专利快速检索-快速检索全球专利，免费商用专利数据库-IPRDB

1. 发明申请

US20100216254A1 DRUG MONITORING ASSAY 失效
标题翻译：药物监测测定
公开(公告)号：US20100216254A1
公开(公告)日：2010-08-26
申请号：US12678840
申请日：2008-09-26
申请人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
发明人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
IPC分类号： G01N33/566 , C07D403/14
CPC分类号： G01N33/94
摘要： A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invention also pertains to the respectively created binding agents and derivatives. Furthermore, drug monitoring assays using said binding agents for monitoring pharmaceutically active forms of said parent compound are provided.
摘要翻译：通过使用所述母体化合物的特殊衍生物来描述获得结合药物活性形式的化合物的方法，其具有比化合物的药物活性形式更高的特异性。本发明还涉及分别产生的结合剂和衍生物。此外，提供使用所述结合剂监测所述母体化合物的药学活性形式的药物监测测定。

2. 发明授权

US08329872B2 Drug monitoring assay 失效
标题翻译：药物监测测定
公开(公告)号：US08329872B2
公开(公告)日：2012-12-11
申请号：US13290581
申请日：2011-11-07
申请人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
发明人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
IPC分类号： G01N33/53 , G01N33/577 , C07D403/14
CPC分类号： G01N33/94
摘要： A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invention also pertains to the respectively created binding agents and derivatives. Furthermore, drug monitoring assays using said binding agents for monitoring pharmaceutically active forms of said parent compound are provided.
摘要翻译：通过使用所述母体化合物的特殊衍生物来描述获得结合药物活性形式的化合物的方法，其具有比化合物的药物活性形式更高的特异性。本发明还涉及分别产生的结合剂和衍生物。此外，提供使用所述结合剂监测所述母体化合物的药学活性形式的药物监测测定。

3. 发明授权

US08076160B2 Drug monitoring assay 失效
标题翻译：药物监测测定
公开(公告)号：US08076160B2
公开(公告)日：2011-12-13
申请号：US12678840
申请日：2008-09-26
申请人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
发明人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Severine Marrony , Judith Schaefer
IPC分类号： G01N33/53 , G01N33/577 , C07D403/14
CPC分类号： G01N33/94
摘要： A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invention also pertains to the respectively created binding agents and derivatives. Furthermore, drug monitoring assays using said binding agents for monitoring pharmaceutically active forms of said parent compound are provided.
摘要翻译：通过使用所述母体化合物的特殊衍生物来描述获得结合药物活性形式的化合物的方法，其具有比化合物的药物活性形式更高的特异性。本发明还涉及分别产生的结合剂和衍生物。此外，提供使用所述结合剂监测所述母体化合物的药学活性形式的药物监测测定。

4. 发明申请

US20120115247A1 DRUG MONITORING ASSAY 失效
标题翻译：药物监测测定
公开(公告)号：US20120115247A1
公开(公告)日：2012-05-10
申请号：US13290581
申请日：2011-11-07
申请人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Séverine Marrony , Judith Schaefer
发明人： Patrick Albientz , Jean-Michel Grenet , Rainer Hillenbrand , Francois Legay , Peter Marbach , Séverine Marrony , Judith Schaefer
IPC分类号： G01N33/53 , C07D403/14 , C07K16/44
CPC分类号： G01N33/94
摘要： A method for obtaining at least one binding agent which binds a pharmaceutically active form of the compound with a higher specificity than a pharmaceutically inactive form of the compound is described by using special derivatives of said parent compound. The invention also pertains to the respectively created binding agents and derivatives. Furthermore, drug monitoring assays using said binding agents for monitoring pharmaceutically active forms of said parent compound are provided.
摘要翻译：通过使用所述母体化合物的特殊衍生物来描述获得结合药物活性形式的化合物的方法，其具有比化合物的药物活性形式更高的特异性。本发明还涉及分别产生的结合剂和衍生物。此外，提供使用所述结合剂监测所述母体化合物的药学活性形式的药物监测测定。

5. 发明授权

US08753632B2 Antibodies to modified human IGF-1/E peptides 失效
标题翻译：修饰的人IGF-1 / E肽的抗体
公开(公告)号：US08753632B2
公开(公告)日：2014-06-17
申请号：US13128335
申请日：2009-11-10
申请人： Mara Fornaro , John Xu , Yuan Gao , Rainer Hillenbrand , Francois Legay , Daniela Stoellner
发明人： Mara Fornaro , John Xu , Yuan Gao , Rainer Hillenbrand , Francois Legay , Daniela Stoellner
IPC分类号： A61K39/395 , C12N5/12 , C12N15/00 , C07K16/22
CPC分类号： G01N33/54306 , C07K14/65 , C07K16/22 , C07K2317/33 , C07K2317/34 , G01N2333/65
摘要： High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples.
摘要翻译：高特异性抗体可以区分修饰的（例如hIGF-1 / Ea 3mut）和内源性野生型人IGF-1蛋白。这些抗体与hIGF-1或hIGF-2几乎没有或没有交叉反应性。它们也与啮齿动物IGF-1或IGF-2几乎没有或没有交叉反应。该抗体可以用于向人或动物施用的IGF-1 / E肽的药代动力学（PK）/药物动力学（PD）评估。使用本发明的抗体作为捕获抗体的夹心ELISA测定可以定量样品中的突变型IGF-1 / E蛋白质。

