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1. 发明申请

US20110152734A1 DEVICE FOR PNEUMATIC TREATMENT OF AN INFERIOR LIMB HAVING PERIPHERAL ARTERIOPATHY PROBLEMS 审中-公开
标题翻译：具有外周性脑血管病的感染性肢体的气体治疗装置
公开(公告)号：US20110152734A1
公开(公告)日：2011-06-23
申请号：US13003155
申请日：2008-07-07
申请人： Paolo Zamboni , Fabio Manfredini
发明人： Paolo Zamboni , Fabio Manfredini
IPC分类号： A61H7/00
CPC分类号： A61H9/0092 , A61H9/0078 , A61H2201/0103 , A61H2201/165 , A61H2201/5071 , A61H2205/108
摘要： A device (1) for compression treatments of an inferior limb (A) of a subject, said device (1) comprising an inflatable element (2) apt to being placed in contact with a portion of said inferior limb (A) to exert an action of compression and decompression on said portion of inferior limb (A), wherein the inflatable element (2) includes a rigid element (3), positionable on the medial part of the thigh of the subject for compression of the internal femoral vein.
摘要翻译： 1.一种用于受试者的下肢（A）的压缩处理的装置（1），所述装置（1）包括易于与所述下肢（A）的一部分接触的可膨胀元件（2），以施加在下肢（A）的所述部分上的压缩和减压作用，其中所述可充气元件（2）包括刚性元件（3），所述刚性元件可定位在所述受试者的大腿的内侧部分上，以压缩所述内股静脉。

2. 发明授权

US07891342B2 Method and system for controlling operating pressure in a common-rail fuel injection system, particularly for a diesel engine 有权
标题翻译：用于控制共轨燃料喷射系统中的操作压力的方法和系统，特别是用于柴油发动机
公开(公告)号：US07891342B2
公开(公告)日：2011-02-22
申请号：US12470315
申请日：2009-05-21
申请人： Maura Dintino , Roberto Vernassa , Paolo Zamboni
发明人： Maura Dintino , Roberto Vernassa , Paolo Zamboni
IPC分类号： F02M59/36 , F02B3/00
CPC分类号： F02D41/405 , F02D41/3863 , F02D41/3872 , F02D2200/0602 , F02D2250/31 , F02M63/0225 , F02M63/0235 , Y02T10/44
摘要： In a fuel injection system of an internal combustion engine that includes, but is not limited to injectors (I1-I4), each of which is adapted to deliver a predetermined amount of pressurized fuel to a combustion chamber of a respective cylinder (C1-C4) of the engine, a high-pressure accumulator volume common to the injectors (I1-I4) and arranged to maintain the fuel at high-pressure, a pressure sensor for measuring fuel pressure in the accumulator volume, a metering unit for adjusting the fuel pressure in the accumulator volume as a function of the measured pressure, so as to maintain a predetermined target injection pressure set-point dependent on the engine operating point by returning excess fuel to a fuel tank; and an electronic control unit arranged for controlling fuel injection timing and quantity by operating injectors control valves, the operating pressure is controlled by triggering retarded injections (INJpost) of a predetermined quantity of fuel to the combustion chamber of the cylinders (C1-C4) of the engine during a respective exhaust stroke, when pressure above a predetermined threshold (THover) is detected in the accumulator volume, so as to discharge fuel from the accumulator volume without it taking part to the combustion process, thereby reducing pressure in the accumulator volume.
摘要翻译：在内燃机的燃料喷射系统中，其包括但不限于喷射器（I1-I4），每个喷射器适于将预定量的加压燃料输送到相应汽缸（C1-C4）的燃烧室），喷射器（I1-I4）共同并被布置成将燃料保持在高压下的高压蓄能器容积，用于测量蓄能器容积中的燃料压力的压力传感器，用于调节燃料的计量单元作为测量压力的函数的蓄能器体积中的压力，以便通过将多余的燃料返回到燃料箱来维持取决于发动机工作点的预定目标喷射压力设定点; 以及电子控制单元，其布置成通过操作喷射器控制阀来控制燃料喷射正时和数量，通过将预定量的燃料的延迟喷射（INJpost）触发到气缸（C1-C4）的燃烧室当在蓄能器体积中检测到高于预定阈值（止点）的压力时，在相应的排气行程期间，发动机，以便在没有参与燃烧过程的情况下从蓄能器容积排出燃料，从而减小蓄能器容积中的压力。

