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1. 发明申请

US20120302609A1 Pyrazolines for the Modulation of PKM2 审中-公开
标题翻译：吡唑啉用于调节PKM2
公开(公告)号：US20120302609A1
公开(公告)日：2012-11-29
申请号：US13479131
申请日：2012-05-23
申请人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Daniel Sherman , Vered Behar , Osnat Kashtan , Alexander Konson
发明人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Daniel Sherman , Vered Behar , Osnat Kashtan , Alexander Konson
IPC分类号： A61K31/4155 , A61K31/415 , C07D405/10 , C07D405/14 , C07D401/06 , A61P35/00 , C07D409/04 , A61P37/00 , A61P37/06 , A61P29/00 , A61P3/00 , C07D231/06 , A61K31/4439
CPC分类号： C07D231/06 , C07D401/06 , C07D405/04 , C07D405/06 , C07D405/12 , C07D405/14 , C07D409/04
摘要： The invention relates to pyrazoline substituted compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译：本发明涉及吡唑啉取代的化合物和激活PKM2的方法。所述化合物和方法可用于治疗或预防选自癌症，细胞增殖性疾病，炎症性疾病，代谢紊乱和免疫系统疾病的疾病或病症。

2. 发明授权

US08692001B2 Sulfonamides for the modulation of PKM2 失效
标题翻译：用于调节PKM2的磺酰胺
公开(公告)号：US08692001B2
公开(公告)日：2014-04-08
申请号：US13281929
申请日：2011-10-26
申请人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号： C07D405/02 , A61K31/405
CPC分类号： C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译：本发明涉及磺酰胺化合物和激活PKM2的方法。所述化合物和方法可用于治疗或预防选自癌症，细胞增殖性疾病，炎症性疾病，代谢紊乱和免疫系统疾病的疾病或病症。

3. 发明申请

US20120108631A1 Sulfonamides for the Modulation of PKM2 失效
标题翻译：用于调节PKM2的磺酰胺
公开(公告)号：US20120108631A1
公开(公告)日：2012-05-03
申请号：US13281929
申请日：2011-10-26
申请人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
发明人： Oren M. Becker , Alina Shitrit , Nili Schutz , Efrat Ben-Zeev , Avihai Yacovan , Rachel Ozeri , Tzofit Kehat , Sima Mirilashvili , Alex Aizikovich , Daniel Sherman , Vered Behar , Osnat Kashtan
IPC分类号： A61K31/404 , C07D319/18 , C07D403/12 , C07D209/08 , A61P37/00 , A61K31/4709 , A61K31/357 , A61P35/00 , A61P29/00 , A61P3/00 , C07D405/12 , C07D405/14
CPC分类号： C07D209/08 , C07D319/18 , C07D403/12 , C07D413/12 , C07D413/14
摘要： The invention relates to sulfonamide compounds and methods for activating PKM2. The compounds and methods are useful in treating or preventing a disease or disorder selected from cancer, cell proliferative disorder, inflammatory disorder, metabolic disorder, and immune system disorder.
摘要翻译：本发明涉及磺酰胺化合物和激活PKM2的方法。所述化合物和方法可用于治疗或预防选自癌症，细胞增殖性疾病，炎性疾病，代谢紊乱和免疫系统疾病的疾病或病症。

4. 发明授权

US4349982A Refillable rodent bait station container 失效
标题翻译：可补充的啮齿动物诱饵站集装箱
公开(公告)号：US4349982A
公开(公告)日：1982-09-21
申请号：US202670
申请日：1980-10-31
申请人： Daniel Sherman
发明人： Daniel Sherman
IPC分类号： A01M25/00
CPC分类号： A01M25/004
摘要： This invention relates to rodent bait stations in general and more specifically to a bait station which is spill proof, tamper proof, and provides metered amounts of rodentcide divided between two separate feeding compartments within the bait station.
摘要翻译：本发明一般涉及啮齿动物诱饵站，更具体地涉及一种防瘟，防篡改的诱饵站，并且在诱饵站内的两个分开的进料室之间提供计量量的杀鼠剂。

