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1. 发明授权

US4855283A Novel pharmaceutically active N-(2-aminoacylamido-2-deoxy-hexosyl)-amides, -carbamates and -ureas 失效
标题翻译：新型药物活性N-（2-氨基酰氨基-2-脱氧己糖基） - 酰胺， - 氨基甲酸酯和脲
公开(公告)号：US4855283A
公开(公告)日：1989-08-08
申请号：US874983
申请日：1986-06-16
申请人： Oswald Lockhoff , Yutaka Hayauchi , Peter Stadler , Klaus G. Stunkel , Gert Streissle , Arnold Paessens , Volker Klimetzek , Hans-Joachim Zeiler , Karl G. Metzger , Hein-Peter Kroll , Helmut Brunner , Klaus Schaller
发明人： Oswald Lockhoff , Yutaka Hayauchi , Peter Stadler , Klaus G. Stunkel , Gert Streissle , Arnold Paessens , Volker Klimetzek , Hans-Joachim Zeiler , Karl G. Metzger , Hein-Peter Kroll , Helmut Brunner , Klaus Schaller
IPC分类号： A61K31/70 , A61K31/7024 , A61K31/7028 , A61K39/39 , A61P1/16 , A61P11/00 , A61P27/16 , A61P29/00 , A61P31/04 , A61P31/12 , A61P37/00 , C07H13/04 , C07H13/06 , C07H13/12 , C07H15/04 , C07H15/12
CPC分类号： C07H13/04 , A61K39/39 , C07H13/12 , A61K2039/55511
摘要： Compounds of the formula ##STR1## in which R.sup.1 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms,X represents --CH.sub.2 --, --O-- or --NH--,R.sup.2 denotes hydrogen or a saturated or singly or multiply unsaturated alkyl radical having up to 50 carbon atoms,R.sup.3, R.sup.4 and R.sup.5, independently of one another, denotes hydrogen or acyl--CO--R.sup.6, R.sup.6 being an alkyl radical having up to 10 carbon atoms,R.sup.7 denotes hydrogen, C.sub.1 -C.sub.7 -alkyl-, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-(methylthio)-ethyl, 3-aminopropyl, 3-ureidopropyl, 3-guanidyl-propyl, 4-aminobutyl, carboxymethyl, carbamylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andR.sup.8 represents hydrogen or methyl, andR.sup.9 represents hydrogen, acetyl, benzoyl, trichloroacetyl, trifluoroacetyl, methoxycarbonyl, t-butyloxycarbonyl or benzyloxycarbonyl andR.sup.7 and R.sup.8 together can denote --CH.sub.2 --CH.sub.2 --CH.sub.2, and pharmaceutically acceptable salts thereof stimulate the immune system and can be used in conjuction with antibiotics and vaccines. New intermediates are also shown.
摘要翻译：其中R 1表示氢或具有至多50个碳原子的饱和或单或多不饱和烷基的式“IMAGE”的化合物，X表示-CH 2 - ， - O-或-NH-，R 2表示氢或饱和或具有多达50个碳原子的单或多不饱和烷基，R 3，R 4和R 5彼此独立地表示氢或酰基-CO-R 6，R 6是具有至多10个碳原子的烷基，R 7表示氢，C 1 C 1-7 - 烷基 - ，羟甲基，1-羟乙基，巯基甲基，2-（甲硫基） - 乙基，3-氨丙基，3-脲基丙基，3-氨基丙基 - 丙基，4-氨基丁基，羧甲基，氨基甲酰甲基，2-羧乙基，乙酰基，苯甲酰基，三氯乙酰基，三氟乙酰基，甲氧基羰基，叔丁氧基羰基或苄氧基羰基，R7和R8一起可以表示（C 1 -C 6）烷基，苄基，4-羟基苄基，3-吲哚基甲基或4-咪唑基甲基，R 8表示氢或甲基， -CH 2 -CH 2 -CH 2，及其药学上可接受的盐模拟免疫系统，并可与抗生素和疫苗结合使用。还显示了新的中间体。

