专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明授权

US5734056A Process for the preparation of certain 9-substituted camptothecins 失效
标题翻译：制备某些9-取代喜树碱的方法
公开(公告)号：US5734056A
公开(公告)日：1998-03-31
申请号：US451079
申请日：1995-05-25
申请人： Patrick Lee Burk , Joseph Marian Fortunak , Antonietta Rose Mastrocola , Mark Mellinger , Jeffrey Lee Wood
发明人： Patrick Lee Burk , Joseph Marian Fortunak , Antonietta Rose Mastrocola , Mark Mellinger , Jeffrey Lee Wood
IPC分类号： A61K31/47 , A61K31/33 , A61K31/41 , A61P35/00 , C07D20060101 , C07D491/22 , C07D491/12
CPC分类号： C07D491/22
摘要： A process for the preparation of water soluble camptothecin analogs, including methods for the preparation of intermediates thereof, and the compounds prepared by said process. Water soluble camptothecin analogs are prepared which may be used for inhibiting the growth of tumor cells sensitive to such analogs.
摘要翻译：一种制备水溶性喜树碱类似物的方法，包括制备其中间体的方法和由所述方法制备的化合物。制备水溶性喜树碱类似物，其可用于抑制对这些类似物敏感的肿瘤细胞的生长。

2. 发明授权

US07182854B1 Sanitation system 有权
标题翻译：卫生系统
公开(公告)号：US07182854B1
公开(公告)日：2007-02-27
申请号：US10888319
申请日：2004-07-09
申请人： John Kroesser , Paul Mellinger , Mark Mellinger , Lynn Wallace , Art Smith , Randy Lego , Scott Hudson , Melvyn Wayne Mellinger
发明人： John Kroesser , Paul Mellinger , Mark Mellinger , Lynn Wallace , Art Smith , Randy Lego , Scott Hudson , Melvyn Wayne Mellinger
IPC分类号： C02F1/70 , C02F1/76 , C02F1/78
CPC分类号： C02F1/004 , C02F1/444 , C02F1/72 , C02F1/722 , C02F1/76 , C02F1/766 , C02F1/78 , C02F2201/008 , C02F2303/26
摘要： A sanitation system comprising of a first tank for receiving waste water fluid typically comprising solids, a maceration pump for pulling waste water fluid from the first tank, a cross flow filter comprising of media for receiving the sheared fluid forming unfiltered waste water and product water, a second tank for receiving the product water from a product water manifold connected to the second segment, a vented loop in communication with the second tank for receiving raw water and displacing product water from the second tank, a macerating water jet adapted to pull product water into the vented loop and on demand further macerate the product water, then into a third tank for receiving water from the vented loop and raw water for de-chlorinating the product water, and a control panel comprising a microprocessor to optimize the operation of the sanitation system.
摘要翻译：一种卫生系统，包括用于接收通常包括固体的废水流体的第一罐，用于从第一罐抽出废水流体的浸渍泵，包括用于接收形成未过滤的废水和产品水的剪切流体的介质的交叉流过滤器，用于从与第二段连接的产品水歧管接收产品水的第二罐，与第二罐连通的通风回路，用于接收原水并从第二罐中移出产品水，适于拉出产品水的浸渍水喷射器进入排气回路，并且根据需要进一步浸渍产品水，然后进入第三罐，以从通风回路接收水和用于对产品水进行脱氯的原水，以及包括微处理器以控制卫生操作的控制面板系统。

3. 发明申请

US20050171152A1 Method for the synthesis of quinoline derivatives 审中-公开
标题翻译：喹啉衍生物的合成方法
公开(公告)号：US20050171152A1
公开(公告)日：2005-08-04
申请号：US11093701
申请日：2005-03-30
申请人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
发明人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
IPC分类号： C07D215/48 , A61K31/47 , A61P11/06 , C07D215/52 , C07D491/147 , A61K31/4709 , C07D215/36
CPC分类号： C07D215/36 , C07D215/38 , C07D215/52
摘要： This invention relates to novel intermediates and processes for preparing phamaceutically active quinoline compounds, including (−)-(S)-N-(α-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.
摘要翻译：本发明涉及制备药物活性喹啉化合物的新型中间体和方法，包括（ - ） - （S）-N-（α-乙基苄基）-3-羟基-2-苯基喹啉-4-甲酰胺。

