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1. 发明申请

US20190032060A1 APTAMER AGAINST INSULIN RECEPTOR AND PHARMACEUTICAL COMPOSITION CONTAINING THE SAME 审中-公开
公开(公告)号：US20190032060A1
公开(公告)日：2019-01-31
申请号：US15746654
申请日：2016-05-03
申请人： POSCO , POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人： Sung Ho RYU , Na-Oh YUNN , Jong Hun IM , Ara KOH , Eun Ju OH , Sehoon PARK , Jiyoun LEE , Sung Key JANG , Seungmin HAN , Youndong KIM
IPC分类号： C12N15/113 , A61K38/28 , A61K31/7088 , A61P3/10 , G01N33/74
CPC分类号： C12N15/1138 , A61K31/7088 , A61K31/711 , A61K38/28 , A61P3/10 , C12N15/115 , C12N2310/16 , C12N2310/335 , G01N33/53 , G01N33/74 , G01N2333/62
摘要： The present disclosure relates to a DNA aptamer which specifically binds to an insulin receptor, and a composition for treating diabetes and a composition for diagnosing diabetes which contain the same as an active ingredient, and the aptamer is characterized by being able to treat and diagnose diabetes more effectively than side effects caused by insulin such as increased incidence of cancer and atherosclerosis by having a different binding mechanism from existing insulin.

2. 发明申请

US20150359911A1 Aptamer Specific to Integrin alpha-v-beta-3 and Use Thereof 审中-公开
标题翻译：适用于整合素α-v-β-3的用途及其用途
公开(公告)号：US20150359911A1
公开(公告)日：2015-12-17
申请号：US14418266
申请日：2013-07-31
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , YONSEI UNIVERSITY, UNIVERSITY-INDUSTRY FOUNDATION (UIF)
发明人： Jung Hwan LEE , Seungjoo HAAM , Yong-min HUH , Young Chan CHAE , Sung Ho RYU , Eun-kyung LIM , Jong In KIM
IPC分类号： A61K49/18 , G01N33/574
CPC分类号： A61K49/1866 , C12N15/115 , C12N2310/16 , C12Q1/6886 , G01N33/57492 , G01N2333/70557
摘要： The present invention relates to DNA aptamer specifically binding to integrin αvβ3, and a composition for diagnosis of cancer or cancer metastasis comprising the same as an active ingredient. And, the present invention relates to a composition for imaging tumor regions comprising the aptamer, and a contrast medium comprising the same.
摘要翻译：本发明涉及与整联蛋白αv＆bgr3特异性结合的DNA适配体，以及包含其作为活性成分的癌症或癌症转移的诊断用组合物。另外，本发明涉及包含该适体的肿瘤区域成像用组合物和包含该适体的造影剂。

3. 发明申请

US20160116468A1 METHOD OF ANALYZING BINDING ASPECT OF MEMBRANE PROTEIN IN A LIVING CELL 有权
标题翻译：分析细胞膜蛋白的结合方式的方法
公开(公告)号：US20160116468A1
公开(公告)日：2016-04-28
申请号：US14891555
申请日：2014-05-16
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人： Sung Ho RYU , Dohyeon KIM , Nam Ki LEE , Dong Kyun KIM , Soyeon PARK , Yonghoon KWON , Kai ZHOU
IPC分类号： G01N33/557
CPC分类号： G01N33/557 , G01N33/554
摘要： The present invention relates to a method for analyzing the pattern of live intercellular membrane protein binding. The method for analyzing the pattern according to the present invention can analyze accurately, sensitively, quickly, and readily the binding pattern of a target membrane protein and a candidate substance to be specifically bound therewith without tagging to a ligand, and thus measure directly and accurately the position and quantitative information of the binding of the membrane protein and the target substance. Such effects make it possible to apply the method for various uses such as dissociation constant, mutant study, complex formation, and signal transduction. Moreover, it is expected to use the method for searching out undiscovered membrane proteins and target substances.
摘要翻译：本发明涉及一种分析活细胞间膜蛋白结合模式的方法。根据本发明的分析方法可以准确，灵敏，快速，容易地分析靶蛋白和候选物质的结合模式，而不需要将其标记到配体上，从而直接和准确地测量膜蛋白和靶物质结合的位置和定量信息。这样的效果使得可以应用诸如解离常数，突变体研究，复合物形成和信号转导等各种用途的方法。此外，预期使用用于搜索未发现的膜蛋白和靶物质的方法。

4. 发明申请

US20180296615A1 PHARMACEUTICAL COMPOSITION OR FUNCTIONAL HEALTH FOOD FOR PREVENTING AND TREATING METABOLIC DISEASES, CONTAINING WATER EXTRACT OF PLEUROTUS ERYNGII VAR. FERULAE (PF.) AS ACTIVE INGREDIENT 审中-公开
公开(公告)号：US20180296615A1
公开(公告)日：2018-10-18
申请号：US15576768
申请日：2016-05-09
申请人： KYONGSANGBUK-DO , POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人： Sung Ho RYU , Jaewang GHIM , Jong In KIM , Jaeyoon KIM , Yongmi KIM , Youngwoo CHOI , Kyung-Jin JO , Wook Dong KIM , Sang Kap SHIM , Woo Jae CHEON , Jong Hyeok NAM
IPC分类号： A61K36/07 , A61P3/04 , A61P3/10 , A61K9/16 , A61K9/20 , A61K9/48 , A61K9/08 , A61K47/26 , A61K9/00 , A61K47/02 , A23L31/00 , A23L33/10
摘要： The present invention relates to a composition for preventing and treating metabolic disorders, containing a water extract of Pleurotus eryngii var. ferulea (Pf) as an active ingredient, wherein the water extract of Pleurotus eryngii var. ferulea (Pf) has a remarkable effect of being able to be used as a pharmaceutical composition or functional health food for preventing or treating obesity or diabetes by confirming the functionality whereby fat accumulation and blood glucose increase generated when taking a high fat diet can be inhibited.

