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1. 发明申请

US20130324820A1 TISSUE IMPLANTABLE MICROBIOSENSOR 有权
标题翻译：组织可植入式微生物传感器
公开(公告)号：US20130324820A1
公开(公告)日：2013-12-05
申请号：US13991113
申请日：2011-12-01
申请人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
发明人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
IPC分类号： A61B5/1486 , C25D7/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B2562/12 , C25D7/00
摘要： A biosensor system comprises a capillary substrate, conductive electrode, and a plurality of nanoparticles having an enzyme deposited thereon formed in a cavity at one end of the capillary substrate. The substrate may have an optional reinforcing layer (which may be conductive or non-conductive) and optional insulating layer thereon. A cannula having an optional conductive layer, insulating layer, and reference electrode may also form part of the system.
摘要翻译：生物传感器系统包括毛细管基底，导电电极和在毛细管基底的一端形成在腔中的沉积有酶的多个纳米颗粒。衬底可以具有可选的增强层（其可以是导电的或不导电的）和其上的可选的绝缘层。具有可选导电层，绝缘层和参考电极的插管也可以形成系统的一部分。

2. 发明授权

US09468402B2 Tissue implantable microbiosensor 有权
标题翻译：组织植入式微生物传感器
公开(公告)号：US09468402B2
公开(公告)日：2016-10-18
申请号：US13991113
申请日：2011-12-01
申请人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
发明人： Peter A. Petillo , George S. Wilson , Judy Z. Wu , Mark L. Richter , David A. Johnson , Daniel V. Aillon
IPC分类号： A61B5/05 , A61B5/1486 , A61B5/145 , C25D7/00
CPC分类号： A61B5/14865 , A61B5/14532 , A61B2562/12 , C25D7/00
摘要： A biosensor system comprises a capillary substrate, conductive electrode, and a plurality of nanoparticles having an enzyme deposited thereon formed in a cavity at one end of the capillary substrate. The substrate may have an optional reinforcing layer (which may be conductive or non-conductive) and optional insulating layer thereon. A cannula having an optional conductive layer, insulating layer, and reference electrode may also form part of the system.
摘要翻译：生物传感器系统包括毛细管基底，导电电极和在毛细管基底的一端形成在腔中的沉积有酶的多个纳米颗粒。衬底可以具有可选的增强层（其可以是导电的或不导电的）和其上的可选的绝缘层。具有可选导电层，绝缘层和参考电极的插管也可以形成系统的一部分。

3. 发明申请

US20130172705A1 ENZYME CO-FACTOR ENHANCEMENT OF BIOSENSOR PERFORMANCE 审中-公开
标题翻译：生物传感器性能的酶合成因子增强
公开(公告)号：US20130172705A1
公开(公告)日：2013-07-04
申请号：US13821903
申请日：2011-09-12
申请人： Peter A. Petillo , Daniel V. Aillon , Brian S. Barrett
发明人： Peter A. Petillo , Daniel V. Aillon , Brian S. Barrett
IPC分类号： C12N9/96 , A61B5/145 , A61B5/1486
CPC分类号： C12N9/96 , A61B5/14532 , A61B5/14865 , C12Q1/004 , G01N33/573
摘要： The present invention is broadly concerned with the crafting and manufacturability of an implantable enzymatic-based sensor characterized by a small size, optimum geometry, linearity of response over the concentration range of interest, extended shelf-life, selectivity for the analyte in question, and the ability to exclude bioactive interferents. More particularly, it is preferably concerned with a general approach to optimize the performance of the biorecognition elements required to produce biosensors of the type designed to provide, and in conjunction with a suitable signal processing unit, a current which is proportional to the concentration of the analyte of interest. The biosensors described herein may be implanted in vivo, including intra-cerebral, sub-cutaneous, intra-muscular, inter-peritoneal oral, serum, and vascular implantation, the majority of which may act as a surrogate for systemic monitoring and used to monitor analytes of interest in real-time. Multiple biosensors can be joined together to allow for the simultaneous recording of multiple analytes of interest. In addition to the in vivo applications, sensors of the design described herein may also find use in medical monitoring, industrial processes, fermentation, environmental monitoring, and waste water stream monitoring. The present invention offers co-factor enhancement of the biorecognition element, providing access to a range of biorecognition elements heretofore difficult to incorporate into a manufacturing process for the large-scale production of biosensors.
摘要翻译：本发明广泛涉及可植入酶基传感器的制作和可制造性，其特征在于在所关注的浓度范围内具有小尺寸，最佳几何形状，响应线性，延长的保质期，所述分析物的选择性，以及排除生物活性干扰物的能力。更具体地，优选地涉及优化生物识别元件的性能的一般方法，所述生物识别元件产生生物传感器的类型，所述生物传感器被设计成提供并与合适的信号处理单元结合，其电流与感兴趣的分析物本文描述的生物传感器可以植入体内，包括脑内，皮下，肌内，腹膜内口服，血清和血管植入，其中大多数可以用作系统监测的替代物并用于监测实时分析物。多个生物传感器可以连接在一起以允许同时记录多个感兴趣的分析物。除了体内应用之外，本文所述设计的传感器还可用于医疗监测，工业过程，发酵，环境监测和废水流监测。本发明提供了生物识别元件的辅因子增强，提供了到目前难以并入用于大规模生产生物传感器的制造过程中的一系列生物识别元件的获取。

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