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1. 发明授权

US5874411A Oligosaccharide glycosides having mammalian immunosuppresive and tolerogenic properties 失效
标题翻译：具有哺乳动物免疫抑制和耐受性的寡糖糖苷
公开(公告)号：US5874411A
公开(公告)日：1999-02-23
申请号：US754097
申请日：1996-11-13
申请人： Om P. Srivastava , Geeta Srivastava , Roman Szweda , David R. Bundle , Ole Hindsgaul , H. Rizk Hanna , Kevin Holme , Frank W. Barresi , Minghui Du
发明人： Om P. Srivastava , Geeta Srivastava , Roman Szweda , David R. Bundle , Ole Hindsgaul , H. Rizk Hanna , Kevin Holme , Frank W. Barresi , Minghui Du
IPC分类号： C07H3/04 , C07H3/06 , C07H9/02 , C07H15/00 , A61K31/70
CPC分类号： C07H3/04 , C07H15/00 , C07H3/06 , C07H9/02
摘要： Disclosed are novel oligosaccharide glycosides having mammalian immunosuppressive and tolerogenic properties, pharmaceutical compositions containing such oligosaccharide glycosides and to methods of using such oligosaccharide glycosides to modulate cell-mediated immune responses in a mammal.
摘要翻译：公开了具有哺乳动物免疫抑制和耐受性的新型寡糖糖苷，含有这种寡糖糖苷的药物组合物以及使用这种寡糖糖苷来调节哺乳动物细胞介导的免疫应答的方法。

2. 发明授权

US06303764B1 Synthesis of 4,7-dialkyl chromogenic glycosides of N-acetylneuraminic acids 失效
标题翻译： N-乙酰神经氨酸的4,7-二烷基显色糖苷的合成
公开(公告)号：US06303764B1
公开(公告)日：2001-10-16
申请号：US09406024
申请日：1999-09-24
申请人： Om Srivastava , Geeta Srivastava , Minghui Du , Ole Hindsgaul , David R. Bundle , Avraham Liav
发明人： Om Srivastava , Geeta Srivastava , Minghui Du , Ole Hindsgaul , David R. Bundle , Avraham Liav
IPC分类号： G07G300
CPC分类号： C07K14/005 , C12N2760/16122 , C12N2760/16222 , C12P19/14
摘要： The present invention provides an improved method of preparing a 4,7-di-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in detecting influenza virus types A and B. The ketosides are substrates that are selectively cleaved by a neuraminidase on influenza virus, but not be neuraminidases found on other viruses or on bacteria. The synthesis is efficient and provides large quantities of the ketoside for commercial development. The synthesis includes a step of alkylating the 4- and 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by a process that comprises contacting the derivative with a composition comprising an alkyl halide to form a 4,7-di-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The synthesis alternatively includes protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.
摘要翻译：本发明提供一种制备用于检测A型和B型流感病毒的N-乙酰神经氨酸（Neu5Ac）的4,7-二-O-烷基显色酮面的改进方法。酮是一种由神经氨酸酶对流感病毒，但不是在其他病毒或细菌上发现的神经氨酸酶。该合成是有效的，并为商业开发提供大量的酮基。该合成包括通过包括使衍生物与包含烷基卤的组合物接触以形成4,7-二-O-的方法使得Neu5Ac的被保护的烷基酯烷基酮酮衍生物的4-和7-羟基烷基化的步骤烷基保护的烷基酯Neu5Ac的烷基酮基衍生物。合成交替地包括通过形成Neu5Ac的8,9-环氧化物保护的烷基酯烷基酮内酯衍生物来保护Neu5Ac的烷基酯烷基酮酮衍生物的8-和9-羟基。

