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1. 发明申请

US20060239969A1 Rhesus her2/neu, nucleotides encoding same, and uses thereof 失效
标题翻译：恒河猴her2 / neu，编码相同的核苷酸及其用途
公开(公告)号：US20060239969A1
公开(公告)日：2006-10-26
申请号：US10541270
申请日：2003-12-29
申请人： Paolo Monaci , Maurizio Nuzzo , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
发明人： Paolo Monaci , Maurizio Nuzzo , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C12N5/06 , C12N15/861 , C07K14/82
CPC分类号： A61K38/1709 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C07K14/71 , C12N15/86 , C12N2710/10343 , C12N2799/022
摘要： Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2/neu tumor-associated antigen, wherein aberrant HER2/neu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2/neu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：编码恒河猴HER2 / neu的多核苷酸已被分离，克隆和测序。编码HER2 / neu的基因通常与上皮衍生的人类癌的发展有关。本发明提供了引发或增强对由HER2 / neu肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常HER2 / neu表达与癌或其发展相关。本发明具体提供携带rhHER2 / neu的腺病毒载体构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

2. 发明授权

US07282365B2 Rhesus HER2/neu, nucleotides encoding same, and uses thereof 失效
标题翻译：恒河猴HER2 / neu，编码相同的核苷酸及其用途
公开(公告)号：US07282365B2
公开(公告)日：2007-10-16
申请号：US10541270
申请日：2003-12-29
申请人： Paolo Monaci , Maurizio Nuzzo , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
发明人： Paolo Monaci , Maurizio Nuzzo , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
IPC分类号： C07K14/71 , C12N5/10 , C12N15/12 , C07K14/485
CPC分类号： A61K38/1709 , A61K2039/5256 , A61K2039/53 , A61K2039/545 , C07K14/71 , C12N15/86 , C12N2710/10343 , C12N2799/022
摘要： Polynucleotides encoding rhesus monkey HER2/neu have been isolated, cloned and sequenced. The gene encoding the HER2/neu is commonly associated with the development of epithelial-derived human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the HER2/neu tumor-associated antigen, wherein aberrant HER2/neu expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhHER2/neu and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：编码恒河猴HER2 / neu的多核苷酸已被分离，克隆和测序。编码HER2 / neu的基因通常与上皮衍生的人类癌的发展有关。本发明提供了引发或增强对由HER2 / neu肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常HER2 / neu表达与癌或其发展相关。本发明具体提供携带rhHER2 / neu的腺病毒载体构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

3. 发明申请

US20060228335A1 Rhesus carcino embryonic antigen, nucleotides encoding same, and uses thereof 审中-公开
标题翻译：恒河猴胚胎胚胎抗原，编码其的核苷酸及其用途
公开(公告)号：US20060228335A1
公开(公告)日：2006-10-12
申请号：US10545515
申请日：2004-02-09
申请人： Luigi Aurisicchio , Fabio Palombo , Paolo Monaci , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
发明人： Luigi Aurisicchio , Fabio Palombo , Paolo Monaci , Nicola La Monica , Gennaro Ciliberto , Armin Lahm
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C07K14/82 , C12N5/06
CPC分类号： A61K39/0011 , A61K38/00 , A61K2039/5256 , A61K2039/53 , C07K14/70503 , C07K16/3007
摘要： DNAs encoding rhesus monkey carcinoembryonic antigen (rhCEA) have been isolated, cloned and sequenced. The gene encoding CEA is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the CEA tumor-associated antigen, wherein aberrant CEA expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector constructs carrying rhCEA and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：已经分离，克隆和测序编码恒河猴癌胚抗原（rhCEA）的DNA。编码CEA的基因通常与人类癌的发展有关。本发明提供了引发或增强由CEA肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常CEA表达与癌症或其发展相关。本发明具体提供携带rhCEA的腺病毒载体构建体，并公开了它们在预防和治疗癌症的疫苗和药物组合物中的用途。

