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1. 发明申请

US20080255106A1 Novel 2-Phenyl-Imidazo[4,5-B]Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase for the Treatment of Dementia and Neurodegenerative Disorders 审中-公开
标题翻译：新型2-苯基 - 咪唑并[4,5-B]吡啶衍生物作为糖原合酶激酶抑制剂治疗痴呆和神经退行性疾病
公开(公告)号：US20080255106A1
公开(公告)日：2008-10-16
申请号：US12088897
申请日：2006-10-02
申请人： Per I. Arvidsson , Erwan Arzel , Jeremy Burrows , Helena Gyback , Tobias Rein , Didier Rotticci , Peter Soderman
发明人： Per I. Arvidsson , Erwan Arzel , Jeremy Burrows , Helena Gyback , Tobias Rein , Didier Rotticci , Peter Soderman
IPC分类号： A61K31/437 , A61P25/00 , C07D471/04 , A61K31/541 , A61K31/496 , A61P3/10 , A61K31/5377
CPC分类号： C07D471/04
摘要： Compounds of formula I wherein R1, R2, R3, R4, R5, R6 and R7 are as defined in the specification, as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation and new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：其中R 1，R 2，R 3，R 4，R 5，R 5，R 4， R 6和R 7如说明书中所定义，作为其盐或其盐的碱或其药学上可接受的盐，溶剂化物或溶剂合物，其方法为制剂和其中使用的新中间体，含有所述化合物的药物制剂和所述化合物在治疗中的用途。

2. 发明申请

US20080255085A1 Novel Imidazo [4,5-b] Pyridine Derivatives as Inhibitors of Glycogen Synthase Kinase 3 for Use in the Treatment of Dementia and Neurodegenerative Disorders 审中-公开
标题翻译：新型咪唑并[4,5-b]吡啶衍生物作为糖原合成酶激酶3抑制剂用于治疗痴呆和神经退行性疾病
公开(公告)号：US20080255085A1
公开(公告)日：2008-10-16
申请号：US12089002
申请日：2006-10-02
申请人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
发明人： Per I Arvidsson , Erwan Arzel , Jeremy Burrows , Martina Claesson , Colin Ray , Tobias Rein , Didier Rotticci , Peter Soderman
IPC分类号： A61K31/5377 , C07D487/04 , A61K31/496 , A61P25/16 , A61P25/28 , A61K31/437 , A61K31/551
CPC分类号： C07D471/04
摘要： Compounds of formula I wherein X is or Y; and wherein A, Y, R1, R2, R3, R4 and R5 are as defined in the specification as a base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, processes for their preparation, new intermediates used therein, pharmaceutical formulations containing said compounds and to the use of said compounds in therapy.
摘要翻译：其中X为或Y的式I化合物; 并且其中A，Y，R 1，R 2，R 3，R 4和R 4， 5的定义如本说明书中作为其盐或其药学上可接受的盐，溶剂化物或其盐的溶剂化物，其制备方法，其中使用的新中间体，含有所述化合物的药物制剂以及所述化合物的用途治疗。

3. 发明申请

US20100234593A1 Imidazo[4,5-B]Pyridine-7-Carboxamides 704 审中-公开
标题翻译：咪唑并[4,5-B]吡啶-7-羧酰胺704
公开(公告)号：US20100234593A1
公开(公告)日：2010-09-16
申请号：US12593432
申请日：2008-03-28
申请人： Per Arvidsson , Jeremy Burrows , Peter Soderman , Ulrika Yngve
发明人： Per Arvidsson , Jeremy Burrows , Peter Soderman , Ulrika Yngve
IPC分类号： C07D413/14 , C07D471/04
CPC分类号： C07D471/04
摘要： The present invention relates to new compounds of formula (I) as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及作为其盐的游离碱或其药学上可接受的盐，溶剂合物或溶剂化物的新的式（I）化合物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

4. 发明申请

US20130345272A1 Cycloalkyl Ether Compounds and Their Use as Bace Inhibitors 有权
标题翻译：环烷基醚化合物及其作为抑制剂的用途
公开(公告)号：US20130345272A1
公开(公告)日：2013-12-26
申请号：US13916740
申请日：2013-06-13
申请人： Sofia Karlstrom , Peter Soderman , Britt-Marie Swahn , Laszlo Rakos , Liselotte Ohberg
发明人： Sofia Karlstrom , Peter Soderman , Britt-Marie Swahn , Laszlo Rakos , Liselotte Ohberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/428
CPC分类号： C07D235/02 , A61K31/428 , A61K45/06
摘要： Cycloalkyl ether compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration and pharmaceutical compositions containing such compounds.
摘要翻译：环烷基醚化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，神经变性与诸如阿尔茨海默病或痴呆的疾病相关，包括混合血管和退行性疾病的痴呆，老年痴呆，老年性痴呆和与帕金森病相关的老年痴呆，进行性核上性麻痹或皮层基底变性以及含有这些化合物的药物组合物。

