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1. 发明授权

US06861593B2 Weighing sensor with calibration weight 有权
标题翻译：带校准重量的称重传感器
公开(公告)号：US06861593B2
公开(公告)日：2005-03-01
申请号：US10428949
申请日：2003-05-05
申请人： Otto Kuhlmann , Thorsten Capelle , Peter Fleischer , Friedrich Helmsen , Detlev Erben , Rudolf Mueller
发明人： Otto Kuhlmann , Thorsten Capelle , Peter Fleischer , Friedrich Helmsen , Detlev Erben , Rudolf Mueller
IPC分类号： G01G21/24 , G01G23/01
CPC分类号： G01G23/012 , G01G21/244
摘要： A weighing sensor including a base (1) fixed to a housing, a load sensor (2) connected to the base in a displaceable manner via two arms (3, 4), a lever system (8 . . . 11) having at least one lever and transmitting the load acting on the load sensor to a transducer (12, 13), and a built-in calibration weight (40) which may be lowered onto a support region (30/38) for checking and/or calibrating the sensitivity of the weighing sensor. The support region is guided in a parallel manner by two additional arms (21, 22) and is connected to a lever (9/39) of the lever system (8 . . . 11) via a coupling element (26). Relatively large loads on the weighing sensor may be simulated with relatively small calibration weights, without the need for complicated lifting devices. The two additional arms (21, 22) are connected on the one hand to the support region (30/38) and on the other hand to the load sensor (2) and are located on the side of the load sensor (2) opposite from the lever system (8 . . . 11).
摘要翻译：一种称重传感器，包括固定到壳体的基座（1），经由两个臂（3,4）以可移位方式连接到基座的负载传感器（2），至少具有至少一个杠杆并将作用在负载传感器上的负载传递到换能器（12,13），以及内置的校准配重（40），其可以降低到支撑区域（30/38）上，用于检查和/或校准称重传感器的灵敏度。支撑区域通过两个附加臂（21,22）以平行的方式被引导，并且经由联接元件（26）连接到杠杆系统（8 ... 11）的杠杆（9/39）。称重传感器上的相对较大的载荷可以用相对较小的校准砝码来模拟，而不需要复杂的提升装置。两个附加臂（21,22）一方面连接到支撑区域（30/38），另一方面连接到负载传感器（2），并且位于负载传感器（2）的相反侧从杠杆系统（8 ... 11）。

2. 发明授权

US08507482B2 Bicyclic amide derivatives for enhancing glutamatergic synaptic responses 有权
标题翻译：用于增强谷氨酸能突触反应的双环酰胺衍生物
公开(公告)号：US08507482B2
公开(公告)日：2013-08-13
申请号：US13348171
申请日：2012-01-11
申请人： Rudolf Mueller , Leslie J. Street
发明人： Rudolf Mueller , Leslie J. Street
IPC分类号： A61K31/5375 , C07D265/28
CPC分类号： C07D498/08 , A61K31/5375 , A61K45/06 , A61K2300/00
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, among others. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。参与如记忆障碍相关的认知能力的这些脑网络，例如在各种痴呆症中观察到的，在不同脑区域之间的神经元活动不平衡中，正如帕金森病，精神分裂症，睡眠呼吸暂停症，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及诸如卒中诱发的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征等疾病。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

3. 发明授权

US08173644B2 3-substituted-[1,2,3]-benzotriazinone compound for enhancing glutamatergic synaptic responses 有权
标题翻译： 3-取代 - [1,2,3] - 苯并三嗪酮化合物，用于增强谷氨酸能突触应答
公开(公告)号：US08173644B2
公开(公告)日：2012-05-08
申请号：US12448784
申请日：2007-12-28
申请人： Alexis Cordi , Gary Rogers , Rudolf Mueller
发明人： Alexis Cordi , Gary Rogers , Rudolf Mueller
IPC分类号： C07D498/04 , A61K31/5365
CPC分类号： C07D498/04
摘要： This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, an in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to a compound useful for treatment of such conditions, and methods of using this compound for such treatment.
摘要翻译：本发明涉及预防和治疗脑功能不全，包括在负责高阶行为的脑网络突触中增强受体功能。这些脑网络涉及与记忆障碍相关的认知能力，例如在各种痴呆症中观察到的，不同脑区域之间神经元活动的不平衡，如帕金森病，精神分裂症和情感障碍等疾病中所提出的。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用该化合物进行这种治疗的方法。

