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1. 发明申请

US20110287113A1 TREATMENT OF PSORIASIS 审中-公开
标题翻译：治疗PSORIASIS
公开(公告)号：US20110287113A1
公开(公告)日：2011-11-24
申请号：US13146725
申请日：2010-01-22
申请人： Paul Davis , Andrew Austin , Jan Jezek
发明人： Paul Davis , Andrew Austin , Jan Jezek
IPC分类号： A61K33/00 , A61P17/06
CPC分类号： A61K9/0014 , A61K9/7007 , A61K33/00 , A61K47/32
摘要： The invention relates to an aqueous composition capable of delivering nitric oxide for use in the treatment of psoriasis, particularly plaque psoriasis, e.g. by application of a skin dressing.
摘要翻译：本发明涉及一种能够输送一氧化氮以用于治疗牛皮癣，特别是斑块性银屑病的含水组合物。通过应用皮肤敷料。

2. 发明申请

US20140255379A1 STABILIZED COMPOSITIONS AGAINST IONISING RADIATION 审中-公开
标题翻译：稳定化合物防止离子辐射
公开(公告)号：US20140255379A1
公开(公告)日：2014-09-11
申请号：US14238532
申请日：2012-08-10
申请人： Paul Davis , Jan Jezek , Andrew Austin
发明人： Paul Davis , Jan Jezek , Andrew Austin
IPC分类号： A61K47/22 , A61K47/20 , A61K47/14 , A61B5/145 , A61B5/1468 , A61K38/44 , A61K47/18
CPC分类号： A61K47/22 , A61B5/14546 , A61B5/1468 , A61K38/443 , A61K47/14 , A61K47/183 , A61K47/20 , A61L2/0029 , A61L15/38 , A61L15/56 , C12Q1/005 , C12Q1/26
摘要： This invention relates to improvements to medical devices such as biosensors containing proteins such as oxidoreductases, for example oxidase and/or peroxidase enzymes. More generally it relates to novel compositions containing proteins which are stabilised to ionising radiation.
摘要翻译：本发明涉及医疗装置的改进，例如含有蛋白质如氧化还原酶例如氧化酶和/或过氧化物酶的生物传感器。更一般地，它涉及含有稳定化成电离辐射的蛋白质的新型组合物。

3. 发明申请

US20070190122A1 Skin dressings 审中-公开
标题翻译：皮肤敷料
公开(公告)号：US20070190122A1
公开(公告)日：2007-08-16
申请号：US10587547
申请日：2005-01-28
申请人： Paul Davis , Andrew Austin , Jan Jezek
发明人： Paul Davis , Andrew Austin , Jan Jezek
IPC分类号： A61L15/00 , A61K38/44
CPC分类号： A61L15/38 , A61F13/00 , A61L15/60
摘要： A skin dressing of the general form disclosed in WO 03/030800 comprises oxidoreductase enzyme in hydrated condition in a hydrated hydrogel of hydrophilic polymer material, wherein hydrogel comprises at least 25% by weight of the polymer material. A currently preferred dressing comprises a lower, skin-contacting layer (18) comprising a hydrated hydrogel comprising 30% by weight sodium poly-AMPS and 5% by weight glucose, and an upper layer (16) comprising a hydrated hydrogel comprising 15% by weight sodium poly-AMPS, 15% by weight ammonium poly-AMPS, and glucose oxidase. Using hydrogels with a higher concentration of polymer material is found to affect the rate of oxygen generation and hence the oxygen concentration profile beneath the dressing in use in a manner beneficial to wound healing.
摘要翻译：在WO 03/030800中公开的通用形式的皮肤敷料包括水合状态的亲水性聚合物材料的水合水凝胶中的氧化还原酶，其中水凝胶包含至少25重量％的聚合物材料。目前优选的敷料包括下部皮肤接触层（18），其包含水合水凝胶，其包含30重量％的聚-AMPS钠和5重量％的葡萄糖，以及包含水合水凝胶的上层（16），其包含15％重量多聚AMPS钠，15％（重量）聚氨基甲酸铵和葡萄糖氧化酶。发现使用具有较高浓度聚合物材料的水凝胶以有利于伤口愈合的方式影响使用中氧气产生速率和因此在敷料之下的氧浓度分布。

4. 发明申请

US20070148117A1 Skin dressings 审中-公开
标题翻译：皮肤敷料
公开(公告)号：US20070148117A1
公开(公告)日：2007-06-28
申请号：US10587420
申请日：2005-01-28
申请人： Paul Davis , Andrew Austin , Jan Jezek
发明人： Paul Davis , Andrew Austin , Jan Jezek
IPC分类号： A61K8/73 , A61K8/65
CPC分类号： A61L15/38 , A61L15/60
摘要： A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin.
摘要翻译：皮肤敷料包括水合水凝胶材料，其包括乳酸盐离子源和葡萄糖供应，任选地还包括锌离子源和碘离子源。敷料对皮肤有益。

