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1. 发明申请

US20160125599A1 IMAGE FUSION SCHEME FOR DIFFERENTIAL PHASE CONTRAST IMAGING 有权
标题翻译：图像融合方案进行差分相位成像
公开(公告)号：US20160125599A1
公开(公告)日：2016-05-05
申请号：US14896531
申请日：2014-05-28
申请人： PAUL SCHERRER INSTITUT
发明人： MARCO STAMPANONI , ZHENTIAN WANG
IPC分类号： G06T7/00 , A61B6/00 , G06T7/60 , G06T11/00 , G06T11/60 , G06K9/52
CPC分类号： G06T7/0012 , A61B6/481 , A61B6/483 , A61B6/484 , A61B6/502 , A61B6/5235 , A61B6/5258 , G06K9/52 , G06T5/50 , G06T7/60 , G06T7/73 , G06T11/003 , G06T11/60 , G06T2207/10072 , G06T2207/10116 , G06T2207/20052 , G06T2207/20064 , G06T2207/20221 , G06T2207/30068
摘要： The latest progresses in breast imaging using differential phase contrast techniques pose the question of how to fuse multiple information sources, yielded by absorption, differential phase, and scattering signals, into a single, informative image for clinical diagnosis. It is proposed to use an image fusion scheme based on a multiple-resolution framework. The three signals are first transformed into multiple bands presenting information at different frequencies and then a two-step processing follows: (1) intra-band processing enhances the local signal-to-noise ratio using a novel noise estimation method and context modeling; and (2) inter-band processing weights each band by considering their characteristics and contributions, and suppressing the global noise level. The fused image, looking similar to a conventional mammogram but with significantly enhanced detail features, is reconstructed by inverse transform. The fused image is compatible with clinical settings and enables the radiologists to use their years of diagnosis experiences in mammography.
摘要翻译：使用差分相位对比技术在乳腺成像中的最新进展提出了如何将由吸收，差分相位和散射信号产生的多个信息源融合成单个信息图像用于临床诊断的问题。提出了基于多分辨率框架的图像融合方案。首先将三个信号转换成呈现不同频率信息的多个频带，然后进行两步处理：（1）使用新颖的噪声估计方法和上下文建模，带内处理增强了本地信噪比; （2）通过考虑其特性和贡献，并且抑制全局噪声水平，带间处理对每个频带进行加权。通过逆变换重建融合图像，看起来类似于常规乳房X线照片但具有显着增强的细节特征。融合图像与临床设置兼容，使放射科医生能够在乳腺X线照相术中使用他们多年的诊断经验。

2. 发明申请

US20160113611A1 QUANTITATIVE X-RAY RADIOLOGY USING THE ABSORPTION AND SCATTERING INFORMATION 有权
标题翻译：使用吸收和散射信息的量化X射线放射学
公开(公告)号：US20160113611A1
公开(公告)日：2016-04-28
申请号：US14890006
申请日：2014-04-25
申请人： PAUL SCHERRER INSTITUT
发明人： MARCO STAMPANONI , ZHENTIAN WANG
IPC分类号： A61B6/00
CPC分类号： A61B6/502 , A61B6/4035 , A61B6/4291 , A61B6/483 , A61B6/484 , A61B6/5217 , G01N23/083 , G01N23/20083
摘要： A quantitative radiographic method uses X-ray imaging. The method uses a ratio of the absorption signal and the (small-angle) scattering signal (or vice-versa) of the object as a signature for the materials. The ratio image (dubbed R image) is independent from the thickness of the object in a wide sense, and therefore can be used to discriminate materials in a radiographic approach. This can be applied to imaging systems, which can record these two signals from the underlying object (for instance, an X-ray grating interferometer). Possible applications could be in material science, non-destructive testing and medical imaging. Specifically, the method can be used to estimate a volumetric breast density. The use of the R image and the corresponding algorithm are also presented hereafter.
摘要翻译：定量射线照相方法使用X射线成像。该方法使用物体的吸收信号和（小角度）散射信号（或反之亦然）的比例作为材料的签名。比例图像（称为R图像）在广义上与物体的厚度无关，因此可以用于在放射照相方法中区分材料。这可以应用于成像系统，其可以从底层对象（例如，X射线光栅干涉仪）记录这两个信号。可能的应用可能在材料科学，非破坏性测试和医学成像。具体来说，该方法可用于估计体积乳房密度。下文还介绍了使用R图像和相应的算法。

3. 发明申请

US20180246046A1 OMNIDIRECTIONAL SCATTERING- AND BIDIRECTIONAL PHASE-SENSITIVITY WITH SINGLE SHOT GRATING INTERFEROMETRY 审中-公开
公开(公告)号：US20180246046A1
公开(公告)日：2018-08-30
申请号：US15755215
申请日：2016-07-20
申请人： PAUL SCHERRER INSTITUT
发明人： MATIAS KAGIAS , MARCO STAMPANONI , ZHENTIAN WANG
IPC分类号： G01N23/041 , G01N23/20 , G01N23/201 , G21K1/06 , A61B6/03 , A61B6/00 , G02B5/18
CPC分类号： G01N23/041 , A61B6/032 , A61B6/4035 , A61B6/4092 , A61B6/4233 , A61B6/4291 , A61B6/484 , G01N23/04 , G01N23/20075 , G01N23/201 , G02B5/1838 , G02B5/1871 , G21K1/06 , G21K2207/005
摘要： X-ray scattering imaging can provide complementary information about the unresolved microstructures of a sample. The scattering signal can be accessed with various methods based on coherent illumination, which span from self-imaging to speckle scanning. The directional sensitivity of the existing methods is limited to a few directions on the imaging plane and it requires the scanning of the optical components, or the rotation of either the sample or the imaging setup, if the full range of possible scattering directions is desired. A new arrangement is provided that allows the simultaneous acquisition of the scattering images in all possible directions in a single shot. This is achieved by a specialized phase grating and a device for recording the generated interference fringe with sufficient spatial resolution. The technique decouples the sample dark-field signal with the sample orientation, which can be crucial for medical and industrial applications.

4. 发明申请

US20170082559A1 TILTED-GRATING APPROACH FOR SCANNING-MODE X-RAY GRATING INTERFEROMETRY 审中-公开
公开(公告)号：US20170082559A1
公开(公告)日：2017-03-23
申请号：US15309222
申请日：2015-02-25
申请人： PAUL SCHERRER INSTITUT
发明人： CAROLINA ARBOLEDA , MARCO STAMPANONI , ZHENTIAN WANG
IPC分类号： G01N23/083 , G21K1/06 , G01N23/04
CPC分类号： A61B6/4291 , A61B6/4035 , A61B6/4208 , A61B6/484 , G01N23/04 , G21K1/025 , G21K2207/005
摘要： Among the existent X-ray phase-contrast modalities, grating interferometry appears as a promising technique for commercial applications, since it is compatible with conventional X-ray tubes. However, since applications such as medical imaging and homeland security demand covering a considerable field of view, the fabrication of challenging and expensive large-area gratings would be needed. A scanning setup is a good solution, because it uses cheaper line detectors instead of large-area 2D detectors and would require smaller gratings. In this setup, the phase-retrieval using the conventional phase-stepping approach would be slow, so having a faster method to record the signals becomes fundamental. To tackle this problem, a scanning-mode grating interferometer configuration is used, in which a grating is tilted to form Moire fringes perpendicular to the grating lines. The sample is then translated along the fringes, so each line detector records a different phase step for each slice of the sample.

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