4. 发明授权

US07662586B2 Synthetic gene encoding human epidermal growth factor 2/neu antigen and uses thereof 有权
标题翻译：编码人表皮生长因子2 / neu抗原的合成基因及其用途
公开(公告)号：US07662586B2
公开(公告)日：2010-02-16
申请号：US12291886
申请日：2008-11-14
申请人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
发明人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
IPC分类号： C12P21/06 , C12N15/00 , C12N5/00 , C07H21/04
CPC分类号： C07K14/71 , C07K16/32 , C12N7/00 , C12N2710/10043
摘要： Synthetic polynucleotides encoding human HER2/neu or a truncated form thereof, are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding hHER2 is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the hHER2 tumor-associated antigen, wherein aberrant hHER2 expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimized human HER2 and codon-optimized truncated HER2, and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码人HER2 / neu或其截短形式的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码hHER2的基因通常与人类癌的发展有关。本发明提供了引发或增强对由hHER2肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常hHER2表达与癌症或其发展相关。本发明具体提供携带密码子优化的人HER2和密码子优化的截短的HER2的腺病毒载体和质粒构建体，并公开了它们用于预防和治疗癌症的疫苗和药物组合物中。

5. 发明申请

US20090098604A1 Synthetic gene encoding human epidermal growth factor 2/NEU antigen and uses thereof 有权
标题翻译：编码人表皮生长因子2 / NEU抗原的合成基因及其用途
公开(公告)号：US20090098604A1
公开(公告)日：2009-04-16
申请号：US12291886
申请日：2008-11-14
申请人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
发明人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
IPC分类号： C12P21/04 , C12N15/11 , C12N15/00 , C12N5/08
CPC分类号： C07K14/71 , C07K16/32 , C12N7/00 , C12N2710/10043
摘要： Synthetic polynucleotides encoding human HER2/neu or a truncated form thereof, are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding hHER2 is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the hHER2 tumor-associated antigen, wherein aberrant hHER2 expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimized human HER2 and codon-optimized truncated HER2, and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码人HER2 / neu或其截短形式的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码hHER2的基因通常与人类癌的发展有关。本发明提供了引发或增强对由hHER2肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常hHER2表达与癌症或其发展相关。本发明具体提供携带密码子优化的人HER2和密码子优化的截短的HER2的腺病毒载体和质粒构建体，并公开了它们用于预防和治疗癌症的疫苗和药物组合物中。

6. 发明申请

US20110286916A1 GENERATION AND CHARACTERIZATION OF ANTI-NOTCH ANTIBODIES FOR THERAPEUTIC AND DIAGNOSTIC USE 审中-公开
标题翻译：用于治疗和诊断用途的抗麻醉抗体的产生和表征
公开(公告)号：US20110286916A1
公开(公告)日：2011-11-24
申请号：US13130441
申请日：2009-11-16
申请人： Jose Miguel Aste-Amezaga , Ningyan Zhang , Fubao Wang , Andrew Bett , Anna Demartis , Maurizio Nuzzo , Paolo Monaci , Stephen Blacklow , Jon Aster
发明人： Jose Miguel Aste-Amezaga , Ningyan Zhang , Fubao Wang , Andrew Bett , Anna Demartis , Maurizio Nuzzo , Paolo Monaci , Stephen Blacklow , Jon Aster
IPC分类号： A61K39/395 , C12N1/20 , A61P35/00 , A61K49/00 , A61K51/10 , C12N9/96 , C07K16/28 , G01N33/53
CPC分类号： C07K16/28 , A61K2039/505 , C07K2317/56 , C07K2317/565 , C07K2317/622 , G01N33/57415
摘要： The present invention relates to mammalian antibodies, preferably fully human monoclonal antibodies and antigen-binding portions thereof that specifically bind to a cell surface receptor, wherein the receptor protein is a Notch1 receptor protein. Some of the disclosed antibodies bind Notch1 to the exclusion of other members of the Notch receptor family, while other antibodies bind Notch 1 and Notch3. Nucleic acid molecules encoding the Notch antibodies as well as methods of use thereof are also disclosed. Also included are pharmaceutical compositions comprising these antibodies and methods of using the antibodies and compositions thereof for treatment and diagnosis of pathological hyperproliferative oncogenic disorders associated with expression of Notch1 or Notch3 including aberrant activation of each of these receptors.
摘要翻译：本发明涉及特异性结合细胞表面受体的哺乳动物抗体，优选完全人单克隆抗体及其抗原结合部分，其中受体蛋白是Notch1受体蛋白。一些所公开的抗体结合Notch1排除Notch受体家族的其他成员，而其他抗体结合Notch1和Notch3。还公开了编码Notch抗体的核酸分子及其使用方法。还包括包含这些抗体的药物组合物和使用抗体及其组合物用于治疗和诊断与Notch1或Notch3表达相关的病理性过度增殖性致癌性疾病的方法，包括这些受体中的每一种的异常活化。