5. 发明申请

US20100330025A1 Surface Independent, Surface-Modifying, Multifunctional Coatings and Applications Thereof 有权
标题翻译：表面独立，表面改性，多功能涂料及其应用
公开(公告)号：US20100330025A1
公开(公告)日：2010-12-30
申请号：US12793653
申请日：2010-06-03
申请人： Phillip B. Messersmith , Andrea R. Statz Sloan , Bruce P. Lee , Jeffrey L. Dalsin , Daniel Sherman , Haeshin Lee
发明人： Phillip B. Messersmith , Andrea R. Statz Sloan , Bruce P. Lee , Jeffrey L. Dalsin , Daniel Sherman , Haeshin Lee
IPC分类号： C09D5/16 , B05D3/10 , C07C215/00
CPC分类号： C09D5/1693 , A61L27/34 , A61L27/50 , A61L29/085 , A61L29/14 , A61L31/10 , A61L31/14 , A61L2400/18 , B05D1/185 , B05D3/10 , B82Y30/00 , B82Y40/00 , C09D5/1637 , C23C18/1844 , C23C18/31 , C08L89/00 , C08L71/02
摘要： The invention provides surface treatments that reduce or eliminate marine biofouling of various surfaces. A surface that is to be subjected to a marine environment can be treated with a mPEG-DOPA. The treated surface is thus rendered less susceptible to fouling of the surface.
摘要翻译：本发明提供了减少或消除各种表面的海洋生物污损的表面处理。要经受海洋环境的表面可以用mPEG-DOPA处理。因此，处理过的表面不易受到表面的结垢的影响。

6. 发明申请

US20060204414A1 Bed support media 审中-公开
标题翻译：床支持媒体
公开(公告)号：US20060204414A1
公开(公告)日：2006-09-14
申请号：US11078776
申请日：2005-03-11
申请人： Dean Warner , Hassan Niknafs , Daniel Sherman
发明人： Dean Warner , Hassan Niknafs , Daniel Sherman
IPC分类号： B01J8/02
CPC分类号： B01J8/0453 , B01J19/30 , B01J2208/025 , B01J2219/30223 , B01J2219/30238 , B01J2219/30416 , B01J2219/30475 , B01J2219/312 , B01J2219/315
摘要： A system for treatment of one or more flowing materials includes a support bed (32) comprising a plurality of support elements (34). The support bed may have a void fraction of at least 45%. An active bed (36), such as a bed of catalytic elements, may be supported by the support bed. The void fraction of the support bed may be larger than that of an equivalent bed of conventional, spherical elements, enabling significant improvements in the flow rate of reactants through the bed and/or a reduced pressure drop across the support bed.
摘要翻译：用于处理一种或多种流动材料的系统包括包括多个支撑元件（34）的支撑床（32）。支撑床可具有至少45％的空隙率。活动床（36），例如催化元件床，可以由支撑床支撑。支撑床的空隙率可以大于常规球形元件的等效床的空隙率，可以显着改善反应物通过床的流速和/或在支撑床上的降低的压降。

7. 发明申请

US20050112566A1 Method and apparatus for the in-situ preparation of macromolecules via uniform glow discharge plasma 审中-公开
标题翻译：通过均匀辉光放电等离子体原位制备大分子的方法和装置
公开(公告)号：US20050112566A1
公开(公告)日：2005-05-26
申请号：US10257827
申请日：2001-10-10
申请人： Kimberly Kelly-Wintenberg , Daniel Sherman , Suzanne South
发明人： Kimberly Kelly-Wintenberg , Daniel Sherman , Suzanne South
IPC分类号： A61N1/44 , C12N1/06 , C12N15/10 , C12Q1/68 , C12Q1/6806 , G01N33/543 , B05D3/00 , G01N33/53
CPC分类号： C12N13/00 , A61N1/44 , C12M47/06 , C12N1/06 , C12N1/066 , C12N15/1003 , C12Q1/6806 , G01N33/54353 , C12Q2527/109
摘要： The present invention is directed toward an apparatus for the in-situ preparation of macromolecules via uniform glow discharge plasma, and a method for using the apparatus. The method and apparatus are designed for preparing macromolecules from biological materials, including at least DNA, RNA, saccharides, lipids and proteins, in a manner which eliminates the need for biological solvents or chemicals, grinders, freezing, or detergents. The present invention is capable of operating at one atmosphere of pressure. The present method is a non-destructive, thus rendering the yielded macromolecules amenable for further modification or analysis via exposure to the glow discharge plasma sustained at substantially atmospheric pressure in air or modified gas environments. The device includes a spaced apart pair of metallic electrodes. At least one of the electrodes is covered with a high dielectric insulation material. A power supply is provided for energizing the electrodes. In the method, the biological material is placed on a substrate or suspended in solution and then placed within the device. The biological material is immersed in direct contact with the plasma or an active species generated by the plasma such that the exterior of the biological material is disrupted, yielding the macromolecules generally intact and available for analysis and/or modification.
摘要翻译：本发明涉及一种用于通过均匀辉光放电等离子体原位制备大分子的装置，以及使用该装置的方法。该方法和设备被设计用于从生物材料制备大分子，包括至少包括DNA，RNA，糖类，脂质和蛋白质，以不需要生物溶剂或化学品，研磨剂，冷冻或去污剂的方式。本发明能够在一个压力的气氛下操作。本方法是非破坏性的，因此使得产生的大分子可以通过暴露于空气或改性气体环境中基本上大气压下持续的辉光放电等离子体进行进一步的修饰或分析。该装置包括间隔开的一对金属电极。至少一个电极被高介电绝缘材料覆盖。提供用于对电极通电的电源。在该方法中，将生物材料放置在基底上或悬浮在溶液中，然后置于装置内。将生物材料浸入与等离子体或由等离子体产生的活性物质直接接触，使得生物材料的外部破裂，产生大体完整的大分子并且可用于分析和/或修饰。

