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1. 发明申请

US20130309295A1 BIOSYNTHETIC FUNCTIONAL CELLULOSE (BC) FIBERS AS SURGICAL SUTURES AND REINFORCEMENT OF IMPLANTS AND GROWING TISSUE 审中-公开
标题翻译：生物功能纤维素（BC）纤维作为外科手术和植入物的增强和生长组织
公开(公告)号：US20130309295A1
公开(公告)日：2013-11-21
申请号：US13983709
申请日：2012-02-06
申请人： Paul Gatenholm
发明人： Paul Gatenholm
IPC分类号： C12P19/04 , A61L27/20 , A61L17/10
CPC分类号： C12P19/04 , A61B17/06166 , A61L17/005 , A61L17/06 , A61L17/10 , A61L27/20 , A61L27/38 , A61L27/54 , A61L2300/404 , A61L2300/41 , A61L2300/414 , A61L2300/64 , A61L2400/12 , C08L1/02
摘要： Embodiments of the invention are based on the fermentation of bacteria to produce nano-cellulose in oxygen permeable tubular bioreactors. The resulting hydrogel non-hollow fiber can be stretched and dewatered to form strong, stiff yet flexible fiber. The fiber can be dehydrated by freeze drying or solvent exchange to form macroporous material and then optionally soaked with a solution of growth factors, anti-inflammatory drugs, and/or anitibacterial agents to provide a slow release drug delivery device in fiber form. The surface of the fiber is composed of nano-structured cellulose which promotes cell migration, tissue integration, and the healing process. BC fibers are not degraded in the human body and thus are well suited as reinforcement of implants and growing tissue. Uses for the BC fibers include surgical sutures, and reinforcing and promoting regeneration of damaged tissue or implants.
摘要翻译：本发明的实施方案是基于在透氧管状生物反应器中产生纳米纤维素的细菌的发酵。所得到的水凝胶非中空纤维可以被拉伸和脱水以形成强而硬的柔性纤维。纤维可以通过冷冻干燥或溶剂交换脱水以形成大孔材料，然后任选地用生长因子，抗炎药物和/或抗菌剂的溶液浸泡以提供纤维形式的缓释药物递送装置。纤维表面由促进细胞迁移，组织整合和愈合过程的纳米结构纤维素组成。 BC纤维在人体内不会降解，因此非常适合作为植入物和生长组织的增强。 BC纤维的用途包括手术缝线，以及加强和促进受损组织或植入物的再生。

2. 发明申请

US20100278893A1 IMPLANTABLE MATERIAL COMPRISING CELLULOSE AND THE GLYCOPEPTIDE XYLOGLUCAN-GRGDS 审中-公开
标题翻译：包含纤维素和糖蛋白XYLOGLUCAN-GRGDS的可植入材料
公开(公告)号：US20100278893A1
公开(公告)日：2010-11-04
申请号：US12528800
申请日：2008-02-26
申请人： Aase Bodin , Paul Gatenholm , Helen Fink , Bo Risberg , Harry Brumer , Nils Lage Ahrenstedt
发明人： Aase Bodin , Paul Gatenholm , Helen Fink , Bo Risberg , Harry Brumer , Nils Lage Ahrenstedt
IPC分类号： A61K9/00 , C12N9/10 , C12N5/071 , A01N1/00 , A61K35/12 , A61P9/00
CPC分类号： A61L27/507 , A61L27/34 , A61L27/54 , A61L33/08 , A61L2300/25 , A61L2300/414 , C08L1/00
摘要： Implantable materials for medical or surgical applications comprising specific chemical groups on their surface to alter the physico-chemical properties of said material rendering it suitable implantation or biocompatible properties.
摘要翻译：用于医疗或外科应用的植入材料包括其表面上的特定化学基团，以改变所述材料的物理化学性质，使其具有合适的植入或生物相容性质。

