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1. 发明申请

US20070219118A1 Therapeutic methods for nucleic acid delivery vehicles 审中-公开
标题翻译：核酸递送载体的治疗方法
公开(公告)号：US20070219118A1
公开(公告)日：2007-09-20
申请号：US11591611
申请日：2006-11-02
申请人： Patrick Lu , Puthupparampil Scaria , Martin Woodle , Frank Xie , Jun Xu , Quinn Tang
发明人： Patrick Lu , Puthupparampil Scaria , Martin Woodle , Frank Xie , Jun Xu , Quinn Tang
IPC分类号： A61K31/7052 , A61K38/00
CPC分类号： A61K48/0041 , A61K48/0008 , A61K48/0083 , A61K48/0091
摘要： It has been found that certain synthetic vectors and nucleic acid sequences that encode viral genomic sequences can, for example, be administered to a subject repeatedly as a vehicle for effectively delivering one or more therapeutic nucleic acid molecules or polypeptides to a cell or tissue. Accordingly, the disclosed nucleic acid delivery vehicles can be used, for instance, as part of a therapeutic regimen that involves an ongoing use of a therapeutic nucleic acid molecule or polypeptide.
摘要翻译：已经发现，编码病毒基因组序列的某些合成载体和核酸序列可以例如作为用于有效地将一种或多种治疗性核酸分子或多肽有效递送至细胞或组织的载体重复施用于受试者。因此，所公开的核酸递送载体可用于例如涉及正在使用治疗性核酸分子或多肽的治疗方案的一部分。

2. 发明申请

US20060211637A1 Methods of down regulating target gene expression in vivo by introduction of interfering rna 审中-公开
标题翻译：通过引入干扰rna在体内下调靶基因表达的方法
公开(公告)号：US20060211637A1
公开(公告)日：2006-09-21
申请号：US10523714
申请日：2003-08-06
申请人： Puthupparampil Scaria , Martin Woodle , Patrick Lu , Qingquan Tang , Jun Xu , Frank Xie
发明人： Puthupparampil Scaria , Martin Woodle , Patrick Lu , Qingquan Tang , Jun Xu , Frank Xie
IPC分类号： A61K48/00 , C12N15/87 , C08L89/00
CPC分类号： A61K48/00 , C12N15/111 , C12N2310/111 , C12N2310/14 , C12N2310/351 , C12N2310/3513 , C12N2310/53 , C12N2320/32
摘要： Methods and compositions are provided for down regulation of target gene expression in vivo by RNA interference. The methods are useful for target discovery and validation of gene-based drug development, and for treatment of human diseases.
摘要翻译：提供了通过RNA干扰在体内下调靶基因表达的方法和组合物。该方法可用于基于基因的药物开发和人类疾病治疗的靶发现和验证。

3. 发明申请

US20070203082A1 RNAI Agents For Anti-SARS Coronavirus Therapy 审中-公开
标题翻译：用于抗SARS冠状病毒治疗的RNAI试剂
公开(公告)号：US20070203082A1
公开(公告)日：2007-08-30
申请号：US10554442
申请日：2004-04-26
申请人： Quinn Tang , Patrick Lu , Frank Xie , Yija Liu , Jun Xu , Martin Woodle
发明人： Quinn Tang , Patrick Lu , Frank Xie , Yija Liu , Jun Xu , Martin Woodle
IPC分类号： A61K48/00 , C12Q1/70 , C12Q1/68 , C07H21/02
CPC分类号： C12Q1/701 , C12N15/1131 , C12N2310/14 , C12N2310/53
摘要： The present invention provides compositions and methods that are useful for the treatment of severe acute respiratory syndrome (SARS). More specifically, nucleic acid agents such as siRNA molecules and their analogues that target respiratory infections including SARS coronavirus and their methods of use are described, for clinical treatments of SARS, respiratory viral infections, for prevention and treatment of respiratory infections as needed for bio-defense, for treatment of respiratory diseases, and for discovery of therapeutic targets for respiratory diseases and infections.
摘要翻译：本发明提供可用于治疗严重急性呼吸综合征（SARS）的组合物和方法。更具体地，描述了靶向呼吸道感染（包括SARS冠状病毒及其使用方法）的siRNA分子及其类似物的核酸试剂，用于SARS，呼吸道病毒感染的临床治疗，用于预防和治疗呼吸道感染，防治呼吸道疾病治疗，以及发现呼吸系统疾病和感染的治疗靶点。

