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1. 发明授权

US08906906B2 Viral replication inhibitors 有权
标题翻译：病毒复制抑制剂
公开(公告)号：US08906906B2
公开(公告)日：2014-12-09
申请号：US13388712
申请日：2010-08-05
申请人： Patrick Chaltin , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Wim Smets , Arnout Voet , Frauke Christ
发明人： Patrick Chaltin , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Wim Smets , Arnout Voet , Frauke Christ
IPC分类号： C07D239/26 , A61K31/505 , C07D239/42
CPC分类号： C07D491/052 , C07D239/26 , C07D239/38 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.
摘要翻译：本发明涉及一系列具有抗病毒活性的新化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。本发明还涉及制备这些化合物的方法，以及可用于这种合成的一个或多个步骤的新型中间体。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

2. 发明申请

US20120129840A1 NOVEL VIRAL REPLICATION INHIBITORS 有权
标题翻译：新型病毒复制抑制剂
公开(公告)号：US20120129840A1
公开(公告)日：2012-05-24
申请号：US13388712
申请日：2010-08-05
申请人： Patrick Chaltin , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Wim Smets , Arnout Voet , Frauke Christ
发明人： Patrick Chaltin , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Wim Smets , Arnout Voet , Frauke Christ
IPC分类号： A61K31/55 , A61K31/505 , C07D239/26 , C07D401/04 , C07D413/04 , A61K31/5377 , C07D403/04 , A61K31/506 , A61K31/551 , C07D413/14 , C07D407/10 , C07D239/34 , A61K31/538 , A61P31/12 , C07D239/42
CPC分类号： C07D491/052 , C07D239/26 , C07D239/38 , C07D239/42 , C07D401/04 , C07D401/14 , C07D403/04 , C07D405/04 , C07D409/04 , C07D413/14 , C07D417/04
摘要： The present invention relates to a series of novel compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.
摘要翻译：本发明涉及一系列具有抗病毒活性的新化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。本发明还涉及制备这些化合物的方法，以及可用于这种合成的一个或多个步骤的新型中间体。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

3. 发明授权

US08785638B2 Thieno [2, 3-B] pyridine derivatives as viral replication inhibitors 有权
标题翻译：噻吩并[2,3-B]吡啶衍生物作为病毒复制抑制剂
公开(公告)号：US08785638B2
公开(公告)日：2014-07-22
申请号：US13320519
申请日：2010-05-17
申请人： Dorothée Bardiot , Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
发明人： Dorothée Bardiot , Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
IPC分类号： C07D513/04 , A61K31/4365
CPC分类号： C07D495/20 , A61K31/4365 , A61K31/4375 , A61K45/06 , C07D495/04 , C07D495/14
摘要： The present invention relates to a series of compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutic amount of such compounds, optionally combined with one or more other drugs having anti-viral activity.
摘要翻译：本发明涉及具有抗病毒活性的一系列化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。本发明还涉及制备这些化合物的方法，以及可用于这种合成的一个或多个步骤的新型中间体。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

4. 发明授权

US09132129B2 Antiviral compounds 有权
标题翻译：抗病毒化合物
公开(公告)号：US09132129B2
公开(公告)日：2015-09-15
申请号：US13885526
申请日：2011-11-15
申请人： Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
发明人： Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
IPC分类号： A61K31/519 , C07D487/00 , C07D487/14 , C07D491/16 , C07D221/06 , C07D221/08 , C07D221/10 , C07D401/04 , C07D417/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D491/048 , C07D491/06 , C07D495/04 , C07D495/14 , C07D519/00 , A61K31/437 , A61K31/473 , A61K45/06 , C07D221/16
CPC分类号： A61K31/519 , A61K31/437 , A61K31/473 , A61K45/06 , C07D221/06 , C07D221/08 , C07D221/10 , C07D221/16 , C07D401/04 , C07D417/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/048 , C07D491/06 , C07D491/16 , C07D495/04 , C07D495/14 , C07D519/00 , A61K2300/00
摘要： The present invention relates to compounds of formula (A), as further defined herein, having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. The invention further relates to the use of such compounds, optionally combined with one or more other drugs having antiviral activity, for the treatment of animals suffering from viral infections, in particular HIV infection.
摘要翻译：本发明涉及如本文进一步定义的具有抗病毒活性，更具体地，HIV（人类免疫缺陷病毒）复制抑制性质的式（A）化合物。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这样的化合物，任选地与一种或多种具有抗病毒活性的其它药物组合用于治疗患有病毒感染，特别是HIV感染的动物的用途。