3. 发明申请

US20100129642A1 POLYMERIC FILM OR COATING COMPRISING HEMICELLULOSE 有权
标题翻译：聚合物膜或包覆HEMICELLULOSE的涂层
公开(公告)号：US20100129642A1
公开(公告)日：2010-05-27
申请号：US12527070
申请日：2008-02-19
申请人： Maria Gröndahl , Lisa Bindgard , Paul Gatenholm , Thomas Hjertberg
发明人： Maria Gröndahl , Lisa Bindgard , Paul Gatenholm , Thomas Hjertberg
IPC分类号： C09D105/14 , B05D3/02 , B32B19/02 , C09D101/02
CPC分类号： C08L5/14 , B05D3/0254 , C08J5/18 , C08J2305/14 , C08K3/346 , C08K3/36 , C08K5/053 , C08L1/02 , C08L29/04 , C08L2201/06 , C09D101/02 , C09D105/14 , D21H21/16 , Y10T428/251 , Y10T428/277 , C08L2666/26 , C08L2666/04
摘要： A film forming composition and a polymeric film or coating comprising hemicellulose and at least one component selected from the group consisting of plasticizers, cellulose, and an oligomer or polymer, is disclosed, said polymeric film or coating further comprising at least one additive/reactant increasing the liquid/moisture resistance and mixed with and/or reacting with the hemicellulose and said at least one component before or in conjunction with the forming of the film or coating. The use of said film or coating is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the liquid/moisture resistance of hemicellulose. Said at least one additive/reactant increasing the liquid/moisture resistance is either a cross-linking agent or a hydrophobizing agent. In another preferred embodiment the additive is a 2:1 layered phyllosilicate. The additive forms a nanocomposite with the hemicellulose as a matrix. The hemicellulose/phyllosilicate nanocomposite reinforced material provides excellent liquid/moisture resistance. Heat treatment of all of the films increases their liquid/moisture resistance and reduces their oxygen permeability.
摘要翻译：公开了一种成膜组合物和包含半纤维素和至少一种选自增塑剂，纤维素和低聚物或聚合物的组分的聚合物膜或涂层，所述聚合物膜或涂层还包含至少一种添加剂/反应物增加液体/耐湿性，并与半纤维素和所述至少一种组分在形成薄膜或涂层之前或结合之后混合和/或与半纤维素和所述至少一种组分反应。还公开了所述膜或涂层的使用。此外，公开了制造所述聚合物膜或涂层的方法，以及用于改善半纤维素的液体/耐湿性的方法。所述至少一种增加液体/耐湿性的添加剂/反应物是交联剂或疏水剂。在另一个优选的实施方案中，添加剂是2:1层状页硅酸盐。添加剂形成与半纤维素作为基质的纳米复合材料。半纤维素/页硅酸盐纳米复合材料增强材料提供优异的液体/防潮性。所有这些膜的热处理增加了它们的液体/耐湿性并降低了它们的透氧性。

4. 发明授权

US07427643B2 Polymeric film or coating comprising hemicellulose 有权
标题翻译：聚合物膜或包含半纤维素的涂层
公开(公告)号：US07427643B2
公开(公告)日：2008-09-23
申请号：US10548799
申请日：2004-03-18
申请人： Paul Gatenholm , Aase Bodin , Maria Gröndahl , Sofia Dammstrom , Lisa Eriksson
发明人： Paul Gatenholm , Aase Bodin , Maria Gröndahl , Sofia Dammstrom , Lisa Eriksson
IPC分类号： C08L3/00 , C08L89/00 , D21H19/54
CPC分类号： C08J5/18 , C08J2305/14 , C09D105/14
摘要： A film-forming composition and a polymeric film or coating comprising hemicellulose, having a molecular weight of less than 50 000 g/mol, and at least one component selected from the group consisting of plasticizers, cellulose and a synthetic oligomer or polymer is disclosed. The use of said film or coating as an oxygen barrier is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the film-forming properties of hemicellulose having a molecular weight of less than 50 000 g/mol.
摘要翻译：公开了一种成膜组合物和包含分子量小于50 000g / mol的半纤维素和至少一种选自增塑剂，纤维素和合成低聚物或聚合物的组分的聚合物膜或涂层。还公开了所述膜或涂层作为氧阻挡层的用途。此外，公开了制造所述聚合物膜或涂层的方法，以及改进分子量小于50 000g / mol的半纤维素的成膜性能的方法。