4. 发明申请

US20100041647A1 3-Substituted-[1,2,3]-Benzotriazinone compounds for enhancing glutamatergic synaptic responses 审中-公开
标题翻译： 3-取代 - [1,2,3] - 苯并三嗪酮化合物，用于增强谷氨酸能突触反应
公开(公告)号：US20100041647A1
公开(公告)日：2010-02-18
申请号：US12448770
申请日：2007-12-28
申请人： Rudolf Mueller , Stephen Lee , Sean O'Hare , Gary Rogers , Stan Rachwal , Leslie Street
发明人： Rudolf Mueller , Stephen Lee , Sean O'Hare , Gary Rogers , Stan Rachwal , Leslie Street
IPC分类号： C07D498/14 , A61K31/5365 , C07D413/10 , A61K31/5355 , A61P25/00 , A61P25/18
CPC分类号： C07D498/14 , C07D253/08 , C07D487/04 , C07D498/04
摘要： This invention relates to the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for higher order behaviors. These brain networks are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias and in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia and affective disorders. In a particular aspect, the present invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及预防和治疗脑功能不全，包括在负责高阶行为的脑网络突触中增强受体功能。这些脑网络涉及与记忆障碍相关的认知能力，例如在各种痴呆症中观察到的，以及在不同脑区域之间的神经元活动的不平衡，如在帕金森病，精神分裂症和情感障碍等疾病中所提出的。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用这些化合物进行这种治疗的方法。

5. 发明授权

US4902136A Arrangement for high-resolution spectroscopy 失效
标题翻译：高分辨光谱法的安排
公开(公告)号：US4902136A
公开(公告)日：1990-02-20
申请号：US261489
申请日：1988-10-24
申请人： Rudolf Mueller , Wolfgang Albertshofer
发明人： Rudolf Mueller , Wolfgang Albertshofer
IPC分类号： G01J3/36 , G01J3/26 , G01J3/28 , H01L27/144 , H01L31/0216 , H01L31/10
CPC分类号： G01J3/26 , G01J3/2803 , H01L27/1446 , H01L31/02165 , G01J2003/2806
摘要： An arrangement for high resolution spectroscopy includes a spatially or chronologically tunable interference filter with a wavelength selective diode array composed of a plurality of diode elements arranged side-by-side.
摘要翻译：用于高分辨率光谱的布置包括空间上或时间上可调的干涉滤光器，其具有由并排布置的多个二极管元件组成的波长选择二极管阵列。

6. 发明授权

US4813705A Spring system for vehicles, especially motor vehicles 失效
标题翻译：用于车辆，特别是汽车的弹簧系统
公开(公告)号：US4813705A
公开(公告)日：1989-03-21
申请号：US118050
申请日：1987-11-09
申请人： Hans Hagen , Rudolf Mueller
发明人： Hans Hagen , Rudolf Mueller
IPC分类号： B60G17/0165 , B60G23/00 , B60G17/02
CPC分类号： B60G17/0165
摘要： In a vehicle spring system, the rear wheel spring system is constructed as active spring system and the front wheel spring system as passive spring system. The control pulses for the active rear wheel spring system are supplied from the vehicle front wheels which act as road surface sensors.
摘要翻译：在车辆弹簧系统中，后轮弹簧系统被构造为主动弹簧系统和前轮弹簧系统作为被动弹簧系统。用于主动后轮弹簧系统的控制脉冲从用作路面传感器的车辆前轮提供。

