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1. 发明申请

US20190271004A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA 审中-公开
公开(公告)号：US20190271004A1
公开(公告)日：2019-09-05
申请号：US16411671
申请日：2019-05-14
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： RAFAEL HERRMANN , MICHAEL LASSNER , ALBERT L. LU , MARK EDWARD NELSON , JAMES KEVIN PRESNAIL , JANET RICE
IPC分类号： C12N15/82 , C12N15/113 , A01N65/44 , A01N65/20
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

2. 发明申请

US20220267792A1 COMPOSITIONS AND METHODS TO CONTROL INSECT PESTS 有权
公开(公告)号：US20220267792A1
公开(公告)日：2022-08-25
申请号：US17661297
申请日：2022-04-29
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： XU HU , BLISS MARIE KERNODLE , MOLLIE MARY MCMAHON , ADANE KASSA , XIPING NIU , JAMES KEVIN PRESNAIL , ALBERT L. LU , NINA RICHTMAN , JONATHAN WILLIAM ROBESON
IPC分类号： C12N15/82 , C07K14/435 , A01N37/46 , A01N65/00 , A01N63/60 , C12N15/113
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a plant insect pest, such as Coleopteran, Hemiptera, or Lepidopteran plant pest, including a Diabrotica, Leptinotarsa, Phyllotreta, Acyrthosiphan, Bemisia, Halyomorpha, Nezara, or Spodoptera plant pest, decrease the expression of a target sequence in the pest. Disclosed are various target polynucleotides set forth in any one of SEQ ID NOS: 1-53 or 107-254 disclosed herein, or variants and fragments thereof, or complements thereof, wherein a decrease in expression of one or more of the sequences in the target pest controls the pest and pest population by insect sterilization (i.e., male and female sterility, reduction of sperm count, egg production and viability) and mating-based sterile insect technique (SIT). Plants, plant parts, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

3. 发明申请

US20180042242A1 INSECTICIDAL COMBINATIONS OF PIP-72 AND METHODS OF USE 审中-公开
公开(公告)号：US20180042242A1
公开(公告)日：2018-02-15
申请号：US15556785
申请日：2016-03-03
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： SCOTT HENRY DIEHN , XU HU , ALBERT L. LU , LU LIU , JAMES KEVIN PRESNAIL , GARY A. SANDAHL , UTE SCHELLENBERGER , GUSUI WU
IPC分类号： A01N63/02 , A01N57/20 , C12N15/113 , A01N37/46 , C12N15/82 , C07K14/21
CPC分类号： A01N63/02 , A01N37/46 , A01N57/20 , C07K14/21 , C12N15/1138 , C12N15/8286 , C12N2310/11 , Y02A40/162
摘要： Compositions and methods for controlling pests are provided. The methods involve transforming organisms with one or more nucleic acid sequence encoding insecticidal protein(s) and one or more silencing element(s). In particular, the nucleic acid sequences are useful for preparing plants and microorganisms that possess insecticidal activity. Thus, transformed bacteria, plants, plant cells, plant tissues and seeds are provided. Compositions are insecticidal nucleic acids and proteins of bacterial species. The sequences find use in the construction of expression vectors for subsequent transformation into organisms of interest including plants, as probes for the isolation of other homologous (or partially homologous) genes. The molecular and breeding stacks find use in controlling, inhibiting growth or killing Lepidopteran, Coleopteran, Dipteran, fungal, Hemipteran and nematode pest populations and for producing compositions with insecticidal activity.

4. 发明申请

US20180030472A1 COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS 审中-公开
公开(公告)号：US20180030472A1
公开(公告)日：2018-02-01
申请号：US15730315
申请日：2017-10-11
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： KAREN E. BROGLIE , DAVID CHARLES CERF , RAFAEL HERRMANN , ALBERT L. LU , BRIAN MCGONIGLE , JAMES KEVIN PRESNAIL
IPC分类号： C12N15/82 , A01N65/44 , A01N57/16 , C12N15/113 , A01N65/00
CPC分类号： C12N15/8286 , A01N57/16 , A01N65/00 , A01N65/44 , C12N15/113 , C12N15/8218 , C12N2310/14 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