5. 发明申请

US20210108098A1 PREPARATION AND APPLICATIONS OF BIOCOMPATIBLE CONDUCTIVE INKS BASED ON CELLULOSE NANOFIBRILS FOR 3D PRINTING OF CONDUCTIVE BIOMEDICAL DEVICES AND FOR USE AS MODELS FOR STUDY OF NEURODEGENERATIVE DISORDERS AND CONNECTION BETWEEN BRAIN/NEURONS AND COMMUNICATION OR OTHER ELECTRONIC DEVICES 有权
公开(公告)号：US20210108098A1
公开(公告)日：2021-04-15
申请号：US16608714
申请日：2018-04-25
申请人： Paul Gatenholm , Erdem Karabulut
发明人： Paul Gatenholm , Erdem Karabulut
IPC分类号： C09D11/14 , A61L27/08 , A61L27/20 , A61L27/36 , A61L27/38 , A61L27/44 , A61L27/50 , C09D11/037
摘要： The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10−1 S cm−1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks. The devices prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and/or be used to link the human brain with electronic and/or communication devices. They can also be implanted to replace neural tissue or stimulate guiding of neural cells. They can also be used to stimulate the heart by using electrical signaling or to repair myocardial infarction and/or damage related thereto.

6. 发明授权

US08557033B2 Polymeric film or coating comprising hemicellulose 有权
标题翻译：聚合物膜或包含半纤维素的涂层
公开(公告)号：US08557033B2
公开(公告)日：2013-10-15
申请号：US12527070
申请日：2008-02-19
申请人： Maria Gröndahl , Lisa Bindgard , Paul Gatenholm , Thomas Hjertberg
发明人： Maria Gröndahl , Lisa Bindgard , Paul Gatenholm , Thomas Hjertberg
IPC分类号： C08L1/00 , C08L3/00 , C08L5/00 , C09D101/00 , C09D103/00 , C09D105/00 , C09J101/00 , C09J103/00 , C09J105/00 , C08K3/34 , C08K9/04 , D21H19/58 , C09C1/42
CPC分类号： C08L5/14 , B05D3/0254 , C08J5/18 , C08J2305/14 , C08K3/346 , C08K3/36 , C08K5/053 , C08L1/02 , C08L29/04 , C08L2201/06 , C09D101/02 , C09D105/14 , D21H21/16 , Y10T428/251 , Y10T428/277 , C08L2666/26 , C08L2666/04
摘要： A film forming composition and a polymeric film or coating comprising hemicellulose and at least one component selected from the group consisting of plasticizers, cellulose, and an oligomer or polymer, is disclosed, said polymeric film or coating further comprising at least one additive/reactant increasing the liquid/moisture resistance and mixed with and/or reacting with the hemicellulose and said at least one component before or in conjunction with the forming of the film or coating. The use of said film or coating is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the liquid/moisture resistance of hemicellulose. Said at least one additive/reactant increasing the liquid/moisture resistance is either a cross-linking agent or a hydrophobizing agent. In another preferred embodiment the additive is a 2:1 layered phyllosilicate. The additive forms a nanocomposite with the hemicellulose as a matrix. The hemicellulose/phyllosilicate nanocomposite reinforced material provides excellent liquid/moisture resistance. Heat treatment of all of the films increases their liquid/moisture resistance and reduces their oxygen permeability.
摘要翻译：公开了一种成膜组合物和包含半纤维素和至少一种选自增塑剂，纤维素和低聚物或聚合物的组分的聚合物膜或涂层，所述聚合物膜或涂层还包含至少一种添加剂/反应物增加液体/耐湿性，并与半纤维素和所述至少一种组分在形成薄膜或涂层之前或结合之后混合和/或与半纤维素和所述至少一种组分反应。还公开了所述膜或涂层的使用。此外，公开了制造所述聚合物膜或涂层的方法，以及用于改善半纤维素的液体/耐湿性的方法。所述至少一种增加液体/耐湿性的添加剂/反应物是交联剂或疏水剂。在另一个优选的实施方案中，添加剂是2:1层状页硅酸盐。添加剂形成与半纤维素作为基质的纳米复合材料。半纤维素/页硅酸盐纳米复合材料增强材料提供优异的液体/防潮性。所有这些膜的热处理增加了它们的液体/耐湿性并降低了它们的透氧性。

