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1. 发明申请

US20210379385A1 SYSTEM AND METHOD FOR DETERMINING A STIMULATION THRESHOLD FOR CLOSED LOOP SPINAL CORD STIMULATION 有权
公开(公告)号：US20210379385A1
公开(公告)日：2021-12-09
申请号：US17411017
申请日：2021-08-24
申请人： Pacesetter, Inc.
发明人： Wenbo Hou , Fujian Qu , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
摘要： System and methods are provided for determining a stimulation threshold for closed loop spinal cord stimulation (SCS). The system and methods provide a lead coupled to an implantable pulse generator (IPG). The system and methods deliver SCS pulses from the IPG to the lead electrodes in accordance with an SCS therapy and determine an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy. The system and methods increase the SCS therapy by increasing at least one of an amplitude, a duration, and number of the SCS pulses associated with the SCS therapy. The system and methods also include iteratively repeat the delivering, determining and increasing operations until the ECAP amplitude exhibits a downward trend divergence. The system and methods define a stimulation threshold based on the ECAP amplitude at the trend divergence.

2. 发明授权

US09162065B2 Systems and methods for estimating central arterial blood pressure of a patient 有权
标题翻译：用于估计患者中央动脉血压的系统和方法
公开(公告)号：US09162065B2
公开(公告)日：2015-10-20
申请号：US14616519
申请日：2015-02-06
申请人： PACESETTER, INC.
发明人： Edward Karst , Brian Jeffrey Wenzel , Timothy A. Fayram , Allen Keel , Wenbo Hou , Taraneh Ghaffari Farazi , Jong Gill
IPC分类号： A61B5/02 , A61N1/365 , A61B5/021 , A61B5/0215 , A61B5/0452 , A61N1/39
CPC分类号： A61N1/36585 , A61B5/02125 , A61B5/02154 , A61B5/0452 , A61N1/36564 , A61N1/3962 , A61N1/3987
摘要： In specific embodiments, a method for estimating central arterial blood pressure (CBP), comprises determining a time t1 from a predetermined feature of a signal indicative of electrical activity to a predetermined feature of one of a first and second signals, the time t1 being a first pulse arrival time (PAT1) indicative of how long it takes a pulse wave to travel from the aorta to one of a first and second sites, determining a time t2, the time t2 being a second pulse arrival time (PAT2) indicative of how long it takes a pulse wave to travel from the aorta to the other of the first and second sites, and (f) estimating the patient's central arterial blood pressure (CBP) based on the first pulse arrival time (PAT1) and the second pulse arrival time (PAT2).
摘要翻译：在具体实施例中，一种用于估计中央动脉血压（CBP）的方法包括从指示电活动的信号的预定特征到第一和第二信号之一的预定特征来确定时间t1，时间t1为第一脉冲到达时间（PAT1），其指示脉搏波从主动脉行进到第一和第二位置之一所需的时间，确定时间t2，时间t2是指示如何的第二脉冲到达时间（PAT2）长时间，需要脉冲波从主动脉行进到第一和第二部位的另一个，以及（f）基于第一脉冲到达时间（PAT1）和第二脉冲到达时估计患者的中心动脉血压（CBP）时间（PAT2）。

3. 发明申请

US20150051661A1 Method and System for Validating Local Capture in Multisite Pacing Delivery 有权
标题翻译：用于验证多站点起搏传送中的本地捕获的方法和系统
公开(公告)号：US20150051661A1
公开(公告)日：2015-02-19
申请号：US13968233
申请日：2013-08-15
申请人： PACESETTER, INC.
发明人： Wenbo Hou , Stuart Rosenberg , Xiaoyi Min , Allen Keel
IPC分类号： A61N1/37
CPC分类号： A61N1/3712 , A61B5/04525
摘要： A method for use with an implantable system including a lead having multiple electrodes implantable proximate to a patient's left ventricular (LV) chamber includes simultaneously delivering pacing pulses over corresponding pacing vectors defined by electrodes proximate to the LV chamber. The method includes recording evoked responses responsive to the pacing pulses that are measured over separate corresponding sensing channels. The method also includes comparing the evoked responses to a template that represents local capture of a local LV tissue region along one or more of the corresponding pacing vectors. The comparison is used to determine whether the pacing pulses achieved local capture along the corresponding pacing vectors. At least one of the pacing pulses or pacing vectors are updated based on the comparison of the evoked responses to the template in order to determine a local capture threshold for the corresponding pacing vectors.
摘要翻译：一种与可植入系统一起使用的方法，其包括具有可植入到患者左心室（LV））腔内的多个电极的引线，包括在靠近LV室的电极限定的相应起搏向量上同时输送起搏脉冲。该方法包括响应于在单独的相应感测通道上测量的起搏脉冲记录诱发响应。该方法还包括将诱发反应与模板进行比较，该模板表示沿着一个或多个相应起搏向量的局部LV组织区域的局部捕获。比较用于确定起搏脉冲是否实现沿着相应起搏向量的局部捕获。基于对模板的诱发响应的比较来更新起搏脉冲或起搏向量中的至少一个，以便确定相应起搏向量的局部捕获阈值。