7. 发明申请

US20130190351A1 BICYCLIC AMIDES FOR ENHANCING GLUTAMATERGIC SYNAPTIC RESPONSES 有权
标题翻译：用于增强谷氨酸反应性的双酚A
公开(公告)号：US20130190351A1
公开(公告)日：2013-07-25
申请号：US13557681
申请日：2012-07-25
申请人： Rudolf Mueller , Leslie Street
发明人： Rudolf Mueller , Leslie Street
IPC分类号： A61K31/46 , C07D451/06 , C07D451/04 , A61K45/06 , C07D471/08 , A61K31/4245 , A61K31/439 , C07D451/02 , C07D487/08
CPC分类号： A61K31/46 , A61K31/4245 , A61K31/439 , A61K31/519 , A61K31/53 , A61K45/06 , C07D209/52 , C07D451/02 , C07D451/04 , C07D451/06 , C07D453/06 , C07D471/08 , C07D487/08 , C07D491/08
摘要： This invention relates to bicyclic amide compounds, pharmaceutical compositions and methods for use in the prevention and treatment of a variety of conditions and/or disease states including cerebral insufficiency, through the enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors as defined herein. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in other disorders wherein a deficiency in neurotrophic factors is implicated, as well as other disorders as described herein.
摘要翻译：本发明涉及双环酰胺化合物，药物组合物和用于预防和治疗各种病症和/或疾病状态（包括脑功能不全）的方法，其通过增强负责基本和高等级的脑网络中的突触中的受体功能行为如本文所定义。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的其它疾病以及本文所述的其它病症。

8. 发明授权

US08404682B2 Di-substituted amides for enhancing glutamatergic synaptic responses 有权
标题翻译：用于增强谷氨酸能突触反应的二取代酰胺
公开(公告)号：US08404682B2
公开(公告)日：2013-03-26
申请号：US13226146
申请日：2011-09-06
申请人： Leslie Street , Rudolf Mueller , Steven Lee
发明人： Leslie Street , Rudolf Mueller , Steven Lee
IPC分类号： A61K31/5377 , A61K31/4245 , A61K31/4439 , A61K31/454 , A61K31/433 , A61K31/498
CPC分类号： A61K31/4245 , A61K45/06 , C07D271/12 , C07D285/14 , C07D405/12 , C07D413/12 , C07D417/12
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in regulation of breathing, and cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, respiratory depression, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as in disorders of respiration such as overdose of an alcohol, an opiate, an opioid, a barbiturate, an anesthetic, or a nerve toxin, or where the respiratory depression results form a medical condition such as central sleep apnea, stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。涉及呼吸调节的这些脑网络，以及与记忆障碍有关的认知能力，例如在各种痴呆中观察到的，在不同脑区域之间的神经元活动不平衡中，如在帕金森病，精神分裂症，呼吸抑制，睡眠呼吸暂停，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及呼吸障碍，例如过量的酒精，阿片剂，阿片样物质，巴比妥酸盐，麻醉剂或神经毒素，或呼吸抑制结果形成中枢性睡眠呼吸暂停，中风引起的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性通气不足综合征，肥胖低通气综合征，婴儿猝死综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondines诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的化合物，以及使用这些化合物进行这种治疗的方法。

