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1. 发明授权

US06399581B1 Compound possessing potent thrombin receptor antagonist activity 失效
标题翻译：化合物具有有效的凝血酶受体拮抗剂活性
公开(公告)号：US06399581B1
公开(公告)日：2002-06-04
申请号：US09568694
申请日：2000-05-11
申请人： Paul Stead , Amy E. Wright , Shirley A. Pomponi , David Langley
发明人： Paul Stead , Amy E. Wright , Shirley A. Pomponi , David Langley
IPC分类号： A01N4304
CPC分类号： A61K31/70
摘要： The subject invention concerns eryloside F, a novel disaccharide of the steroidal carboxylic acid penasterol. This compound can be isolated from an extract of the marine sponge Erylus formosus. The compound is a potent thrombin receptor antagonist and, furthermore, inhibits human platelet aggregation. Longer chain penasterol oligosaccharides were also isolated and characterized but these had weaker activity than eryloside F. The subject invention also concerns methods for inhibiting thrombin receptor activity and methods for inhibiting platelet aggregation through the administration of eryloside F, or a salt, derivative or analog thereof.
摘要翻译：本发明涉及红霉素F，一种新型的甾体羧酸penasterol二糖。该化合物可以从海绵Elyus formosus的提取物中分离出来。该化合物是有效的凝血酶受体拮抗剂，此外抑制人血小板聚集。还分离和表征较长链的Penasterol寡糖，但它们的活性比红景天素F弱。本发明还涉及抑制凝血酶受体活性的方法以及通过给予红霉素F或其盐，衍生物或类似物来抑制血小板聚集的方法。

2. 发明授权

US06252855B1 Method and apparatus for identifying a maximum frame size to maintain delay at or below an acceptable level 失效
标题翻译：用于识别最大帧大小以维持等于或低于可接受水平的延迟的方法和装置
公开(公告)号：US06252855B1
公开(公告)日：2001-06-26
申请号：US08996115
申请日：1997-12-22
申请人： David Langley
发明人： David Langley
IPC分类号： H04J324
CPC分类号： H04L47/36 , H04L47/10 , H04L47/16 , H04L47/283
摘要： A method and apparatus negotiates a maximum frame size to be used over a frame relay network. A local maximum frame size is identified by a first endpoint device of a frame relay network so that other frames sent and received using that size will not cause other frames sent by the network device to be sent a period of time exceeding an acceptable delay after the other frames are received. The acceptable delay is the lowest acceptable delay among originators and recipients of frames that use the endpoint device. The frame size identified is transmitted to other endpoint devices that can communicate with the first endpoint device. These other endpoint devices identify acceptable delays that correspond to the originators and recipients of such endpoint devices. The other endpoint devices transmit their acceptable delays to the first endpoint device. If the first endpoint device has a payload of information to send to any of the other endpoint devices, the first endpoint device sends the payload using frame sizes not larger than either of the frame size identified by the first endpoint device and the frame size received from the endpoint device to which the frame will be transmitted.
摘要翻译：一种方法和装置协商在帧中继网络上使用的最大帧大小。局部最大帧大小由帧中继网络的第一端点设备识别，使得使用该大小发送和接收的其他帧不会导致由网络设备发送的其他帧发送超过可接受延迟的时间段其他帧被接收。可接受的延迟是使用端点设备的帧的发起者和接收者之间的最低可接受的延迟。所识别的帧大小被发送到可以与第一端点设备通信的其他端点设备。这些其他端点设备识别对应于这种端点设备的发起者和接收者的可接受的延迟。其他端点设备将其可接受的延迟发送到第一端点设备。如果第一端点设备具有要发送到任何其他端点设备的信息的有效载荷，则第一端点设备使用不大于由第一端点设备识别的帧大小中的任何一个的帧大小和从将发送帧的端点设备。

