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1. 发明申请

US20090044875A1 MICROFLUIDIC SYSTEM 失效
标题翻译：微流体系
公开(公告)号：US20090044875A1
公开(公告)日：2009-02-19
申请号：US12092446
申请日：2006-11-24
申请人： Patrick Griss , Bjorn Samel , Goran Stemme , Frederic Neftel , Laurent-Dominique Piveteau
发明人： Patrick Griss , Bjorn Samel , Goran Stemme , Frederic Neftel , Laurent-Dominique Piveteau
IPC分类号： B81B7/02 , B01J19/00 , F15C3/00
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0825 , B01L2300/0861 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/0672 , F04B43/043 , F16K99/0001 , F16K99/0026 , F16K99/0036 , F16K99/004 , F16K99/0061 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , G01N27/3271 , G01N33/4905 , Y10T137/2191 , Y10T137/2196
摘要： Microfluidic system (1, 2, 10, 11, 16) comprising a first portion (3, 4, 24, 25) and a second portion (5-7), said first portion (3, 4) comprising a material which is able to change its volume when activated by an exciting factor, characterized by the fact that said first portion (3, 4) and said second portion (5-7) define a zone (3-7) which, when said first portion (3,4) is not yet activated by said exciting factor, shows a first topography devoid of any fluidic pathway and which, after activation by said exciting factor, shows a second topography (9, 14) which is adapted to contain at least one fluidic pathway, said microfluidic system furthermore comprising a tight cover surface (20) situated above said first portion (3, 4) and said second portion (5-7).
摘要翻译：包括第一部分（3,4,24,25）和第二部分（5-7）的微流体系统（1,2,10,11,16），所述第一部分（3,4）包括能够当由激励因素激活时改变其体积，其特征在于所述第一部分（3,4）和所述第二部分（5-7）限定区域（3-7），当所述第一部分（3） 4）尚未被所述激发因子激活，显示没有任何流体通路的第一形貌，并且在由所述激发因子激活之后，显示适于包含至少一个流体路径的第二形貌（9,14）所述微流体系统还包括位于所述第一部分（3,4）和所述第二部分（5-7）上方的紧密覆盖表面（20）。

2. 发明申请

US20090324676A1 POROUS COATING INCORPORATING FLUID RESERVOIRS 审中-公开
标题翻译：多孔涂料包含流体储存
公开(公告)号：US20090324676A1
公开(公告)日：2009-12-31
申请号：US12376124
申请日：2007-08-07
申请人： Heinrich Hofmann , Laurent-Dominique Piveteau , Frederic Neftel
发明人： Heinrich Hofmann , Laurent-Dominique Piveteau , Frederic Neftel
IPC分类号： A61F2/00
CPC分类号： A61L31/146 , A61F2250/0068 , A61K9/0024 , A61L27/54 , A61L27/56 , A61L31/16 , A61L2300/416 , A61L2300/60 , A61L2400/12
摘要： Porous coating for the controlled release of fluids such as drugs comprising a porous structure with internal reservoirs and passages, said reservoirs communicating with the external environment through said passages, in such a way that a fluid can move between the reservoirs and the external environment, characterized by the fact that for at least a group of said passages, each passage contains a restricting element which partially restricts the passage cross section.
摘要翻译：用于控制释放流体的多孔涂层，例如包含具有内部储存器和通道的多孔结构的药物，所述储存器通过所述通道与外部环境连通，使得流体可以在储存器和外部环境之间移动，其特征在于通过对于至少一组所述通道，每个通道包含部分地限制通道横截面的限制元件。