5. 发明申请

US20130345248A1 Cyclohexane-1,2'-Naphthalene-1',2"-Imidazol Compounds and Their Use as Bace 有权
标题翻译：环己烷-1,2'-萘-1'，2“ - 咪唑化合物及其作为Bace的用途
公开(公告)号：US20130345248A1
公开(公告)日：2013-12-26
申请号：US13916731
申请日：2013-06-13
申请人： Sofia Karlstrom , Lars Sandberg , Peter Soderman , Karin Kolmodin , Liselotte Ohberg
发明人： Sofia Karlstrom , Lars Sandberg , Peter Soderman , Karin Kolmodin , Liselotte Ohberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/4439 , A61K31/4184 , C07D401/04
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04 , C07D491/107
摘要： Cyclohexane-1,2′-naphthalene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
摘要翻译：环己烷-1,2'-萘-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

6. 发明申请

US20130345247A1 Cyclohexane-1,2'-Indene-1',2"-Imidazol Compounds and Their Use as Bace Inhibitors 有权
标题翻译：环己烷-1,2'-茚-1'，2“ - 咪唑化合物及其作为阻止剂的用途
公开(公告)号：US20130345247A1
公开(公告)日：2013-12-26
申请号：US13916701
申请日：2013-06-13
申请人： Sofia Karlstrom , Peter Soderman , Laszlo Rakos , Liselotte Ohberg , Karin Kolmodin , Lars Sandberg
发明人： Sofia Karlstrom , Peter Soderman , Laszlo Rakos , Liselotte Ohberg , Karin Kolmodin , Lars Sandberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/4439 , A61K31/4184 , C07D401/04
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04
摘要： Cyclohexane-1,2′-indene-1′,2″-imidazole compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration, methods of therapy using such compounds, and pharmaceutical compositions containing such compounds.
摘要翻译：环己烷-1,2'-茚-1'，2“ - 咪唑化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年痴呆，老年痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮层基底变性，使用这些化合物的治疗方法，以及含有这些化合物的药物组合物。

7. 发明申请

US20080161269A1 Compounds 620 审中-公开
标题翻译：化合物620
公开(公告)号：US20080161269A1
公开(公告)日：2008-07-03
申请号：US11959604
申请日：2007-12-19
申请人： Stefan Berg , Sofia Karlstrom , Karin Kolmodin , Johan Lindstrom , Jan-Erik Nystrom , Fernando Sehgelmeble , Peter Soderman
发明人： Stefan Berg , Sofia Karlstrom , Karin Kolmodin , Johan Lindstrom , Jan-Erik Nystrom , Fernando Sehgelmeble , Peter Soderman
IPC分类号： A61K31/695 , C07F7/08 , A61P25/00
CPC分类号： C07F7/0812 , C07D233/86 , C07D233/88 , C07D401/10 , C07D403/10
摘要： This invention relates to novel compounds having the structural formula I below: and to their pharmaceutically acceptable salt, compositions and methods of use. These novel compounds provide a treatment or prophylaxis of cognitive impairment, Alzheimer Disease, neurodegeneration and dementia.
摘要翻译：本发明涉及具有以下结构式I的新化合物及其药学上可接受的盐，组合物和使用方法。这些新化合物提供了认知障碍，阿尔茨海默病，神经变性和痴呆症的治疗或预防。

8. 发明申请

US20060116362A1 Nobel compounds having selective inhibiting effect at gsk3 失效
标题翻译：诺贝尔化合物在gsk3具有选择性抑制作用
公开(公告)号：US20060116362A1
公开(公告)日：2006-06-01
申请号：US10539543
申请日：2003-12-15
申请人： Stefan Berg , Sven Hellberg , Peter Soderman
发明人： Stefan Berg , Sven Hellberg , Peter Soderman
IPC分类号： A61K31/497 , A61K31/4965 , C07D403/02 , C07D241/26
CPC分类号： C07D401/12
摘要： The present invention relates to new compounds of formula (I) wherein: Z is N and X is CH or N; Y is CONR5; P is phenyl or a 5 or 6 membered heteroaromatic ring containing one or more heteroatoms selected from N, O or S; Q is phenyl or a 5 or 6 membered aromatic heterocyclicc ring containing one or more nitrogen atoms; R is C1-6alkylNR10R11 or C1-6alkylazetidine; R10 is hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C0-6alkylC3-6cycloalkyl, C0-6alkylaryl, C0-61alkylheteroaryl or C1-6alkylNR8R9; R11 is C1-6alkylNR8R9, C0-6alkylC3-6cycloalkyl or C0-6alkylheterocycloalkyl; as a free base or a pharmaceutically acceptable salt, solvate or solvate of salt thereof, a process for their preparation and new intermediates used therein, pharmaceutical formulations containing said therapeutically active compounds and to the use of said active compounds in therapy.
摘要翻译：本发明涉及新的式（I）化合物，其中：Z是N，X是CH或N; Y为CONR 5; P是苯基或含有一个或多个选自N，O或S的杂原子的5或6元杂芳环; Q是苯基或含有一个或多个氮原子的5或6元芳族杂环环; R是C 1-6烷基，R 10，或C 1-6烷基氮杂环丁烷; R 10是氢，C 1-6烷基，C 2-6 - 烯基，C 2-6 - 炔基，C 0-6-6烷基C 3-6环烷基，C 0-6烷基芳基，C 0-6-烷基杂芳基或C 1-6烷基N R 8 R 9; R 11是C 1-6烷基，R 8，R 9，C 0-6，烷基C 3-6环烷基或C 0-6-6烷基杂环烷基; 作为其盐的游离碱或其药学上可接受的盐，溶剂化物或溶剂化物，其制备方法和其中使用的新中间体，含有所述治疗活性化合物的药物制剂和所述活性化合物在治疗中的用途。

