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1. 发明授权

US6110697A Histone deacetylase as target for antiprotozoal agents 失效
公开(公告)号：US6110697A
公开(公告)日：2000-08-29
申请号：US716978
申请日：1996-09-20
申请人： Paula M. Dulski , Robert W. Myers , Anne M. Gumett , Sandra J. Rattray , Dennis M. Schmatz
发明人： Paula M. Dulski , Robert W. Myers , Anne M. Gumett , Sandra J. Rattray , Dennis M. Schmatz
IPC分类号： A61K38/00 , A61K38/12 , C07K5/12 , C12Q1/02 , C12Q1/18 , G01N33/68 , C12Q1/48 , A61K38/43
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

2. 发明授权

US06428983B1 Histone deacetylase as target for antiprotozoal agents 有权
标题翻译：组蛋白脱乙酰酶作为抗原虫剂的靶标
公开(公告)号：US06428983B1
公开(公告)日：2002-08-06
申请号：US09296834
申请日：1999-04-22
申请人： Paula M. Dulski , Robert W. Myers , Anne M. Gumett , Sandra J. Rattray , Dennis M. Schmatz
发明人： Paula M. Dulski , Robert W. Myers , Anne M. Gumett , Sandra J. Rattray , Dennis M. Schmatz
IPC分类号： C12N2106
CPC分类号： G01N33/6875 , A61K38/005 , A61K38/12 , C07K5/126 , C12Q1/025 , C12Q1/18 , G01N2333/445 , G01N2333/455 , Y02A50/411 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.
摘要翻译：组蛋白脱乙酰酶抑制提供了鉴定潜在的抗原生动物化合物的靶标。组蛋白脱乙酰酶抑制剂可用作抗原生动物感染的治疗剂。

3. 发明授权

US6068987A Histone deacetylase as target for antiprotozoal agents 有权
公开(公告)号：US6068987A
公开(公告)日：2000-05-30
申请号：US443003
申请日：1999-11-18
申请人： Paula M. Dulski , Robert W. Myers , Anne M. Gurnett , Sandra J. Rattray , Dennis M. Schmatz
发明人： Paula M. Dulski , Robert W. Myers , Anne M. Gurnett , Sandra J. Rattray , Dennis M. Schmatz
IPC分类号： C12Q1/02 , G01N33/68 , C12Q1/34 , C12N9/14 , C12N15/09 , H01N43/02
CPC分类号： C12Q1/025 , G01N33/6875 , G01N2333/445 , G01N2333/455 , Y10S514/895
摘要： Histone deacetylase inhibition provides a target for identifying potential antiprotozoal compounds. Histone deacetylase inhibitors are useful as therapeutic agents against protozoal infections.

4. 发明申请

US20080046876A1 Computer Method and System for Composite State Management of Software Change Requests 有权
标题翻译：软件变更请求复合状态管理的计算机方法与系统
公开(公告)号：US20080046876A1
公开(公告)日：2008-02-21
申请号：US11459743
申请日：2006-07-25
申请人： Geoffrey M. Clemm , Robert W. Myers , Stuart W. Poulin , William Morgan Stair
发明人： Geoffrey M. Clemm , Robert W. Myers , Stuart W. Poulin , William Morgan Stair
IPC分类号： G06F9/44
CPC分类号： G06Q10/10 , G06F8/20
摘要： Computer method and apparatus manage requests to make changes to a given software system (e.g., application program or program portion). The invention method and apparatus form a change request object representing a user's request to make a change to the given software system. The invention method and apparatus form one or more hierarchies of objects and sub-objects to represent work to be performed and work performed in making the requested change. One embodiment creates a root issue object for each change request object and allows a user to partition an issue object into issue sub-objects. The embodiment (a) allows a user to create a task object to define the work needed to address an issue and allows a user to partition a task object into task sub-objects, and (b) allows a user to create an activity object to track work performed and allows a user to partition an activity object into activity sub-objects. Issue objects and issue sub-objects are relatable to task objects and task sub-objects. Task objects and task sub-objects are relatable to activity objects and activity sub-objects. State of an object is determined based on the status of each of its related objects and sub-objects.
摘要翻译：计算机方法和装置管理对给定软件系统（例如，应用程序或程序部分）进行改变的请求。本发明的方法和装置形成表示用户对给定软件系统进行改变的请求的变更请求对象。本发明的方法和装置形成对象和子对象的一个或多个层次，以表示要进行的工作和进行所请求的改变时所执行的工作。一个实施例为每个改变请求对象创建根问题对象，并且允许用户将问题对象分成问题子对象。实施例（a）允许用户创建任务对象以定义解决问题所需的工作，并允许用户将任务对象分成任务子对象，并且（b）允许用户创建活动对象执行跟踪工作，并允许用户将活动对象分为活动子对象。问题对象和问题子对象对于任务对象和任务子对象是相关的。任务对象和任务子对象与活动对象和活动子对象相关。基于每个相关对象和子对象的状态来确定对象的状态。