3. 发明申请

US20080294029A1 System to Measure Blood Coagulation Related Parameters 审中-公开
标题翻译：血液凝固相关参数测量系统
公开(公告)号：US20080294029A1
公开(公告)日：2008-11-27
申请号：US12091953
申请日：2006-11-24
申请人： Laurent-Dominique Piveteau , Veronique Vallet , Frederic Neftel , Lynda Metref , Nicolas Blanc
发明人： Laurent-Dominique Piveteau , Veronique Vallet , Frederic Neftel , Lynda Metref , Nicolas Blanc
IPC分类号： A61B5/00
CPC分类号： B01L3/50273 , B01L3/502738 , B01L3/502746 , B01L2300/0816 , B01L2300/0825 , B01L2300/0861 , B01L2300/0887 , B01L2400/0481 , B01L2400/0655 , B01L2400/0672 , F04B43/043 , F16K99/0001 , F16K99/0026 , F16K99/0036 , F16K99/004 , F16K99/0061 , F16K2099/008 , F16K2099/0084 , F16K2099/0086 , G01N27/3271 , G01N33/4905 , Y10T137/2191 , Y10T137/2196
摘要： System to measure blood coagulation related parameters comprising one first channel (6) adapted to contain a blood sample; said system containing, at least partially, an expandable material which is able to increase its volume when activated by an exciting source; said system furthermore comprising several excitable regions distributed close to said first channel (6), in such a way that, when one of said excitable region is activated, said expandable material increases to such an extend that the channel cross section is reduced to a location situated at or near to said excitable region.
摘要翻译：用于测量凝血相关参数的系统，包括适于容纳血液样本的一个第一通道（6）所述系统至少部分地包含可膨胀材料，所述可膨胀材料当由激发源激活时能够增加其体积; 所述系统还包括分布在所述第一通道（6）附近的若干可激发区域，使得当所述可激发区域中的一个被激活时，所述可膨胀材料增加到使得通道横截面减小到位置位于或接近所述可兴奋区域。

4. 发明申请

US20090177273A1 ANISOTROPIC NANOPOROUS COATINGS FOR MEDICAL IMPLANTS 审中-公开
标题翻译：用于医疗植入物的各向异性纳米涂层
公开(公告)号：US20090177273A1
公开(公告)日：2009-07-09
申请号：US12300182
申请日：2007-05-16
申请人： Laurent-Dominique Piveteau , Heinrich Hofmann , Frederic Neftel
发明人： Laurent-Dominique Piveteau , Heinrich Hofmann , Frederic Neftel
IPC分类号： A61F2/28 , B32B3/26 , A61K47/02 , B05D3/02 , B05D3/06 , A61F2/82
CPC分类号： A61M31/002 , A61B17/68 , A61C8/0004 , A61C8/0013 , A61C8/0015 , A61C2008/0046 , A61F2/82 , A61F2240/001 , A61F2250/0068 , A61L27/28 , A61L27/56 , A61L31/08 , A61L31/146 , A61L2400/12 , Y10T428/24942 , Y10T428/249979
摘要： The present invention relates to a process for fabricating a porous coatings with controlled structure in the micro and nano-size domain. In particular, but not exclusively, it relates to a process for fabricating coatings with an anisotropic pore size distribution and to coatings obtained using such coatings. It describes in particular the use of ink-jet method to deposit in a controlled way such coatings. It also relates to porous coatings with controlled structure in the micro and nano-size domain. The coating has a thickness between 10 nanometers and 10 millimeters and its porosity is created in such a way that the pore size distribution is anisotropic. It finally describes objects covered with this coating.
摘要翻译：本发明涉及一种在微纳米尺寸领域制造具有受控结构的多孔涂层的方法。特别地但并不排他地涉及一种制备具有各向异性孔径分布的涂层以及使用这种涂层获得的涂层的方法。它特别描述了使用喷墨方法以受控的方式沉积这样的涂层。它还涉及在微尺寸和纳米尺寸域中具有受控结构的多孔涂层。涂层的厚度在10纳米到10毫米之间，其孔隙度是以孔径分布是各向异性的方式产生的。最后描述了这种涂层所覆盖的物体。