3. 发明申请

US20120225791A1 ARRAY-BASED METHOD FOR DETECTION OF COPY NUMBER VARIATIONS IN THE HLA LOCUS FOR THE GENETIC DETERMINATION OF SUSCEPTIBILITY OF DEVELOPMENT OF VENOUS MALFORMATIONS IN THE EXTRACRANIAL SEGMENTS OF THE CEREBROSPINAL VEINS AND KIT THEREOF 审中-公开
标题翻译：用于检测HLA位置中复制数变化的遗传方法用于遗传性确定宫颈病毒及其工具包的外部部分中的门静脉畸形发展的可能性
公开(公告)号：US20120225791A1
公开(公告)日：2012-09-06
申请号：US13391572
申请日：2010-08-31
申请人： Paolo Zamboni , Alessandra Ferlini , Matteo Bovolenta
发明人： Paolo Zamboni , Alessandra Ferlini , Matteo Bovolenta
IPC分类号： C40B30/04 , C40B40/06
CPC分类号： C12Q1/6883 , C12Q2600/156
摘要： Method for in vitro diagnosis of susceptiblility of developing venous malformations i the extracranial segment of the cerebrospinal veins in a patient comprising the detection of copy number variations (CNVs) in chromosome 6p21 in a sample of genomic DNA of the patient, wherein the venous malformations are associated with the development of multiple sclerosis.
摘要翻译：用于体外诊断发展为静脉畸形的易感性的方法我包括在患者的基因组DNA样品中检测6p21染色体中的拷贝数变异（CNV）的脑脊液静脉的颅外节段，其中静脉畸形是与多发性硬化症的发展相关。

4. 发明授权

US08239118B2 Method and system for controlling a high pressure pump, particularly for a diesel engine fuel injection system 有权
标题翻译：用于控制高压泵的方法和系统，特别是用于柴油发动机燃料喷射系统
公开(公告)号：US08239118B2
公开(公告)日：2012-08-07
申请号：US12471960
申请日：2009-05-26
申请人： Maura Dintino , Paolo Zamboni
发明人： Maura Dintino , Paolo Zamboni
IPC分类号： F02D41/30 , F02M57/02
CPC分类号： F02D41/3845 , F02D41/2441 , F02D41/2464 , F02D2250/31 , F02M59/366 , F02M63/023
摘要： In a fuel injection system of an internal combustion engine, including, but not limited to a high pressure pump adapted to deliver a fuel mass conveyed from a fuel tank to a high pressure region to which a plurality of injectors is connected, including a fuel metering device for adjusting the fuel quantity to be delivered to the high pressure region, a pressure sensor for measuring fuel pressure in the high pressure region; and an electronic control unit arranged for driving the fuel metering device through an energizing signal (Inom; Iact) as a function of the measured fuel pressure and the engine operating mode, where the electronic control unit is arranged for determining the energizing signal (Inom; Iact) for driving the fuel metering device according to a nominal characteristic curve (A) of the high pressure pump representative of a predetermined relationship between the energizing signal and the fuel mass delivered by the pump, the operating pressure is controlled by driving the fuel metering device with an energizing signal determined according to an updated characteristic curve (B) estimated by applying to the nominal characteristic curve (A) an offset between the actual energizing signal value (Iact) related to the controlled fuel mass delivered to the high pressure region in a predetermined engine operating point and a nominal energizing signal (Inom) related to the controlled fuel mass according to the nominal characteristic curve (A).
摘要翻译：在内燃机的燃料喷射系统中，包括但不限于适于将从燃料箱输送的燃油质量输送到连接有多个喷射器的高压区域的高压泵，包括燃料计量用于调节要输送到高压区域的燃料量的装置，用于测量高压区域中的燃料压力的压力传感器; 以及电子控制单元，其布置成通过作为所测量的燃料压力和发动机操作模式的函数的激励信号（Inom; Iact）来驱动燃料计量装置，其中电子控制单元被布置用于确定激励信号（Inom; Iact），用于根据代表由泵输送的燃料质量之间的预定关系的高压泵的标称特性曲线（A）驱动燃料计量装置，通过驱动燃料计量来控制操作压力装置，其具有根据通过施加到所述标称特性曲线（A）估计的经更新的特性曲线（B）确定的激励信号，所述特性曲线（B）与传递到所述高压区域的受控燃料质量相关的实际通电信号值（Iact）预定的发动机工作点和与受控燃料质量相关的额定通电信号（Inom） g到标称特性曲线（A）。