2. 发明授权

US4891425A N-glycosylamide derivatives, processes for their preparation and their use as medicaments 失效
标题翻译： N-糖酰胺衍生物，其制备方法及其作为药物的用途
公开(公告)号：US4891425A
公开(公告)日：1990-01-02
申请号：US7703
申请日：1987-01-28
申请人： Oswald Lockhoff , Yutaka Hayauchi , Peter Stadler , Helmut Brunner
发明人： Oswald Lockhoff , Yutaka Hayauchi , Peter Stadler , Helmut Brunner
IPC分类号： A01N57/16 , A61K31/70 , A61K31/7028 , A61P31/04 , A61P37/00 , C07H13/04 , C07H15/04 , C07H15/12 , C07H15/18
CPC分类号： C07H13/04 , C07H15/04
摘要： A N-glycosylamide derivative of the formula (I) ##STR1## in which R.sup.1 denotes hydrogen or a saturated or mono- or polyunsaturated alkyl radical with one to 50 carbon atoms,R.sup.2 denotes hydrogen or a saturated or mono- or polyunsaturated alkyl radical with one to 50 carbon atoms,R.sup.3 denotes hydrogen or an acyl radical with up to 20 carbon atoms,R.sup.4 denotes hydrogen or an alkyl radical with up to 4 carbon atoms andR.sup.5 and R.sup.6 independently of one another denote hydrogen or an acyl radical with up to 10 carbon atoms or a saturated or an unsaturated alkyl radical or an aralkyl radical with up to 10 carbon atoms, orR.sup.5 l and R.sup.6 together denote a grouping ##STR2## wherein R.sup.7 and R.sup.8 independently of one another denote hydrogen or lower alkyl with up to 5 carbon atoms or an unsubstituted or substituted aryl radical with up to 10 C atoms in the aromatic part. The N-glycosylamide derivatives exhibiting a broad defense-increasing action in the body.
摘要翻译：式（I）的N-糖酰胺衍生物其中R 1表示氢或具有1至50个碳原子的饱和或单或多不饱和烷基，R 2表示氢或饱和或单或多不饱和的具有1至50个碳原子的烷基，R 3表示氢或至多20个碳原子的酰基，R 4表示氢或具有至多4个碳原子的烷基，R 5和R 6彼此独立地表示氢或酰基具有至多10个碳原子或饱和或不饱和的烷基或具有至多10个碳原子的芳烷基，或者R 5和R 6一起表示分组，其中R 7和R 8彼此独立地表示氢或低级烷基具有多至5个碳原子的芳族部分或未被取代的或取代的芳基，其中芳族部分中具有至多10个C原子。 N-糖酰胺衍生物在体内表现出广泛的防御增加作用。

3. 发明授权

US5070190A Substituted N-glycosylamides, process for their preparation, and their use as medicaments 失效
标题翻译：取代的N-甲酰胺，其制备方法及其作为药物的用途
公开(公告)号：US5070190A
公开(公告)日：1991-12-03
申请号：US336497
申请日：1989-04-12
申请人： Oswald Lockhoff , John Goossens , Helmut Brunner , Michael Sperzel , Klaus G. Stunkel
发明人： Oswald Lockhoff , John Goossens , Helmut Brunner , Michael Sperzel , Klaus G. Stunkel
IPC分类号： A61K31/70 , A61K31/7028 , A61P37/04 , C07H15/12
CPC分类号： C07H15/12 , Y10S514/885
摘要： The invention relates to new N-glycosylamides of the general formula I ##STR1## in which R.sup.1 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,R.sup.2 denotes a saturated alkyl radical or a singly, doubly or triply unsaturated alkenyl radical having up to 50 carbon atoms,A represents --CO-- or represents a group ##STR2## in which R.sup.3 represents hydrogen, C.sub.1 -C.sub.7 alkyl, hydroxymethyl, 1-hydroxyethyl, mercaptomethyl, 2-methylthioethyl, 3-aminopropyl, 2-ureidopropyl, 3-guanidylpropyl, 4-aminobutyl, carboxymethyl, carbamoylmethyl, 2-carboxyethyl, 2-carbamoylethyl, benzyl, 4-hydroxybenzyl, 3-indolylmethyl or 4-imidazolylmethyl, andn represents 0 to 10,and which are substituted in the sugar residue with an amino acid residue, as well as process for their preparation and their use as medicaments.
摘要翻译：本发明涉及通式Ⅰ“IMAGE”的新的N-糖基酰胺，其中R 1表示饱和的烷基或具有至多50个碳原子的单，双或三不饱和烯基，R2表示饱和的烷基或单，具有至多50个碳原子的双或三重不饱和烯基，A表示-CO-或代表其中R3表示氢，C1-C7烷基，羟甲基，1-羟乙基，巯基甲基，2-甲硫基乙基，氨基丙基，2-脲基丙基，3-胍基丙基，4-氨基丁基，羧甲基，氨基甲酰基甲基，2-羧基乙基，2-氨基甲酰基乙基，苄基，4-羟基苄基，3-吲哚基甲基或4-咪唑基甲基，n表示0〜10，在糖残基中用氨基酸残基取代，以及其制备方法及其作为药物的用途。

