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1. 发明申请

US20130230543A1 ENGINEERED POLYPEPTIDE CONJUGATES AND METHODS FOR MAKING THEREOF USING TRANSGLUTAMINASE 审中-公开
标题翻译：工程聚氨酯共聚物及其制备方法使用转氨酶
公开(公告)号：US20130230543A1
公开(公告)日：2013-09-05
申请号：US13883535
申请日：2011-11-03
申请人： Jaume Pons , Arvind Rajpal , Pavel Strop , Magdalena Grazyna Dorywalska , David Shelton , Shu-Hui Liu , Russell Dushin
发明人： Jaume Pons , Arvind Rajpal , Pavel Strop , Magdalena Grazyna Dorywalska , David Shelton , Shu-Hui Liu , Russell Dushin
IPC分类号： C07K17/02
CPC分类号： C07K17/02 , A61K47/48369 , A61K47/48384 , A61K47/48569 , A61K47/48715 , A61K47/68 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/31 , C07K2317/73
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.
摘要翻译：本发明提供包含酰基供体谷氨酰胺标签和胺供体试剂的工程改造的多肽缀合物（例如，抗体 - 药物偶联物，毒素 - （生物相容性聚合物）缀合物，抗体 - （生物相容性聚合物）缀合物和双特异性抗体）。一方面，本发明提供了包含式（Fc-含多肽）-TA的工程改造的含Fc多肽缀合物，其中T是在特定位点工程化的含酰基供体谷氨酰胺标签，或包含由 Fc多肽工程，其中A是胺供体试剂，其中胺供体试剂与含酰基供体谷氨酰胺的标签或内源性谷氨酰胺位点特异性结合。本发明还提供了使用转谷氨酰胺酶制备工程化多肽缀合物的方法。

2. 发明授权

US09676871B2 Engineered polypeptide conjugates and methods for making thereof using transglutaminase 有权
公开(公告)号：US09676871B2
公开(公告)日：2017-06-13
申请号：US13883535
申请日：2011-11-03
申请人： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
发明人： Pavel Strop , Magdalena Grazyna Dorywalska , Arvind Rajpal , David Shelton , Shu-Hui Liu , Jaume Pons , Russell Dushin
IPC分类号： A61K47/48 , C07K16/28 , C07K16/30 , C07K16/46 , A61K38/06 , A61K38/08 , C07K17/02
CPC分类号： C07K17/02 , A61K47/48369 , A61K47/48384 , A61K47/48569 , A61K47/48715 , A61K47/68 , A61K47/6803 , A61K47/6851 , A61K47/6889 , C07K16/30 , C07K2317/31 , C07K2317/73
摘要： The present invention provides engineered polypeptide conjugates (e.g., antibody-drug-conjugates, toxin-(biocompatible polymer) conjugates, antibody-(biocompatible polymer) conjugates, and bispecific antibodies) comprising acyl donor glutamine-containing tags and amine donor agents. In one aspect, the invention provides an engineered Fc-containing polypeptide conjugate comprising the formula (Fc-containing polypeptide)-T-A, wherein T is an acyl donor glutamine-containing tag engineered at a specific site or comprises an endogenous glutamine made reactive by the Fc-containing polypeptide engineering, wherein A is an amine donor agent, and wherein the amine donor agent is site-specifically conjugated to the acyl donor glutamine-containing tag or the endogenous glutamine. The invention also provides methods of making engineered polypeptide conjugates using transglutaminase.

3. 发明授权

US08460880B2 Compositions, splice variants and methods relating to ovarian specific genes and proteins 有权
公开(公告)号：US08460880B2
公开(公告)日：2013-06-11
申请号：US12383449
申请日：2009-03-24
申请人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
IPC分类号： G01N33/53
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.

4. 发明申请

US20100136009A1 OVR110 Antibody Compositions and Methods of Use 有权
标题翻译： OVR110抗体组合物和使用方法
公开(公告)号：US20100136009A1
公开(公告)日：2010-06-03
申请号：US12516397
申请日：2007-11-27
申请人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
发明人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
IPC分类号： A61K39/395 , C07K16/00 , A61P35/00 , C12N15/13 , C12N15/63 , C12N5/00 , A01K67/027 , G01N33/53 , G01N33/68
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovrl 10 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovrl 10-expressing cancer cells and alleviating or treating an Ovrl 10-expressing cancer in a mammal. The anti-Ovrl 10 antibodies modulate Ovrl 10 function or internalize upon binding to Ovrl 10 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovrl 10 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovrl 10 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
摘要翻译：提供了针对由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达的Ovr1010的分离的抗体及其抗原结合片段。还提供了用于其生产的细胞和方法及其用于杀死表达Ovr10的癌细胞并减轻或治疗哺乳动物中表达Ovr10的癌症的方法。抗Ovr10抗体调节Ovr10功能或在体外和体内与哺乳动物细胞表达的Ovr1010结合时内化。还提供了包含抗Ovr10抗体和载体的组合物及其制品或试剂盒。此外，提供编码抗Ovr10抗体的分离的核酸，含有分离的核酸的表达载体和含有载体的宿主细胞。