7. 发明申请

US20070111957A1 Synthetic gene encoding human epidermal growth factor 2/neu antigen and uses thereof 审中-公开
标题翻译：编码人表皮生长因子2 / neu抗原的合成基因及其用途
公开(公告)号：US20070111957A1
公开(公告)日：2007-05-17
申请号：US10565418
申请日：2004-07-20
申请人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
发明人： Paolo Monaci , Pasquale Gallo , Maurizio Nuzzo
IPC分类号： A61K48/00 , C07H21/04 , C12P21/06 , C07K14/705 , C12N15/86
CPC分类号： C07K14/71 , C07K16/32 , C12N7/00 , C12N2710/10043
摘要： Synthetic polynucleotides encoding human HER2/neu or a truncated form thereof, are provided, the synthetic polynucleotides being codon-optimized for expression in a human cellular environment. The gene encoding hHER2 is commonly associated with the development of human carcinomas. The present invention provides compositions and methods to elicit or enhance immunity to the protein product expressed by the hHER2 tumor-associated antigen, wherein aberrant hHER2 expression is associated with a carcinoma or its development. This invention specifically provides adenoviral vector and plasmid constructs carrying codon-optimized human HER2 and codon-optimized truncated HER2, and discloses their use in vaccines and pharmaceutical compositions for preventing and treating cancer.
摘要翻译：提供了编码人HER2 / neu或其截短形式的合成多核苷酸，所述合成多核苷酸被密码子优化用于在人细胞环境中表达。编码hHER2的基因通常与人类癌的发展有关。本发明提供了引发或增强对由hHER2肿瘤相关抗原表达的蛋白质产物的免疫的组合物和方法，其中异常hHER2表达与癌症或其发展相关。本发明具体提供携带密码子优化的人HER2和密码子优化的截短的HER2的腺病毒载体和质粒构建体，并公开了它们用于预防和治疗癌症的疫苗和药物组合物中。

8. 发明授权

US07611868B2 Recombinant modified adenovirus fiber protein 失效
标题翻译：重组修饰型腺病毒纤维蛋白
公开(公告)号：US07611868B2
公开(公告)日：2009-11-03
申请号：US10556877
申请日：2004-05-10
申请人： Paolo Monaci , Laura Fontana
发明人： Paolo Monaci , Laura Fontana
IPC分类号： C07K14/75 , C07K14/005 , C12N15/861 , A61K38/00 , A61K48/00
CPC分类号： C07K14/005 , A61K48/00 , C07K2319/00 , C07K2319/735 , C12N15/86 , C12N2710/10322 , C12N2710/10343 , C12N2710/10345 , C12N2810/40 , C12N2810/80 , C12N2840/20
摘要： Recombinant adenoviruses comprising modified fiber proteins which expand the tropism of the adenovirus in comparison to wild-type virus are disclosed. The modified fiber proteins described herein contain a peptide ligand for a cell surface binding site other than CAR comprising a 14 amino acid core sequence containing both fixed and variable amino acid residues. The invention includes isolated nucleic acid molecules encoding the modified adenovirus fiber proteins disclosed, as well as recombinant vectors and host cells containing said nucleic acid molecules. Methods of identifying peptide ligands that bind to cell binding sites other than CAR are included comprising screening a phage-display library of peptide ligands expressed within an adenovirus fiber knob context on CAR-negative cells. Recombinant adenoviruses of the present invention will increase the ability of an adenovirus to transduce important cell and tissue targets as part of a gene therapy/gene vaccination regime that have been shown to be refractory to adenoviral infection.
摘要翻译：公开了包含与野生型病毒相比扩展腺病毒嗜性的修饰的纤维蛋白质的重组腺病毒。本文所述的修饰的纤维蛋白质包含除CAR之外的细胞表面结合位点的肽配体，其包含含有固定和可变氨基酸残基的14个氨基酸核心序列。本发明包括编码公开的修饰的腺病毒纤维蛋白的分离的核酸分子，以及含有所述核酸分子的重组载体和宿主细胞。包括鉴定结合除CAR以外的细胞结合位点的肽配体的方法包括筛选在CAR阴性细胞上的腺病毒纤维旋钮上下文中表达的肽配体的噬菌体展示文库。本发明的重组腺病毒将增加腺病毒转导重要细胞和组织靶标的能力，作为已被证明对腺病毒感染难治的基因治疗/基因疫苗接种方案的一部分。