5. 发明申请

US20130245049A1 Novel Antiviral Compounds 有权
标题翻译：新型抗病毒化合物
公开(公告)号：US20130245049A1
公开(公告)日：2013-09-19
申请号：US13885526
申请日：2011-11-15
申请人： Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
发明人： Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
IPC分类号： A61K31/519 , C07D221/06 , A61K45/06 , C07D221/16 , C07D471/14 , A61K31/437 , C07D487/04 , A61K31/473
CPC分类号： A61K31/519 , A61K31/437 , A61K31/473 , A61K45/06 , C07D221/06 , C07D221/08 , C07D221/10 , C07D221/16 , C07D401/04 , C07D417/04 , C07D471/04 , C07D471/14 , C07D487/04 , C07D487/14 , C07D491/048 , C07D491/06 , C07D491/16 , C07D495/04 , C07D495/14 , C07D519/00 , A61K2300/00
摘要： The present invention relates to compounds of formula (A), as further defined herein, having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. The invention further relates to the use of such compounds, optionally combined with one or more other drugs having antiviral activity, for the treatment of animals suffering from viral infections, in particular HIV infection.
摘要翻译：本发明涉及如本文进一步定义的具有抗病毒活性，更具体地，HIV（人类免疫缺陷病毒）复制抑制性质的式（A）化合物。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这样的化合物，任选地与一种或多种具有抗病毒活性的其它药物组合用于治疗患有病毒感染，特别是HIV感染的动物的用途。

6. 发明申请

US20120316161A1 NOVEL ANTIVIRAL COMPOUNDS 审中-公开
标题翻译：新型抗病毒化合物
公开(公告)号：US20120316161A1
公开(公告)日：2012-12-13
申请号：US13518434
申请日：2010-12-20
申请人： Gunter Carlens , Patrick Chaltin , Frauke Christ , Zeger Debyser , Arnaud Marchand , Damien Marchand , Arnout Voet , Marc De Maeyer
发明人： Gunter Carlens , Patrick Chaltin , Frauke Christ , Zeger Debyser , Arnaud Marchand , Damien Marchand , Arnout Voet , Marc De Maeyer
IPC分类号： C07D487/04 , C07D471/04 , A61P31/18 , A61K31/538 , A61P31/12 , A61K31/519 , A61K31/437
CPC分类号： C07D487/04
摘要： The present invention relates to compounds of formula (A) as defined herein having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutical amount of such compounds, optionally combined with one or more other drugs having antiviral activity.
摘要翻译：本发明涉及具有抗病毒活性的本文定义的式（A）化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

7. 发明申请

US20120059028A1 THIENO [2, 3-B] PYRIDINE DERIVATIVES AS VIRAL REPLICATION INHIBITORS 有权
标题翻译：噻吩[2,3-B]吡啶衍生物作为病毒复制抑制剂
公开(公告)号：US20120059028A1
公开(公告)日：2012-03-08
申请号：US13320519
申请日：2010-05-17
申请人： Dorothée Bardiot , Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
发明人： Dorothée Bardiot , Patrick Chaltin , Frauke Christ , Zeger Debyser , Marc De Maeyer , Arnaud Marchand , Damien Marchand , Arnout Voet
IPC分类号： A61K31/4365 , C07D495/04 , A61P31/12 , C07D491/06 , A61K31/436 , A61K31/4375 , C07D495/14
CPC分类号： C07D495/20 , A61K31/4365 , A61K31/4375 , A61K45/06 , C07D495/04 , C07D495/14
摘要： The present invention relates to a series of compounds having antiviral activity, more specifically HIV (Human Immunodeficiency Virus) replication inhibiting properties. The invention also relates to methods for the preparation of such compounds, as well as to novel intermediates useful in one or more steps of such syntheses. The invention also relates to pharmaceutical compositions comprising an effective amount of such compounds as active ingredients. This invention further relates to the use of such compounds as medicines or in the manufacture of a medicament useful for the treatment of animals suffering from viral infections, in particular HIV infection. This invention further relates to methods for the treatment of viral infections in animals by the administration of a therapeutic amount of such compounds, optionally combined with one or more other drugs having anti-viral activity.
摘要翻译：本发明涉及具有抗病毒活性的一系列化合物，更具体地涉及HIV（人类免疫缺陷病毒）复制抑制性质。本发明还涉及制备这些化合物的方法，以及可用于这种合成的一个或多个步骤的新型中间体。本发明还涉及包含有效量的这些化合物作为活性成分的药物组合物。本发明还涉及这些化合物作为药物或制备用于治疗患有病毒感染，特别是HIV感染的动物的药物的用途。本发明还涉及通过施用治疗量的这种化合物治疗动物中的病毒感染的方法，任选地与一种或多种具有抗病毒活性的其它药物组合。