3. 发明授权

US06700890B1 Method and apparatus for configuring permanent virtual connection (PVC) information stored on network devices in an ATM network logically configured with subnetworks 失效
标题翻译：用于配置存储在逻辑配置有子网络的ATM网络中的网络设备上的永久虚拟连接（PVC）信息的方法和装置
公开(公告)号：US06700890B1
公开(公告)日：2004-03-02
申请号：US08996118
申请日：1997-12-22
申请人： David Langley , Gabriel Lee
发明人： David Langley , Gabriel Lee
IPC分类号： H04L1228
CPC分类号： H04L41/0889 , H04L12/5601 , H04L41/0213 , H04L41/0816 , H04L41/0853 , H04L41/0856 , H04L49/1553 , H04L2012/5626
摘要： A method and apparatus retrieves and stores configuration information for network endpoint devices from other devices in the network, such as a switch adjacent to the endpoint device. When the endpoint device establishes a connection with the network, it generates a sequence of SNMP getnext commands using the ILMI interface to obtain the configuration information from the network device. If the network device sends a trap to the endpoint device indicating a change has been made to the configuration parameters stored in the network device for a PVC, a series of SNMP getrequest commands are made using the ILMI interface to retrieve the configuration information for that PVC from the network device. If the endpoint device detects an interruption in communication with the network device, the endpoint device discards the information retrieved previously.
摘要翻译：方法和装置从网络中的其他设备（例如与端点设备相邻的交换机）检索并存储网络端点设备的配置信息。当端点设备与网络建立连接时，使用ILMI接口生成一系列SNMP getnext命令，以从网络设备获取配置信息。如果网络设备向端点设备发送陷阱，指示已对存储在PVC网络设备中的配置参数进行了更改，则使用ILMI接口进行一系列SNMP getrequest命令，以检索该PVC的配置信息从网络设备。如果端点设备检测到与网络设备通信的中断，则端点设备丢弃先前检索到的信息。

4. 发明授权

US5089045A Substituted 3,6,7,8-tetrahydroimidazo[4,5-d][1,3]diazepine-8-ol herbicides 失效
标题翻译：取代3,6,7,8-四氢去迷迭代（4,5-D）（1,3）二氮杂-8-OL除草剂
公开(公告)号：US5089045A
公开(公告)日：1992-02-18
申请号：US522517
申请日：1990-05-11
申请人： Brian D. Bush , Duncan A. Gates , David Langley
发明人： Brian D. Bush , Duncan A. Gates , David Langley
IPC分类号： A01N43/90 , C07D487/04 , C07H15/26 , C12P17/10
CPC分类号： C07D487/04 , A01N43/90 , C07H15/26 , C12P17/10 , C12R1/04
摘要： Herbicidal 3,6,7,8-tetrahydroimidazo[4,5-d]-[1,3]diazepin-8-ol derivatives of the formula: ##STR1## and sugar conjugates thereof, compositions containing them, and a process for their preparation.

5. 发明授权

US5478854A Deoxy taxols 失效
标题翻译：脱氧紫杉醇
公开(公告)号：US5478854A
公开(公告)日：1995-12-26
申请号：US212447
申请日：1994-03-10
申请人： Vittorio Farina , Shu-Hui Chen , David Langley , Mark D. Wittman , Joydeep Kant , Dolatrai M. Vyas
发明人： Vittorio Farina , Shu-Hui Chen , David Langley , Mark D. Wittman , Joydeep Kant , Dolatrai M. Vyas
IPC分类号： C07D305/14 , C07D407/12 , C07D409/12 , C07F7/18 , C07F9/655 , C07F9/6558 , H01L21/48 , A61K31/33 , A61K31/34 , A61K31/38
CPC分类号： C07D407/12 , C07D305/14 , C07D409/12 , C07F7/1856 , C07F9/65512 , C07F9/65586 , H01L21/4839
摘要： R.sup.g is C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.2-6 alkynyl, C.sub.3-6 cycloalkyl, or a radical of the formula --W--R.sup.x in which W is a bond, C.sub.2-6 alkenediyl, or --(CH.sub.2).sub.t --, in which t is one to six; and R.sup.x is naphthyl, phenyl, or heteroaryl, and furthermore R.sup.x can be optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups;R.sup.2 is --OCOR, H, OH, --OR, --OSO.sub.2 R, --OCONR.sup.o R, --OCONHR, --OCOO(CH.sub.2).sub.t R, or --OCOOR; andR and R.sup.o are independently C.sub.1-6 alkyl, C.sub.2-6 alkenyl, C.sub.3-6 cycloalkyl, C.sub.2-6 alkynyl, or phenyl, optionally substituted with one to three same or different C.sub.1-6 alkyl, C.sub.1-6 alkoxy, halogen or --CF.sub.3 groups.Further provided by this invention are pharmaceutical formulations and intermediates for the the preparation of deoxy taxols of formula I. A method of treating mammalian tumors using a compound of formula I is also provided.
摘要翻译：其中R 1是-COR z，其中R z是RO-或R; R 8为C 1-6烷基，C 2-6烯基，C 2-6炔基，C 3-6环烷基或W-Rx基团，W为键，C 2-6亚烯基或 - （CH 2）t - 其中t为1至6; 并且Rx是萘基，苯基或杂芳基，此外Rx可任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或-CF 3基团取代; R2是-OCOR，H，OH，-OR，-OSO2R，-OCONRoR，-OCONHR，-OCOO（CH2）tR或-OCOOR; 并且R和R 4独立地是C 1-6烷基，C 2-6烯基，C 3-6环烷基，C 2-6炔基或苯基，任选地被一至三个相同或不同的C 1-6烷基，C 1-6烷氧基，卤素或 -CF3组。本发明进一步提供了用于制备式I的脱氧紫杉醇的药物制剂和中间体。还提供了使用式I化合物治疗哺乳动物肿瘤的方法。

