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1. 发明申请

US20090238333A1 TRANS-RAMAN FOR BREAST CANCER 有权
标题翻译：乳腺癌转移瘤
公开(公告)号：US20090238333A1
公开(公告)日：2009-09-24
申请号：US12225928
申请日：2007-04-05
申请人： Pavel Matousek , Anthony William Parker , Nicholas Stone
发明人： Pavel Matousek , Anthony William Parker , Nicholas Stone
IPC分类号： A61B6/04
CPC分类号： G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
摘要： Non invasive in-vivo measurement of composition of a tissue within a part of a human or animal subject is carried out by detecting a Raman spectral characteristic in light scattered through the part using a transmission, rather than a backscattering geometry. The technique is applied to the detection of calcifications in human breast tissues.
摘要翻译：通过使用透射而不是后向散射几何检测通过部件散射的光中的拉曼光谱特性来进行人或动物受试者的一部分内的组织的组成的非侵入性体内测量。该技术应用于人乳腺组织中钙化的检测。

2. 发明申请

US20080129992A1 Apparatus For Depth-Selective Raman Spectroscopy 有权
标题翻译：深度选择性拉曼光谱仪器
公开(公告)号：US20080129992A1
公开(公告)日：2008-06-05
申请号：US11792684
申请日：2005-11-25
申请人： Pavel Matousek , Anthony William Parker
发明人： Pavel Matousek , Anthony William Parker
IPC分类号： G01J3/44
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/441 , A61B5/4504 , G01N21/65 , G01N2021/656
摘要： Apparatus and methods for detecting Raman spectral features non destructively from sub-surface regions of a diffusely scattering sample are disclosed. Incident radiation is supplied at one or more sample surface entry regions, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light, and depth information is derived according to the entry-collection spacings.
摘要翻译：公开了从漫散射样品的子表面区域非破坏性地检测拉曼光谱特征的装置和方法。在一个或多个样品表面进入区域处提供入射辐射，并且从与入口区域间隔开的一个或多个收集区域收集光。在收集的光中检测到拉曼特征，并根据入场收集间隔导出深度信息。

3. 发明授权

US08259902B2 Raman analysis of tissue and/or calcifications 有权
标题翻译：组织和/或钙化的拉曼分析
公开(公告)号：US08259902B2
公开(公告)日：2012-09-04
申请号：US12225928
申请日：2007-04-05
申请人： Pavel Matousek , Anthony William Parker , Nicholas Stone
发明人： Pavel Matousek , Anthony William Parker , Nicholas Stone
IPC分类号： A61B6/04 , A61B6/12 , G01B15/00 , G01J3/44
CPC分类号： G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
摘要： Non invasive in-vivo measurement of composition of a tissue within a part of a human or animal subject is carried out by detecting a Raman spectral characteristic in light scattered through the part using a transmission, rather than a backscattering geometry. The technique is applied to the detection of calcifications in human breast tissues.
摘要翻译：通过使用透射而不是后向散射几何检测通过部件散射的光中的拉曼光谱特性来进行人或动物受试者的一部分内的组织的组成的非侵入性体内测量。该技术应用于人乳腺组织中钙化的检测。

4. 发明授权

US07911604B2 Security screening using raman analysis 有权
标题翻译：使用拉曼分析进行安全筛选
公开(公告)号：US07911604B2
公开(公告)日：2011-03-22
申请号：US12085346
申请日：2006-11-27
申请人： Pavel Matousek , Anthony William Parker
发明人： Pavel Matousek , Anthony William Parker
IPC分类号： G01J3/44 , G01N21/65
CPC分类号： G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
摘要： Method and apparatus for screening objects using Raman scattering methods to detect the presence of predefined substances or classes of substances. The predefined substances may be hazardous, toxic, or explosive. Radiation is supplied to an incident region of an object. Scattered light is collected from a collection region on the surface of the object spaced from the incident region. The characteristics of the scattered light include Raman features related to the predefined substances. The Raman features allow the presence, or not, of the predefined substances to be determined.
摘要翻译：使用拉曼散射法检测物体的方法和装置，以检测预定物质或物质类别的存在。预定义的物质可能是危险的，有毒的或有爆炸性的。辐射被提供给物体的入射区域。从与入射区域间隔开的物体表面上的收集区域收集散射光。散射光的特征包括与预定义物质相关的拉曼特征。拉曼特征允许确定预定义物质的存在或不存在。

