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1. 发明授权

US08647858B2 Automated system for the lysis of microorganisms present in a sample, for extraction and for purification of the nucleic acids of said microorganisms for purposes of analysis 有权
标题翻译：用于溶解样品中存在的微生物的自动化系统，用于提取和纯化所述微生物的核酸用于分析目的
公开(公告)号：US08647858B2
公开(公告)日：2014-02-11
申请号：US13129997
申请日：2009-12-09
申请人： Patrick Broyer , Agnes Dupontfilliard , Massimo Galdiero , Michel Guy , Hermanus Johannes Maria Kreuwel , Emiliano Maione , Emiel Gerebern Maria Verwimp
发明人： Patrick Broyer , Agnes Dupontfilliard , Massimo Galdiero , Michel Guy , Hermanus Johannes Maria Kreuwel , Emiliano Maione , Emiel Gerebern Maria Verwimp
IPC分类号： C12M1/34 , C12M3/00 , C12Q1/68 , C12P19/34 , G01N15/06 , G01N33/00 , G01N33/48
CPC分类号： C12M47/10 , C12M47/06
摘要： The present invention relates to, among other things, a device for collecting airborne microorganisms, said device having: an air collecting module, comprising: i. an upper element having an air admission duct permitting entry of an air stream into said module, said duct being provided, at its base, with means for disturbance of the air stream, ii. a lower element having air evacuating means permitting the air stream created to exit and said upper and lower elements can be made integral with one another so that the air stream can be created within said air collecting module; a cartridge, of roughly cylindrical shape, having a microorganism retention zone, said retention zone having means for lysis of the microorganisms, said cartridge being positioned within said air collecting module.
摘要翻译：本发明尤其涉及一种用于收集空气微生物的装置，所述装置具有：空气收集模块，包括：i。上部元件具有允许空气流进入所述模块的进气管道，所述管道在其底部设置有用于干扰气流的装置，ii。下部元件具有允许产生的空气流出口的空气排出装置，并且所述上部和下部元件可以彼此成一体，使得可以在所述空气收集模块内产生气流; 大致圆筒形的筒，具有微生物保留区，所述保留区具有用于微生物裂解的装置，所述盒位于所述空气收集模块内。

2. 发明申请

US20110250680A1 AUTOMATED SYSTEM FOR THE LYSIS OF MICROORGANISMS PRESENT IN A SAMPLE, FOR EXTRACTION AND FOR PURIFICATION OF THE NUCLEIC ACIDS OF SAID MICROORGANISMS FOR PURPOSES OF ANALYSIS 有权
标题翻译：用于提取微生物的样品的自动化系统，用于提取和纯化用于分析用途的相关微生物的核酸
公开(公告)号：US20110250680A1
公开(公告)日：2011-10-13
申请号：US13129997
申请日：2009-12-09
申请人： Patrick Broyer , Agnes Dupontfilliard , Massimo Galdiero , Michel Guy , Hermanus Johannes Maria Kreuwel , Emiliano Maione , Emiel Gerebern Maria Verwimp
发明人： Patrick Broyer , Agnes Dupontfilliard , Massimo Galdiero , Michel Guy , Hermanus Johannes Maria Kreuwel , Emiliano Maione , Emiel Gerebern Maria Verwimp
IPC分类号： C12N5/07 , C07H1/06 , C12N1/06 , C12M1/04 , C12M1/00 , C12N1/00
CPC分类号： C12M47/10 , C12M47/06
摘要： The present invention relates to, among other things, a device for collecting airborne microorganisms, said device having: an air collecting module, comprising: i. an upper element having an air admission duct permitting entry of an air stream into said module, said duct being provided, at its base, with means for disturbance of the air stream, ii. a lower element having air evacuating means permitting the air stream created to exit and said upper and lower elements can be made integral with one another so that the air stream can be created within said air collecting module; a cartridge, of roughly cylindrical shape, having a microorganism retention zone, said retention zone having means for lysis of the microorganisms, said cartridge being positioned within said air collecting module.
摘要翻译：本发明尤其涉及一种用于收集空气微生物的装置，所述装置具有：空气收集模块，包括：i。上部元件具有允许空气流进入所述模块的进气管道，所述管道在其底部设置有用于干扰气流的装置，ii。下部元件具有允许产生的空气流出口的空气排出装置，并且所述上部和下部元件可以彼此成一体，使得可以在所述空气收集模块内产生气流; 大致圆筒形的筒，具有微生物保留区，所述保留区具有用于微生物裂解的装置，所述盒位于所述空气收集模块内。

3. 发明授权

US10119114B2 Device for the lysis of microorganisms present in an environmental or clinical sample and the extraction of nucleic acids from said microorganisms for analysis 有权
公开(公告)号：US10119114B2
公开(公告)日：2018-11-06
申请号：US12451486
申请日：2008-06-06
申请人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
发明人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
IPC分类号： C12Q1/68 , C12M1/00 , C12M1/12
摘要： A cartridge that can be positioned inside an air collection component and receive a component for recovering nucleic acids is described, the cartridge being substantially cylindrical and containing a microorganism retaining zone, the retaining zone containing a microorganism lysis mechanism. Also described is a device for collecting microorganisms contained in the air and a device for microorganism lysis.