9. 发明授权

US5994083A Process for the preparation of immunogens or diagnostic reagents, and immunogens or diagnostic reagents thereby obtainable 失效
公开(公告)号：US5994083A
公开(公告)日：1999-11-30
申请号：US553257
申请日：1995-11-13
申请人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
发明人： Franco Felici , Alessandra Luzzago , Paolo Monaci , Alfredo Nicosia , Riccardo Cortese
IPC分类号： G01N33/53 , A61K35/76 , A61K39/00 , C07K7/08 , C07K14/02 , C07K14/18 , C07K14/47 , C07K16/32 , C09K8/38 , C12N7/00 , C12N15/09 , C12N15/10 , C40B30/06 , C40B40/02 , G01N33/569 , G01N33/576 , G01N33/537 , G01N33/566
CPC分类号： C40B40/02 , C07K14/005 , C07K14/4713 , C07K16/32 , C12N15/1037 , A61K39/00 , C07K2319/40 , C07K2319/735 , C12N2730/10122 , C12N2770/24222 , Y10S436/811
摘要： A process for the preparation of immunogens or diagnostic reagents that mimic an antigen or a pathogenic organism specific to a disease, essentially characterized by the following operations: identification of at least one antibody that reacts with the antigen or pathogenic organism specific to the disease; construction of phage libraries which display on the surface of the capsid oligopeptides, expressed from random sequence oligonucleotidic inserts introduced into a gene coding for a phage capsid protein using genetic manipulation techniques (for example using a plasmid engineered for the purposes of the invention, the genetic map of which is shown in the figure); selection of the phages that display on the surfaces of the capsid antigenic oligopeptides recognized by said antibody; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of diagnostic kits for the specific pathogenic agent, or in general for the diseases, including immunological disorders typical of so-called autoimmune diseases, with known or unknown etiology and/or pathogenesis; optional use of the selected phages and/or fragments thereof and/or their derivatives for the formulation of an antagonist ofthe antigen-antibody reactions for treatment of the disease induced by said antigen; optional use of the selected phages and/or fragments thereof and/or their derivatives to induce a tolerance of the phenomena of hypersensitivity and/or allergy to compounds and/or natural or synthetic preparations; optional immunization of an organism by means of the selected phages and/or fragments thereof and/or their derivatives; and optional verification of the presence, in the serum of the immunized organism, of antibodies that recognize the above antigen or organism specific to the disease.

10. 发明申请

US20130273081A1 VACCINATION AGAINST PCSKK 9 FOR LOWERING CHOLESTEROL 审中-公开
标题翻译：用于降低胆固醇的PCSKK 9
公开(公告)号：US20130273081A1
公开(公告)日：2013-10-17
申请号：US13637144
申请日：2011-03-25
申请人： Paolo Monaci , Andrea Carfi
发明人： Paolo Monaci , Andrea Carfi
IPC分类号： A61K38/48
CPC分类号： A61K38/482 , A61K39/0005 , A61K2039/53 , C12N9/6408
摘要： The present invention relates to pharmaceutical compositions comprising PCSK9 DNA or PCSK9 proteins or PC-SK9 peptides and CpG adjuvant; this composition is used to lower cholesterol levels specifically LDL cholesterol levels.
摘要翻译：本发明涉及包含PCSK9 DNA或PCSK9蛋白或PC-SK9肽和CpG佐剂的药物组合物; 该组合物用于降低胆固醇水平，特别是低密度脂蛋白胆固醇水平。

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