8. 发明申请

US20080121494A1 MOBILE GASTRONOMIC TABLE FOR SERVING OUT FOOD 审中-公开
标题翻译：用于服务食物的移动胃肠镜
公开(公告)号：US20080121494A1
公开(公告)日：2008-05-29
申请号：US11969159
申请日：2008-01-03
申请人： Marc De Maeyer
发明人： Marc De Maeyer
IPC分类号： B65G41/00
CPC分类号： B65G23/26 , A47F10/06 , B65G21/10 , B65G23/04
摘要： A movable table for serving out food is described, which has an operating position for serving out food, and a transportation position for moving of the table. The movable table comprises at least two modules, each module comprising an automated transferring device, e.g. at least one conveyor belt, for transferring food receptacles from one end of the table to an opposite end thereof. The upper side of the transferring device in operating position forms a working surface of the table. The table is furthermore provided with means for fixing a support above the table surface.Each module may be provided with a transferring mechanism for transferring food receptacles on the automated transferring device of that module when the table is in the operating position. Said transferring mechanism of a module operatively connects as the table is into the operating position and operatively disengages when the table is brought into the transportation position.
摘要翻译：描述了用于食物的活动桌子，其具有用于食物的操作位置和用于移动桌子的运送位置。可移动台包括至少两个模块，每个模块包括自动转移装置，例如，至少一个传送带，用于将食物容器从工作台的一端转移到其相对端。处于操作位置的转印装置的上侧形成工作台的工作表面。桌子还设置有用于将支撑件固定在桌子表面上方的装置。每个模块可以设置有传送机构，用于在桌子处于操作位置时将食物容器转移到该模块的自动转移装置上。当台子进入运输位置时，模块的所述传送机构可操作地连接，并且当桌子进入运输位置时可操作地脱开。

9. 发明授权

US07337895B2 Mobile gastronomic table for serving out food 失效
标题翻译：用于食物的移动美食桌
公开(公告)号：US07337895B2
公开(公告)日：2008-03-04
申请号：US10552600
申请日：2004-04-07
申请人： Marc De Maeyer
发明人： Marc De Maeyer
IPC分类号： B65G21/08
CPC分类号： B65G23/26 , A47F10/06 , B65G21/10 , B65G23/04
摘要： A movable table for serving out food has an operating position for serving out food, and a transportation position for moving of the table. The movable table comprises at least two modules, each module comprising an automated transferring device, e.g. at least one conveyor belt, for transferring food receptacles from one end of the table to an opposite end thereof. The upper side of the transferring device in operating position forms a working surface of the table. The table is furthermore adapted for fixing a support above the table surface. Each module may be provided with a transferring mechanism for transferring food receptacles on the automated transferring device of that module when the table is in the operating position. The transferring mechanism of a module operatively connects as the table is into the operating position and operatively disengages when the table is brought into the transportation position.
摘要翻译：用于食物的活动台具有用于食用的操作位置和用于移动餐桌的运送位置。可移动台包括至少两个模块，每个模块包括自动转移装置，例如，至少一个传送带，用于将食物容器从工作台的一端转移到其相对端。处于操作位置的转印装置的上侧形成工作台的工作表面。桌子还适于将支撑件固定在桌子表面上方。每个模块可以设置有传送机构，用于在桌子处于操作位置时将食物容器转移到该模块的自动转移装置上。当桌子进入运输位置时，模块的传送机构可操作地连接，并且当桌子进入运输位置时可操作地脱开。

10. 发明授权

US5747449A Bovine pancreatic trypsin inhibitor derived inhibitors of factor XA 失效
标题翻译：牛胰蛋白酶抑制剂衍生的因子XA抑制剂
公开(公告)号：US5747449A
公开(公告)日：1998-05-05
申请号：US086630
申请日：1993-07-01
申请人： Ignace Lasters , Marc De Maeyer , William Charles Ripka
发明人： Ignace Lasters , Marc De Maeyer , William Charles Ripka
IPC分类号： C12N15/09 , A61K38/00 , A61K38/55 , A61P7/02 , C07K14/47 , C07K14/81 , C12N1/19 , C12N1/21 , C12N9/99 , C12N15/15 , C12P21/02 , C12P21/08 , C12R1/19 , C12R1/84 , A61K38/57
CPC分类号： C07K14/8117 , A61K38/00
摘要： A compound derived from BPTI which inhibits Factor Xa with an inhibition constant less than 50 nM.
摘要翻译：衍生自BPTI的抑制因子Xa的抑制常数小于50nM的化合物。

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