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1. 发明申请

US20040142390A1 Novel mammalian catecholamine receptor genes and uses 审中-公开
标题翻译：新型哺乳动物儿茶酚胺受体基因及用途
公开(公告)号：US20040142390A1
公开(公告)日：2004-07-22
申请号：US10769131
申请日：2004-01-30
申请人： Oregon Health Sciences University, a non-profit organization
发明人： James R. Bunzow , David K. Grandy
IPC分类号： G01N033/53 , G01N033/567 , C07H021/04 , C07K014/705
CPC分类号： C07K14/723 , A61K38/00
摘要： The present invention relates to novel mammalian catecholamine receptor proteins and genes that encode such proteins. The invention is directed toward the isolation and characterization of mammalian catecholamine receptor proteins. The invention specifically provides isolated complementary DNA copies of mRNA corresponding to rat and human homologues of a mammalian catecholamine receptor gene. Also provided are recombinant expression constructs capable of expressing the mammalian catecholamine receptor genes of the invention in cultures of transformed prokaryotic and eukaryotic cells, as well as such cultures of transformed cells that synthesize the mammalian catecholamine receptor proteins encoded therein. The invention also provides methods for screening compounds in vitro that are capable of binding to the mammalian catecholamine receptor proteins of the invention, and further characterizing the binding properties of such compounds in comparison with known catecholamine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译：本发明涉及新型的哺乳动物儿茶酚胺受体蛋白质和编码这种蛋白质的基因。本发明涉及哺乳动物儿茶酚胺受体蛋白的分离和表征。本发明特别提供了与哺乳动物儿茶酚胺受体基因的大鼠和人类同源物相对应的mRNA的分离的互补DNA拷贝。还提供了能够在转化的原核和真核细胞的培养物中表达本发明的哺乳动物儿茶酚胺受体基因以及合成其中编码的哺乳动物儿茶酚胺受体蛋白质的转化细胞的这种培养物的重组表达构建体。本发明还提供了在体外筛选能够结合本发明的哺乳动物儿茶酚胺受体蛋白的方法，并且与已知的儿茶酚胺受体激动剂和拮抗剂相比进一步表征了这些化合物的结合性质。从而提供改进的药理学筛选方法。

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