4. 发明授权

US06034055A Glycosyl-amides of 2-aminoacylamino-2-deoxy-sugars 失效
标题翻译： 2-氨基酰氨基-2-脱氧糖的糖基酰胺
公开(公告)号：US06034055A
公开(公告)日：2000-03-07
申请号：US255642
申请日：1999-02-22
申请人： Oswald Lockhoff , Burkhard Mielke , Helmut Brunner , Klaus Schaller
发明人： Oswald Lockhoff , Burkhard Mielke , Helmut Brunner , Klaus Schaller
IPC分类号： C07H13/06 , A61K38/00 , A61P37/00 , A61P37/04 , C07H15/12 , C07K5/06 , C07K5/08 , C07K5/10 , C07K9/00 , A61K38/16 , A01N43/04
CPC分类号： C07H15/12 , C07K9/005 , A61K38/00 , Y10S514/885
摘要： The present invention relates to (2-aminoacylamino-2-deoxy-glycosyl)-amides, which are substituted on the nitrogen atom of the amino acid, of the general formula (I) ##STR1## in which the substituents have the meaning given in the description, to processes for their preparation and to their use in medicaments.
摘要翻译：本发明涉及在通式（I）的氨基酸的氮原子上取代的（2-氨基酰基氨基-2-脱氧糖基） - 酰胺，其中取代基具有在说明书中给出的含义，其制备过程及其在药物中的应用。

5. 发明授权

US5905071A Glycosylamides of 2-aminoacylamino-2-deoxy sugars 失效
标题翻译： 2-氨基酰氨基-2-脱氧糖的糖基酰胺
公开(公告)号：US5905071A
公开(公告)日：1999-05-18
申请号：US605031
申请日：1996-06-25
申请人： Oswald Lockhoff , Burkhard Mielke , Helmut Brunner , Klaus Schaller
发明人： Oswald Lockhoff , Burkhard Mielke , Helmut Brunner , Klaus Schaller
IPC分类号： C07H13/06 , A61K38/00 , A61P37/00 , A61P37/04 , C07H15/12 , C07K5/06 , C07K5/08 , C07K5/10 , C07K9/00 , A61K31/70 , A01N43/04 , C07H15/00
CPC分类号： C07H15/12 , C07K9/005 , A61K38/00 , Y10S514/885
摘要： The present invention relates to (2-aminoacylamino-2-deoxy-glycosyl)-amides, which are substituted on the nitrogen atom of the amino acid, of the general formula (I) ##STR1## in which the substituents have the meaning given in the description, to processes for their preparation and to their use in medicaments.
摘要翻译： PCT No.PCT / EP94 / 02736 Sec。 371日期1996年6月25日第 102（e）1996年6月25日PCT PCT 1994年8月17日PCT公布。出版物WO95 / 06654 日期：1995年3月9日本发明涉及在通式（I）的氨基酸的氮原子上被取代的（2-氨基酰基氨基-2-脱氧 - 糖基） - 酰胺，其中取代基具有在描述中给出了它们的制备过程及其在药物中的用途。

