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1. 发明申请

US20130146758A1 HIGH-DENSITY SAMPLE SUPPORT PLATE FOR AUTOMATED SAMPLE ALIQUOTING 有权
标题翻译：高密度样品支持板，用于自动样品均质
公开(公告)号：US20130146758A1
公开(公告)日：2013-06-13
申请号：US13699446
申请日：2011-05-20
申请人： Pawel Urban , Renato Zenobi , Konstantins Jefimovs , Andrea Amantonico , Stephan Fagerer , Nils Goedecke
发明人： Pawel Urban , Renato Zenobi , Konstantins Jefimovs , Andrea Amantonico , Stephan Fagerer , Nils Goedecke
IPC分类号： B01L9/00 , B05D3/00 , H01J49/26
CPC分类号： B01L9/00 , B05D3/007 , H01J49/0418 , H01J49/161 , H01J49/26
摘要： A sample support plate (100) for a variety of possible applications, including MALDI mass spectrometry, is disclosed. A plurality of spatially separated sample recipient sites (101) are arranged on the surface of a substrate. The recipient sites are mutually separated by areas having a different wettability than the recipient sites. They are arranged in a plurality of rows consisting of a plurality of recipient sites whose centers are regularly spaced along a first direction with a predetermined periodicity (D1), the rows being regularly spaced along a second direction perpendicular to the first direction with a predetermined centerline distance (D2). Each recipient site has a maximum lateral dimension that is preferably smaller than the diameter of a beam spot (104) of a desorption laser beam (103). In order to enable unsupervised splitting of bulk liquid samples into droplets at the sample recipient sites, the periodicity along the first direction and the centerline distance along the second direction are chosen such that each recipient sites has a next neighbor at a distance that is less than or equal to three times the minimum lateral dimension of each recipient site. In preferred embodiments, the sample recipient sites are arranged in a checkerboard-type pattern or in rows that are inclined relative to the edges of the sample support plate.
摘要翻译：公开了用于各种可能应用的样品支撑板（100），包括MALDI质谱法。多个空间分离的样品接收部位（101）被布置在基板的表面上。受体部位由具有与受体部位不同的润湿性的区域相互分离。它们被布置成多个行，其由多个接收位点组成，其中心沿着第一方向以规定的周期（D1）规则地间隔开，行沿着与第一方向垂直的第二方向规则地间隔开预定的中心线距离（D2）。每个受体部位具有优选小于解吸激光束（103）的束斑（104）的直径的最大横向尺寸。为了使样本接收点处的大量液体样品无监督分裂成液滴，选择沿着第一方向的周期性和沿第二方向的中心线距离，使得每个接收点位置具有距离小于或等于每个接收者位置的最小横向尺寸的三倍。在优选的实施方案中，样品受体部位以相对于样品支持板的边缘倾斜的棋盘型图案或行排列。

2. 发明授权

US09211542B2 High-density sample support plate for automated sample aliquoting 有权
标题翻译：用于自动样品等分的高密度样品支撑板
公开(公告)号：US09211542B2
公开(公告)日：2015-12-15
申请号：US13699446
申请日：2011-05-20
申请人： Pawel Urban , Renato Zenobi , Konstantins Jefimovs , Andrea Amantonico , Stephan Fagerer , Nils Goedecke
发明人： Pawel Urban , Renato Zenobi , Konstantins Jefimovs , Andrea Amantonico , Stephan Fagerer , Nils Goedecke
IPC分类号： H01J49/00 , B01L9/00 , H01J49/04 , H01J49/16 , B05D3/00 , H01J49/26
CPC分类号： B01L9/00 , B05D3/007 , H01J49/0418 , H01J49/161 , H01J49/26
摘要： A sample support plate (100) for a variety of possible applications, including MALDI mass spectrometry, is disclosed. A plurality of spatially separated sample recipient sites (101) are arranged on the surface of a substrate. The recipient sites are mutually separated by areas having a different wettability than the recipient sites. They are arranged in a plurality of rows consisting of a plurality of recipient sites whose centers are regularly spaced along a first direction with a predetermined periodicity (D1), the rows being regularly spaced along a second direction perpendicular to the first direction with a predetermined centerline distance (D2). Each recipient site has a maximum lateral dimension that is preferably smaller than the diameter of a beam spot (104) of a desorption laser beam (103). In order to enable unsupervised splitting of bulk liquid samples into droplets at the sample recipient sites, the periodicity along the first direction and the centerline distance along the second direction are chosen such that each recipient sites has a next neighbor at a distance that is less than or equal to three times the minimum lateral dimension of each recipient site. In preferred embodiments, the sample recipient sites are arranged in a checkerboard-type pattern or in rows that are inclined relative to the edges of the sample support plate.
摘要翻译：公开了用于各种可能应用的样品支撑板（100），包括MALDI质谱法。多个空间分离的样品接收部位（101）被布置在基板的表面上。受体部位由具有与受体部位不同的润湿性的区域相互分开。它们被布置成多个行，其由多个接收位点组成，其中心沿着第一方向以规定的周期（D1）规则地间隔开，行沿着与第一方向垂直的第二方向规则地间隔开预定的中心线距离（D2）。每个受体部位具有优选小于解吸激光束（103）的束斑（104）的直径的最大横向尺寸。为了使样本接收点处的大量液体样品无监督分裂成液滴，选择沿着第一方向的周期性和沿第二方向的中心线距离，使得每个接收点位置具有距离小于或等于每个接收者位置的最小横向尺寸的三倍。在优选的实施方案中，样品受体部位以相对于样品支持板的边缘倾斜的棋盘型图案或行排列。

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