7. 发明申请

US20060173104A1 Polymeric film or coating comprising hemicelulose 有权
标题翻译：聚合物膜或包含半纤维素的涂层
公开(公告)号：US20060173104A1
公开(公告)日：2006-08-03
申请号：US10548799
申请日：2004-03-18
申请人： Paul Gatenholm , Aase Bodin , Maria Grondahl , Sofia Dammstrom , Lisa Eriksson
发明人： Paul Gatenholm , Aase Bodin , Maria Grondahl , Sofia Dammstrom , Lisa Eriksson
IPC分类号： C08G18/38 , C09D101/00
CPC分类号： C08J5/18 , C08J2305/14 , C09D105/14
摘要： A film-forming composition and a polymeric film or coating comprising hemicellulose, having a molecular weight of less than 50 000 g/mol, and at least one component selected from the group consisting of plasticizers, cellulose and a synthetic oligomer or polymer is disclosed. The use of said film or coating as an oxygen barrier is also disclosed. Further, a method for the manufacture of said polymeric film or coating is disclosed, as well as a method for improving the film-forming properties of hemicellulose having a molecular weight of less than 50 000 g/mol.
摘要翻译：公开了一种成膜组合物和包含分子量小于50 000g / mol的半纤维素和至少一种选自增塑剂，纤维素和合成低聚物或聚合物的组分的聚合物膜或涂层。还公开了所述膜或涂层作为氧阻挡层的用途。此外，公开了制造所述聚合物膜或涂层的方法，以及改进分子量小于50 000g / mol的半纤维素的成膜性能的方法。

8. 发明授权

US10774227B2 Preparation and applications of biocompatible conductive inks based on cellulose nanofibrils for 3D printing of conductive biomedical devices and for use as models for study of neurodegenerative disorders and connection between brain/neurons and communication or other electronic devices 有权
公开(公告)号：US10774227B2
公开(公告)日：2020-09-15
申请号：US15963076
申请日：2018-04-25
申请人： Paul Gatenholm , Erdem Karabulut
发明人： Paul Gatenholm , Erdem Karabulut
IPC分类号： C09D11/14 , C09D11/38 , C09D11/30 , A61L27/08 , A61L27/20 , A61L27/38 , A61L27/36 , B33Y70/00 , B33Y80/00 , C09D11/52 , A61L27/44 , C09D11/324 , C12N5/00 , C09D11/03 , A61L27/50 , C12N5/09 , C12N5/071 , A61N1/05 , A61N1/36 , A61N1/362 , C12N5/0793 , C12N5/077 , C09D11/037
摘要： The present invention relates to preparation and use of nanocellulose fibrils or crystals such as disintegrated bacterial nanocellulose, tunicate-derived nanocellulose, or plant-derived nanocellulose, together with carbon nanotubes, as a biocompatible and conductive ink for 3D printing of electrically conductive patterns. Biocompatible conductive bioinks described in this invention were printed in the form of connected lines onto wet or dried nanocellulose films, bacterial cellulose membrane, or tunicate decellularized tissue. The devices were biocompatible and showed excellent mechanical properties and good electrical conductivity through printed lines (3.8·10−1 S cm−1). Such scaffolds were used to culture neural cells. Neural cells attached selectively on the printed pattern and formed connective networks. The devices prepared by this invention are suited as bioassays to screen drugs against neurodegenerative diseases such as Alzheimer's and Parkinson's, study brain function, and/or be used to link the human brain with electronic and/or communication devices. They can also be implanted to replace neural tissue or stimulate guiding of neural cells. They can also be used to stimulate the heart by using electrical signaling or to repair myocardial infarction and/or damage related thereto.