3. 发明授权

US06420552B1 Syntheses of 4-alkyl chromogenic glycosides and 7-alkyl chromogenic glycosides of N-acetylneuraminic acids 失效
标题翻译： N-乙酰神经氨酸的4-烷基显色糖苷和7-烷基显色糖苷的合成
公开(公告)号：US06420552B1
公开(公告)日：2002-07-16
申请号：US09650162
申请日：2000-08-29
申请人： Om Srivastava , Geeta Srivastava , Minghui Du , Ole Hingsgaul , David R. Bundle
发明人： Om Srivastava , Geeta Srivastava , Minghui Du , Ole Hingsgaul , David R. Bundle
IPC分类号： C07H100
CPC分类号： C07H15/04 , C07H7/027
摘要： The present invention provides improved method of preparing a 4-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) and a 7-O-alkyl chromogenic ketoside of N-acetylneuraminic acid (Neu5Ac) for use in the selective detection of various influenza viruses and parainfluenza viruses. The ketosides are substrates that are selectively cleaved by a neuraminidase on the virus to be detected, but not by neuraminidases found on other viruses or on bacteria, or on the cells of the host. The syntheses are efficient and provide large quantities of the ketosides for commercial development. The synthesis includes a step of alkylating the 4- or 7-hydroxyl groups of a protected alkyl ester alkyl ketoside derivative of Neu5Ac by processes that include contacting the derivative with a composition comprising an alkyl halide to form a 4- or a 7-O-alkyl protected alkyl ester alkyl ketoside derivative of Neu5Ac. The syntheses alternatively include protecting the 8- and 9-hydroxyl groups of an alkyl ester alkyl ketoside derivative of Neu5Ac by forming an 8,9-ketal or an 8,9-epoxide protected alkyl ester alkyl ketoside derivative of Neu5Ac.
摘要翻译：本发明提供了制备用于选择性检测各种流感的N-乙酰神经氨酸（Neu5Ac）的4- O-烷基显色酮面和N-乙酰神经氨酸（Neu5Ac）的7- O-烷基显色酮二酮的改良方法病毒和副流感病毒。酮氧化物是被待检测的病毒上的神经氨酸酶选择性地切割而不是其它病毒或细菌或宿主细胞上发现的神经氨酸酶的底物。合成是有效的，并提供大量用于商业开发的酮基。合成包括通过包括使衍生物与包含烷基卤化物的组合物接触以形成4-或7- O-O-的方法使Neu5Ac的被保护的烷基酯烷基酮酮衍生物的4-或7-羟基烷基化的步骤烷基保护的烷基酯Neu5Ac的烷基酮基衍生物。所述合成交替包括通过形成Neu5Ac的8,9-缩酮或8,9-环氧化物保护的烷基酯酮基衍生物来保护Neu5Ac的烷基酯烷基酮内酯衍生物的8-和9-羟基。

4. 发明授权

US07605255B2 Non-animal based lactose 失效
标题翻译：非动物型乳糖
公开(公告)号：US07605255B2
公开(公告)日：2009-10-20
申请号：US11427543
申请日：2006-06-29
申请人： Donna Day , Minghui Du , Roberto Mendez , Darol Maunder
发明人： Donna Day , Minghui Du , Roberto Mendez , Darol Maunder
IPC分类号： C07H3/04
CPC分类号： C07H1/00 , C07H3/04 , Y02P20/55
摘要： A synthetic procedure for the preparation of non-animal based lactose from 4′-epimeric analogue of lactose by use of orthogonal protecting groups, formation of a suitable leaving group at the 4′-position, stereochemical inversion by nucleophilic attack and deprotection.
摘要翻译：用于通过使用正交保护基团从乳糖的4'-差向异构体类似物制备非动物型乳糖的合成方法，在4'-位上形成合适的离去基团，通过亲核攻击和脱保护进行立体化学反转。

5. 发明授权

US07816563B1 Method for preparing hypocrellin 失效
标题翻译：制备青霉素的方法
公开(公告)号：US07816563B1
公开(公告)日：2010-10-19
申请号：US12633595
申请日：2009-12-08
申请人： Minghui Du , Darol Maunder
发明人： Minghui Du , Darol Maunder
IPC分类号： C07C45/00
CPC分类号： C07C45/29 , C07C45/66 , C07C2603/52 , C07C2603/54 , C07C49/755
摘要： Improved methods of preparing hypocrellin B from 4,9-dihydroxy-3,10-perylenequinones are described.
摘要翻译：描述了从4,9-二羟基-3,10-苝醌制备轻链霉素B的改进方法。

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