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1. 发明申请

US20080135419A1 Hdl Cholesterol Sensor 审中-公开
标题翻译： Hdl胆固醇传感器
公开(公告)号：US20080135419A1
公开(公告)日：2008-06-12
申请号：US11793285
申请日：2005-12-12
申请人： Patricia Mary Elizabeth Roblin , John Morton Broughall , Luet Lok Wong
发明人： Patricia Mary Elizabeth Roblin , John Morton Broughall , Luet Lok Wong
IPC分类号： G01N27/26 , G01N33/92 , C12Q1/60
CPC分类号： C12Q1/60 , C12Q1/001
摘要： A method for the determination of the amount of cholesterol in high density lipoproteins in a high density lipoprotein containing sample, the method comprising reacting the sample with a PEG-ylated protein to selectively complex non-HDL lipoproteins in the sample with the PEG-ylated protein, or with a PEG-ylated enzyme capable of selective reaction with high density lipoproteins, and subsequently measuring the amount of cholesterol in the high density lipoproteins, for example using an electrochemical technique.
摘要翻译：一种用于测定含高密度脂蛋白的样品中高密度脂蛋白中胆固醇含量的方法，该方法包括使样品与PEG-样蛋白质反应以选择性地将样品中的非HDL脂蛋白与PEG-样蛋白，或与能够与高密度脂蛋白选择性反应的PEG-样酶，以及随后测量高密度脂蛋白中胆固醇的量，例如使用电化学技术。

2. 发明申请

US20080276482A1 Freeze Drying of Target Substances 审中-公开
标题翻译：冷冻干燥目标物质
公开(公告)号：US20080276482A1
公开(公告)日：2008-11-13
申请号：US12096779
申请日：2006-12-08
申请人： John Morton Broughall , Charles Richard Wedge , Charles Monroe
发明人： John Morton Broughall , Charles Richard Wedge , Charles Monroe
IPC分类号： F26B5/06
CPC分类号： F26B5/06
摘要： A target substance (8) is subject to a freeze drying process in which the substance is first passed into a freeze chamber (31) to reduce the temperature of the substance, and then passed into a separate vacuum chamber (32) in which a vacuum is applied to promote drying of the target substance. Because the carrier (10) and target substance (8) is moved from a freeze chamber (31) to a separate vacuum chamber (32) the environment can be more closely controlled and the cycling of freezing to drying can be more rapid. In this way the carrier (10) and target substance (8) is subject to the full temperature cycling without the surrounding chamber and apparatus being subject to the full cycle. This reduces time and energy costs. The technique is particularly suited to manufacturing biosensors using freeze dried reagents.
摘要翻译：目标物质（8）经受冷冻干燥过程，其中物质首先进入冷冻室（31）以降低物质的温度，然后进入单独的真空室（32），其中真空用于促进目标物质的干燥。因为载体（10）和目标物质（8）从冷冻室（31）移动到单独的真空室（32），所以可以更加严格地控制环境，并且可以更快速地进行冷冻循环。以这种方式，载体（10）和目标物质（8）经受全温循环，而不会使周围的室和装置经受整个循环。这减少了时间和能源成本。该技术特别适用于使用冷冻干燥试剂制造生物传感器。

3. 发明申请

US20090188812A1 Cholesterol Sensor 审中-公开
标题翻译：胆固醇传感器
公开(公告)号：US20090188812A1
公开(公告)日：2009-07-30
申请号：US12298876
申请日：2007-05-14
申请人： John Morton Broughall , Herbert Frank Askew , Lindy Murphy
发明人： John Morton Broughall , Herbert Frank Askew , Lindy Murphy
IPC分类号： G01N33/92 , C12Q1/60
CPC分类号： G01N33/92 , C12Q1/26 , C12Q1/60 , G01N33/5438
摘要： A method for the determination of the amount of cholesterol in lipoproteins other than high density lipoproteins in a lipoprotein-containing sample, said method comprising (a) electrochemically determining the amount of cholesterol bound to high density lipoproteins in the sample, (b) electrochemically determining the total amount of cholesterol in the sample, and subtracting the result of (a) from the result of (b).
摘要翻译：一种用于测定含脂蛋白样品中高密度脂蛋白以外的脂蛋白中胆固醇含量的方法，所述方法包括（a）电化学测定与样品中高密度脂蛋白结合的胆固醇量，（b）电化学测定样本中胆固醇的总量，并从（b）的结果中减去（a）的结果。

4. 发明授权

US07545148B2 Electrochemical sensor 有权
标题翻译：电化学传感器
公开(公告)号：US07545148B2
公开(公告)日：2009-06-09
申请号：US11660255
申请日：2005-08-03
申请人： Kevin Lorimer , John Griffiths , Mark Hyland , Herbert Frank Askew , John Morton Broughall
发明人： Kevin Lorimer , John Griffiths , Mark Hyland , Herbert Frank Askew , John Morton Broughall
IPC分类号： G01N27/02
CPC分类号： G01N27/48
摘要： In an electrochemical sensor, the potential difference applied to the electrochemical cell is raised to a measuring value at a rate determined to reduce the transient current. The maximum rate of change of the voltage is set to prevent saturation of an IE converter. The electrochemical cell may contain micro-electrodes as working and reference electrodes. The method may be applied to a battery powered, handheld device.
摘要翻译：在电化学传感器中，施加到电化学电池的电势差以确定为减少瞬态电流的速率升高到测量值。设置电压的最大变化率以防止IE转换器的饱和。电化学电池可以包含微电极作为工作电极和参比电极。该方法可以应用于电池供电的手持设备。

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