4. 发明申请

US20100075313A1 DEVICE FOR THE LYSIS OF MICROORGANISMS PRESENT IN AN ENVIRONMENTAL OR CLINICAL SAMPLE AND THE EXTRACTION OF NUCLEIC ACIDS FROM SAID MICROORGANISMS FOR ANALYSIS 审中-公开
标题翻译：用于环境或临床样品中微生物存在的装置和从分析的微生物中提取核酸的装置
公开(公告)号：US20100075313A1
公开(公告)日：2010-03-25
申请号：US12451486
申请日：2008-06-06
申请人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
发明人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
IPC分类号： C12Q1/68 , C12M1/33 , C12N1/00 , C12N1/06 , C07H21/00
CPC分类号： C12M47/06 , C12M25/14 , C12Q1/68
摘要： The present invention relates to a cartridge which can be positioned inside an air collection means and receive a means for recovering nucleic acids, said cartridge being substantially cylindrical and comprising a microorganism retaining zone, said retaining zone comprising microorganism lysis means. The invention also relates to a device for collecting microorganisms contained in the air and a device for microorganism lysis.
摘要翻译：本发明涉及一种可以定位在空气收集装置内部并且容纳用于回收核酸的装置的盒，所述盒基本上是圆柱形的并且包括微生物保留区，所述保持区包括微生物裂解装置。本发明还涉及用于收集空气中所含的微生物的装置和微生物裂解装置。

5. 发明授权

US06764859B1 Device and method for mixing magnetic particles with a fluid 有权
标题翻译：将磁性颗粒与流体混合的装置和方法
公开(公告)号：US06764859B1
公开(公告)日：2004-07-20
申请号：US10031222
申请日：2002-06-04
申请人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
发明人： Hermanus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp
IPC分类号： G01N134
CPC分类号： B01F13/0809 , B03C1/288 , C12Q1/6806 , Y10T436/143333 , Y10T436/255 , C12Q2563/143
摘要： This invention relates to the use of magnetic or magnetizable particles, and, in particular, to methods of mixing magnetic or (super)paramagnetic particles efficiently with a fluid and the separation of the magnetic particles from a fluid, optionally followed by resuspension of the particles in another fluid. The present invention provides a method of mixing, in one or more container(s), magnetic or (super)paramagnetic particles with a fluid, using more than one magnets, whereby the containers are subjected to magnetic fields with different and changing directions by moving the magnets with respect to the position of the container(s) and/or by moving the containers with respect to the positions of the magnets. The invention further provided a device for doing the same. Preferably the holders for the containers and the magnets in the device are placed in intervening array geometrics and the magnets are placed in line in such a way that all magnets that are in line have their poles oriented in the same direction, and that all magnets in a neighboring line have their poles oriented in the reverse direction with respect to the poles of the magnets in the first line.
摘要翻译：本发明涉及磁性或可磁化颗粒的使用，特别是涉及将磁性或（超级）顺磁性颗粒与流体有效混合并将磁性颗粒与流体分离的方法，任选地随后再次悬浮颗粒在另一种流体。本发明提供了在一个或多个容器中使用多于一个磁体将磁性或（超）顺磁性颗粒与流体混合的方法，由此通过移动来使容器经受具有不同和变化方向的磁场相对于容器的位置和/或通过相对于磁体的位置移动容器的磁体。本发明还提供了一种用于进行此操作的装置。优选地，用于容器的容器和装置中的磁体的保持器以中间阵列几何形状放置，并且磁体以这样的方式放置在一起，使得所有在线的磁体的极的方向相同，并且所有磁体在相邻的线具有相对于第一线中的磁体的磁极在相反方向上取向的极。