5. 发明申请

US20120191727A1 SYSTEM FOR DETECTING EXTRA CRANIAL VENOUS FLOW ANOMALIES 审中-公开
标题翻译：用于检测额外的突起气道流量异常的系统
公开(公告)号：US20120191727A1
公开(公告)日：2012-07-26
申请号：US13390141
申请日：2010-07-20
申请人： Paolo Zamboni
发明人： Paolo Zamboni
IPC分类号： G06F17/30
CPC分类号： A61B8/06 , A61B5/02007 , A61B5/02028 , A61B8/0816
摘要： A system for detecting extracranial flow anomalies in a patient, for example for the purposes of the diagnosis of multiple sclerosis comprises:—a detection source (TCCS, ECD) to detect venous hemodynamics parameters representative of extracranial venous flow in a patient and generate corresponding signals, and—a processing device (PC) to receive said signals from the detection source (TCCS, ECD), configured (100, 200, 300, 400, 500), to assign to said venous hemodynami parameters respective insufficiency scores and combine (600) the respective scores assigned to said venous hemodynami parameters and generate an overall insufficiency score indicative of a level of extracranial venous flow anomaly in the patient.
摘要翻译：用于检测患者中的颅外流动异常的系统，例如用于多发性硬化症诊断的目的包括： - 检测源（TCCS，ECD），用于检测代表患者颅外静脉血流的静脉血液动力学参数并产生相应的信号，以及 - 配置（100,200,300,400,500）从所述检测源（TCCS，ECD）接收所述信号的处理装置（PC），以分配给所述静脉血液动力学参数各自的不足评分并组合（600 ）分配给所述静脉血液动力学参数的各个评分，并产生指示患者中颅外静脉血流异常水平的总体不全分数。

6. 发明申请

US20110021986A1 DILATION CATHETER 审中-公开
公开(公告)号：US20110021986A1
公开(公告)日：2011-01-27
申请号：US12921263
申请日：2008-03-07
申请人： Paolo Zamboni
发明人： Paolo Zamboni
IPC分类号： A61M29/00
CPC分类号： A61M25/1002
摘要： A catheter (10) for treating stenotic sites in the human body (e.g. in the azygos vein) includes an expandable portion (12) having, when expanded, an arched shape. The arched shape may extends over an angle (a) of at least 90° degrees, and preferably of between 90° and 120° degrees, with a radius (R) of less than 3 centimetres, and preferably between 2 and 3 centimetres. The expandable portion AZY (12) may include a flexible support member, and expandable members coupled to the support member to impart, when expanded, the desired arched shape to the flexible support member. Alternatively, the expandable portion (12) may includes an actuator member acting longitudinally of and sidewise to the expandable portion to impart thereto the desired arched shape.
摘要翻译：用于治疗人体中的狭窄部位的导管（10）（例如在金属静脉中）包括当膨胀时具有拱形形状的可扩张部分（12）。拱形形状可以在半径（R）小于3厘米，优选在2厘米至3厘米之间的至少90度，优选地在90度和120度之间的角度（a）上延伸。可膨胀部分AZY（12）可以包括柔性支撑构件，以及联接到支撑构件的可膨胀构件，当膨胀时，将所需的拱形形状赋予柔性支撑构件。或者，可膨胀部分（12）可以包括致动器构件，其作用于可膨胀部分的纵向和侧向，以赋予其所需的拱形形状。