6. 发明授权

US5395849A Hybrid antitumor compounds containing a cyclic enediyne and a DNA-binder 失效
标题翻译：含有环烯二烯和DNA-粘合剂的混合抗肿瘤化合物
公开(公告)号：US5395849A
公开(公告)日：1995-03-07
申请号：US132026
申请日：1993-10-05
申请人： Mark D. Wittman , David Langley , John F. Kadow
发明人： Mark D. Wittman , David Langley , John F. Kadow
IPC分类号： C07D207/34 , C07D209/42 , C07D233/58 , A61K31/40 , A61K31/44 , C07D207/50 , C07D209/10 , C07D401/08
CPC分类号： C07D207/34 , C07D209/42
摘要： The present invention provides novel antitumor agents which are hybrid molecules consisting of a cyclic enediyne unit attached to a DNA-binding unit via a linker unit, and having the general formula (I)D--(OCH.sub.2).sub.m --O--(CH.sub.2).sub.n --Ar--Y--CONH--B(I)wherein D is a cyclic enediyne; B is a residue capable of binding to the minor groove of DNA; n is 0 and m is 1, is or n is 1 and m is 0 or 1; Ar is an aromatic residue selected from the group consisting of phenyl, naphthyl, pyridyl, quinolinyl and indolyl; and Y is a direct bond, --CH.sub.2 -- or --CH.dbd.CH--; or a pharmaceutically acceptable salt thereof.
摘要翻译：本发明提供了新的抗肿瘤剂，它们是通过连接单元连接到DNA结合单元的环状烯二炔单元和具有通式（I）D-（OCH 2）m O-（CH 2）n -Ar -Y-CONH-B（I）其中D是环戊烯二烯; B是能够结合DNA的小沟的残基; n为0，m为1，is或n为1，m为0或1; Ar是选自苯基，萘基，吡啶基，喹啉基和吲哚基的芳族残基; 并且Y是直接键，-CH 2 - 或-CH = CH-; 或其药学上可接受的盐。

7. 发明申请

US20190133832A1 Absorbent Adhesive Nipple Cover 审中-公开
公开(公告)号：US20190133832A1
公开(公告)日：2019-05-09
申请号：US15804857
申请日：2017-11-06
申请人： Heather Langley , David Langley
发明人： Heather Langley , David Langley
IPC分类号： A61F13/14
摘要： An absorbent, self-adhesive nipple cover for absorbing fluids from a lactating woman's nipple while concealing the nipple and areola in such a way so as to flatter the appearance of the woman's breast for intimate wear or to disguise that the woman is nursing. The inner layer, facing the woman's breast, is comprised of two sections: a central section made of absorbent material, and a perimeter section made of one or more adhesive appendages that secure the nipple cover completely to the woman's breast. The outer layer, facing away from the woman's breast, is comprised of protective aesthetic material to prevent fluids from leaking through the absorbent material onto clothes or other materials that may come into contact with the nipple cover, and to promote the appearance of the woman's breasts while concealing the nipple and areola.