5. 发明申请

US20090199917A1 Microfluidic Device with Variable Volume Material 失效
标题翻译：具有可变体积材料的微流体装置
公开(公告)号：US20090199917A1
公开(公告)日：2009-08-13
申请号：US12302384
申请日：2007-05-29
申请人： Veronique Vallet , Frederic Neftel , Laurent-Dominique Piveteau , Niklaus Schneeberger
发明人： Veronique Vallet , Frederic Neftel , Laurent-Dominique Piveteau , Niklaus Schneeberger
IPC分类号： B81B7/00 , B81B7/04 , F15C3/00
CPC分类号： F16K99/0003 , B01J19/0093 , B01J2219/00783 , B01J2219/00984 , B01L3/502738 , B01L2200/12 , B01L2300/0874 , B01L2300/0887 , B01L2300/12 , B01L2400/0481 , B01L2400/0655 , B01L2400/0661 , F16K99/0001 , F16K99/0036 , F16K99/0046 , F16K99/0065 , F16K2099/0074 , F16K2099/0084 , Y10T137/2191 , Y10T137/2196 , Y10T137/2213 , Y10T137/2224
摘要： The invention relates to a microfluidic device comprising a first plate forming the substrate and including at least one perforation and, on either side of said first plate, at several locations, a material for defining passage portions consisting, in at least one of said locations, of an activatable material varying in volume on activation, said material being disposed at said locations in an arrangement that, during a first phase and upon activation of at least one location consisting of said activatable material, transforms it from a first configuration to a second configuration, modifying a three-dimensional network corresponding, in the second configuration and depending on the selected location(s) that are activated in said first phase, to different liquid paths including passage portions in offset planes parallel to the plane of the first plate, at least on either side of said first plate, and between which at least one of said perforations is located.
摘要翻译：本发明涉及一种微流体装置，其包括形成基板的第一板，并且包括至少一个穿孔，并且在所述第一板的任一侧上在几个位置处形成用于限定通道部分的材料，所述材料在至少一个所述位置中，所述材料在所述位置处被布置为在第一阶段期间和在由所述可激活材料组成的至少一个位置的激活之后将其从第一构型转变成第二构型修改在第二配置中并且依赖于在所述第一阶段被激活的所选择的位置对应于不同的液体路径的三维网络，所述液体路径包括平行于第一板的平面的偏移平面中的通道部分，在至少在所述第一板的任一侧上，并且其中至少一个所述穿孔位于所述第一板之间。

6. 发明申请

US20090098178A1 Porous Coating Loaded with a Liquid or a Solid Substance 失效
标题翻译：用液体或固体物质加载的多孔涂层
公开(公告)号：US20090098178A1
公开(公告)日：2009-04-16
申请号：US11991751
申请日：2006-09-15
申请人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
发明人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
IPC分类号： A61F2/28 , A61K9/00
CPC分类号： A61L27/28 , A61L27/54 , A61L27/56 , A61L31/08 , A61L31/146 , A61L31/16 , A61L2300/00 , Y10T428/249978
摘要： The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps: -providing a support having a surface, -depositing on said surface one mono-layer of temporary particles, -depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, -eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a pail of the pores communicating with the external environment, -applying a coating fixation step, characterized by the fact that it furthermore comprise a filling step where said pores are at least partially filled with a liquid or solid substance. The invention also concerns a coating and an object which can be obtained with this process.
摘要翻译：本发明涉及一种用于制造具有微米或纳米尺寸结构域的多孔涂层的方法，其特征在于以下步骤： - 提供具有表面的载体， - 在所述表面上沉积一个单层临时颗粒 - 在所述临时颗粒上沉积涂层，使得所述涂层的厚度小于颗粒直径， - 消除所述临时颗粒，从而获得多孔涂层，所述涂层的孔对应于先前由临时颗粒占据的空间颗粒和至少一个与外部环境连通的孔的桶，使用涂层固定步骤，其特征在于，其还包括填充步骤，其中所述孔至少部分地填充有液体或固体物质。本发明还涉及可以用该方法获得的涂层和物体。