5. 发明申请

US20170175133A1 COMPOSITIONS AND METHODS FOR THE SUPPRESSION OF TARGET POLYNUCLEOTIDES FROM LEPIDOPTERA 审中-公开
公开(公告)号：US20170175133A1
公开(公告)日：2017-06-22
申请号：US15446107
申请日：2017-03-01
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E I DU PONT DE NEMOURS AND COMPANY
发明人： RAFAEL HERRMANN , MICHAEL LASSNER , ALBERT L. LU , MARK EDWARD NELSON , JAMES KEVIN PRESNAIL , JANET A. RICE
IPC分类号： C12N15/82 , A01N65/44 , A01N65/20 , C12N15/113
CPC分类号： C12N15/8286 , A01N65/20 , A01N65/44 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2320/32 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.

6. 发明申请

US20150025124A1 Compositions and Methods for the Suppression of Target Polynucleotides from Lepidoptera 审中-公开
标题翻译：抑制鳞翅目标多核苷酸的组合物和方法
公开(公告)号：US20150025124A1
公开(公告)日：2015-01-22
申请号：US14501240
申请日：2014-09-30
申请人： PIONEER HI BRED INTERNATIONAL INC , E I DU PONT DE NEMOURS AND COMPANY
发明人： RAFAEL HERRMANN , MICHAEL LASSNER , ALBERT L. LU , MARK EDWARD NELSON , JAMES KEVIN PRESNAIL , JANET A. RICE
IPC分类号： C12N15/82 , C12N15/113
CPC分类号： C12N15/8286 , A01N65/20 , A01N65/44 , C12N15/113 , C12N2310/11 , C12N2310/14 , C12N2310/531 , C12N2320/32 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a pest from the Lepidoptera order, they are capable of decreasing the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides target polynucleotides encoding polypeptides from specific protein families and various target polynucleotides set forth in SEQ ID NOS: 1, 2, 3, 4, 5, 6, 7, 8, 9, 10, 11, 12, 13, 14, 15, 16, 17, 18, 19, 20, 21, 22, 23, 24, 25, 26, 27, 28, 29, 30, 31, 32, 33, 34, 35, 36, 37, 38, 39, 40, 41, 42, 43, 44, 45, 46, 47, 48, 49, or 50 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Spodoptera frugiperda. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当沉积元件在被害虫如来自鳞翅目序列的害虫中摄取时，它们能够降低害虫中靶序列的表达。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供编码来自特定蛋白质家族的多肽的多核苷酸和SEQ ID NO：1,2,3,4,5,6,7,8,9,10,11,12,13,14中所示的各种靶多核苷酸的靶多核苷酸，15，16，17，18，19，20，21，22，23，24，25，26，27，28，29，30，31，32，33，34，35，36，37，38，39 ，40,41,42,43,44,45,46,47,48,49或50个或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即，具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是草地夜蛾（Spodoptera frugiperda）。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

7. 发明申请

US20190071689A1 MAIZE EVENT DP-033121-3 AND METHODS FOR DETECTION THEREOF 审中-公开
公开(公告)号：US20190071689A1
公开(公告)日：2019-03-07
申请号：US16128583
申请日：2018-09-12
申请人： E. I. DU PONT DE NEMOURS AND COMPANY , PIONEER HI-BRED INTERNATIONAL, INC.
发明人： MARY BEATTY , KENT BRINK , VIRGINIA CRANE , SCOTT DIEHN , ALBERT L. LU , GREGORY J. YOUNG
IPC分类号： C12N15/82 , C12Q1/6895 , C07K14/325 , A01H5/10
摘要： The disclosure provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-033121-3 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.

8. 发明申请

US20180171348A1 PLANT REGULATORY ELEMENTS AND METHODS OF USE THEREOF 审中-公开
公开(公告)号：US20180171348A1
公开(公告)日：2018-06-21
申请号：US15735545
申请日：2016-06-16
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： SCOTT DIEHN , ALBERT L. LU , MICHELLE VAN ALLEN
IPC分类号： C12N15/82
摘要： The present disclosure provides compositions and methods for regulating expression of heterologous nucleotide sequences in a plant. Compositions include a novel nucleotide sequence for regulatory elements from Eupatorium Vein Clearing Virus. A method for expressing a heterologous nucleotide sequence in a plant using the regulatory element sequences disclosed herein is provided. The method comprises transforming a plant or plant cell with a nucleotide sequence operably linked to one of the regulatory elements of the present disclosure.