5. 发明授权

US4621204A Sensor integrator system 失效
标题翻译：传感器积分器系统
公开(公告)号：US4621204A
公开(公告)日：1986-11-04
申请号：US634574
申请日：1984-07-26
申请人： Mark C. Loessel , Randall W. Miller , Robert W. Myers
发明人： Mark C. Loessel , Randall W. Miller , Robert W. Myers
IPC分类号： H03M1/52 , G01J1/44 , G01J1/46 , G01N21/27 , H03M1/00 , H03K19/14 , H03K5/00 , H03K5/22
CPC分类号： G01N21/27 , G01J1/44 , H03M1/445 , G01J1/46 , G01J2001/446 , G01N2021/478 , G01N2201/126
摘要： A sensor-integrator circuit having a sensor for producing a current varying in accordance with the sensed parameter or a reference current source, a comparator having inverting and noninverting inputs and an output and charge storage device coupled to the inverting input. The circuit is energized to obtain a given positive steady state reset voltage, a reference voltage is applied to the noninverting input of a comparator which is less positive than the steady state voltage and integration is initiated solely by alternately applying the current from the sensor and the reference current to the inverting input of the comparator.
摘要翻译：一种传感器积分电路，其具有用于产生根据感测参数或参考电流源变化的电流的传感器，具有反相和同相输入的比较器以及耦合到反相输入的输出和电荷存储装置。电路通电以获得给定的正稳态复位电压，参考电压施加到比稳态电压小正比的比较器的非反相输入，并且仅通过交替施加来自传感器的电流和参考电流到比较器的反相输入。

6. 发明授权

US4558584A Combination cable crimper and cutter 失效
标题翻译：组合电缆卷曲机和切割机
公开(公告)号：US4558584A
公开(公告)日：1985-12-17
申请号：US691733
申请日：1985-01-16
申请人： Robert W. Myers
发明人： Robert W. Myers
IPC分类号： H01R43/042 , B21D7/00 , B21D41/04
CPC分类号： H01R43/0421
摘要： A combination cable crimper and cutter. A frame mounts a piston for reciprocating axial movement. A reciprocating drive is connected to the piston. A pair of cable-crimping jaws is pivotally mounted on the frame and connected by links to the piston. A cutter anvil is mounted on the frame adjacent one of the jaws. A cutter is mounted on the jaw in cable-cutting relation to the cutter anvil.
摘要翻译：组合电缆卷曲机和切割机。框架安装用于往复运动的活塞。往复式驱动器连接到活塞上。一对电缆夹压爪枢转地安装在框架上并通过连接到活塞的连接件连接。刀架砧安装在相邻一个颚板的框架上。切割器以切割砧座的方式与钳子安装在钳口上。

7. 发明授权

US4293730A Method and apparatus for detecting a ground on electric furnaces 失效
标题翻译：用于检测电炉的地面的方法和装置
公开(公告)号：US4293730A
公开(公告)日：1981-10-06
申请号：US093772
申请日：1979-11-13
申请人： Robert W. Myers
发明人： Robert W. Myers
IPC分类号： H02H3/16 , H02H5/10 , H05B3/00 , C03B5/02
CPC分类号： H05B3/0023 , H02H5/105
摘要： A method of and apparatus for detecting a ground on an electric furnace comprising connecting an electrode, which is located in the furnace, to ground potential and sensing the current flowing from the electrode to ground. The method and apparatus may also include comparing the sensed current with a first and second reference signal and actuating an appropriate alarm when the sensed current is greater than the first reference signal or less than the second reference signal and interrupting the electrical power to the furnace when the sensed current is greater than the first reference signal.
摘要翻译：一种用于在电炉上检测地面的方法和装置，包括将位于炉中的电极连接到地电位并感测从电极流到地面的电流。所述方法和装置还可以包括将感测到的电流与第一和第二参考信号进行比较，并且当感测到的电流大于第一参考信号或小于第二参考信号时致动适当的报警，并且当中断当电感测电流大于第一参考信号。