7. 发明授权

US07901727B2 Reinforced porous coating 有权
标题翻译：增强多孔涂层
公开(公告)号：US07901727B2
公开(公告)日：2011-03-08
申请号：US12066114
申请日：2006-09-15
申请人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
发明人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
IPC分类号： B05D1/00 , B05D3/12 , B05D1/36
CPC分类号： A61L27/28 , A61L27/54 , A61L27/56 , A61L31/08 , A61L31/146 , A61L31/16 , A61L2300/00 , Y10T428/249978
摘要： The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps: —providing a support having a surface, —depositing on said surface one mono-layer of temporary particles, —depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, —eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment, —applying a coating fixation step, characterized by the fact that said temporary particles are deposited on said surface in such a way that, after particle deposition, more than 50% of the temporary particles are in contact with a maximum of two adjacent particles and otherwise are separated by an empty space. The invention also concerns a coating and an object which can be obtained with this process.
摘要翻译：本发明涉及一种用于制造具有微米或纳米尺寸结构域的多孔涂层的方法，其特征在于以下步骤： - 提供具有表面的载体， - 在所述表面上沉积一个单层临时颗粒 - 在所述临时颗粒上沉积涂层，使得所述涂层的厚度小于颗粒直径， - 消除所述临时颗粒，从而获得多孔涂层，所述涂层的孔对应于先前由临时颗粒占据的空间颗粒和与外部环境连通的至少一部分孔，使用涂层固定步骤，其特征在于所述临时颗粒沉积在所述表面上，使得在颗粒沉积之后，超过50％的临时颗粒与最多两个相邻的颗粒接触，否则由空的空间分开。本发明还涉及可以用该方法获得的涂层和物体。

8. 发明申请

US20080249616A1 Reinforced Porous Coating 有权
标题翻译：增强多孔涂层
公开(公告)号：US20080249616A1
公开(公告)日：2008-10-09
申请号：US12066114
申请日：2006-09-15
申请人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
发明人： Heinrich Hofmann , Frederic Neftel , Laurent-Dominique Piveteau
IPC分类号： A61L27/28 , B32B3/26 , A61F2/82 , A61L31/08
CPC分类号： A61L27/28 , A61L27/54 , A61L27/56 , A61L31/08 , A61L31/146 , A61L31/16 , A61L2300/00 , Y10T428/249978
摘要： The present invention relates to a process for manufacturing a porous coating with structures in the micro or nano-size domain characterized by the following steps: -providing a support having a surface, -depositing on said surface one mono-layer of temporary particles, -depositing a coating on said temporary particles in such a way that the thickness of said coating is less than the particle diameter, -eliminating said temporary particles and thereby obtaining a porous coating, the pores of said coating corresponding to the spaces previously occupied by the temporary particles and at least a part of the pores communicating with the external environment, -applying a coating fixation step, characterized by the fact that said temporary particles are deposited on said surface in such a way that, after particle deposition, more than 50% of the temporary particles are in contact with a maximum of two adjacent particles and otherwise are separated by an empty space. The invention also concerns a coating and an object which can be obtained with this process.
摘要翻译：本发明涉及一种用于制造具有微米或纳米尺寸结构域的多孔涂层的方法，其特征在于以下步骤： - 提供具有表面的载体， - 在所述表面上沉积一个单层临时颗粒 - 在所述临时颗粒上沉积涂层，使得所述涂层的厚度小于颗粒直径， - 消除所述临时颗粒，从而获得多孔涂层，所述涂层的孔对应于先前由临时颗粒占据的空间颗粒和与外部环境连通的至少一部分孔，使用涂层固定步骤，其特征在于所述临时颗粒沉积在所述表面上，使得在颗粒沉积之后，超过50％的临时颗粒与最多两个相邻的颗粒接触，否则由空的空间分开。本发明还涉及可以用该方法获得的涂层和物体。