9. 发明申请

US20150052643A1 COMPOSITIONS AND METHODS FOR INSECTICIDAL CONTROL OF STINKBUGS 审中-公开
标题翻译： STINKBUGS的杀虫剂控制组合物和方法
公开(公告)号：US20150052643A1
公开(公告)日：2015-02-19
申请号：US14525482
申请日：2014-10-28
申请人： PIONEER HI BRED INTERNATIONAL INC , E I DU PONT DE NEMOURS AND COMPANY
发明人： KAREN E. BROGLIE , DAVID CHARLES CERF , RAFAEL HERRMANN , ALBERT L. LU , BRIAN MCGONIGLE , JAMES KEVIN PRESNAIL
IPC分类号： C12N15/82 , A01N57/16 , C12N15/113
CPC分类号： C12N15/8286 , A01N57/16 , A01N65/00 , A01N65/44 , C12N15/113 , C12N15/8218 , C12N2310/14 , C12N2310/531 , Y02A40/162
摘要： Methods and compositions are provided which employ a silencing element that, when ingested by a pest, such as a Pentatomidae plant pest or a N. viridula, Acrosternum hilare, Piezodorus guildini, and/or Halymorpha halys plant pest, decrease the expression of a target sequence in the pest. In specific embodiments, the decrease in expression of the target sequence controls the pest and thereby the methods and compositions are capable of limiting damage to a plant. The present invention provides various target polynucleotides set forth in any one of SEQ ID NOS: 1-292 or 302-304 or active variants and fragments thereof, wherein a decrease in expression of one or more the sequences in the target pest controls the pest (i.e., has insecticidal activity). Further provided are silencing elements which when ingested by the pest decrease the level of the target polypeptide and thereby control the pest. In specific embodiment, the pest is Pentatomidae. Plants, plant part, bacteria and other host cells comprising the silencing elements or an active variant or fragment thereof of the invention are also provided.
摘要翻译：提供了使用沉积元件的方法和组合物，当被害虫摄入时，例如五子科植物害虫或N. viridula，Acrosternum hilare，Piezodorus guildini和/或Halymorpha halys植物害虫，降低靶的表达序列在害虫中。在具体实施方案中，靶序列的表达降低控制有害生物，因此方法和组合物能够限制对植物的损害。本发明提供了SEQ ID NO：1-292或302-304中任一项所述的各种靶多核苷酸或其活性变体和片段，其中目标害虫中一个或多个序列的表达降低控制害虫（即具有杀虫活性）。进一步提供的是沉积元件，当受害虫摄入时，降低靶多肽的水平，从而控制害虫。在具体实施方案中，害虫是五角科。还提供了包含本发明的沉默元件或其活性变体或片段的植物，植物部分，细菌和其它宿主细胞。

10. 发明申请

US20180273975A1 MAIZE EVENT DP-032218-9 AND METHODS FOR DETECTION THEREOF 审中-公开
公开(公告)号：US20180273975A1
公开(公告)日：2018-09-27
申请号：US16002017
申请日：2018-06-07
申请人： PIONEER HI-BRED INTERNATIONAL, INC. , E. I. DU PONT DE NEMOURS AND COMPANY
发明人： MARY BEATTY , KENT BRINK , VIRGINIA CRANE , SCOTT DIEHN , ALBERT L. LU , GREGORY J. YOUNG
IPC分类号： C12N15/82 , C12Q1/6895 , A01H5/10
CPC分类号： C12N15/8286 , A01H5/10 , C12N15/8277 , C12Q1/6895 , C12Q2600/13 , C12Q2600/158 , Y02A40/162
摘要： The disclosure provides DNA compositions that relate to transgenic insect resistant maize plants. Also provided are assays for detecting the presence of the maize DP-032218-9 event based on the DNA sequence of the recombinant construct inserted into the maize genome and the DNA sequences flanking the insertion site. Kits and conditions useful in conducting the assays are provided.

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