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1. 发明申请

US20100008972A1 Film for active ingredients dermal and transdermal administration 审中-公开
标题翻译：用于活性成分的皮肤皮肤和透皮给药
公开(公告)号：US20100008972A1
公开(公告)日：2010-01-14
申请号：US12459361
申请日：2009-06-30
申请人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
发明人： Paolo Colombo , Pier Luigi Catellani , Cristina Padula , Patrizia Santi , Gaia Colombo
IPC分类号： A61K9/70 , A61P43/00
CPC分类号： A61K9/0009 , A61K9/7007 , A61K9/7015
摘要： Single-layer film for active ingredients dermal and transdermal administration containing at least an active ingredient, a film-forming agent, and a hydrophilic adhesive polymer.
摘要翻译：含有至少活性成分，成膜剂和亲水性粘合剂聚合物的用于活性成分的皮肤和透皮给药的单层膜。

2. 发明申请

US20100074926A1 MODULES, NEW ASSEMBLAGE KITS AND NEW ASSEMBLES FOR THE CONTROLLED RELEASE OF SUBSTANCES 审中-公开
标题翻译：用于控制释放物质的模块，新组装工具和新组件
公开(公告)号：US20100074926A1
公开(公告)日：2010-03-25
申请号：US12312831
申请日：2006-12-05
申请人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
发明人： Paolo Colombo , Patrizia Santi , Ruggero Bettini , Orazio Luca Strusi , Fabio Sonvico , Gaia Colombo
IPC分类号： A61K9/00 , A61J3/10
CPC分类号： A61K9/2072 , A61K9/0065
摘要： A module which is destroyed in the presence of water solution, composed of a compressed powdery mixture, the said powdery mixture comprising a matrix building component, suitable to release an optionally included active substance into a surrounding aqueous liquid, and one or more tabletting aids chosen from the group consisting of lubricants, glidants, and anti-adherent agents, the said module being provided with particular male topological features allowing its connection to a corresponding female module, giving raise to an assembly that can be safely handled on industrial scale, wherein, in the composition of the male module, the percentage ratio between the tabletting aid and the matrix building component is comprised between 1:2.5 and 1:999. The module can be employed to convey pharmaceuticals, nutraceuticals, agrochemicals or other active principles to the intended site of action.
摘要翻译：在水溶液存在下被破坏的模块，由压缩的粉末混合物组成，所述粉末混合物包含基质构建组分，其适于将任选包含的活性物质释放到周围的水性液体中，并且选择一种或多种压片助剂从由润滑剂，助流剂和抗粘附剂组成的组中，所述模块具有特定的男性拓扑特征，允许其连接到相应的阴模块，从而提高可以以工业规模安全地处理的组件，其中，在阳模组合物中，压片助剂和基质构成成分之间的百分比为1:2.5至1:9999。该模块可用于将药物，营养品，农用化学品或其他活性成分输送到预期的作用位置。

3. 发明申请

US20100233276A1 COMPOSITIONS IN POWDER FORM MADE OF SOFT AGGLOMERATES OF A MICRONIZED DRUG AND OF A TWO-COMPONENTS EXCIPIENT, AND PROCESS FOR THEIR PREPARATION 审中-公开
标题翻译：一种微量药物和两种组分的软组合粉末形式的组合物及其制备方法
公开(公告)号：US20100233276A1
公开(公告)日：2010-09-16
申请号：US12734300
申请日：2007-10-26
申请人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
发明人： Renata Raffin , Paolo Colombo , Fabio Sonvico , Gaia Colombo , Alessandra Rossi , Francesca Buttini
IPC分类号： A61K9/14 , A61K9/50 , A61K9/58 , A61K9/60 , A61K9/62 , A61K9/64
CPC分类号： A61K9/1617 , A61K9/1623
摘要： The described agglomeration of drug microparticles blended with excipient microparticles is a technique for the size enlargement of micronized products that could be damaged by granulation or compaction techniques. These agglomerates can be used as oral prompt or delayed-release dosage forms administered as they are or dispersed in a liquid. The composition and quantity of the excipient microparticles resulted to be the crucial factors for the agglomerate quality. Therefore, adjusting the content of surface-active agent between 8-20%, of the excipient microparticles it is possible to agglomerate microparticles of drugs that could not be agglomerated per se. Increasing the surfactant concentration in the spray-dried excipient microparticles or increasing the fraction of these excipient microparticles in the blend, the agglomeration was improved. The spray drying technique concentrates the surface-active agent on the microparticle surface. By tumbling, the surface-active agent present on microparticles excipient surface was spread to fill the inter-particle interstices of drug particles giving rise to more resistant agglomerates. This phenomenon occurred also by vibration; the production in this case was quicker.
摘要翻译：与赋形剂微粒混合的药物微粒的所述团聚是用于通过造粒或压实技术损坏的微粉化产品的尺寸增大的技术。这些附聚物可以作为口服或缓释剂型使用，或者分散在液体中。赋形剂微粒的组成和数量是聚集质量的关键因素。因此，调整表面活性剂的含量在8〜20％之间，赋形剂微粒可能聚集本身不能团聚的药物微粒。增加喷雾干燥的赋形剂微粒中的表面活性剂浓度或增加共混物中这些赋形剂微粒的分数，聚集得到改善。喷雾干燥技术将表面活性剂浓缩在微粒表面上。通过翻滚，存在于微粒赋形剂表面上的表面活性剂被扩散以填充药物颗粒的颗粒间隙，从而产生更多的抗凝结物质。这种现象也是由振动引起的。在这种情况下的生产更快。

4. 发明申请

US20130274209A1 SPRAYABLE PHARMACEUTICAL COMPOSITIONS FOR TOPICAL APPLICATION COMPRISING SUCRALFATE GEL 审中-公开
标题翻译：用于包含酸性凝胶的局部应用的可喷涂药物组合物
公开(公告)号：US20130274209A1
公开(公告)日：2013-10-17
申请号：US13996780
申请日：2011-12-21
申请人： Gaia Colombo , Paolo Colombo , Laura Gallina , Alessandra Scagliarini , Fabio Sonvico
发明人： Gaia Colombo , Paolo Colombo , Laura Gallina , Alessandra Scagliarini , Fabio Sonvico
IPC分类号： A61K47/32
CPC分类号： A61K47/32 , A61K31/7016 , A61L26/0014 , A61L26/0066 , A61L26/0076 , A61L26/008 , A61L2300/232 , C08L29/04
摘要： A pharmaceutical composition is described comprising sucralfate gel, PVA and optionally a vegetable product comprising tocotrienols and tocopherols. In particular, this composition proved to be suitable for being sprayed, and is advantageously used in the treatment of skin lesions, even deep lesions, such as second-degree burns.
摘要翻译：描述了包含硫糖铝凝胶，PVA和任选的包含生育三烯酚和生育酚的植物产品的药物组合物。特别地，该组合物被证明适合于喷雾，并且有利地用于治疗皮肤损伤，甚至深度损伤，例如二度烧伤。

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