8. 发明授权

US08677319B2 Computer method and system for composite state management of software change requests 有权
标题翻译：软件变更请求复合状态管理的计算机方法与系统
公开(公告)号：US08677319B2
公开(公告)日：2014-03-18
申请号：US11459743
申请日：2006-07-25
申请人： Geoffrey M. Clemm , Robert W. Myers , Stuart W. Poulin , William Morgan Stair
发明人： Geoffrey M. Clemm , Robert W. Myers , Stuart W. Poulin , William Morgan Stair
IPC分类号： G06F9/44
CPC分类号： G06Q10/10 , G06F8/20
摘要： Computer method and apparatus manage requests to make changes to a given software system (e.g., application program or program portion). The invention method and apparatus form a change request object representing a user's request to make a change to the given software system. The invention method and apparatus form one or more hierarchies of objects and sub-objects to represent work to be performed and work performed in making the requested change. One embodiment creates a root issue object for each change request object and allows a user to partition an issue object into issue sub-objects. The embodiment (a) allows a user to create a task object to define the work needed to address an issue and allows a user to partition a task object into task sub-objects, and (b) allows a user to create an activity object to track work performed and allows a user to partition an activity object into activity sub-objects. Issue objects and issue sub-objects are relatable to task objects and task sub-objects. Task objects and task sub-objects are relatable to activity objects and activity sub-objects. State of an object is determined based on the status of each of its related objects and sub-objects.
摘要翻译：计算机方法和装置管理对给定软件系统（例如，应用程序或程序部分）进行改变的请求。本发明的方法和装置形成表示用户对给定软件系统进行改变的请求的变更请求对象。本发明的方法和装置形成对象和子对象的一个或多个层次，以表示要进行的工作和进行所请求的改变时所执行的工作。一个实施例为每个改变请求对象创建根问题对象，并且允许用户将问题对象分成问题子对象。实施例（a）允许用户创建任务对象以定义解决问题所需的工作，并允许用户将任务对象分成任务子对象，并且（b）允许用户创建活动对象执行跟踪工作，并允许用户将活动对象分为活动子对象。问题对象和问题子对象对于任务对象和任务子对象是相关的。任务对象和任务子对象与活动对象和活动子对象相关。基于每个相关对象和子对象的状态来确定对象的状态。

9. 发明授权

US5932559A Treatment of hyperandrogenic conditions 失效
标题翻译：治疗雄激素过多症状
公开(公告)号：US5932559A
公开(公告)日：1999-08-03
申请号：US51948
申请日：1998-04-23
申请人： Herb G. Bull , Georgianna Harris , Robert W. Myers
发明人： Herb G. Bull , Georgianna Harris , Robert W. Myers
IPC分类号： C07C217/52 , C07C229/48 , C07C233/81 , C07C237/06 , C07D207/16 , C07D207/26 , C07D209/08 , C07D211/14 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/61 , C07D215/18 , C07D215/20 , C07D233/86 , C07D239/26 , C07D249/08 , C07D249/12 , C07D257/04 , C07D261/08 , C11D3/395 , C11D17/00 , A61K31/505 , C07D471/02
CPC分类号： C07D257/04 , C07C217/52 , C07C229/48 , C07C233/81 , C07C237/06 , C07D207/16 , C07D207/26 , C07D209/08 , C07D211/14 , C07D211/58 , C07D211/62 , C07D213/38 , C07D213/61 , C07D215/18 , C07D215/20 , C07D233/86 , C07D239/26 , C07D249/08 , C07D249/12 , C07D261/08
摘要： The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa and 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
摘要翻译： PCT No.PCT / US96 / 16871 Sec。 371日期：1998年4月23日 102（e）1998年4月23日PCT PCT 1996年10月22日PCT公布。出版物WO97 / 15305 日期1997年5月1日本发明涉及通过形成具有1,2-环氧乙烷的3-氧代-4-氧杂环戊烷和4-硫代甾烷醇的人5α-还原酶的新的基于机理的不可逆抑制剂来治疗人中雄激素过多的病症，双键和5α-还原酶NADPH的吡啶 - 核苷酸辅因子。本发明还涉及分离的抑制剂 - 辅因子复合物。

10. 发明授权

US5756480A Treatment of hyperandrogenic conditions 失效
标题翻译：治疗雄激素过多症状
公开(公告)号：US5756480A
公开(公告)日：1998-05-26
申请号：US738546
申请日：1996-10-24
申请人： Herb G. Bull , Georgianna Harris , Robert W. Myers
发明人： Herb G. Bull , Georgianna Harris , Robert W. Myers
IPC分类号： C07H19/04 , C07H19/048 , A61K31/705
CPC分类号： A61K31/7076
摘要： The invention concerns the treatment of hyperandrogenic conditions in humans by the formation of a novel mechanism-based irreversible inhibitor of human 5.alpha.-reductase enzymes from 3-oxo-4-oxa end 4-thiasteroids having a 1,2-double bond and the pyridine-nucleotide cofactor of the 5.alpha.-reductase enzyme, NADPH. The invention further relates to the isolated inhibitor-cofactor complex.
摘要翻译：本发明涉及通过从具有1,2-双键的3-氧代-4-氧杂末端4-硫代甾烷醇形成人类5α-还原酶的基于机制的新型不可逆抑制剂来治疗人类中雄激素过多的病症， 5α-还原酶，NADPH的吡啶核苷酸辅因子。本发明还涉及分离的抑制剂 - 辅因子复合物。

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