8. 发明授权

US06829242B2 Method and apparatus for associating PVC identifiers with domain names of home gateways 失效
标题翻译：将PVC标识符与家庭网关的域名相关联的方法和装置
公开(公告)号：US06829242B2
公开(公告)日：2004-12-07
申请号：US09107743
申请日：1998-06-30
申请人： Michael Davison , Rene Tio , David Langley
发明人： Michael Davison , Rene Tio , David Langley
IPC分类号： H04L1266
CPC分类号： H04L63/0272 , H04L12/2856 , H04L12/2898 , H04L12/4633
摘要： A method and apparatus associates a domain name of a home gateway with one or more PVCs. After the PVC is established, a tunneling protocol is used to request the domain name of the home gateway, and the domain name is associated with the PVC. When a user logs on via an access communication device, the user will provide a domain name of a home gateway with which the user desires to communicate. A PVC associated with the home gateway is then used to allow the user to communicate with the home gateway. The domain name of the home gateway may be periodically verified to detect any changes.
摘要翻译：一种方法和装置将家庭网关的域名与一个或多个PVC相关联。建立PVC后，使用隧道协议请求家庭网关的域名，域名与PVC相关联。当用户通过访问通信设备登录时，用户将提供用户希望与之通信的家庭网关的域名。然后使用与家庭网关相关联的PVC来允许用户与家庭网关通信。可以周期性地验证家庭网关的域名以检测任何改变。

9. 发明授权

US06810040B1 Method and apparatus for configuring network devices 失效
标题翻译：用于配置网络设备的方法和设备
公开(公告)号：US06810040B1
公开(公告)日：2004-10-26
申请号：US08996117
申请日：1997-12-22
申请人： Gabriel Lee , David Langley
发明人： Gabriel Lee , David Langley
IPC分类号： H04L1228
CPC分类号： H04L12/5601 , H04L2012/5623 , H04L2012/5626 , H04L2012/5631
摘要： A method and apparatus retrieves and stores configuration information for network endpoint devices from other devices in the network, such as a switch adjacent to the endpoint device. When the endpoint device establishes a connection with the network, it generates a sequence of SNMP getnext commands using the ILMI interface to obtain the configuration information from the network device. If the network device sends a trap to the endpoint device indicating a change has been made to the configuration parameters stored in the network device for a PVC, a series of SNMP getrequest commands are made using the ILMI interface to retrieve the configuration information for that PVC from the network device. If the endpoint device detects an interruption in communication with the network device, the endpoint device discards the information retrieved previously.
摘要翻译：方法和装置从网络中的其他设备（例如与端点设备相邻的交换机）检索并存储网络端点设备的配置信息。当端点设备与网络建立连接时，使用ILMI接口生成一系列SNMP getnext命令，以从网络设备获取配置信息。如果网络设备向端点设备发送陷阱，指示已对存储在PVC网络设备中的配置参数进行了更改，则使用ILMI接口进行一系列SNMP getrequest命令，以检索该PVC的配置信息从网络设备。如果端点设备检测到与网络设备通信的中断，则端点设备丢弃先前检索到的信息。

10. 发明授权

US06714972B1 Method and apparatus for configuring network devices with subnetworks in an ATM environment and retrieving permanent virtual channel (PVC) configuration information from network devices 有权
标题翻译：用于在ATM环境中配置具有子网络的网络设备并从网络设备检索永久虚拟通道（PVC）配置信息的方法和装置
公开(公告)号：US06714972B1
公开(公告)日：2004-03-30
申请号：US10010811
申请日：2001-11-13
申请人： Gabriel Lee , David Langley
发明人： Gabriel Lee , David Langley
IPC分类号： G06F15177
CPC分类号： H04L41/0889 , H04L12/5601 , H04L41/0213 , H04L41/0816 , H04L41/0853 , H04L41/0856 , H04L49/1553 , H04L2012/5626
摘要： A method and apparatus retrieves and stores configuration information for network endpoint devices from other devices in the network, such as a switch adjacent to the endpoint device. When the endpoint device establishes a connection with the network, it generates a sequence of SNMP getnext commands using the ILMI interface to obtain the configuration information from the network device. If the network device sends a trap to the endpoint device indicating a change has been made to the configuration parameters stored in the network device for a PVC, a series of SNMP getrequest commands are made using the ILMI interface to retrieve the configuration information for that PVC from the network device. If the endpoint device detects an interruption in communication with the network device, the endpoint device discards the information retrieved previously.
摘要翻译：方法和装置从网络中的其他设备（例如与端点设备相邻的交换机）检索并存储网络端点设备的配置信息。当端点设备与网络建立连接时，使用ILMI接口生成一系列SNMP getnext命令，以从网络设备获取配置信息。如果网络设备向端点设备发送陷阱，指示已对存储在PVC网络设备中的配置参数进行了更改，则使用ILMI接口进行一系列SNMP getrequest命令，以检索该PVC的配置信息从网络设备。如果端点设备检测到与网络设备通信的中断，则端点设备丢弃先前检索到的信息。

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