6. 发明授权

US4895803A Method for decontamination of mycoplasma-infected cell cultures 失效
标题翻译：支原体感染细胞培养物去污方法
公开(公告)号：US4895803A
公开(公告)日：1990-01-23
申请号：US921995
申请日：1986-10-22
申请人： Gunter E. Hubner , Helmut Brunner , Hans-Joachim Zeiler
发明人： Gunter E. Hubner , Helmut Brunner , Hans-Joachim Zeiler
IPC分类号： C12N5/06 , A61L2/00 , C07D215/56 , C07D401/04 , C12N1/38 , C12N5/00 , C12R1/91
CPC分类号： A61L2/0088 , C12N1/38
摘要： A method for decontaminating cell cultures comprising contacting cell cultures with quinolone- and 1,8-naphthyridonecarboxylic acids of the formula (I) ##STR1## in which R.sup.1 represents methyl, ethyl, propyl, isopropyl, cyclopropyl, vinyl, 2-hydroxyethyl, 2-fluorethyl, methoxy, amino, methylamino, dimethylamino, ethylamino, phenyl, 4-fluorophenyl or 2,4-difluorophenyl,R.sup.2 represents hydrogen, alkyl having 1 to 4 carbon atoms, or (5-methyl-2-oxo-1,3-dioxol-4-yl)-methyl,R.sup.3 represents methyl or a cyclic amino group such as ##STR2## in which R.sup.4 represents hydrogen, alkyl having 1 to 4 carbon atoms, 2-hydroxyethyl, allyl, propargyl, 2-oxopropyl, 3-oxobutyl, phenacyl, formyl, CFCl.sub.2 --S--, CFCl.sub.2 --SO.sub.2 --, CH.sub.3 O--CO--S--, benzyl, 4-aminobenzyl or ##STR3## R.sup.5 represents hydrogen or methyl, R.sup.6 represents hydrogen, alkyl having 1 to 4 carbon atoms, phenyl or benzyloxomethyl,R.sup.7 represents hydrogen, amino, methylamino, ethylamino, aminomethyl, methylaminomethyl, ethylaminomethyl, dimethylaminomethyl, hydroxyl, or hydroxymethyl,R.sup.8 represents hydrogen, methyl, ethyl or chlorineX represents fluorine, chlorine or nitro andA represents N or C-R.sup.9, in whichR.sup.9 represents hydrogen, halogen such as fluorine or chlorine, methyl or nitro, or can also, together with R.sup.1, form a bridge of the structure --O--CH.sub.2 --CH--CH.sub.3, --S--CH.sub.2 --CH--CH.sub.3 or --CH.sub.2 --CH.sub.2 --CH--CH.sub.3.
摘要翻译：一种净化细胞培养物的方法，包括使细胞培养物与式（I）的化合物和其中R1代表甲基，乙基，丙基，异丙基，环丙基，乙烯基，2-羟基乙基，2- - 甲氧基，氨基，甲基氨基，二甲基氨基，乙基氨基，苯基，4-氟苯基或2,4-二氟苯基，R 2表示氢，具有1至4个碳原子的烷基，或（5-甲基-2-氧代-1,3 R 3表示氢，具有1至4个碳原子的烷基，2-甲基苯基，2-甲氧基丙基，羟乙基，烯丙基，炔丙基，2-氧代丙基，3-氧代丁基，苯甲酰甲基，甲酰基，CFCl 2 -S-，CFCl 2 -SO 2 - ，CH 3 O-CO-S-，苄基，4-氨基苄基或R 5表示氢或甲基， R6表示氢，具有1至4个碳原子的烷基，苯基或苄氧基甲基，R7表示氢，氨基，甲基氨基，乙基氨基，氨基甲基，甲基氨基甲基，乙基氨基甲基，一分子羟基或羟甲基，R 8表示氢，甲基，乙基或氯，X表示氟，氯或硝基，A表示N或C-R 9，其中R 9表示氢，卤素如氟或氯，甲基或硝基，或也可以与R1一起形成结构-O-CH 2 -CH-CH 3，-S-CH 2 -CH-CH 3或-CH 2 -CH 2 -CH-CH 3的桥。

7. 发明授权

US06320866B2 Network termination 失效
标题翻译：网络终止
公开(公告)号：US06320866B2
公开(公告)日：2001-11-20
申请号：US09045309
申请日：1998-03-20
申请人： Michael Wolf , Helmut Brunner
发明人： Michael Wolf , Helmut Brunner
IPC分类号： H04J102
CPC分类号： H04Q11/045 , H04Q11/0471
摘要： Network terminations are made available to a customer and installed by a network operator of a digital communications network. The customer is responsible for the supply of power to the network terminations. In the event of a power failure, a network termination of the digital communications network sends an error message (FM) to the customer who is responsible for correcting the power failure. The error message (FM) is sent in the payload of the digital message signals. The network termination (NT) includes a power supply (USV) which in the event of the power failure can sustain output for a predetermined period of time, in which the error can be signaled. To signal the error, the payload may be overwritten with a predetermined bit pattern (BM).
摘要翻译：网络终端可由客户使用并由数字通信网络的网络运营商安装。客户负责向网络终端提供电源。在电源故障的情况下，数字通信网络的网络终端向负责纠正电源故障的客户发送错误消息（FM）。在数字信息信号的有效载荷中发送错误信息（FM）。网络终端（NT）包括电源（USV），其在电源故障的情况下可以在可以发出错误的预定时间段内维持输出。为了发信号通知错误，有效载荷可以用预定位模式（BM）覆盖。

