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    • 3. 发明授权
    • Cancer-associated gene
    • 癌症相关基因
    • US07790866B2
    • 2010-09-07
    • US10535733
    • 2003-11-20
    • Osamu OharaTakahiro NagaseReiko KikunoShin-ichi Funahashi
    • Osamu OharaTakahiro NagaseReiko KikunoShin-ichi Funahashi
    • C07H21/02C07H21/04C07K14/00C07K17/00C12P21/06C12P19/34C12N15/64
    • C12N9/1048C07K14/4748
    • The present invention provides: a novel DNA, a carcinoma-associated gene comprising the DNA, a recombinant protein encoded by the DNA, an antibody binding to the protein, an anti-carcinoma agent comprising the antibody, a low-molecular-weight compound binding to the protein, and a screening system. An example of such a novel DNA is a DNA comprising a nucleotide sequence encoding the following polypeptide (a) or (b): (a) a polypeptide, consisting of an amino acid sequence identical to or substantially identical to the amino acid sequence represented by SEQ ID NO: 2; or (b) a polypeptide, consisting of an amino acid sequence derived from the amino acid sequence represented by SEQ ID NO: 2 by deletion, substitution, or addition of one or a plurality of amino acids and having biological activity substantially equivalent to the functions of the polypeptide (a).
    • 本发明提供:新型DNA,包含DNA的癌相关基因,由DNA编码的重组蛋白,与蛋白结合的抗体,包含抗体的抗癌剂,结合 蛋白质和筛选系统。 这样的新型DNA的实例是包含编码以下多肽(a)或(b)的核苷酸序列的DNA:(a)多肽,由与氨基酸序列相同或基本相同的氨基酸序列组成, SEQ ID NO:2; 或(b)通过缺失,取代或添加一个或多个氨基酸并具有与功能基本相同的生物学活性的由SEQ ID NO:2所示的氨基酸序列衍生的氨基酸序列组成的多肽 的多肽(a)。
    • 4. 发明申请
    • Gene Encoding G-Protein Coupled Receptor and Gene Product Thereof
    • 基因编码G蛋白偶联受体及其基因产物
    • US20090203073A1
    • 2009-08-13
    • US12409847
    • 2009-03-24
    • Osamu OharaTakahiro NagaseMichio OhishiDaisuke OkajimaHiroshi Yokota
    • Osamu OharaTakahiro NagaseMichio OhishiDaisuke OkajimaHiroshi Yokota
    • C12P21/00C12N15/11C12N15/00C12N5/06
    • G01N33/74G01N2333/726
    • The present invention, the objects of which are to find out a gene encoding a protein having functions equivalent to those of G-protein-coupled receptor (GPCR) and the protein, and to provide a method for identifying a compound that regulates functions and/or expression of the protein, and to provide a useful mean for preventing and/or treating diseases related to the gene and the protein, provides a DNA comprising base sequence described in SEQ ID NO: 1 or complementary strand thereof, complementary strand of the DNA, a protein encoded by the DNA, a vector containing the DNA, a transformant containing the vector, an antibody against the protein, a method for identifying a compound that regulates functions and/or expression of the protein using aforementioned members, an agent for improving and a method for improving depression state, a pharmaceutical composition, and a reagent kit.
    • 本发明的目的是找出编码具有与G蛋白偶联受体(GPCR)和蛋白质相同功能的蛋白质的基因,并提供一种鉴定调节功能的化合物和/ 或蛋白质的表达,并且为预防和/或治疗与该基因和蛋白质相关的疾病提供有用的平均值,提供包含SEQ ID NO:1或其互补链中所述的碱基序列的DNA,DNA的互补链 ,由DNA编码的蛋白质,含有该载体的载体,含有该载体的转化子,针对该蛋白质的抗体,使用上述成员鉴定调节蛋白质的功能和/或表达的化合物的方法,改善剂 以及改善抑郁状态的方法,药物组合物和试剂盒。
    • 7. 发明申请
    • Novel genes and proteins encoded thereby
    • 由此编码的新型基因和蛋白质
    • US20060160082A1
    • 2006-07-20
    • US10530880
    • 2003-10-16
    • Osamu OharaTakahiro NagaseReiko Kikuno
    • Osamu OharaTakahiro NagaseReiko Kikuno
    • C12Q1/68C07H21/02C12P21/06C07K14/705C07K16/28
    • C07K14/47
    • A novel DNA comprising a protein-encoding region is directly cloned from cDNA library originating from human adult whole brain and human fetal whole brain, the base sequence thereof is determined, and the functions thereof are identified. A DNA comprising a base sequence encoding the following polypeptide (a) or (b): (a) a polypeptide consisting of an amino acid sequence which is identical or substantially identical with the amino acid sequence represented by SEQ ID No.1, (b) a polypeptide consisting of an amino acid sequence represented by SEQ ID No.1 in which part of amino acids are deleted, substituted or added, and having substantially the same biological activity as the function of the polypeptide (a), recombinant polypeptide encoded by the above DNAs, and protein comprising the polypeptide.
    • 从源自人成人全脑和人胎儿全脑的cDNA文库直接克隆包含蛋白质编码区的新型DNA,确定其碱基序列,鉴定其功能。 包含编码以下多肽(a)或(b)的碱基序列的DNA:(a)由与SEQ ID No.1所代表的氨基酸序列相同或基本相同的氨基酸序列组成的多肽 )由SEQ ID No.1所示的氨基酸序列组成的多肽,其中部分氨基酸缺失,取代或添加,并且具有与多肽(a)的功能基本上相同的生物学活性,由 上述DNA和包含该多肽的蛋白质。
    • 8. 发明授权
    • Method for detecting DNA polymorphism applying triple strand DNA formation technique
    • 检测应用三链DNA形成技术的DNA多态性的方法
    • US06849410B2
    • 2005-02-01
    • US09989526
    • 2001-11-21
    • Yasushi ShigemoriMichio OishiOsamu Ohara
    • Yasushi ShigemoriMichio OishiOsamu Ohara
    • C12N15/09C07H21/02C07H21/04C12P19/34C12Q1/68
    • C12Q1/6827C12Q1/6839C12Q2537/119C12Q2527/107C12Q2521/507
    • An objective of this invention is to provide a method for detecting DNA polymorphism that has high sensitivity and efficiency and does not need long DNA searching region.A homologous recombination protein RecA makes partial triple strand DNA from target double DNA and oligonucleotide probe complementary to the DNA. The triple strand DNA maintains stable triple strand DNA after RecA protein is removed. The present inventors found that the thermostability of triple strand DNA changes greatly when there is a mismatch between target DNA and oligonucleotide probe because of the existence of polymorphism in the target DNA. Utilizing this change of thermostability, efficient detection of polymorphism in labeled DNA is possible by examining whether oligonucleotide probe is released and the triple strand DNA is solved after heat treatment of triple strand DNA formed using homologous recombination protein.
    • 本发明的目的是提供一种检测DNA多态性的方法,其具有高灵敏度和高效性并且不需要长的DNA搜索区。同源重组蛋白RecA使得来自靶双重DNA的部分三链DNA和与DNA互补的寡核苷酸探针 。 在除去RecA蛋白后,三链DNA保持稳定的三链DNA。 本发明人发现,由于目标DNA中存在多态性,当靶DNA和寡核苷酸探针之间存在错配时,三链DNA的热稳定性变化很大。 利用这种热稳定性的变化,可以通过检查寡核苷酸探针是否被释放并且在使用同源重组蛋白形成的三链DNA热处理后求解三链DNA来有效地检测标记的DNA中的多态性。