9. 发明申请

US20190209738A1 PREPARATION AND APPLICATIONS OF MODIFIED CELLULOSE NANOFIBRILS WITH EXTRACELLULAR MATRIX COMPONENTS AS 3D BIOPRINTING BIOINKS TO CONTROL CELLULAR FATE PROCESSES SUCH AS ADHESION, PROLIFERATION AND DIFFERENTIATION 审中-公开
公开(公告)号：US20190209738A1
公开(公告)日：2019-07-11
申请号：US16307852
申请日：2017-06-09
申请人： Paul Gatenholm
发明人： Paul Gatenholm
IPC分类号： A61L27/60 , A61K35/36 , C12N5/0793 , C12Q1/02 , C12N5/071 , C12N5/077 , A61L27/24 , A61L27/36 , A61P25/28 , A61P25/16
CPC分类号： A61L27/60 , A61K35/12 , A61K35/28 , A61K35/32 , A61K35/33 , A61K35/36 , A61K47/61 , A61L27/20 , A61L27/24 , A61L27/362 , A61L27/3813 , A61L27/54 , A61L2300/414 , A61L2400/12 , A61L2430/40 , A61P25/16 , A61P25/28 , C08B15/06 , C08H1/00 , C12N5/0068 , C12N5/0619 , C12N5/0629 , C12N5/0655 , C12N5/0656 , C12N5/0696 , C12N2501/15 , C12N2501/155 , C12N2513/00 , C12N2533/52 , C12N2533/54 , C12N2533/74 , C12N2533/78 , C12N2533/80 , C12N2533/90 , C12Q1/025 , G01N33/5088 , C08L1/02
摘要： The present invention relates to modification of cellulose nanofibrils (CNF) with extracellular matrix components such as collagen, elastin, fibronectin or RGD sequences or growth factors such as TGFBeta using for example EDS-NHS conjugation method and preparation of bioinks for 3D Bioprinting of tissue models such as human skin or neural tissue. Cellulose nanofibrils provide excellent printing fidelity which is crucial for diffusion of oxygen and diffusion of nutrients into the 3D bioprinted constructs. The surface conjugated extracellular matrix components induce biological activity by providing adhesion sites or inducing differentiation process. 3D Bioprinted bioinks based on CNF bioinks showed great ability inducing adhesion of human fibroblasts and stimulating Collagen I production. Such bioinks are thus suitable for 3D Bioprinting of tissue models.

10. 发明授权

US09637561B2 Plasticizer-free flexible oxygen barrier films and laminates based on negatively charged and acetylated non-cellulosic polysaccharides isolated from biomass 有权
公开(公告)号：US09637561B2
公开(公告)日：2017-05-02
申请号：US13984209
申请日：2012-02-08
申请人： Paul Gatenholm
发明人： Paul Gatenholm
IPC分类号： C08B37/00 , C08B37/14 , C08L5/14 , C08H8/00 , C12P19/04 , D21C5/00 , B65D81/18 , D21H27/10 , D21H21/16
CPC分类号： C08B37/006 , B65D81/18 , C08B37/0003 , C08B37/0057 , C08H8/00 , C08L5/14 , C12P19/04 , C12P2201/00 , D21C5/005 , D21H21/16 , D21H27/10 , Y10T428/31986
摘要： Food, consumer, and industrial product packaging materials are provided by embodiments of the present invention. Films and laminates based on a combination of negatively charged polysaccharides are provided as such packaging materials. The films can be prepared by mildly treating soft wood with steam followed by alkali extraction and enzymatic treatment. Negatively charged non-cellulosic polysaccharides are isolated with weight average molecular weight Mw higher than 10,000 g/mol and molecular structure comprising a xylan main chain substituted with more than 15 molar % of glucuronic acid and more than 5 molar % arabinose. The negatively charged non-cellulosic polysaccharides can be casted from water solution on a suitable carrier and surface acetylated or coated with acetylated polysaccharide to obtain oxygen and water barrier packaging laminate. Inventive packaging materials can have strength at break above 55 MPa, elongation to break above 2.5%, cohesive and adhesive properties and good oxygen and moisture barrier properties.

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