9. 发明申请

US20060189923A1 System for performing fluid administration 有权
标题翻译：执行流体管理的系统
公开(公告)号：US20060189923A1
公开(公告)日：2006-08-24
申请号：US10565782
申请日：2004-08-02
申请人： Frederic Neftel , Florent Junod , Didier Vecten
发明人： Frederic Neftel , Florent Junod , Didier Vecten
IPC分类号： A61M1/00
CPC分类号： A61M1/28 , A61M5/44 , A61M2205/128 , F04B43/1253
摘要： The invention concerns a system and a method of use of said system for performing fluid administration on a patient, the system comprising: a liquid pump (1), a liquid distribution system (2) connected to said pump (1) in such a way that liquid can flow from the liquid distribution system (2) to the pump (1) and vice versa, liquid supply means (3) for supplying liquid to a patient (4) via said liquid distribution system (2) and said pump (1), a patient conduit (5) adapted for connecting said liquid distribution system (2) to a patient (4), the system being characterized by the fact that said liquid pump (1) is unidirectional and that said liquid distribution system (2) comprises switching means designed to alternatively connect the pump enter line (56) with the supply means (3) or with the patient conduit (5).
摘要翻译：本发明涉及一种用于对患者进行流体给药的系统和方法，该系统包括：液体泵（1），以这种方式连接到所述泵（1）的液体分配系统（2）液体可以从液体分配系统（2）流到泵（1），反之亦然，液体供应装置（3）通过所述液体分配系统（2）和所述泵（1）向患者（4）供应液体），适于将所述液体分配系统（2）连接到患者（4）的患者导管（5），所述系统的特征在于所述液体泵（1）是单向的，并且所述液体分配系统（2）包括设计成交替地将泵进入管线（56）与供应装置（3）或患者导管（5）连接的切换装置。

10. 发明授权

US5480386A Pump assembly for medical use 失效
标题翻译：泵组件用于医疗用途
公开(公告)号：US5480386A
公开(公告)日：1996-01-02
申请号：US244028
申请日：1994-07-06
申请人： Michael Brohy , Frederic Neftel
发明人： Michael Brohy , Frederic Neftel
IPC分类号： A61M5/14 , A61M5/142 , A61M37/00
CPC分类号： A61M5/142 , A61M5/1413 , A61M2205/12 , A61M5/14244
摘要： A portable pump assembly for medical uses, and more particularly a portable micropump designed for the parenteral administration of medicamentous solutions includes a first module (2) provided with a container (8) designed for cooperating with a second motor module (4), the functioning of the pump being ensured by the assembling of the two modules. The first module (2) is provided with a removable filtering and sterilizing device (3), fastened to the filling septum orifice (10) of the container and including a filtering sterile plug (25) and a needle (28) surrounded by a flexible sleeve (29). A support arm (33) includes a guiding part (34) for guiding the device (3) when piercing the septurn and an anchoring casing (40) closing the housing (39) for the second module (4). The first module (2) with the device (3) is provided in a sterile sealed pouch. The assembly is very easy to use, and aseptic conditions are guaranteed during the filling of the container (8).
摘要翻译： PCT No.PCT / CH93 / 00222 Sec。 371日期：1994年7月6日 102（e）日期1994年7月6日PCT提交1993年9月14日PCT公布。出版物WO94 / 06491 日期为1994年3月31日。用于医疗用途的便携式泵组件，更具体地，专门用于非肠道给药药物溶液的便携式微型泵，包括设置有容器（8）的第一模块（2），该容器设计成与第二电动机模块（4），通过组装两个模块确保泵的功能。第一模块（2）设置有可移除的过滤消毒装置（3），其紧固到容器的填充隔膜孔口（10），并且包括过滤无菌塞（25）和由柔性袖子（29）。支撑臂（33）包括用于在刺穿隔板时引导装置（3）的引导部分（34）和闭合用于第二模块（4）的壳体（39）的锚定壳体（40）。具有装置（3）的第一模块（2）设置在无菌密封袋中。该组件非常容易使用，并且在容器（8）的填充期间保证无菌条件。

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