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1. 发明授权

US08686347B2 Device for use in normalizing readings on a testing machine 有权
标题翻译：用于在测试机上对读数进行归一化的设备
公开(公告)号：US08686347B2
公开(公告)日：2014-04-01
申请号：US13750330
申请日：2013-01-25
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： Example apparatus and methods for use in normalization of testing machines used to test samples in vessels are disclosed. An example apparatus includes verification source and a photon emitter positioned in the verification source. The example photon emitter includes a C14 source, a scintillator adjacent to the C14 source, and a filter adjacent to the scintillator. The example photon emitter is to emit photons through the filter for detection by a photon counter.
摘要翻译：公开了用于在容器中测试样品的试验机的标准化中使用的示例性装置和方法。示例性设备包括位于验证源中的验证源和光子发射器。示例性光子发射器包括C14源，与C14源相邻的闪烁体和与闪烁体相邻的滤光器。示例性光子发射器将通过滤光器发射光子，以由光子计数器检测。

2. 发明授权

US08368009B2 Device for use in normalizing readings on a testing machine 有权
标题翻译：用于在测试机上对读数进行归一化的设备
公开(公告)号：US08368009B2
公开(公告)日：2013-02-05
申请号：US13465408
申请日：2012-05-07
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译：公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。

3. 发明申请

US20120217385A1 DEVICE FOR USE IN NORMALIZING READINGS ON A TESTING MACHINE 有权
标题翻译：用于测试机器读数正常化的设备
公开(公告)号：US20120217385A1
公开(公告)日：2012-08-30
申请号：US13465408
申请日：2012-05-07
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G12B13/00 , G21G4/00 , G01T1/20
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An example optic module verification device for use in periodic normalization of a testing machine used to test samples in wells is disclosed. The example testing machine includes a plurality of photon counters that each count photons emitted from different wells. The example verification device includes a plurality of verification wells located so as to each be associated with one of the photon counters when used in the testing machine. The example device also includes a photon emitter in each verification well, each photon emitter including a C14 source, a scintillator adjacent the C14 source, and a filter over the scintillator. The example photon emitters each have a determined initial base value for emitted photons, and each photon emitter is positioned in its verification well to emit photons through the filter to the associated photon counter when used in the testing machine.
摘要翻译：公开了一种用于在井中测试样品的测试机的周期性归一化中使用的示例性光学模块验证装置。示例性测试机器包括多个光子计数器，每个光子计数器计数从不同孔发射的光子。示例性验证装置包括多个验证孔，其位于当在测试机器中使用时各自与光子计数器中的一个相关联。示例性装置还包括每个验证井中的光子发射器，每个光子发射器包括C14源，与C14源相邻的闪烁体和闪烁体上的滤光器。示例性光子发射器各自具有用于发射光子的确定的初始基值，并且当在测试机中使用时，每个光子发射器位于其验证井中，以将光子通过滤光器发射到相关联的光子计数器。

4. 发明授权

US07858924B2 Device for use in normalizing readings on a testing machine 有权
标题翻译：用于在测试机上对读数进行归一化的设备
公开(公告)号：US07858924B2
公开(公告)日：2010-12-28
申请号：US11637314
申请日：2006-12-12
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G01D18/00 , G12B13/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译：用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。

5. 发明申请

US20130140444A1 DEVICE FOR USE IN NORMALIZING READINGS ON A TESTING MACHINE 有权
标题翻译：用于测试机器读数正常化的设备
公开(公告)号：US20130140444A1
公开(公告)日：2013-06-06
申请号：US13750330
申请日：2013-01-25
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： H01J65/08 , G01J1/20
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： Example apparatus and methods for use in normalization of testing machines used to test samples in vessels are disclosed. An example apparatus includes verification source and a photon emitter positioned in the verification source. The example photon emitter includes a C14 source, a scintillator adjacent to the C14 source, and a filter adjacent to the scintillator. The example photon emitter is to emit photons through the filter for detection by a photon counter.
摘要翻译：公开了用于在容器中测试样品的试验机的标准化中使用的示例性装置和方法。示例性设备包括位于验证源中的验证源和光子发射器。示例性光子发射器包括C14源，与C14源相邻的闪烁体和与闪烁体相邻的滤光器。示例性光子发射器将通过滤光器发射光子，以由光子计数器检测。

6. 发明授权

US08173972B2 Device for use in normalizing readings on a testing machine 有权
标题翻译：用于在测试机上对读数进行归一化的设备
公开(公告)号：US08173972B2
公开(公告)日：2012-05-08
申请号：US12951783
申请日：2010-11-22
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G21G4/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译：用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。周期性地使用该装置进行标准化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望水平以下时，可以更新该装置。

7. 发明申请

US20110062352A1 DEVICE FOR USE IN NORMALIZING READINGS ON A TESTING MACHINE 有权
标题翻译：用于测试机器读数正常化的设备
公开(公告)号：US20110062352A1
公开(公告)日：2011-03-17
申请号：US12951783
申请日：2010-11-22
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G21G4/00
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译：用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。