4. 发明申请

US20140343652A1 METHOD TO ENHANCE ELECTRODE LOCALIZATION OF A LEAD 审中-公开
公开(公告)号：US20140343652A1
公开(公告)日：2014-11-20
申请号：US14448860
申请日：2014-07-31
申请人： PACESETTER, INC.
发明人： Stuart Rosenberg , Thao Ngo , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Steve Koh , Michael Yang
IPC分类号： A61N1/05
CPC分类号： A61B5/0538 , A61B5/0536 , A61B2562/0209 , A61N1/05 , A61N1/056
摘要： An exemplary method includes positioning a lead in a patient where the lead has a longitudinal axis that extends from a proximal end to a distal end and where the lead includes an electrode with an electrical center offset from the longitudinal axis of the lead body; measuring electrical potential in a three-dimensional potential field using the electrode; and based on the measuring and the offset of the electrical center, determining lead roll about the longitudinal axis of the lead body where lead roll may be used for correction of field heterogeneity, placement or navigation of the lead or physiological monitoring (e.g., cardiac function, respiration, etc.). Various other methods, devices, systems, etc., are also disclosed.

5. 发明申请

US20140343649A1 METHOD TO ENHANCE ELECTRODE LOCALIZATION OF A LEAD 审中-公开
标题翻译：提高电极电极定位的方法
公开(公告)号：US20140343649A1
公开(公告)日：2014-11-20
申请号：US14448739
申请日：2014-07-31
申请人： PACESETTER, INC.
发明人： Stuart Rosenberg , Thao Ngo , Kyungmoo Ryu , Kjell Noren , Allen Keel , Wenbo Hou , Steve Koh , Michael Yang
IPC分类号： A61N1/05
CPC分类号： A61B5/0538 , A61B5/0536 , A61N1/05 , A61N1/056
摘要： An exemplary method includes positioning a lead in a patient where the lead has a longitudinal axis that extends from a proximal end to a distal end and where the lead includes an electrode with an electrical center offset from the longitudinal axis of the lead body; measuring electrical potential in a three-dimensional potential field using the electrode; and based on the measuring and the offset of the electrical center, determining lead roll about the longitudinal axis of the lead body where lead roll may be used for correction of field heterogeneity, placement or navigation of the lead or physiological monitoring (e.g., cardiac function, respiration, etc.). Various other methods, devices, systems, etc., are also disclosed.
摘要翻译：一种示例性方法包括将引线定位在患者体内，其中引线具有从近端延伸到远端的纵向轴线，并且其中引线包括具有偏离引线主体的纵向轴线的电中心的电极; 使用所述电极测量三维势场中的电位; 并且基于电气中心的测量和偏移，确定围绕引线主体的纵轴的引导辊，其中引导辊可用于校正磁场异质性，引线的放置或导航或生理监测（例如，心脏功能，呼吸等）。还公开了各种其它方法，装置，系统等。

6. 发明申请

US20140336719A1 METHOD FOR HEMODYNAMIC OPTIMIZATION USING PLETHYSMOGRAPHY 审中-公开
标题翻译：使用PLDHYSMOGRAPHY进行血液动力学优化的方法
公开(公告)号：US20140336719A1
公开(公告)日：2014-11-13
申请号：US14148504
申请日：2014-01-06
申请人： PACESETTER, INC.
发明人： Gene A. Bornzin , Wenbo Hou , Edward Karst , Brian J. Wenzel , Timothy A. Fayram
IPC分类号： A61N1/365 , A61N1/368
CPC分类号： A61N1/36585 , A61B5/02416 , A61B5/726 , A61N1/3627 , A61N1/36564 , A61N1/3684 , A61N1/3686
摘要： Time delays between a feature of a signal indicative of electrical activity of a patient's heart and a feature of a plethysmograph signal indicative of changes in arterial blood volume are used to arrange the operation of an implantable device, such as a pacemaker. Shorter time delays between the feature of the signal indicative of electrical activity of a patient's heart and the feature of the plethysmograph signal indicative of changes in arterial blood volume are indicative of larger cardiac stroke volumes. The time delay can be used to select a pacing site or combination of pacing sites and/or to select a pacing interval set.
摘要翻译：使用指示患者心脏的电活动的信号的特征与指示动脉血容量变化的体积描记信号的特征之间的时间延迟来布置诸如起搏器的可植入装置的操作。指示患者心脏的电活动的信号的特征与指示动脉血容量变化的体积描记器信号的特征之间的更短的时间延迟指示较大的心脏搏动量。时间延迟可用于选择起搏站点或起搏站点的组合和/或选择起搏间隔集。