4. 发明申请

US20070003519A1 Targets for tumor growth inhibition 失效
标题翻译：靶向肿瘤生长抑制
公开(公告)号：US20070003519A1
公开(公告)日：2007-01-04
申请号：US10551667
申请日：2004-04-01
申请人： Patrick Lu , Frank Xie , Martin Woodle , Yijin Liu , Quinn Tang , Jun Xu
发明人： Patrick Lu , Frank Xie , Martin Woodle , Yijin Liu , Quinn Tang , Jun Xu
IPC分类号： A61K48/00
CPC分类号： C12Q1/6886 , A61K48/00 , A61K2039/53 , C07K14/4748 , C07K14/475 , C07K14/71 , C07K16/30 , C12N15/111 , C12N15/1135 , C12N15/1138 , C12N2310/14 , C12N2320/12 , C12Q2600/112 , G01N33/57407 , G01N2500/00
摘要： The present invention relates to methods for treating cancers by manipulating a target gene expression by up-regulation, silencing and/or down-regulation of the gene, such as EGFR-RP, TRA1, MFGE8, TNFSF13 and ZFP236, respectively. The methods are useful in treating cancers and/or inhibiting tumor growth by enhancing expression of a gene that is validated as a target such as ICT1030, for protein, peptide drug and gene therapy modalities; or by RNA interference to silence and/or down-regulate targets such as ICT1024, ICT1025 and ICT1031 and ICB1003 that are validated for antibody, small molecule and other inhibitor drug modalities.
摘要翻译：本发明涉及通过分别通过上调，沉默和/或下调基因如EGFR-RP，TRA1，MFGE8，TNFSF13和ZFP236来操纵靶基因表达来治疗癌症的方法。该方法可用于通过增强作为靶标的基因（例如ICT1030）的蛋白质，肽药物和基因治疗方式的表达来治疗癌症和/或抑制肿瘤生长; 或通过RNA干扰来沉默和/或下调诸如针对抗体，小分子和其他抑制剂药物形态验证的ICT1024，ICT1025和ICT1031和ICB1003的靶标。

5. 发明申请

US20070237718A1 Multi-disciplinary approach to validating or indentifying targets using an in vivo system 审中-公开
标题翻译：使用体内系统验证或识别目标的多学科方法
公开(公告)号：US20070237718A1
公开(公告)日：2007-10-11
申请号：US11717603
申请日：2007-03-12
申请人： Patrick Lu , Puthupparampil Scaria , Martin Woodle
发明人： Patrick Lu , Puthupparampil Scaria , Martin Woodle
IPC分类号： G01N33/48 , C12Q1/00 , C12Q1/68
CPC分类号： G01N33/6803 , C12Q1/6886 , G01N33/5088 , G01N33/574
摘要： The present invention embodies a multi-disciplinary approach to validate or identify targets involved in any given biological process or pathway, such as an immune response, or progression or regression of disease. By introducing a target(s) with, e.g., gene delivery vector(s) or other foreign substance(s) to an in vivo system and by integrating, for example, pathological, pharmacological, bioassay, microarray and bioinformatics data obtained from the in vivo system, the present inventors are able to (1) identify one or more targets, e.g., genes, that are involved in a biological pathway of interest, (2) implement these identified targets for further analysis of the biological process or pathway and (3) provide a scalable approach in vivo for potential large quantities of target(s) discovery and validation. This process can be used in any number of applications, including the identification of agonists and antagonists to a biological process or pathway, which can lead to drugs and vaccine discovery.
摘要翻译：本发明体现了一种多学科方法来验证或鉴定涉及任何给定生物过程或途径（例如免疫应答或疾病进展或消退）的靶标。通过将诸如基因递送载体或其他外来物质的靶引入体内系统，并通过整合例如病理学，药理学，生物测定，微阵列和生物信息学数据，从本发明人能够（1）识别涉及生物学途径的一个或多个目标，例如基因，（2）实施这些鉴定的目标以进一步分析生物过程或途径和（ 3）为潜在的大量目标发现和验证在体内提供可扩展的方法。该方法可用于任何数量的应用，包括鉴定可导致药物和疫苗发现的生物过程或途径的激动剂和拮抗剂。