8. 发明申请

US20080135743A1 Device for use in normalizing readings on a testing machine 有权
标题翻译：用于在测试机上对读数进行归一化的设备
公开(公告)号：US20080135743A1
公开(公告)日：2008-06-12
申请号：US11637314
申请日：2006-12-12
申请人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
发明人： Paul A. Matuszewski , Omar S. Khalil , Kurt M. Klosterman , James L. Dempski , Jose Pioquinto
IPC分类号： G12B13/00 , G21H3/02
CPC分类号： H01J65/08 , G01J1/20 , G01N23/223 , G01N2223/076
摘要： An optic module verification device for normalizing between X photon counters, including a verification tray with X verification wells and a modular photon emitter in each verification well. Each photon emitter includes a spring, a Beta source disk, a scintillator disk adjacent the Beta source disk, and a neutral density filter over the scintillator disk, all of which are encapsulated in a cylindrical chamber with the filter adjacent an opening on one end of the chamber and the spring biasing the Beta source disk and the scintillator disk toward the opening. The device is periodically used for normalization, and may be updated when emitted photons fall below a desired level by replacing the scintillator disk and then determining a new normalized reference values for each photon emitter.
摘要翻译：用于在X光子计数器之间进行归一化的光学模块验证装置，包括具有X个验证孔的验证盘和每个验证井中的模块化光子发射器。每个光子发射器包括弹簧，β源盘，与β源盘相邻的闪烁体盘，以及在闪烁体盘上的中性密度滤光片，所有这些都被封装在圆柱形腔室中，过滤器邻近一端的开口腔室和弹簧将Beta源盘和闪烁体盘偏置到开口。周期性地使用该装置进行归一化，并且当发射的光子通过替换闪烁体盘然后确定每个光子发射器的新的归一化参考值而降低到期望的水平以下时，可以更新该装置。

9. 发明授权

US08326388B2 Method and apparatus for non-invasive measurement of living body characteristics by photoacoustics 有权
标题翻译：通过光声学对生物体特征进行非侵入性测量的方法和装置
公开(公告)号：US08326388B2
公开(公告)日：2012-12-04
申请号：US10532691
申请日：2003-10-28
申请人： Shoichi Kanayama , Kazuhiro Itsumi , Omar S. Khalil , Stanislaw Kantor
发明人： Shoichi Kanayama , Kazuhiro Itsumi , Omar S. Khalil , Stanislaw Kantor
IPC分类号： A61B5/1455
CPC分类号： A61B5/0095 , A61B5/14532 , A61B5/6843
摘要： A method and apparatus for non-invasive measurement of living body information comprises a light source configured to generate light containing a specific wavelength component, an irradiation unit configured to irradiate a subject with the light, and at least one acoustic signal detection unit including piezoelectric devices formed of a piezoelectric single crystal containing lead titanate and configured to detect an acoustic signal which is generated due to the energy of the irradiation light absorbed by a specific substance present in or on a subject.
摘要翻译：一种生物体信息的非侵入式测量方法和装置，具备：生成包含特定波长成分的光的光源，被配置为对被检体照射的照射部，以及包含压电装置的至少一个声信号检测部由包含钛酸铅的压电单晶形成，并且被配置为检测由于存在于被摄体中的特定物质吸收的照射光的能量而产生的声信号。

10. 发明授权

US07254425B2 Method for detecting artifacts in data 有权
标题翻译：检测数据中伪像的方法
公开(公告)号：US07254425B2
公开(公告)日：2007-08-07
申请号：US10763548
申请日：2004-01-23
申请人： Michael G. Lowery , Eric B. Shain , Omar S. Khalil
发明人： Michael G. Lowery , Eric B. Shain , Omar S. Khalil
IPC分类号： A61B5/00
CPC分类号： A61B5/1455 , A61B5/14532 , A61B5/14535 , A61B5/7207 , G01N21/49
摘要： A method for identifying artifacts occurring during a measurement of the concentration of an analyte in a biological sample by means of an apparatus that employs temperature-controlled optical probes, introduces electromagnetic radiation into tissue, and collects and detects radiation emitted at a distance from the point at which the electromagnetic radiation is introduced. The values of intensity of radiation emitted at different wavelengths, at different distances between the light introduction site(s) and the light collection site(s), and at different temperatures are collected and used in the method to generate a relationship between these values and the concentration of an analyte in the tissue or the disease state of a patient. The method involves the use of an algorithm that identifies artifacts in the data resulting from motion of the patient and allows the rejection of data sets that contain these artifacts. The algorithm identifies sudden changes in the magnitude and direction in a sequence of collected signals.
摘要翻译：一种用于识别通过使用温度控制的光学探针的装置测量生物样品中的分析物的浓度而发生的伪影的方法，将电磁辐射引入组织中，并且收集并检测距离该点电磁辐射被引入。收集在不同波长下，在光引入部位与光采集部位之间的不同距离以及不同温度下发射的辐射强度值，并用于该方法中以产生这些值与组织中分析物的浓度或患者的疾病状态。该方法涉及使用识别由患者运动产生的数据中的伪影的算法，并允许拒绝包含这些伪像的数据集。该算法识别收集信号序列中的幅度和方向的突变。

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