤以及T2辅助细胞（TH2）介导的疾病，因此TLR7激动剂潜在地用于治疗这些疾病。我们现在发现了一系列作为TLR7激动剂的咪唑并吡啶酮。提供式（I）化合物或其药学上可接受的盐或溶剂合物，其中R1是3-8元饱和杂环基，其中一个环成员是-O-; 且R 2为苯基或吡啶基，各自任选被C 1 -C 6烷基取代。

7. 发明授权

US4374932A 5-ASA Drug delivery system 失效
标题翻译： 5-ASA药物输送系统
公开(公告)号：US4374932A
公开(公告)日：1983-02-22
申请号：US271748
申请日：1981-06-08
申请人： Barnett S. Pitzele , Peter H. Jones
发明人： Barnett S. Pitzele , Peter H. Jones
IPC分类号： A61K31/785 , A61K47/48 , A61P1/04 , C07C245/08 , B01J41/14 , A61K31/74
CPC分类号： A61K47/48184 , C07C245/08
摘要： The present invention relates to novel compounds for the prophylaxis and treatment of Inflammatory Bowel disease (IBD) via the administration of an effective amount in a suitable pharmaceutical dosage of a polymeric agent for releasing 5,5'-azobis-salicylic acid which comprises a non-degradable anionic exchange resin and the dianionic form of 5,5'-azobis-salicylic acid. The 5,5'-azobis-salicylic acid undergoes bacterial cleavage in the mammalian lower bowel to release 5-aminosalicylic acid.
摘要翻译：本发明涉及用于预防和治疗炎症性肠病（IBD）的新化合物，其通过以合适的药物剂量施用有效量的用于释放5,5'-偶氮双 - 水杨酸的聚合物，其包含非 - 可降解的阴离子交换树脂和5,5'-偶氮双 - 水杨酸的二阴离子形式。 5,5'-偶氮双 - 水杨酸在哺乳动物下肠中经历细菌切割以释放5-氨基水杨酸。

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