5. 发明申请

US20050181026A1 Skin dressings 审中-公开
标题翻译：皮肤敷料
公开(公告)号：US20050181026A1
公开(公告)日：2005-08-18
申请号：US11044715
申请日：2005-01-28
申请人： Paul Davis , Andrew Austin , Jan Jezek
发明人： Paul Davis , Andrew Austin , Jan Jezek
IPC分类号： A61K9/70 , A61K31/19 , A61K31/70 , A61L15/60
CPC分类号： A61L15/60
摘要： A skin dressing comprises a hydrated hydrogel material including a source of lactate ions and a supply of glucose, optionally also including a source of zinc ions and a source of iodide ions. The dressing has beneficial effects on skin.
摘要翻译：皮肤敷料包括水合水凝胶材料，其包括乳酸盐离子源和葡萄糖供应，任选地还包括锌离子源和碘离子源。敷料对皮肤有益。

6. 发明授权

US08815234B2 Treatment of human or animal body surface infection 有权
标题翻译：治疗人体或动物体表面感染
公开(公告)号：US08815234B2
公开(公告)日：2014-08-26
申请号：US13318241
申请日：2010-04-30
申请人： Paul Davis , Andrew Austin
发明人： Paul Davis , Andrew Austin
IPC分类号： A61K38/44 , C12N9/08 , C12N9/04
CPC分类号： A61L26/0066 , A61L15/38 , A61L15/46 , A61L26/0047 , A61L2300/11 , A61L2300/254
摘要： A method of treatment of a human or animal body surface infection, particularly a fungal infection, comprises applying an aqueous liquid to the infected body surface, e.g. nail region, followed by applying a dressing comprising a source of hydrogen peroxide. Also provided is a combination of the liquid and dressing for use in the method.
摘要翻译：治疗人或动物体表面感染，特别是真菌感染的方法包括将水性液体施加到感染的身体表面，例如，指甲区域，然后施加包含过氧化氢源的敷料。还提供了用于该方法的液体和敷料的组合。

7. 发明申请

US20120058101A1 TREATMENT OF HUMAN OR ANIMAL BODY SURFACE INFECTION 有权
标题翻译：人体或动物体表面感染的治疗
公开(公告)号：US20120058101A1
公开(公告)日：2012-03-08
申请号：US13318241
申请日：2010-04-30
申请人： Paul Davis , Andrew Austin
发明人： Paul Davis , Andrew Austin
IPC分类号： A61K38/44 , A61P31/10
CPC分类号： A61L26/0066 , A61L15/38 , A61L15/46 , A61L26/0047 , A61L2300/11 , A61L2300/254
摘要： A method of treatment of a human or animal body surface infection, particularly a fungal infection, comprises applying an aqueous liquid to the infected body surface, e.g. nail region, followed by applying a dressing comprising a source of hydrogen peroxide. Also provided is a combination of the liquid and dressing for use in the method.
摘要翻译：治疗人或动物体表面感染，特别是真菌感染的方法包括将水性液体施加到感染的身体表面，例如，指甲区域，然后施加包含过氧化氢源的敷料。还提供了用于该方法的液体和敷料的组合。

8. 发明申请

US20060275350A1 Skin dressings containing oxidoreductase enzyme 有权
标题翻译：含有氧化还原酶的皮肤敷料
公开(公告)号：US20060275350A1
公开(公告)日：2006-12-07
申请号：US10557998
申请日：2004-06-04
申请人： Paul Davis , Andrew Austin
发明人： Paul Davis , Andrew Austin
IPC分类号： A61K38/44 , A61L15/00
CPC分类号： C12N9/0004 , A61L15/38 , C12N9/96
摘要： A skin dressing comprises a first dressing component (16) carrying oxidoreductase enzyme in dried condition; and a second dressing component (18) carrying a source of water, such that when the first and second dressing components are placed in fluid communication with each other, water migrates from the second component towards the first comportent and acts to hydrate enzyme carried by the first component, at least at the surface of the first component. The dressing components are kept separate before use, e.g. being sealed in separate sterile, water-impervious packages such as laminated aluminium foil pouches. In use of the dressing, the second dressing component is located on the skin of a human or animal, e.g. over a wound to be treated or on a region of skin to be treated for cosmetic or therapeutic purposes such as for treatment of acne or other skin conditions. The first dressing component is placed on top of the second component in fluid communication therewith. In embodiments comprising only first and second dressing components, the first dressing component is placed in direct contact with the second dressing component. Water from the second component migrates towards the first comportent and acts to hydrate enzyme carried by the first component, at least at points of contact at the interface between the first and second components. Once hydrated, the oxidoreductase enzyme can immediately begin functioning in known manner with beneficial effects.
摘要翻译：皮肤敷料包括在干燥状态下携带氧化还原酶的第一敷料组分（16）以及第二敷料组分（18），其携带水源，使得当所述第一和第二敷料组分彼此流体连通时，水从所述第二组分向所述第一压缩物迁移并且用于使由所述第二组分携带的酶水合第一组分，至少在第一组分的表面。敷料组分在使用前保持分开，例如密封在单独的无菌，防水包装如层压铝箔袋中。在敷料的使用中，第二敷料组分位于人或动物的皮肤上，例如，在待治疗的伤口上或在用于治疗痤疮或其他皮肤病症的化妆品或治疗目的的皮肤区域上。第一敷料组分放置在与其流体连通的第二组分的顶部上。在仅包括第一和第二敷料组分的实施方案中，第一敷料组分被放置成与第二敷料组件直接接触。至少在第一和第二组分之间的界面处的接触点处，来自第二组分的水向第一组分迁移并用于水合由第一组分携带的酶。一旦水合，氧化还原酶可以以已知的方式立即开始起作用，具有有益效果。