6. 发明授权

US08691781B2 Compositions for treating respiratory viral infections and their use 有权
标题翻译：用于治疗呼吸道病毒感染及其用途的组合物
公开(公告)号：US08691781B2
公开(公告)日：2014-04-08
申请号：US11792179
申请日：2005-11-04
申请人： Qingquan Tang , Patrick Lu , Martin Woodle , Bojian Zheng
发明人： Qingquan Tang , Patrick Lu , Martin Woodle , Bojian Zheng
IPC分类号： A01N43/04 , C12Q1/68 , C12N15/58 , C07H21/02 , C07H21/04
CPC分类号： A61K31/711 , A61K31/7105 , C12N15/1131 , C12N2310/111 , C12N2310/14 , C12N2310/53 , C12N2760/16111 , C12N2760/18511
摘要： The invention provides siRNA compositions that interfere with viral replication in respiratory viral infections, including respiratory syncytial virus and avian influenza A, including the H5N1 strain. The invention further provides uses of the siRNA compositions to inhibit expression of viral genes in respiratory virus-infected cells, and to uses in the treatment of respiratory virus infections in a subject. Generally the invention provides polynucleotide that includes a first nucleotide sequence of 15 to 30 bases that targets the genome of a respiratory syncytial virus or an influenza A virus, a complement thereof, a double stranded polynucleotide or a hairpin polynucleotide. Additionally the invention provides vectors, cells and pharmaceutical compositions containing siRNA sequences.
摘要翻译：本发明提供干扰呼吸道病毒感染（包括呼吸道合胞病毒和禽流感A）包括H5N1毒株在内的病毒复制的siRNA组合物。本发明还提供siRNA组合物用于抑制呼吸道病毒感染细胞中病毒基因表达的用途，以及用于治疗受试者中的呼吸道病毒感染的用途。本发明通常提供多核苷酸，其包含15至30个碱基的第一核苷酸序列，其靶向呼吸道合胞病毒或甲型流感病毒的基因组，其补体，双链多核苷酸或发夹多核苷酸。另外，本发明提供了含有siRNA序列的载体，细胞和药物组合物。

7. 发明申请

US20070226241A1 System and method for generating a custom application 有权
标题翻译：用于生成自定义应用程序的系统和方法
公开(公告)号：US20070226241A1
公开(公告)日：2007-09-27
申请号：US11095443
申请日：2005-03-30
申请人： Bobby Ng , Matthew Grumbach , Alex Warshavsky , Ashwin Kashyap , Patrick Lu , Che Chang , Wenzhi Lai , Peklui Cheng
发明人： Bobby Ng , Matthew Grumbach , Alex Warshavsky , Ashwin Kashyap , Patrick Lu , Che Chang , Wenzhi Lai , Peklui Cheng
IPC分类号： G06F7/00
CPC分类号： G06F17/3056 , G06F17/30893 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： Systems and methods for generating a custom application are disclosed. In one embodiment, a request to generate an application for modifying a database may be received. In response to the request, the application may be generated based on a previously defined view of another database, e.g. a repository containing metadata describing the database. Services (e.g. network services) may be validating and files (e.g. sample server pages, library files and instructional files) may be generated for customization.
摘要翻译：公开了用于生成定制应用的系统和方法。在一个实施例中，可以接收生成用于修改数据库的应用的请求。响应于该请求，可以基于先前定义的另一个数据库的视图来生成应用，例如，包含描述数据库的元数据的存储库。服务（例如，网络服务）可以是有效的，并且可以生成用于定制的文件（例如，样本服务器页面，库文件和指令文件）。