7. 发明授权

US08634919B1 Intracardiac implantable medical device for biatrial and/or left heart pacing and method of implanting same 有权
标题翻译：用于心房和/或左心室起搏的心内可植入医疗装置及其植入方法
公开(公告)号：US08634919B1
公开(公告)日：2014-01-21
申请号：US13722878
申请日：2012-12-20
申请人： Pacesetter, Inc.
发明人： Wenbo Hou , Xiaoyi Min , Edward Karst
IPC分类号： A61N1/375
CPC分类号： A61N1/3756 , A61N1/368 , A61N2001/0585
摘要： An intra-cardiac implantable medical device (IIMD) and method of implant are provided. The IIMD comprises a housing configured to be implanted entirely within a coronary sinus (CS) of the heart. The IIMD has at least one intra-cardiac device extension (ICDE).
摘要翻译：提供心脏内植入式医疗装置（IIMD）和植入方法。 IIMD包括构造成完全植入心脏的冠状窦（CS）内的壳体。 IIMD至少有一个心脏内设备扩展（ICDE）。

8. 发明申请

US20180126169A1 SYSTEM AND METHOD FOR DETERMINING A STIMULATION THRESHOLD FOR CLOSED LOOP SPINAL CORD STIMULATION 审中-公开
公开(公告)号：US20180126169A1
公开(公告)日：2018-05-10
申请号：US15345163
申请日：2016-11-07
申请人： PACESETTER, INC.
发明人： Wenbo Hou , Fujian Qu , Stuart Rosenberg , Kyungmoo Ryu
IPC分类号： A61N1/36 , A61N1/05 , A61N1/372
CPC分类号： A61N1/36139 , A61N1/0551 , A61N1/36071 , A61N1/37247 , A61N1/37264
摘要： System and methods are provided for determining a stimulation threshold for closed loop spinal cord stimulation (SCS). The system and methods provide a lead coupled to an implantable pulse generator (IPG). The system and methods deliver SCS pulses from the IPG to the lead electrodes in accordance with an SCS therapy, and determine an evoked compound action potential (ECAP) amplitude based on an ECAP waveform resulting from the SCS therapy. The system and methods increase the SCS therapy by increasing at least one of an amplitude, a duration, and number of the SCS pulses associated with the SCS therapy. The system and methods also include iteratively repeat the delivering, determining and increasing operations until the ECAP amplitude exhibits a downward trend divergence. The system and methods define a stimulation threshold based on the ECAP amplitude at the trend divergence.

9. 发明授权

US09931510B2 System and method to control a non-paresthesia stimulation based on sensory action potentials 有权
公开(公告)号：US09931510B2
公开(公告)日：2018-04-03
申请号：US15470223
申请日：2017-03-27
申请人： PACESETTER, INC.
发明人： Wenbo Hou , Melanie Goodman Keiser , Xiaoyi Min , Bruce A. Morley
IPC分类号： A61N1/00 , A61N1/372 , A61N1/36
CPC分类号： A61N1/37241 , A61N1/36071 , A61N1/36135 , A61N1/37264
摘要： A system and method for controlling non-paresthesia stimulation of neural tissue of a patient. The method delivers a non-paresthesia stimulation waveform, senses sensory action potential (SAP) signals from the neural tissue of interest, and analyzes the SAP signals to obtain SAP activity data for at least one of an SAP C-fiber component or an SAP A-delta fiber component. The method determines whether the SAP activity data satisfies a criteria of interest and adjusts at least one of the therapy parameters to change the non-paresthesia stimulation waveform when the SAP activity data does not satisfy the criteria of interest.

10. 发明申请

US20170312524A1 SYSTEMS FOR, AND METHODS OF, GUIDANCE BASED INTRAOPERATIVE CARDIAC RESYNCHRONIZATION THERAPY OPTIMIZATION 有权
公开(公告)号：US20170312524A1
公开(公告)日：2017-11-02
申请号：US15141065
申请日：2016-04-28
申请人： PACESETTER, INC.
发明人： Wenbo Hou , Craig D. Markovitz , Chunlan Jiang , Stuart Rosenberg
IPC分类号： A61N1/368 , A61N1/05 , A61B5/06
CPC分类号： A61N1/3688 , A61B5/062 , A61B34/10 , A61B34/20 , A61B2034/2051 , A61B2034/2072 , A61B2090/376 , A61N1/056 , A61N1/3682 , A61N1/3684 , A61N1/36842 , A61N2001/0585
摘要： The present disclosure may take the form of a method of optimizing CRT wherein candidate pacing settings are administered at a candidate lead implantation site. Such a method may comprise: determining a navigation sensor path at a measurement site for each candidate pacing setting at the candidate lead implantation site; and identifying which navigation sensor path corresponds to a most efficient cardiac tissue displacement.

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