9. 发明申请

US20060034816A1 Wound dressings comprising hydrated hydrogels and enzymes 有权
标题翻译：伤口敷料包含水合水凝胶和酶
公开(公告)号：US20060034816A1
公开(公告)日：2006-02-16
申请号：US10512440
申请日：2003-04-23
申请人： Paul Davis , Andrew Austin
发明人： Paul Davis , Andrew Austin
IPC分类号： A61K38/44 , A61K9/66
CPC分类号： A61F13/00063 , A61F13/023 , A61F2013/00229 , A61F2013/00561 , A61F2013/00604 , A61F2013/00748 , A61F2013/00902 , A61F2013/00927 , A61L15/38 , A61L15/60
摘要： A skin dressing, particularly a wound dressing, comprises oxidoreductase enzyme and, optionally, peroxidase enzyme, wherein the enzyme(s) are present in hydrated condition, e.g. being present in one or more hydrated hydrogels. The dressing is used by being located on the skin of a human or animal e.g. over a wound. The oxidoreductase enzyme catalyses a reaction that produces hydrogen peroxide from an appropriate substrate, the substrate either being naturally present in body fluids and/or being supplied separately and/or being incorporated into the dressing. The currently preferred oxidoreductase enzyme is glucose oxidase. The catalyses reaction of β-D-glucose substrate to give hydrogen peroxide and gluconic acid. A mixture of oxidoreductase enzyme can undergo reaction (optionally catalysed by the peroxidase enzyme) to produce a variety of species including reactive oxygen intermediates that have antimicrobial properties and that can therefore assist in promoting wound healing.
摘要翻译：皮肤敷料，特别是伤口敷料，包含氧化还原酶和任选的过氧化物酶，其中所述酶以水合条件存在，例如，存在于一种或多种水合水凝胶中。敷料通过位于人或动物的皮肤上而被使用，例如在伤口上氧化还原酶催化从适当的底物产生过氧化氢的反应，衬底天然存在于体液中和/或单独供应和/或并入敷料中。目前优选的氧化还原酶是葡萄糖氧化酶。 β-D-葡萄糖底物的催化反应产生过氧化氢和葡萄糖酸。氧化还原酶的混合物可以进行反应（任选被过氧化物酶催化）以产生各种物质，包括具有抗微生物性质的活性氧中间体，因此有助于促进伤口愈合。

10. 发明申请

US20130344583A1 BIOSENSOR COMPRISING AN OXIDASE ENZYME AND A HYDROGEN PEROXIDE INDICATOR MEANS 审中-公开
标题翻译：包含氧化酶的生物传感器和过氧化氢指示剂
公开(公告)号：US20130344583A1
公开(公告)日：2013-12-26
申请号：US14003522
申请日：2012-03-06
申请人： Paul Davis , Andrew Austin
发明人： Paul Davis , Andrew Austin
IPC分类号： C12Q1/26
CPC分类号： C12Q1/26 , C12Q1/005 , G01N33/52
摘要： A biosensor for detecting the concentration of an analyte in wound fluid, the biosensor being at least substantially free of catalase and comprising a sensing means comprising an oxidase enzyme and a hydrogen peroxide indicator means, the arrangement being such that, when a sample of wound fluid comprising the analyte is brought into contact with the sensing means, the oxidase enzyme reacts with the analyte to produce hydrogen peroxide which triggers the indicator means to indicate the presence of the analyte in the wound fluid.
摘要翻译：一种生物传感器，用于检测伤口液体中分析物的浓度，所述生物传感器至少基本上不含过氧化氢酶，并且包括含有氧化酶和过氧化氢指示剂装置的感测装置，该装置使得当伤口液包括分析物与感测装置接触，氧化酶与分析物反应产生过氧化氢，其触发指示剂装置以指示分析物在伤口液中的存在。

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