7. 发明申请

US20120191112A1 EXPANDABLE CATHETER ASSEMBLY AND CORRESPONDING KIT 审中-公开
标题翻译：可扩展的导管组件和相应的工具包
公开(公告)号：US20120191112A1
公开(公告)日：2012-07-26
申请号：US13390136
申请日：2010-07-27
申请人： Paolo Zamboni
发明人： Paolo Zamboni
IPC分类号： A61B17/22
CPC分类号： A61M25/104 , A61B17/320725 , A61B2017/22001 , A61B2017/22054 , A61B2017/22061 , A61M25/1002 , A61M25/1011
摘要： A catheter (10) comprises an expandable portion (12) for the treatment of stenotic sites (S) of vessels (JV1, JV2) in the body of a patient. The aforesaid expandable portion (12) includes:—an expandable formation (122), which, when expanded, is able to undergo a localized depression in an area corresponding to an annulus or stenosing ring (S) in the vessel treated (JV1, JV2), detecting the presence of said stenosing ring; and—a cutting formation (124, 126), which can be positioned at the stenosing ring for cutting the stenosing ring so as to bring about yielding of the stenosis produced by said ring. Preferential application is in the treatment of internal jugular veins.
摘要翻译：导管（10）包括用于治疗患者体内血管（JV1，JV2）的狭窄部位（S）的可膨胀部分（12）。上述可膨胀部分（12）包括： - 可膨胀形式（122），其在膨胀时能够在对应于处理的容器（JV1，JV2）中的环形或狭窄环（S）的区域中经历局部凹陷），检测所述狭窄环的存在; 和切割结构（124,126），其可以位于所述狭窄环处以切割所述狭窄环，从而导致由所述环产生的狭窄的产生。优惠适用于治疗颈内静脉。

8. 发明申请

US20110009749A1 SYSTEM FOR DIAGNOSING MULTIPLE SCLEROSIS 审中-公开
标题翻译：诊断多发性硬化症的系统
公开(公告)号：US20110009749A1
公开(公告)日：2011-01-13
申请号：US12919315
申请日：2008-02-26
申请人： Paolo Zamboni
发明人： Paolo Zamboni
IPC分类号： A61B8/06
CPC分类号： A61B8/06 , A61B5/02007 , A61B5/02028 , A61B5/026 , A61B5/4064 , A61B5/7275 , A61B8/0808 , A61B8/0816
摘要： A system for determining at least one index out of a blood reflux rate index and increased blood resistance index in cerebral veins in a patient including a detection source set (TCCS, ECD) for detecting: —i) a blood reflux in at least one of the deep cerebral veins, —ii) a blood reflux in at least one of the internal jugular and/or vertebral veins; —iii) a stenose in at least one of the internal jugular vein; —iv) a lack of Doppler detectable blood flow in at least one of the internal jugular and/or vertebral veins; and —v) a negative difference between the cross-sectional area of at least one of the internal jugular veins in the supine posture and in the erect posture of said patient. The system further includes a processing module (PC) operatively connected to the detection source set (TCCS, ECD) to sense the condition where at least two of indexes i) to v) are positive so that the processing module (PC) emits an advice signal in case said condition is sensed.
摘要翻译：一种用于确定患者的血液回流率指数中的至少一个指标和增加的脑静脉血压指数的系统，包括用于检测以下各项的检测源组（TCCS，ECD）：-i）至少一个深静脉，-ii）至少一个颈内静脉和/或脊椎静脉血液回流; -iii）至少一个颈内静脉中的狭窄; -iv）在颈内静脉和/或脊椎静脉中的至少一个中缺乏多普勒可检测的血流; 和-v）仰卧姿态中的至少一个颈内静脉的横截面积与所述患者的直立姿势之间的负差值。该系统还包括可操作地连接到检测源组（TCCS，ECD）的感测其中至少两个索引i）至v）为正的状态的处理模块（PC），使得处理模块（PC）发出建议在所述条件被感测的情况下的信号。

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