9. 发明申请

US20130345246A1 2H-Imidazol-4-Amine Compounds and Their Use as Bace Inhibitors 有权
标题翻译： 2H-咪唑-4-胺化合物及其作为抑制剂的用途
公开(公告)号：US20130345246A1
公开(公告)日：2013-12-26
申请号：US13916690
申请日：2013-06-13
申请人： Sofia Karlstrom , Gabor Csjernyik , Britt-Marie Swahn , Lars Sandberg , Karin Kolmodin , Peter Soderman , Liselotte Ohberg
发明人： Sofia Karlstrom , Gabor Csjernyik , Britt-Marie Swahn , Lars Sandberg , Karin Kolmodin , Peter Soderman , Liselotte Ohberg
IPC分类号： C07D235/02 , A61K45/06 , A61K31/4439 , C07D401/04 , A61K31/4184
CPC分类号： C07D235/02 , A61K31/4184 , A61K31/4439 , A61K45/06 , C07D401/02 , C07D401/04
摘要： 2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration. methods of therapy, and pharmaceutical compositions containing such compounds.
摘要翻译： 2H-咪唑-4-胺化合物，其治疗上可接受的盐，其制备方法，这些化合物治疗Abeta相关病症如唐氏综合征，β-淀粉样血管病，阿尔茨海默病，记忆丧失，注意力缺陷症状相关的治疗用途阿尔茨海默病，与阿尔茨海默病或痴呆等疾病相关的神经变性，包括混合血管和退行性痴呆，老年痴呆，老年性痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。治疗方法和含有这些化合物的药物组合物。

10. 发明申请

US20130210837A1 Compounds and Their Use as BACE Inhibitors 有权
标题翻译：化合物及其用作BACE抑制剂
公开(公告)号：US20130210837A1
公开(公告)日：2013-08-15
申请号：US13833221
申请日：2013-03-15
申请人： Gabor Csjernyik , Sofia Karlstrom , Annika Kers , Karin Kolmodin , Martin Nylof , Liselotte Ohberg , Laszlo Rakos , Lars Sandberg , Fernando Sehgelmeble , Peter Soderman , Britt-Marie Swahn , Stefan Von Berg
发明人： Gabor Csjernyik , Sofia Karlstrom , Annika Kers , Karin Kolmodin , Martin Nylof , Liselotte Ohberg , Laszlo Rakos , Lars Sandberg , Fernando Sehgelmeble , Peter Soderman , Britt-Marie Swahn , Stefan Von Berg
IPC分类号： C07D491/107 , C07D491/20 , C07D471/04 , C07D235/02
CPC分类号： A61K31/497 , A61K31/4184 , A61K31/4188 , A61K31/437 , A61K31/4439 , A61K31/506 , A61K45/06 , A61K2300/00 , C07D235/02 , C07D401/04 , C07D401/12 , C07D403/12 , C07D405/12 , C07D471/04 , C07D491/107 , C07D491/20
摘要： The present invention relates to compounds of formula (I) and their pharmaceutical compositions. In addition, the present invention relates to therapeutic methods for the treatment and/or prevention of Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy such as but not limited to cerebral amyloid angiopathy or hereditary cerebral hemorrhage, disorders associated with cognitive impairment such as but not limited to MCI (“mild cognitive impairment”), Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration.
摘要翻译：本发明涉及式（I）化合物及其药物组合物。此外，本发明涉及用于治疗和/或预防与Abeta相关的病理学的治疗方法，例如唐氏综合征，β-淀粉样变性血管病，例如但不限于脑淀粉样血管病或遗传性脑出血，与认知障碍相关的疾病例如但不限于MCI（“轻度认知障碍”），阿尔茨海默病，记忆丧失，与阿尔茨海默病相关的注意力缺陷症状，与诸如阿尔茨海默病或痴呆的疾病相关的神经变性，包括混合血管和退行性起源的痴呆，老年性痴呆，老年性痴呆和与帕金森病相关的痴呆，进行性核上性麻痹或皮质基底变性。

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