6. 发明申请

US20110218145A1 ANTIBODIES TO MODIFIED HUMAN IGF-1/E PEPTIDES 失效
标题翻译：改良人IGF-1 / E肽的抗体
公开(公告)号：US20110218145A1
公开(公告)日：2011-09-08
申请号：US13128335
申请日：2009-11-10
申请人： Mara Fornaro , John Xu , Yuan Gao , Rainer Hillenbrand , Francois Legay , Daniela Stoellner
发明人： Mara Fornaro , John Xu , Yuan Gao , Rainer Hillenbrand , Francois Legay , Daniela Stoellner
IPC分类号： A61K38/30 , C07K16/00 , C12N5/16 , C07K7/06 , C07H21/00 , C12N15/63 , G01N33/53 , C07K14/575 , C12N5/10 , A61P21/00
CPC分类号： G01N33/54306 , C07K14/65 , C07K16/22 , C07K2317/33 , C07K2317/34 , G01N2333/65
摘要： High-specificity antibodies can distinguish between modified (e.g, hIGF-1/Ea 3mut) and endogenous wild-type human IGF-1 proteins. These antibodies have little or no cross-reactivity with hIGF-1 or hIGF-2. They also have little or no cross-reactivity with rodent IGF-1 or IGF-2. The antibodies can be used in pharmacokinetic (PK)/pharamcodynamic (PD) assessments of IGF-1/E peptides that have been administered to humans or animals. A sandwich ELISA assay, using the antibody of the invention as a capture antibody, can quantify the mutant IGF-1/E proteins in samples.
摘要翻译：高特异性抗体可以区分修饰的（例如hIGF-1 / Ea 3mut）和内源性野生型人IGF-1蛋白。这些抗体与hIGF-1或hIGF-2几乎没有或没有交叉反应性。它们也与啮齿动物IGF-1或IGF-2几乎没有或没有交叉反应。该抗体可以用于向人或动物施用的IGF-1 / E肽的药代动力学（PK）/药物动力学（PD）评估。使用本发明的抗体作为捕获抗体的夹心ELISA测定可以定量样品中的突变型IGF-1 / E蛋白质。

7. 发明授权

US07738115B2 Optical device for measuring modulated signal light 有权
标题翻译：用于测量调制信号光的光学装置
公开(公告)号：US07738115B2
公开(公告)日：2010-06-15
申请号：US11997386
申请日：2006-09-27
申请人： Nenad Ocelic , Rainer Hillenbrand
发明人： Nenad Ocelic , Rainer Hillenbrand
IPC分类号： G01B11/02
CPC分类号： G01Q60/22 , G11B7/005 , G11B7/1387
摘要： An optical device for determining at least one signal light component being characteristic for an optical near-field interaction of a probe with an object to be investigated, wherein the near-field interaction is subjected to a fundamental modulation at a fundamental frequency Ω, comprises an interferometer device with an illumination light path (I) being directed to the probe, a reference light path (II) being directed to a detector device for obtaining detector output signals including signal light components, and a signal light path (III) being directed from the probe to the detector device, wherein the reference and signal light paths (II, III) are superimposed at the detector device, and a demodulation device for determining the signal light components by demodulating the detector output signals, wherein the reference light path (II) does not contain the probe, an interferometer phase modulator is arranged in the reference light path (II) or signal light path (III) for changing an interferometer phase comprising the optical phase difference between the reference light and the signal light, and the demodulation device is adapted for determining the signal light components from the detector output signals obtained at three or more different interferometer states, which represent three or more different interferometer phases or at least two different interferometer phases with at least one state wherein the reference light path (II) is blocked.
摘要翻译：一种光学装置，用于确定至少一个信号光分量是探针与待研究物体的光学近场相互作用的特征，其中所述近场相互作用在基频ωg下进行基本调制，包括具有照明光路（I）的干涉仪装置被引导到探针，参考光路（II）被引导到检测器装置，用于获得包括信号光分量的检测器输出信号和指向的信号光路（III）从所述探针到所述检测器装置，其中所述参考信号光路（II，III）叠加在所述检测器装置处，以及解调装置，用于通过解调所述检测器输出信号来确定所述信号光分量，其中所述参考光路径 II）不包含探针，在参考光路（II）或信号光路（III）中布置干涉仪相位调制器包括参考光和信号光之间的光学相位差的干涉仪相位，并且所述解调装置适用于从三个或更多个不同的干涉仪状态获得的检测器输出信号中确定信号光分量，所述干涉仪表示三个或更多个不同的干涉仪相位或具有至少一个状态的至少两个不同的干涉仪相位，其中参考光路（II）被阻挡。