9. 发明授权

US08119632B2 Bicyclic amide derivatives for enhancing glutamatergic synaptic responses 有权
标题翻译：用于增强谷氨酸能突触反应的双环酰胺衍生物
公开(公告)号：US08119632B2
公开(公告)日：2012-02-21
申请号：US12657908
申请日：2010-01-29
申请人： Rudolf Mueller , Leslie J. Street
发明人： Rudolf Mueller , Leslie J. Street
IPC分类号： A61K31/535 , C07D498/02 , C07D265/00
CPC分类号： C07D498/08 , A61K31/5375 , A61K45/06 , A61K2300/00
摘要： This invention relates to compounds, pharmaceutical compositions and methods for use in the prevention and treatment of cerebral insufficiency, including enhancement of receptor functioning in synapses in brain networks responsible for basic and higher order behaviors. These brain networks, which are involved in cognitive abilities related to memory impairment, such as is observed in a variety of dementias, in imbalances in neuronal activity between different brain regions, as is suggested in disorders such as Parkinson's disease, schizophrenia, sleep apneas, attention deficit hyperactivity disorder and affective or mood disorders, and in disorders wherein a deficiency in neurotrophic factors is implicated, as well as conditions such as stroke-induced central sleep apnea, obstructive sleep apnea, congenital hypoventilation syndrome, obesity hypoventilation syndrome, sudden infant death syndrome, Rett syndrome, spinal cord injury, traumatic brain injury, Cheney-Stokes respiration, Ondines curse, Prader-Willi's syndrome and drowning. In a particular aspect, the invention relates to bicyclic amide compounds useful for treatment of such conditions, and methods of using these compounds for such treatment.
摘要翻译：本发明涉及用于预防和治疗脑功能不全的化合物，药物组合物和方法，包括在负责基本和高级行为的脑网络中的突触中增强受体功能。参与如记忆障碍相关的认知能力的这些脑网络，例如在各种痴呆症中观察到的，在不同脑区域之间的神经元活动不平衡中，正如帕金森病，精神分裂症，睡眠呼吸暂停症，注意缺陷多动障碍和情感或情绪障碍，以及涉及神经营养因子缺乏的疾病，以及诸如卒中诱导的中枢性睡眠呼吸暂停，阻塞性睡眠呼吸暂停，先天性低通气综合征，肥胖低通气综合征，婴儿猝死综合征综合征，Rett综合征，脊髓损伤，创伤性脑损伤，Cheney-Stokes呼吸，Ondine诅咒，Prader-Willi综合征和溺水。在一个特定方面，本发明涉及可用于治疗这些病症的双环酰胺化合物，以及使用这些化合物进行这种治疗的方法。

10. 发明授权

US07735338B2 Method and device for producing thin glass panes 有权
标题翻译：生产薄玻璃板的方法和装置
公开(公告)号：US07735338B2
公开(公告)日：2010-06-15
申请号：US11867424
申请日：2007-10-04
申请人： Rudolf Mueller , Horst Loch , Dirk Sprenger , Jose Zimmer , Holger Wegener
发明人： Rudolf Mueller , Horst Loch , Dirk Sprenger , Jose Zimmer , Holger Wegener
IPC分类号： C03B18/02
CPC分类号： C03B17/067 , C03B17/06 , C03B17/064 , Y02P40/57
摘要： The method of making thin glass panes includes conveying a glass melt through a vertical inlet to a drawing tank with a slit nozzle; drawing a glass ribbon downward from the slit nozzle; setting a total throughput by setting length and cross section of the inlet and by heating and cooling the inlet to control glass melt viscosity so that pressure in the inlet decreases; and setting a throughput per unit of length in a lateral direction along the glass ribbon via nozzle system geometry and by heating and cooling of the drawing tank and slit nozzle to control melt viscosity, so that glass does not wet an underside of the slit nozzle near a breaking edge. The setting of the total throughput and the throughput per unit length are largely decoupled to simplify process control. An inventive apparatus for performing the method is also disclosed.
摘要翻译：制造薄玻璃板的方法包括将玻璃熔体通过垂直入口输送到具有狭缝喷嘴的拉伸槽; 从狭缝喷嘴向下拉一个玻璃带; 通过设置入口的长度和横截面来设置总吞吐量，并通过加热和冷却入口来控制玻璃熔体粘度，使入口中的压力降低; 并且通过喷嘴系统几何形状沿着玻璃带沿横向设置每单位长度的通过量，并且通过加热和冷却拉伸槽和狭缝喷嘴以控制熔体粘度，使得玻璃不会在狭缝喷嘴的下侧附近一个突破。总吞吐量的设置和每单位长度的吞吐量大部分是去耦的，以简化过程控制。还公开了一种用于执行该方法的发明装置。

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