5. 发明申请

US20090263411A1 Compositions, splice variants and methods relating to ovarian specific genes and proteins 有权
标题翻译：与卵巢特异性基因和蛋白质有关的组合物，剪接变体和方法
公开(公告)号：US20090263411A1
公开(公告)日：2009-10-22
申请号：US12383449
申请日：2009-03-24
申请人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto A. Macina , Leah R. Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
IPC分类号： A61K39/00 , C12N15/11 , C12Q1/68 , C12N15/00 , C12N1/21 , C12P21/02 , C07K14/00 , C07K16/18
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

6. 发明申请

US20090257484A1 METHOD FOR AUDIO-VIDEO ENCODING AND APPARATUS FOR MULTIMEDIA STORAGE 审中-公开
标题翻译：用于多媒体存储的音视频编码方法和装置
公开(公告)号：US20090257484A1
公开(公告)日：2009-10-15
申请号：US12103187
申请日：2008-04-15
申请人： Shu-Hui Liu
发明人： Shu-Hui Liu
IPC分类号： H04N11/02
CPC分类号： G11B27/3027 , H04N21/4334 , H04N21/4341 , H04N21/439
摘要： The invention relates a method for audio-video encoding and an apparatus for multimedia storage. First, a video chunk and an audio chunk are read from a audio-video file. Then the video chunk is divided into a plurality of video blocks, wherein size of each video block at least equals to the size of one unit frame. The audio chunk is divided into a plurality of audio blocks. Finally, according to a playing sequence, at least one audio block is employed between each two video blocks.
摘要翻译：本发明涉及音视频编码方法和多媒体存储装置。首先，从音频 - 视频文件读取视频块和音频块。然后，视频块被分成多个视频块，其中每个视频块的大小至少等于一个单位帧的大小。音频块被分成多个音频块。最后，根据播放顺序，在两个视频块之间采用至少一个音频块。

7. 发明授权

US08444971B2 OVR110 antibody compositions and methods of use 有权
标题翻译： OVR110抗体组合物和使用方法
公开(公告)号：US08444971B2
公开(公告)日：2013-05-21
申请号：US12516397
申请日：2007-11-27
申请人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
发明人： Jackie Papkoff , Gundo Diedrich , Shu-Hui Liu , Agnes Nowakowski
IPC分类号： A61K39/395
CPC分类号： C07K16/2827 , A61K39/39558 , A61K45/06 , A61K47/6817 , A61K47/6823 , A61K47/6849 , A61K47/6855 , A61K51/1027 , A61K2039/505 , C07K16/18 , C07K16/30 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/76 , C07K2317/77 , C07K2317/92 , C12N9/96 , G01N33/57492 , A61K2300/00
摘要： Isolated antibodies and antigen binding fragments thereof directed against Ovr110 which is expressed by head and neck, ovarian, endometrial, kidney, pancreatic, lung or breast cancer are provided. Also provided are cells and methods for their production as well as methods for their use in killing an Ovr110-expressing cancer cells and alleviating or treating an Ovr110-expressing cancer in a mammal. The anti-Ovr110 antibodies modulate Ovr110 function or internalize upon binding to Ovr110 expressed by mammalian cells in vitro and in vivo. Compositions comprising an anti-Ovr110 antibody and a carrier as well as articles of manufacture or kits thereof are also provided. In addition, isolated nucleic acids encoding an anti-Ovr110 antibody, expression vectors containing the isolated nucleic acids, and host cells containing the vectors are provided.
摘要翻译：提供了针对由头颈部，卵巢，子宫内膜，肾，胰腺，肺或乳腺癌表达的Ovr110的分离的抗体及其抗原结合片段。还提供了用于其生产的细胞和方法及其用于杀死表达Ovr110的癌细胞并减轻或治疗哺乳动物中表达Ovr110的癌症的方法。抗Ovr110抗体在体外和体内与哺乳动物细胞表达的Ovr110结合时调节Ovr110功能或内在化。还提供了包含抗Ovr110抗体和载体及其制品或试剂盒的组合物。此外，提供编码抗Ovr110抗体的分离的核酸，含有分离的核酸的表达载体和含有载体的宿主细胞。