5. 发明申请

US20090244533A1 Raman Analysis 有权
标题翻译：拉曼分析
公开(公告)号：US20090244533A1
公开(公告)日：2009-10-01
申请号：US12083073
申请日：2007-04-05
申请人： Pavel Matousek , Anthony William Parker
发明人： Pavel Matousek , Anthony William Parker
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , A61B5/417 , G01N2021/656 , G07D7/1205
摘要： Properties of turbid or scattering samples are determined using Raman spectroscopy with probe light delivered to and subsequently collected from the sample using a transmission geometry. The technique may be applied to pharmaceutical products such as tablets, diagnostic tests such as lateral flow diagnostic strips, and elsewhere.
摘要翻译：使用拉曼光谱法测定混浊或散射样品的性质，其中使用传输几何形式将样品中的探针光输送至随后的样品。该技术可以应用于药物制品如片剂，诊断试验如侧流诊断条和其他地方。

6. 发明申请

US20080076985A1 Raman Spectral Analysis Of Sub-Surface Tissues And Fluids 有权
标题翻译：亚表面组织和液体的拉曼光谱分析
公开(公告)号：US20080076985A1
公开(公告)日：2008-03-27
申请号：US11792701
申请日：2005-11-25
申请人： Pavel Matousek , Anthony Parker
发明人： Pavel Matousek , Anthony Parker
IPC分类号： A61B5/00
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/441 , A61B5/4504 , G01N21/65 , G01N2021/656
摘要： Apparatus and methods for determining, in-vivo, characteristics of sub-surface tissues or fluids in the human or animal body are disclosed. Incident radiation is supplied at one or more entry regions on a surface, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light and depth related information derived therefrom.
摘要翻译：公开了用于确定人体或动物体内的亚表面组织或流体的体内特征的装置和方法。在表面上的一个或多个入口区域处提供入射辐射，并且从与入射区域间隔开的一个或多个收集区域收集光。在从其中得到的收集的光和深度相关信息中检测到拉曼特征。

7. 发明授权

US08692990B2 Illumination of diffusely scattering media 有权
标题翻译：散射介质的照明
公开(公告)号：US08692990B2
公开(公告)日：2014-04-08
申请号：US12531265
申请日：2008-03-14
申请人： Pavel Matousek
发明人： Pavel Matousek
IPC分类号： G01N21/47 , G01N21/65 , G01J3/44
CPC分类号： G01N21/47 , G01J3/10 , G01J3/44 , G01N21/49 , G01N21/65 , G01N21/658 , G01N2021/4735
摘要： The invention provides a technique for increasing the illumination intensity of probe light in a diffusely scattering sample without increasing the power of the probe beam. Generally, an optical filter is used which permits a collimated probe beam of light to pass through to the sample, but which reflects back towards the sample much of the backscattered scattered probe light emerging at a wider range of angles. In particular embodiments a collimated laser beam is delivered to the sample through a multi-layer dielectric filter covering a portion of the sample. The filter is transmissive to the laser light at normal incidence, but reflective at shallower angles of incidence characteristic of the backscattered light.
摘要翻译：本发明提供了一种用于在不增加探测光束的功率的情况下增加漫散射样品中的探测光的照明强度的技术。通常，使用光学滤光器，其允许准直的探测光束通过样品，但是反射回样品大部分在更宽范围的角度上出现的背散射的散射探测光。在特定实施例中，准直激光束通过覆盖样品的一部分的多层介质滤波器传送到样品。滤光器在正常入射时对激光透射，但反射在较浅的背散射光入射角。