8. 发明申请

US20180089044A1 TECHNOLOGIES FOR PROVIDING NETWORK INTERFACE SUPPORT FOR REMOTE MEMORY AND STORAGE FAILOVER PROTECTION 审中-公开
公开(公告)号：US20180089044A1
公开(公告)日：2018-03-29
申请号：US15277522
申请日：2016-09-27
申请人： Francesc Guim Bernat , Karthik Kumar , Thomas Willhalm , Patrick Lu , Daniel Rivas Barragan
发明人： Francesc Guim Bernat , Karthik Kumar , Thomas Willhalm , Patrick Lu , Daniel Rivas Barragan
IPC分类号： G06F11/20 , G06F12/14
摘要： Technologies for providing network interface support for remote memory and storage failover protection include a compute node. The compute node includes a memory to store one or more protected resources and a network interface. The network interface is to receive, from a requestor node in communication with the compute node, a request to access one of the protected resources. The request identifies the protected resource by a memory address. Additionally, the network interface is to determine an identity of the requestor node and determine, as a function of the identity and permissions data associated with the memory address, whether the requestor node has permission to access the protected resource. Other embodiments are described and claimed.

9. 发明授权

US07603375B2 System and method for generating a custom application 有权
标题翻译：用于生成自定义应用程序的系统和方法
公开(公告)号：US07603375B2
公开(公告)日：2009-10-13
申请号：US11095443
申请日：2005-03-30
申请人： Bobby Ng , Matthew Grumbach , Alex Warshavsky , Ashwin Kashyap , Patrick Lu , Rita Chang , Wenzhi Lai , Peklui Cheng
发明人： Bobby Ng , Matthew Grumbach , Alex Warshavsky , Ashwin Kashyap , Patrick Lu , Rita Chang , Wenzhi Lai , Peklui Cheng
IPC分类号： G06F17/30
CPC分类号： G06F17/3056 , G06F17/30893 , Y10S707/99943 , Y10S707/99944 , Y10S707/99945
摘要： Systems and methods for generating a custom application are disclosed. In one embodiment, a request to generate an application for modifying a database may be received. In response to the request, the application may be generated based on a previously defined view of another database, e.g. a repository containing metadata describing the database. Services (e.g. network services) may be validated and files (e.g. sample server pages, library files and instructional files) may be generated for customization.
摘要翻译：公开了用于生成定制应用的系统和方法。在一个实施例中，可以接收生成用于修改数据库的应用的请求。响应于该请求，可以基于先前定义的另一个数据库的视图来生成应用，例如，包含描述数据库的元数据的存储库。可以验证服务（例如网络服务），并且可以生成用于定制的文件（例如，样本服务器页面，库文件和说明文件）。

10. 发明申请

US20190303162A1 BRANCH PREDICTION BASED ON COHERENCE OPERATIONS IN PROCESSORS 审中-公开
公开(公告)号：US20190303162A1
公开(公告)日：2019-10-03
申请号：US15940408
申请日：2018-03-29
申请人： Christopher Wilkerson , Binh Pham , Patrick Lu , Jared Warner Stark, IV
发明人： Christopher Wilkerson , Binh Pham , Patrick Lu , Jared Warner Stark, IV
IPC分类号： G06F9/38 , G06F9/30
摘要： In an embodiment, a processor includes a branch prediction circuit and a plurality of processing engines. The branch prediction circuit is to: detect a coherence operation associated with a first memory address; identify a first branch instruction associated with the first memory address; and predict a direction for the identified branch instruction based on the detected coherence operation. Other embodiments are described and claimed.

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