4. 发明申请

US20110269774A1 PYRAZOLYLAMINOPYRIDINES AS INHIBITORS OF FAK 审中-公开
标题翻译：作为FAK的抑制剂的吡唑啉酰亚胺
公开(公告)号：US20110269774A1
公开(公告)日：2011-11-03
申请号：US13097271
申请日：2011-04-29
申请人： Jerry ADAMS , Thomas Faitg , Neil Johnson , Jiri Kasparec , Hong Lin , Mark Mellinger , Xin Peng , Ren Xie
发明人： Jerry ADAMS , Thomas Faitg , Neil Johnson , Jiri Kasparec , Hong Lin , Mark Mellinger , Xin Peng , Ren Xie
IPC分类号： A61K31/497 , C07D401/12 , A61P35/00 , A61K31/44 , A61K31/4439 , C07D211/72 , C07D409/14
CPC分类号： A61K31/4439 , A61K31/337 , A61K31/4375 , A61K31/47 , C07D401/12 , C07D401/14 , G01N33/57423
摘要： The present invention relates to a compound of formula (I): or a pharmaceutically acceptable salt thereof, wherein R1, R2, R3, R11, R12, R13, Q, Z, and p are as described herein. Compounds of the present invention are useful for the treatment of cancers.
摘要翻译：本发明涉及式（I）化合物或其药学上可接受的盐，其中R 1，R 2，R 3，R 11，R 12，R 13，Q，Z和p如本文所述。本发明的化合物可用于治疗癌症。

5. 发明申请

US20050095150A1 Centrifugal multistage pump 有权
标题翻译：离心式多级泵
公开(公告)号：US20050095150A1
公开(公告)日：2005-05-05
申请号：US10975943
申请日：2004-10-28
申请人： Michele Leone , Aleesandro Santoni , Marco Trovi , Giancarlo Roggiolani , Paul Mellinger , Melvyn Mellinger , Mark Mellinger , Case Crowther
发明人： Michele Leone , Aleesandro Santoni , Marco Trovi , Giancarlo Roggiolani , Paul Mellinger , Melvyn Mellinger , Mark Mellinger , Case Crowther
IPC分类号： F04D15/00 , F04B49/00 , F04B49/06
CPC分类号： F04D15/0066 , F04D13/0686 , F04D15/0088 , F04D29/5806 , F04D29/5813 , F04D29/605
摘要： A centrifugal multistage stage pumps described herein. The centrifugal multistage pump includes a pump body having a longitudinal axis, an inlet for receiving a fluid from a first location and an outlet for discharging a pressurized fluid to a second location and a hydraulic assembly disposed within the pump body and adapted to pressurize the fluid. The pump further includes a motor, a first circuit board inverter disposed within the pump body, a microcontroller disposed on the first circuit board inverter, a pressure transducer disposed within the pump body, a heat sink adjacent the first circuit board inverter, a control panel connected to the circuit board inverter and the microcontroller. The pump has a mounting system adapted for rotation of the pump body around the longitudinal axis. In addition, the pump includes software imbedded within the memory, wherein the software includes protection, monitoring and control the features of the pump.
摘要翻译：本文所述的离心式多级级泵。离心多级泵包括具有纵向轴线的泵体，用于从第一位置接收流体的入口和用于将加压流体排放到第二位置的出口和设置在泵体内的液压组件，并适于对流体加压。该泵还包括电动机，设置在泵体内的第一电路板逆变器，设置在第一电路板逆变器上的微控制器，设置在泵体内的压力传感器，与第一电路板逆变器相邻的散热器，控制面板连接到电路板逆变器和微控制器。泵具有适于围绕纵向轴线旋转泵体的安装系统。另外，泵还包括嵌入在存储器内的软件，其中软件包括保护，监测和控制泵的特征。

6. 发明申请

US20060189809A1 Method for the synthesis of quinoline derivatives 审中-公开
公开(公告)号：US20060189809A1
公开(公告)日：2006-08-24
申请号：US11413932
申请日：2006-04-28
申请人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
发明人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
IPC分类号： C07D215/36 , C07D215/38
CPC分类号： C07D215/36 , C07D215/38 , C07D215/52
摘要： This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)—N-(α-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.