8. 发明授权

US08248600B2 Raman detection of container contents 有权
标题翻译：容器内容物的拉曼检测
公开(公告)号：US08248600B2
公开(公告)日：2012-08-21
申请号：US12516170
申请日：2007-11-21
申请人： Pavel Matousek , Eva Charlotte Eliasson
发明人： Pavel Matousek , Eva Charlotte Eliasson
IPC分类号： G01J3/44
CPC分类号： G01N21/65 , G01J3/44
摘要： Methods and apparatus for screening the unknown contents of containers using Raman spectroscopy are disclosed, especially for security screening applications such as in airports. A probe light beam is directed through the wall of a container to a sample region within the container contents. Light scattered out of the beam within the sample region is collected along a path which passes through a separate part of the container wall, for Raman spectral analysis.
摘要翻译：公开了使用拉曼光谱法筛选容器的未知内容物的方法和装置，特别是对于诸如在机场中的安全筛选应用。探针光束通过容器的壁被引导到容器内容器内的样品区域。沿着通过容器壁的单独部分的路径收集在样品区域内从光束散射的光，以进行拉曼光谱分析。

9. 发明申请

US20100110425A1 ILLUMINATION OF DIFFUSELY SCATTERING MEDIA 有权
标题翻译：散射散射介质的照明
公开(公告)号：US20100110425A1
公开(公告)日：2010-05-06
申请号：US12531265
申请日：2008-03-14
申请人： Pavel Matousek
发明人： Pavel Matousek
IPC分类号： G01J3/44 , G02B27/00 , G01J3/00 , G02B5/02 , G02B5/20
CPC分类号： G01N21/47 , G01J3/10 , G01J3/44 , G01N21/49 , G01N21/65 , G01N21/658 , G01N2021/4735
摘要： The invention provides a technique for increasing the illumination intensity of probe light in a diffusely scattering sample without increasing the power of the probe beam. Generally, an optical filter is used which permits a collimated probe beam of light to pass through to the sample, but which reflects back towards the sample much of the backscattered scattered probe light emerging at a wider range of angles. In particular embodiments a collimated laser beam is delivered to the sample through a multi-layer dielectric filter covering a portion of the sample. The filter is transmissive to the laser light at normal incidence, but reflective at shallower angles of incidence characteristic of the backscattered light.
摘要翻译：本发明提供了一种用于在不增加探测光束的功率的情况下增加漫散射样品中的探测光的照明强度的技术。通常，使用光学滤光器，其允许准直的探测光束通过样品，但是反射回样品大部分在更宽范围的角度上出现的背散射的散射探测光。在特定实施例中，准直激光束通过覆盖样品的一部分的多层介质滤波器传送到样品。滤光器在正常入射时对激光透射，但反射在较浅的背散射光入射角。

10. 发明授权

US07652763B2 Apparatus for depth-selective Raman spectroscopy 有权
标题翻译：深度选择拉曼光谱仪器
公开(公告)号：US07652763B2
公开(公告)日：2010-01-26
申请号：US11792684
申请日：2005-11-25
申请人： Pavel Matousek , Anthony William Parker
发明人： Pavel Matousek , Anthony William Parker
IPC分类号： G01J3/44
CPC分类号： A61B5/0059 , A61B5/0071 , A61B5/0075 , A61B5/441 , A61B5/4504 , G01N21/65 , G01N2021/656
摘要： Apparatus and methods for detecting Raman spectral features non destructively from sub-surface regions of a diffusely scattering sample are disclosed. Incident radiation is supplied at one or more sample surface entry regions, and light is collected from one or more collection regions spaced from the entry regions. Raman features are detected in the collected light, and depth information is derived according to the entry-collection spacings.
摘要翻译：公开了从漫散射样品的子表面区域非破坏性地检测拉曼光谱特征的装置和方法。在一个或多个样品表面进入区域处提供入射辐射，并且从与入口区域间隔开的一个或多个收集区域收集光。在收集的光中检测到拉曼特征，并根据入场收集间隔导出深度信息。

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