6. 发明授权

US08187460B2 Devices for separating, mixing and concentrating magnetic particles with a fluid 有权
标题翻译：用于分离，混合和浓缩磁性颗粒与流体的装置
公开(公告)号：US08187460B2
公开(公告)日：2012-05-29
申请号：US13116333
申请日：2011-05-26
申请人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
发明人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
IPC分类号： B03C1/02 , G01N1/34 , G01N1/38
CPC分类号： B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2300/0858 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N35/0098
摘要： The present invention is related to devices for manipulating magnetic particles that are suspended in a fluid, possibly containing a biological entity of interest, the magnetic particles being able to bind the entity of interest, the fluid being contained in a reaction vessel constituted by a large upper compartment with a funnel shape, an elongate lower compartment with a substantially constant cross-section and a closed base. The devices are especially useful in methods for the extraction of nucleic acid to enable them for further processing.
摘要翻译：本发明涉及用于操纵悬浮在可能含有感兴趣的生物体的流体中的磁性颗粒的装置，磁性颗粒能够结合感兴趣的实体，流体包含在由大的具有漏斗形状的上隔室，具有基本上恒定的横截面的细长的下隔室和封闭的基部。这些装置在提取核酸以使其能够进一步加工的方法中特别有用。

7. 发明申请

US20110220567A1 DEVICES FOR SEPARATING, MIXING AND CONCENTRATING MAGNETIC PARTICLES WITH A FLUID 有权
标题翻译：用流体分离，混合和浓缩磁性颗粒的装置
公开(公告)号：US20110220567A1
公开(公告)日：2011-09-15
申请号：US13116333
申请日：2011-05-26
申请人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
发明人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
IPC分类号： B03C1/02
CPC分类号： B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2300/0858 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N35/0098
摘要： The present invention is related to devices for manipulating magnetic particles that are suspended in a fluid, possibly containing a biological entity of interest, the magnetic particles being able to bind the entity of interest, the fluid being contained in a reaction vessel constituted by a large upper compartment with a funnel shape, an elongate lower compartment with a substantially constant cross-section and a closed base. The devices are especially useful in methods for the extraction of nucleic acid to enable them for further processing.
摘要翻译：本发明涉及用于操纵悬浮在可能含有感兴趣的生物体的流体中的磁性颗粒的装置，磁性颗粒能够结合感兴趣的实体，流体包含在由大的具有漏斗形状的上隔室，具有基本上恒定的横截面的细长的下隔室和封闭的基部。这些装置在提取核酸以使其能够进一步加工的方法中特别有用。

8. 发明授权

US07972516B2 Device and method for separating, mixing and concentrating magnetic particles with a fluid and use thereof in purification methods 有权
标题翻译：用于分离，混合和浓缩磁性颗粒与流体的装置和方法及其在净化方法中的应用
公开(公告)号：US07972516B2
公开(公告)日：2011-07-05
申请号：US11572574
申请日：2005-07-22
申请人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
发明人： Hermannus Johannes Maria Kreuwel , Emiel Gerebern Maria Verwimp , Bernardus Jozef Maria Beerling , Franciscus Gerardus Spee
IPC分类号： G01N1/34 , G01N1/38
CPC分类号： B01L3/5085 , B01L2200/025 , B01L2200/0647 , B01L2300/0858 , B03C1/01 , B03C1/0332 , B03C1/288 , B03C2201/18 , B03C2201/26 , G01N1/34 , G01N35/0098
摘要： A process for manipulating magnetic particles suspended in a fluid that are able to bind to an entity of interest, the fluid being contained in a reaction vessel having a large funnel shaped upper compartment, an elongate lower compartment of substantially constant cross-section and a closed base. The process consists of: a) subjecting the magnetic particles to two simultaneously applied magnetic fields to separate all said magnetic particles present in at least the upper compartment of the vessel from the fluid, b) transferring the separated magnetic particles from the upper compartment to the lower compartment, c) removing the fluid from the vessel, d) adding a washing liquid to the lower compartment, e) subjecting the magnetic particles to at least two magnetic fields applied successively with changing directions to wash all the magnetic particles present in the lower compartment, and concentrating said magnetic particles in said lower compartment.
摘要翻译：用于操纵悬浮在流体中的能够结合感兴趣实体的磁性颗粒的方法，所述流体包含在具有大漏斗形上部隔间的反应容器中，具有基本恒定横截面的细长下部隔室和封闭的基础。该方法包括：a）使磁性颗粒经受两个同时施加的磁场，以将存在于容器的至少上部隔室中的所有磁性颗粒与流体分离，b）将分离的磁性颗粒从上隔室转移到下部隔室，c）从容器中取出流体，d）向下部隔室添加洗涤液体，e）使磁性颗粒经受连续地随着改变方向施加的至少两个磁场，以清洗下部的所有磁性颗粒并且将所述磁性颗粒集中在所述下部隔室中。

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