5. 发明申请

US20160375073A1 COMPOSITION FOR TREATMENT OR PREVENTION OF OBESITY, CONTAINING WATER EXTRACTS OF FOMITELLA FRAXINEA 审中-公开
标题翻译：用于治疗或预防肥胖的组合物，含有FOMITELLA FRAXINEA的水提取物
公开(公告)号：US20160375073A1
公开(公告)日：2016-12-29
申请号：US15239352
申请日：2016-08-17
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION , KYEONGSANGBUK-DO
发明人： Sung Ho RYU , Hyeongji LEE , Taehoon LEE , Jaeyoon KIM , Jong-Vong EUN , Kang-Ha KIM , Sang-Gap SHIM , Woo-Jae CHEON
IPC分类号： A61K36/07
CPC分类号： A61K36/07 , A23L2/52 , A23L33/105 , A61K36/06 , A61K2236/331
摘要： The present invention relates to a composition for the treatment or prevention of obesity, the composition containing water extracts of Fomitella fraxinea as an active ingredient, and to a medicine and a dietary supplement, containing the extracts.
摘要翻译：本发明涉及用于治疗或预防肥胖症的组合物，含有作为活性成分的Fomitella fraxinea的水提取物的组合物和含有提取物的药物和膳食补充剂。

6. 发明申请

US20160361288A1 PHARMACEUTICAL COMPOSITIONS FOR PREVENTING OR TREATING DIABETIC NEPHROPATHY COMPRISING THE ACTIVITY INHIBITOR OF TENC1 审中-公开
标题翻译：用于预防或治疗包含TENC1活性抑制剂的糖尿病患者的药物组合物
公开(公告)号：US20160361288A1
公开(公告)日：2016-12-15
申请号：US15176064
申请日：2016-06-07
申请人： POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人： Sung Ho RYU , Jiyoun LEE , Heeyoon JEONG , Ara KOH
IPC分类号： A61K31/343
CPC分类号： A61K31/343 , A61K31/4706
摘要： Provided is a pharmaceutical composition for preventing or treating diabetic nephropathy, comprising a tensin like C1 domain containing phosphatase (TENC1) inhibitor as an active ingredient. A new target for treating diabetic nephropathy is presented by confirming that TENC1 expression is increased in kidney tissue of diabetes or a podocyte cell line to which a high blood glucose environment is given and experimentally proving that nephrin phosphorylation inhibited by the PTPase activity of TENC1 affects the permeability and mTORC1 signaling of the podocytes resulting in inducing podocyte hypertrophy. As the pharmaceutical composition comprising a TENC1 inhibitor as an active ingredient inhibits nephrin dephosphorylation by TENC1, podocytes damaged from an early stage of the diabetic nephropathy may be protected and the structure and filtration function of the podocytes may be maintained, therefore the pharmaceutical composition is expected to be widely used in preventing or treating the diabetic nephropathy from an early stage.
摘要翻译：提供了用于预防或治疗糖尿病性肾病的药物组合物，其包含含有磷酸酶（TENC1）抑制剂作为活性成分的张力样C1结构域。通过证实在糖尿病的肾组织或给予高血糖环境的足细胞细胞系中TENC1表达增加，并且实验证明由TENC1的PTPase活性抑制的肾上腺素磷酸化影响了糖尿病肾病的新靶点通透性和mTORC1信号的足细胞导致足细胞肥大。作为含有TENC1抑制剂作为活性成分的药物组合物，可以通过TENC1抑制尼泊金去磷酸化，可以保护从糖尿病肾病早期受损的足细胞，保持足细胞的结构和过滤功能，因此预期药物组合物被广泛用于早期预防或治疗糖尿病肾病。

7. 发明申请

US20150337309A1 APTAMER FOR PERIOSTIN AND ANTI-CANCER COMPOSITION INCLUDING SAME 有权
标题翻译：用于孕激素和抗癌组合物的APTAMER包括它们
公开(公告)号：US20150337309A1
公开(公告)日：2015-11-26
申请号：US14411176
申请日：2012-11-12
申请人： UNIST ACADEMY-INDUSTRY RESEARCH CORPORATION , POSTECH ACADEMY-INDUSTRY FOUNDATION
发明人： Pann-Ghill SUH , Il Shin KIM , Yu Jin LEE , Youn Dong KIM , Young Chan CHAE , Jong Hun IM , Sung Ho RYU
IPC分类号： C12N15/115 , G01N33/574
CPC分类号： C12N15/115 , A61K31/7088 , C12N2310/16 , C12N2310/335 , C12N2320/30 , G01N33/57492 , G01N2333/705
摘要： This disclosure relates to DNA aptamer specifically binding to periostin, which is cancer-related protein, a composition for inhibiting cancer and/or cancer metastasis and/or a composition for diagnosis of cancer and/or cancer metastasis, comprising the same as an active ingredient, wherein the aptamer has different binding mechanism from the existing antibodies, and thus, may inhibit and diagnose cancer/cancer metastasis more effectively.
摘要翻译：本公开涉及特异性结合骨膜素的DNA适体，其是与癌症相关的蛋白质，用于抑制癌症和/或癌症转移的组合物和/或癌症和/或癌症转移的诊断用组合物，其包含其作为活性成分其中适体与现有抗体具有不同的结合机制，因此可以更有效地抑制和诊断癌症/癌症转移。

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