8. 发明申请

US20060273656A1 Braking system for a lift truck 有权
标题翻译：叉车制动系统
公开(公告)号：US20060273656A1
公开(公告)日：2006-12-07
申请号：US11369468
申请日：2006-03-07
申请人： Daniel Sherman , Joe Hammer
发明人： Daniel Sherman , Joe Hammer
IPC分类号： B60T17/16
CPC分类号： B60T13/04 , B60T13/662 , B60T13/74 , B60T13/746 , B66F9/07509
摘要： A braking system for a lift truck performs all service braking using truck traction drive motors. Mechanical, spring applied, electrically released brakes are coupled to wheels on opposite sides of the truck with the mechanical brakes applying unequal braking forces to the wheels. The mechanical brakes perform park braking and, in the event an electrical system problem arises, backup braking as well that can be modulated by an operator of the truck regardless of the operating condition of the truck.
摘要翻译：用于起重车的制动系统使用卡车牵引驱动电机执行所有的制动。机械，弹簧应用，电气释放的制动器与卡车的相对侧上的车轮相连，机械制动器对车轮施加不相等的制动力。机械制动器执行停车制动，并且在出现电气系统问题的情况下，也可以由卡车的操作者调节后备制动器，而不管卡车的操作状况如何。

9. 发明申请

US20060251555A1 Bed support media 有权
公开(公告)号：US20060251555A1
公开(公告)日：2006-11-09
申请号：US11124969
申请日：2005-05-09
申请人： Dean Warner , Hassan Niknafs , Daniel Sherman
发明人： Dean Warner , Hassan Niknafs , Daniel Sherman
IPC分类号： B01J8/02 , B01J35/02
CPC分类号： B01J8/025 , B01J8/02 , B01J8/0278 , B01J8/0292 , B01J8/0453 , B01J8/0492 , B01J19/30 , B01J35/0006 , B01J35/023 , B01J35/10 , B01J2208/00539 , B01J2208/00548 , B01J2208/00672 , B01J2208/00681 , B01J2208/0069 , B01J2208/025 , B01J2219/30207 , B01J2219/30215 , B01J2219/30219 , B01J2219/30223 , B01J2219/30234 , B01J2219/30238 , B01J2219/30242 , B01J2219/30246 , B01J2219/30296 , B01J2219/30408 , B01J2219/30416 , B01J2219/30466 , B01J2219/30475 , B01J2219/3083
摘要： A system for treatment of one or more flowing materials includes a support bed (32) comprising a plurality of support elements (34). The support bed may have a void fraction of at least 45%. An active bed (36), such as a bed of catalytic elements, may be supported by the support bed. The void fraction of the support bed may be larger than that of an equivalent bed of conventional, spherical elements, enabling significant improvements in the flow rate of reactants through the bed and/or a reduced pressure drop across the support bed.

10. 发明授权

US4908980A Flying insect control device 失效
标题翻译：飞行昆虫控制装置
公开(公告)号：US4908980A
公开(公告)日：1990-03-20
申请号：US264375
申请日：1988-10-31
申请人： Daniel Sherman
发明人： Daniel Sherman
IPC分类号： A01M1/04 , A01M1/20
CPC分类号： A01M1/2083 , A01M1/04 , A01M2200/012
摘要： This invention relates to the control of flying insects in and around homes, commercial establishments, farm buildings and the like. Specifically, the formulation, design and technique involved in the device allows the user to maintain an insect free environment and to dispense an insecticide capable of eliminating flying insects in a safe and effective manner. The use of a translucent shield that contains an insecticide that leeches to the surface through the heat of ambient light, while converting ambient light into a spectrum that attracts flying insects provides an economical method of delivering a killing agent to the insect.
摘要翻译：本发明涉及在家庭，商业场所，农场建筑物等内及其周围飞行昆虫的控制。具体地说，该装置所涉及的配方，设计和技术允许用户保持无昆虫的环境，并以安全有效的方式分配能够消除飞虫的杀虫剂。使用含有通过环境光的热量向表面渗透的杀虫剂的半透明屏蔽物，同时将环境光转换成吸引飞虫的光谱提供了向昆虫递送杀伤剂的经济方法。

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