7. 发明授权

US06335448B1 Method for the synthesis of quinoline derivatives 失效
标题翻译：喹啉衍生物的合成方法
公开(公告)号：US06335448B1
公开(公告)日：2002-01-01
申请号：US09508358
申请日：2000-03-09
申请人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
发明人： Joseph Sisko , Mark Mellinger , Conrad Kowalski
IPC分类号： C07D21538
CPC分类号： C07D215/36 , C07D215/38 , C07D215/52
摘要： This invention relates to novel intermediates and processes for preparing pharmaceutically active quinoline compounds, including (−)-(S)-N-(&agr;-ethylbenzyl)-3-hydroxy-2-phenylquinoline-4-carboxamide.
摘要翻译：本发明涉及新型的中间体和制备药用活性喹啉化合物的方法，包括（ - ） - （S）-N-（α-乙基苄基）-3-羟基-2-苯基喹啉-4-甲酰胺。

8. 发明授权

US06178628B2 Apparatus and method for direct attachment of heat sink to surface mount 失效
标题翻译：用于将散热片直接连接到表面安装件的装置和方法
公开(公告)号：US06178628B2
公开(公告)日：2001-01-30
申请号：US09151927
申请日：1998-09-11
申请人： Donald L. Clemens , Mark Mellinger , Gary Kuzmin
发明人： Donald L. Clemens , Mark Mellinger , Gary Kuzmin
IPC分类号： H05K334
CPC分类号： H01L23/3672 , H01L23/4093 , H01L2924/0002 , Y10T29/4913 , Y10T29/49144 , H01L2924/00
摘要： An apparatus and method for thermally coupling a heat sink directly to a surface mount heat generating device package in a manner which provides a more efficient thermal path between the heat sink and the device package, and which allows for a simplified assembly process. The heat sink is mounted in direct thermal communication with the heat generating device package which is surface mounted to a printed circuit board or other substrate. The inventive heat sink has a reservoir of thermal preform which allows the heat sink to be secured to a device package at the same time as the device package is being secured to the surface mount substrate, as opposed to doing so in a separate step in the assembly process after the electronic device packages have already been secured to the surface mount substrate. The inventive heat sink thereby simplifies the assembly process by eliminating steps in the manufacturing process and by allowing for the further automation of the assembly process.
摘要翻译：一种用于以散热器和器件封装之间提供更有效的热路径的方式将散热器直接热耦合到表面贴装发热器件封装的装置和方法，并且允许简化的组装过程。散热器与表面安装到印刷电路板或其它基板上的发热器件封装直接热连接。本发明的散热器具有热预成型件的储存器，其允许在器件封装被固定到表面安装基板的同时将散热器固定到器件封装，而不是在单独的步骤中电子设备封装已经固定到表面安装基板之后的组装过程。本发明的散热器因此通过消除制造过程中的步骤并允许组装过程的进一步自动化来简化组装过程。

9. 发明授权

US5155225A Method for making certain pyrano[3',4':6,7]indolizino-[1,2-B]quinolinones 失效
标题翻译：制备某些PYRANO（3'，4'：6,7）吲哚啉 - （1,2-B）喹啉酮的方法
公开(公告)号：US5155225A
公开(公告)日：1992-10-13
申请号：US589848
申请日：1990-09-28
申请人： Joseph M. Fortunak , Mark Mellinger , Jeffery L. Wood
发明人： Joseph M. Fortunak , Mark Mellinger , Jeffery L. Wood
IPC分类号： C07D471/14 , C07D491/22
CPC分类号： C07D471/14
摘要： A method for making 8-methyl-7-(1-oxopropyl)indolizino[1,2-b]quinolin-9(11H)-ones from 4-ethyl-4-hydroxy-1H-pyrano[3',4':6,7]indolizino[1,2-b]quinolin-3,14(4H,12H)-diones, said method being graphically illustrated as follows: ##STR1##
摘要翻译：由4-乙基-4-羟基-1H-吡喃并[3'，4'：4'：2-（4-甲氧基丙基）吲哚并[1,2-b]喹啉-9（11H） 6,7]吲嗪并[1,2-b]喹啉-3,14（4H，12H） - 二酮，所述方法如图所示： + TR

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式