8. 发明申请

US20060078913A1 Compositions, splice variants and methods relating to cancer specific genes and proteins 审中-公开
标题翻译：与癌症特异性基因和蛋白质有关的组合物，剪接变体和方法
公开(公告)号：US20060078913A1
公开(公告)日：2006-04-13
申请号：US11183261
申请日：2005-07-15
申请人： Roberto Macina , Leah Turner , Steffan Vartanian , Shu-Hui Liu , Maria Rodriguez , Huei-Mei Chen
发明人： Roberto Macina , Leah Turner , Steffan Vartanian , Shu-Hui Liu , Maria Rodriguez , Huei-Mei Chen
IPC分类号： C12Q1/68 , C07H21/04
CPC分类号： C07K14/4748 , G01N33/57484
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, intestine and colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, intestine and colon, lung, ovarian or prostate, identifying breast, intestine and colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast, intestine and colon, lung, ovarian or prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在乳腺，肠和结肠，肺，卵巢或前列腺中识别，诊断，监测，分期，成像和治疗乳腺，肠和结肠，肺，卵巢或前列腺癌和非癌性疾病状态，鉴定乳腺，肠和结肠，肺，卵巢或前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生以及工程乳房，肠和结肠，肺，卵巢或前列腺组织的生产用于治疗和研究。

9. 发明申请

US20070154886A1 Composition, splice variants and methods relating to ovarian specific genes and proteins 审中-公开
标题翻译：与卵巢特异性基因和蛋白质相关的组合物，剪接变体和方法
公开(公告)号：US20070154886A1
公开(公告)日：2007-07-05
申请号：US10537743
申请日：2003-12-08
申请人： Roberto Macina , Leah Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
发明人： Roberto Macina , Leah Turner , Yongming Sun , Shu-Hui Liu , Huei-Mei Chen
IPC分类号： C12Q1/68 , G01N33/574 , C07H21/04 , C12P21/06 , C07K14/82 , C07K16/30
CPC分类号： C07K14/82 , C07K14/47 , G01N33/57449
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic ovarian cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating ovarian cancer and non-cancerous disease states in ovarian, identifying ovarian tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered ovarian tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤性卵巢细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括鉴定，诊断，监测，分期，成像和治疗卵巢癌和非癌性疾病状态，确定卵巢组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的生产，以及用于治疗和研究的工程化卵巢组织的生产。

10. 发明申请

US20050272067A1 Compositions, splice variants and methods relating to cancer specific genes and proteins 审中-公开
标题翻译：与癌症特异性基因和蛋白质有关的组合物，剪接变体和方法
公开(公告)号：US20050272067A1
公开(公告)日：2005-12-08
申请号：US11077386
申请日：2005-03-10
申请人： Roberto Macina , Leah Turner , Huei-Mei Chen , Maria Rodriguez , Shu-Hui Liu
发明人： Roberto Macina , Leah Turner , Huei-Mei Chen , Maria Rodriguez , Shu-Hui Liu
IPC分类号： C07H21/04 , C07K14/47 , C07K14/82 , C12N15/09 , C12Q1/68
CPC分类号： C07K14/4748
摘要： The present invention relates to newly identified nucleic acid molecules and polypeptides present in normal and neoplastic cells, including fragments, variants and derivatives of the nucleic acids and polypeptides. The present invention also relates to antibodies to the polypeptides of the invention, as well as agonists and antagonists of the polypeptides of the invention. The invention also relates to compositions containing the nucleic acid molecules, polypeptides, antibodies, agonists and antagonists of the invention and methods for the use of these compositions. These uses include identifying, diagnosing, monitoring, staging, imaging and treating breast, intestine and colon, lung, ovarian or prostate cancer and non-cancerous disease states in breast, intestine and colon, lung, ovarian or prostate, identifying breast, intestine and colon, lung, ovarian or prostate tissue, monitoring and identifying and/or designing agonists and antagonists of polypeptides of the invention. The uses also include gene therapy, production of transgenic animals and cells, and production of engineered breast, intestine and colon, lung, ovarian or prostate tissue for treatment and research.
摘要翻译：本发明涉及存在于正常和肿瘤细胞中的新鉴定的核酸分子和多肽，包括核酸和多肽的片段，变体和衍生物。本发明还涉及本发明多肽的抗体，以及本发明多肽的激动剂和拮抗剂。本发明还涉及含有本发明的核酸分子，多肽，抗体，激动剂和拮抗剂以及使用这些组合物的方法的组合物。这些用途包括在乳腺，肠和结肠，肺，卵巢或前列腺中识别，诊断，监测，分期，成像和治疗乳腺，肠和结肠，肺，卵巢或前列腺癌和非癌性疾病状态，鉴定乳腺，肠和结肠，肺，卵巢或前列腺组织，监测和鉴定和/或设计本发明多肽的激动剂和拮抗剂。用途还包括基因治疗，转基因动物和细胞的产生以及工程乳房，肠和结肠，肺，卵巢或前列腺组织的生产用于治疗和研究。

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