8. 发明授权

US09165895B2 Method for separating a plurality of dies and a processing device for separating a plurality of dies 有权
标题翻译：用于分离多个模具的方法和用于分离多个模具的处理装置
公开(公告)号：US09165895B2
公开(公告)日：2015-10-20
申请号：US13290201
申请日：2011-11-07
申请人： Helmut Brunner , Manfred Engelhardt
发明人： Helmut Brunner , Manfred Engelhardt
IPC分类号： H01L21/00 , H01L23/00 , H01L21/683 , H01L21/78
CPC分类号： H01L24/03 , H01L21/6835 , H01L21/78 , H01L24/05 , H01L2221/68354 , H01L2224/03002 , H01L2224/03464 , H01L2224/04026 , H01L2224/05023 , H01L2224/05147 , H01L2224/05568 , H01L2224/05573 , H01L2224/05644 , H01L2224/05647 , H01L2224/32225 , H01L2924/00014 , H01L2924/01322 , H01L2924/1301 , H01L2924/1305 , H01L2924/1306 , Y10T29/49002 , H01L2924/0105 , H01L2924/00 , H01L2224/05552
摘要： A method for separating a plurality of dies is provided. The method may include: selectively removing one or more portions from a carrier including a plurality of dies, for separating the plurality of dies along the selectively removed one or more portions, wherein the one or more portions are located between the dies; and subsequently forming over a back side of the dies, at least one metallization layer for packaging the dies
摘要翻译：提供了一种用于分离多个管芯的方法。该方法可以包括：从包括多个模具的载体中选择性地去除一个或多个部分，用于沿着选择性去除的一个或多个部分分离多个模具，其中一个或多个部分位于模具之间; 并且随后在模具的背面上形成用于包装模具的至少一个金属化层

9. 发明申请

US20130115736A1 METHOD FOR SEPARATING A PLURALITY OF DIES AND A PROCESSING DEVICE FOR SEPARATING A PLURALITY OF DIES 有权
标题翻译：用于分离多个模具的方法和用于分离多个模具的加工装置
公开(公告)号：US20130115736A1
公开(公告)日：2013-05-09
申请号：US13290201
申请日：2011-11-07
申请人： Helmut Brunner , Manfred Engelhardt
发明人： Helmut Brunner , Manfred Engelhardt
IPC分类号： H01L21/50 , H05K13/00
CPC分类号： H01L24/03 , H01L21/6835 , H01L21/78 , H01L24/05 , H01L2221/68354 , H01L2224/03002 , H01L2224/03464 , H01L2224/04026 , H01L2224/05023 , H01L2224/05147 , H01L2224/05568 , H01L2224/05573 , H01L2224/05644 , H01L2224/05647 , H01L2224/32225 , H01L2924/00014 , H01L2924/01322 , H01L2924/1301 , H01L2924/1305 , H01L2924/1306 , Y10T29/49002 , H01L2924/0105 , H01L2924/00 , H01L2224/05552
摘要： A method for separating a plurality of dies is provided. The method may include: selectively removing one or more portions from a carrier including a plurality of dies, for separating the plurality of dies along the selectively removed one or more portions, wherein the one or more portions are located between the dies; and subsequently forming over a back side of the dies, at least one metallization layer for packaging the dies
摘要翻译：提供了一种用于分离多个管芯的方法。该方法可以包括：从包括多个模具的载体中选择性地去除一个或多个部分，用于沿着选择性去除的一个或多个部分分离多个模具，其中一个或多个部分位于模具之间; 并且随后在模具的背面上形成用于包装模具的至少一个金属化层

10. 发明授权

US5091364A Preparation of immunologically active cell wall components from archaebacteria 失效
标题翻译：从ARCHAEBACTERIA制备免疫活性细胞壁组分
公开(公告)号：US5091364A
公开(公告)日：1992-02-25
申请号：US559432
申请日：1990-07-25
申请人： Jorg Baumgarten , Helmut Brunner , Inge Flesch , Heinz Hildebrand , Norbert Piel , Michael Sperzel
发明人： Jorg Baumgarten , Helmut Brunner , Inge Flesch , Heinz Hildebrand , Norbert Piel , Michael Sperzel
IPC分类号： A61K35/74 , A61K38/00 , A61P37/00 , C07K1/20 , C07K14/00 , C07K14/005 , C07K14/195 , C07K14/41 , C12P21/00 , C12R1/01
CPC分类号： C07K14/195 , A61K38/00 , Y10S530/82
摘要： A process for the preparation of glycoproteins and proteins from cultures of archaebacteria, comprising culturing archaebacteria, isolating glycoprotein and/or protein from the archaebacteria or their cell walls, enzymatically degrading the glycoprotein and/or protein, purifying and isolating the degradation products, and separating those fractions in the individual purification steps based on the biological activity of the fraction. The products increase the body's defenses against infection.
摘要翻译：一种从古细菌培养物制备糖蛋白和蛋白质的方法，包括从古细菌或其细胞壁培养古细菌，分离糖蛋白和/或蛋白质，酶促降解糖蛋白和/或蛋白质，纯化和分离降解产物，以及分离基于级分的生物活性的单独纯化步骤中的那些级分。这些产品增加了身体防御感染的能力。

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