8. 发明授权

US07978343B2 Nanoscale optical tomography based on volume-scanning near-field microscopy 有权
标题翻译：基于体积扫描近场显微镜的纳米级光学断层扫描
公开(公告)号：US07978343B2
公开(公告)日：2011-07-12
申请号：US12405449
申请日：2009-03-17
申请人： Jin Sun , John C. Schotland , Rainer Hillenbrand , Paul Scott Carney
发明人： Jin Sun , John C. Schotland , Rainer Hillenbrand , Paul Scott Carney
IPC分类号： G01B11/24
CPC分类号： G01Q60/22
摘要： An apparatus and methods for nanoscale optical tomography based on back-scattering mode near-field scanning optical microscopy with a volumetric scan of the probe. The back-scattered data collected by a volumetric scan of the probe contains three-dimensional structural information of the sample, which enables reconstruction of the dielectric sample without other mechanical movements of the instrument.
摘要翻译：基于背散射模式近场扫描光学显微镜的纳米尺度光学层析成像的装置和方法，具有探针的体积扫描。通过探针的体积扫描收集的背散射数据包含样品的三维结构信息，其能够重建电介质样品而无需仪器的其他机械运动。

9. 发明申请

US20050259252A1 Method and device for recording optical near field interaction signals 审中-公开
标题翻译：用于记录光学近场相互作用信号的方法和装置
公开(公告)号：US20050259252A1
公开(公告)日：2005-11-24
申请号：US10519349
申请日：2003-06-23
申请人： Rainer Hillenbrand , Fritz Keilmann , Thomas Taubner
发明人： Rainer Hillenbrand , Fritz Keilmann , Thomas Taubner
IPC分类号： G01Q60/18 , G01J3/28
CPC分类号： G11B9/14 , G01Q60/22 , G11B9/02 , G11B9/149
摘要： Described are methods for acquiring optical near-field interaction signals in the infrared spectral region, involving the steps of: illuminating an object combination comprising at least two objects (1, 2) with infrared radiation so that an infrared near-field coupling is produced between the objects (1, 2); and acquiring the scattered light which is scattered by the object combination, which scattered light comprises a fraction(s) that has been modified as a result of the near-field coupling; wherein at least one of the objects (1, 2) comprises a polar material which at least in part comprises a polar solid-state structure; and during illumination in at least one of the objects (1, 2) with the polar material at least one phonon resonance is excited with which the modified fraction(s) of the scattered light is strengthened. Also described are applications of the method in the fields of metrology, data storage technology and optical signal processing.
摘要翻译：描述了用于在红外光谱区域中获取光学近场相互作用信号的方法，包括以下步骤：用红外辐射照射包括至少两个物体（1,2）的物体组合，使得在两个物体（1,2）之间产生红外近场耦合，对象（1,2）; 并且获取由对象组合散射的散射光，该散射光包括作为近场耦合的结果而被修改的分数; 其中所述物体（1,2）中的至少一个包括至少部分地包括极性固态结构的极性材料; 并且在至少一个具有极性材料的物体（1,2）中的照射期间，激发至少一个声子共振，从而增强散射光的改性分数。还描述了该方法在计量学，数据存储技术和光信号处理领域的应用。

10. 发明授权

US07591858B2 Mirror optic for near-field optical measurements 有权
标题翻译：用于近场光学测量的镜面光学器件
公开(公告)号：US07591858B2
公开(公告)日：2009-09-22
申请号：US11653601
申请日：2007-01-16
申请人： Fritz Keilmann , Rainer Hillenbrand
发明人： Fritz Keilmann , Rainer Hillenbrand
IPC分类号： G01B15/00
CPC分类号： G01Q60/22 , Y10S977/862
摘要： A mirror optic (10) is provided for near-field optical measurement of a specimen (1), wherein the mirror optic (10) has a reflector (11) with the shape of a paraboloid with a paraboloid axis (12) and a focal point (13), which can be illuminated along a first illumination beam path (I), whereby the reflector 11 has at least one edge recess (14) in such a way that the focal point (13) can be illuminated along a second illumination beam path (II) which deviates from the first illumination beam path (I). A near-field microscope with such a mirror optic is also provided.
摘要翻译：提供了一种用于样本（1）的近场光学测量的镜面光学元件（10），其中镜面光学元件（10）具有反射器（11），其具有抛物面形状，具有抛物面轴（12）和焦点点（13），其可以沿着第一照明光束路径（I）照亮，由此反射器11具有至少一个边缘凹部（14），使得焦点（13）可以沿着第二照明离开第一照明光束路径（I）的光束路径（II）。还提供了具有这种镜面光学器件的近场显微镜。

你已经成功收藏专利！

检索式保存成功!

IPRDB

热门服务

关于我们

友情链接

联系方式